Clinical trials: Rectal Hypersensitivity
Fecal Incontinence
Effect of 7 Days of Dosing With a 10 mg Rectal Suppository of NRL001in Patients With Faecal Incontinence
This is a study to examine the effect of alpha adrenergic stimulation of the anal canal and rectum on parameters affecting the control of defecation in subjects with faecal incontinence.
- Trial name
- NCT01175941
- Testing
- NRL001
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- Norgine
Colorectal Cancer, Gastric Cancer (GC)
Topical Diclofenac for Hand-Foot Syndrome Prevention in Colorectal and Gastric Cancer on Capecitabine (DICLO-HFS)
Hand-foot syndrome (HFS) is a frequent adverse effect of capecitabine, presenting with redness, swelling, pain, and peeling of the skin on the palms and soles.
- Conditions
- Colorectal Cancer, Gastric Cancer (GC), Capecitabine, Hand Foot Syndrome
- Trial name
- DICLO-HFS (NCT07177560)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 151 people
- Sponsor
- Gazi University
Eosinophilic Esophagitis, Gastroesophageal Reflux Disease (GERD)
Indiana University Gastrointestinal Motility Diagnosis Registry
Develop a registry (list of patients) with accurate clinical motility diagnosis. This registry will help the doctors to identify the patients with specific disease conditions.
- Conditions
- Eosinophilic Esophagitis, Gastroesophageal Reflux Disease (GERD), Gastroparesis, Functional Vomiting
- Trial name
- NCT04506593
- Testing
- no intervention
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Indiana University
Colorectal Cancer
SCar-biopsies After Malignant Colorectal Polypectomy of Uncertain RAdicality
After endoscopic removal of a colorectal polyp that harbors (unexpected) adenocarcinoma, pathology usually can not guarantee a radical resection from an oncological point of view.
- Trial name
- SCAPURA (NCT02328664)
- Testing
- Flexible sigmoidoscopy or colonoscopy
- Where
- 36 sites in Netherlands
- Volunteers
- 246 people
- Sponsor
- Dr. Frank ter Borg MD PhD
Colon Cancer, Rectal Cancer
Drug Sensitivity Detection of Micro Tumor (PTC) to Guide Postoperative Adjuvant Treatment Strategy of Colorectal Cancer
The research objectives is to compare vitro 3D drug sensitivity test results of micro tumor (PTC) with the clinical outcomes of patients, evaluate the consistency between the test results of the technology platform and the…
- Conditions
- Colon Cancer, Rectal Cancer, Chemotherapy Effect, PTC
- Trial name
- NCT05424692
- Testing
- 5-fluorouracil + formyltetrahydrofolate/Oxaliplatin + 5-fluorouracil + formyltetrahydrofolate/Irinotecan + 5-fluorouracil + formyltetrahydrofolate/Cetuximab + 5-fluorouracil + formyltetrahydrofolate
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking Union Medical College Hospital
Metastatic Colorectal Cancer (mCRC)
Evaluation of a Diagnostic Test to Identify the Best Drugs for Treatment of Metastatic Colorectal Cancer
DSEE-CRC is a top-tier Norwegian and Swedish public-private partnership for the development of µCAN, a unique patient-centric, therapy-guiding in vitro diagnostic test to improve cancer treatment outcomes for metastatic…
- Trial name
- DSEE-CRC (NCT07171554)
- Testing
- µCAN drug screen test, Standard-of-Care Therapy
- Where
- Norway
- Volunteers
- 75 people
- Sponsor
- Oncosyne AS
Rectal Hypersensitivity, Irritable Bowel Syndrome-Constipation
SAT vs Escitalopram for Rectal Hypersensitivity
Constipation is a common digestive disorder. After excluding dietary factors, drugs and other secondary causes, at least three broad pathophysiologic subtypes are recognized- dyssynergic defecation, constipation-predominant…
- Trial name
- NCT00584571
- Testing
- Sensory Adaptation Training, Escitalopram Therapy
- Where
- 2 sites in United States
- Volunteers
- 55 people
- Sponsor
- Augusta University
Irritable Bowel Syndrome
Effect of Butyrogenic Fibers in IBS Patients
Despite there being no clearcut advantages, one of the most common recommendations in IBS management is to increase the amount of dietary fibres. In some IBS patients fibres have a deleterious effect on pain and bloating.
- Trial name
- NCT00314886
- Testing
- Diet
- Where
- France
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Organoids, Rectal Cancer
Organoids in Predicting Chemoradiation Sensitivity on Rectal Cancer
Patients with locally advanced rectal cancer will receive biopsy before the standard treatment of neoadjuvant chemoradiation. The investigators are going to establish organoids model from the pre-treatment biopsies and expose…
- Conditions
- Organoids, Rectal Cancer, Chemoradiation
- Trial name
- NCT03577808
- Testing
- Biopsy
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Zhen Zhang
All Diagnosed Health Conditions, ADD/ADHD
At-Home Research Study for Patients With Autoimmune, Inflammatory, Genetic, Hematological, Infectious, Neurological, CNS, Oncological, Respiratory, Metabolic Conditions
We are the missing link in clinical trials, connecting patients and researchers seamlessly and conveniently using a mobile health platform to advance medical research.
