Clinical trials: Rectum Neoplasm
Cancer of the Rectum
Efficacy of Neoadjuvant Folfirinox Regimen in Patients With Resectable Locally Advanced Rectal Cancer
National, multi-center, open-label,randomized, 2-arm phase III superiority trial, comparing neoadjuvant chemotherapy (CT) with mFolfirinox followed by preoperative chemoradiotherapy (CRT), versus preoperative CRT in patients with…
- Trial name
- Néofirinox (NCT01804790)
- Testing
- mFolfirinox, Radiotherapy 50 Gy, Capecitabine
- Where
- 36 sites in France
- Volunteers
- 461 people
- Sponsor
- UNICANCER
Rectal Cancer, Consolidation
Chemoradiation and Consolidation Chemotherapy With or Without Oxaliplatin for Distal Rectal Cancer and Watch and Wait
Background: Neoadjuvant chemoradiation (nCRT) has been considered the preferred initial treatment strategy for distal rectal cancer.
- Trial name
- CCHOWW (NCT05000697)
- Testing
- Oxaliplatin, 5FU
- Where
- 24 sites in Argentina, Brazil and 1 more
- Volunteers
- 216 people
- Sponsor
- Hospital Alemão Oswaldo Cruz
Rectal Adenocarcinoma
Evaluation of Rectal Cancer Treatment Response Using PET/MRI
The investigators will be using the combination of FDG-PET and multiparametric MRI in pre- and post-adjuvant chemoradiation therapy in order to attempt to predict pathologic response on surgical resection.
- Trial name
- Rectal PET/MRI (NCT02233595)
- Testing
- Chemoradiation
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of California, San Francisco
Rectal Neoplasms
Endoscopic Submucosal Dissection vs. Transanal Endoscopic Surgery for Rectal Neoplasia
This prospective observational cohort study aims to compare the clinical and procedural outcomes of Endoscopic Submucosal Dissection (ESD) and Transanal Minimally Invasive Surgery (TAMIS) for the treatment of early-stage rectal…
- Trial name
- ESTER (NCT06902701)
- Testing
- Endoscopic Submucosal Dissection (ESD), Transanal Endoscopic Surgery (TES)
- Where
- 5 sites in Turkey (Türkiye)
- Volunteers
- 156 people
- Sponsor
- Turkish Society of Colon and Rectal Surgery
Cancer of Rectum
Standard Dose Versus High Dose of Radiotherapy in Rectal Preservation With Chemo-radiotherapy in Rectal Cancer Patients
In recent years, an increasing number of retrospective and prospective observational studies have indicated that a subset of rectal cancer patients may avoid surgery if they can achieve a complete response to chemoradiotherapy.
- Trial name
- WW3 (NCT04095299)
- Testing
- 50.4 Gy to the tumor and elective volume, 62 Gy to the clinical tumor volume and 50.4 Gy to the elective volume, Capecitabine 825 mg/m2 twice daily on weekdays
- Where
- 5 sites in Denmark
- Volunteers
- 162 people
- Sponsor
- Vejle Hospital
Rectal Cancer
Total Neoadjuvant mFOLFOX6 Plus Suvemcitug and Enlonstobart With Selective Omission of Pelvic Radiotherapy for High-Risk Mid-Rectal Locally Advanced Rectal Cancer
This is a prospective, multicenter, open-label, single-arm Phase II study designed to evaluate the efficacy and safety of total neoadjuvant mFOLFOX6 combined with suvemcitug and enlonstobart in patients with MRI（Magnetic…
- Trial name
- SPARE (NCT07810114)
- Testing
- mFOLFOX6, Suvemcitug, Enlonstobart
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Fudan University
Organoids, Rectal Cancer
Organoids in Predicting Chemoradiation Sensitivity on Rectal Cancer
Patients with locally advanced rectal cancer will receive biopsy before the standard treatment of neoadjuvant chemoradiation. The investigators are going to establish organoids model from the pre-treatment biopsies and expose…
- Conditions
- Organoids, Rectal Cancer, Chemoradiation
- Trial name
- NCT03577808
- Testing
- Biopsy
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Zhen Zhang
Genital Wart, Penile Cancer
A Phase III Study to Evaluate the Efficacy, Immunogenicity and Safety of the 9-valent HPV Vaccine in Chinese Males
This study is designed to evaluate the vaccine efficacy, immunogenicity and safety of the 9-valent (Types 6, 11, 16, 18, 31, 33, 45, 52 and 58) Human Papillomavirus (HPV) Recombinant Vaccine (Hansenula Polymorpha) in Chinese male…
- Conditions
- Genital Wart, Penile Cancer, Anal Cancer, PIN-1
- Trial name
- NCT06465914
- Testing
- 9-valent Human Papillomavirus (Types 6, 11, 16, 18, 31, 33, 45, 52 and 58) Recombinant Vaccine (Hansenula Polymorpha)
- Where
- 5 sites in China
- Volunteers
- 9,000 people, healthy volunteers welcome
- Sponsor
- Shanghai Bovax Biotechnology Co., Ltd.