- Conditions
- All Diagnosed Health Conditions, ADD/ADHD, Alopecia Areata, Ankylosing Spondylitis
- Trial name
- NCT01931644
- Where
- United States
- Volunteers
- 17,667 people, healthy volunteers welcome
- Sponsor
- Sanguine Biosciences
Colo-rectal Cancer
PTC Drug Sensitivity Detection to Guide Postoperative Adjuvant of Colorectal Cancer
The research objectives is to compare vitro 3D drug sensitivity test results of micro tumor (PTC) with the clinical outcomes of patients, evaluate the consistency between the test results of the technology platform and the…
- Trial name
- NCT05978349
- Testing
- adjuvant therapy based on 3D drug sensitivity test results of micro tumor (PTC) in vitro
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Peking Union Medical College Hospital
Ewing Sarcoma, PEComa
Nivolumab (Opdivo®) Plus ABI-009 (Nab-rapamycin) for Advanced Sarcoma and Certain Cancers
This study investigates the safety/toxicity and potential anti-tumor activity of sequential administration of nivolumab and escalating doses of the mammalian target of rapamycin (mTOR) inhibitor nab-rapamycin (ABI-009) in…
- Conditions
- Ewing Sarcoma, PEComa, Epithelioid Sarcoma, Desmoid Tumor
- Trial name
- NCT03190174
- Testing
- Nab-Rapamycin, Nivolumab
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Sarcoma Oncology Research Center, LLC
Irritable Bowel Syndrome
Manipulation of Visceral Hypersensitivity With Probiotic Bacteria in Irritable Bowel Syndrome
Irritable bowel syndrome is a common digestive disorder worldwide. However, there is no effective treatment of irritable bowel syndrome.
- Trial name
- NCT01139736
- Testing
- VSL#3
- Where
- Hong Kong
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Stage IV Colorectal Cancer
Study of FOLFIRI + Panitumumab Using Ultra-selection Technology of Patients With Stage IV Colorectal Cancer Refractory to Irinotecan Without Any Mutation on KRAS, PIK3Ca, BRAF and NRAS Genes Detected With Highly Sensitive Techniques
Open label Phase II study of FOLFIRI + Panitumumab using ultra-selection technology with next generation high sensitivity genotyping of patients with stage IV colorectal cancer refractory to irinotecan without any mutation on…
- Trial name
- ULTRA (NCT01704703)
- Testing
- panitumumab, FOLFIRI
- Where
- Spain
- Volunteers
- 72 people
- Sponsor
- Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD)
Stage II Colorectal Cancer
MRD Test in Common Risk Stage II Colorectal Cancer
Patients with colorectal cancer who were confirmed as stage II general risk type in the postoperative pathological report began to be enrolled.
- Trial name
- HuaMC-1 (NCT05795010)
- Testing
- MRD test
- Where
- China
- Volunteers
- 60 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Irritable Bowel Syndrome
Exploring the Mechanism of a Probiotic Combination VSL#3 in Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is a very common chronic gastrointestinal disorder. Existing therapies for IBS are still far from satisfactory and new therapies are being constantly sought.
- Trial name
- NCT00786123
- Testing
- VSL#3
- Where
- Singapore
- Volunteers
- 40 people
- Sponsor
- National University Hospital, Singapore
Colorectal Cancer, Metastases
S-1 Versus Capecitabine in the First Line Treatment of MCC Patients.
The study is a two-arm randomised phase III trial. Patients will be randomised to receive capecitabine (arm A) or S-1 (arm B). Bevacizumab may be added according to the choice of the investigator.
- Trial name
- SALTO (NCT01918852)
- Testing
- Capecitabine, Teysuno, Bevacizumab
- Where
- 24 sites in Netherlands
- Volunteers
- 161 people
- Sponsor
- Dutch Colorectal Cancer Group
Rectal Adenocarcinoma, Rectal Cancer
ctDNA-Informed Management of Early-Stage Rectal Cancer
This is a phase 2 pragmatic study to examine the utility of ctDNA-informed treatment management for participants with early-stage rectal cancer using the Signatera Genome assay.
- Conditions
- Rectal Adenocarcinoma, Rectal Cancer, Early-stage Rectal Cancer, Locally Advanced Rectal Adenocarcinoma
- Trial name
- ULTIMATE (NCT07209215)
- Testing
- Signatera Genome ultra-sensitive ctDNA blood test + total neoadjuvant therapy (TNT)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of California, Davis
Hand and Foot Syndrome, Erythrodysesthesia Syndrome
Possible Protective Effect of Celecoxib Against Capecitabine Induced Hand and Foot Syndrome in Patients With Colorectal Cancer
Colorectal cancer (CRC) is the third most common cancer and the second leading cause of malignancy-related mortality. Capecitabine has been approved for the treatment of colorectal cancer as first-line therapy.
- Conditions
- Hand and Foot Syndrome, Erythrodysesthesia Syndrome, HFS, Colorectal Cancer
- Trial name
- HFS (NCT05327751)
- Testing
- Celecoxib 200mg, Capecitabine-based chemotherapy
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Tanta University
Locally Advanced Rectal Cancer
Correlation Between Gut Microbiota and Radiosensitivity of Rectal Cancer
The purpose of this process is to clarify the characteristics of gut microbiota changes in patients with locally advanced rectal cancer undergoing preoperative neoadjuvant treatment, and to identify key bacterial species closely…
- Trial name
- GMRSC-LARC (NCT06375434)
- Testing
- No intervention
- Volunteers
- 100 people
- Sponsor
- Jing-kun Liu