Rectal Cancer
Neoadjuvant Treatment With Regorafenib and Capecitabine Combined With Radiotherapy in Locally Advanced Rectal Cancer
Despite treatment of locally advanced rectal cancer relapses are frequent. Several attempts to improve these results with therapy intensification have shown modest effect on disease free survival (DFS) and overall survival (OS).
- Trial name
- RECAP (NCT02910843)
- Testing
- Regorafenib, Capecitabine, Radiotherapy
- Where
- 7 sites in Switzerland
- Volunteers
- 25 people
- Sponsor
- Swiss Cancer Institute
Colorectal Cancer
Biomarkers in Predicting Response to Cetuximab in Patients With Advanced Colorectal Cancer
RATIONALE: Studying samples of tissue in the laboratory from patients who received cetuximab may help doctors understand and predict how well patients will respond to treatment.
- Trial name
- NCT01243372
- Testing
- mutation analysis, laboratory biomarker analysis
- Volunteers
- 1,142 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Parastomal Hernia, Rectal Adenocarcinoma
Chimney Trial of Parastomal Hernia Prevention
Chimney trial is designed to compare the effectiveness and safety of specifically designated polyvinylidene fluoride mesh (PVDF, Dynamesh IPST) to controls in a multi center, randomized setting.
- Conditions
- Parastomal Hernia, Rectal Adenocarcinoma, Abdominoperineal Resection
- Trial name
- NCT03799939
- Testing
- Intervention group
- Where
- 7 sites in Finland, Sweden
- Volunteers
- 141 people
- Sponsor
- University of Oulu
Colorectal Cancer (Diagnosis), Anal Cancer
Mind-Body Sexual Well-Being Program for Female GI Cancer Survivors
This record describes two distinct study phases: 1) A small open pilot trial including up to 10 participants, intended to generate descriptive feedback on regarding perceived benefits and areas for improvement for a group-based…
- Conditions
- Colorectal Cancer (Diagnosis), Anal Cancer, Sexual Dysfunction Female
- Trial name
- NCT07795801
- Testing
- Mind-Body Group Intervention, Enhanced Usual Care Control (EUCC)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Colorectal Cancer
Combination Chemotherapy in Treating Patients With Recurrent or Metastatic Colorectal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00003001
- Testing
- fluorouracil, gemcitabine hydrochloride, leucovorin calcium
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Stony Brook University
Prostate Cancer
SpaceOAR System Pivotal Study
Evaluate the safety of the SpaceOAR System when the hydrogel is injected between the rectum and prostate in men undergoing radiation therapy (IG-IMRT)
- Trial name
- NCT01538628
- Testing
- SpaceOAR System
- Where
- 20 sites in United States
- Volunteers
- 222 people
- Sponsor
- Boston Scientific Corporation
Colorectal Cancer
Computerized Tomographic Colonography Compared With Standard Diagnostic Procedures in Detecting Colorectal Neoplasia
RATIONALE: New diagnostic procedures such as computed tomographic colonography may provide a less invasive method of identifying patients who have colorectal neoplasia.
- Trial name
- ACRIN 6656 (NCT00005809)
- Testing
- computed tomography, diagnostic colonoscopy
- Where
- 11 sites in United States
- Sponsor
- American College of Radiology Imaging Network
Adult Solid Neoplasm, Bladder Carcinoma
Vaccine Therapy and Pembrolizumab in Treating Patients With Solid Tumors That Have Failed Prior Therapy
This phase I trial studies the side effects of vaccine therapy and pembrolizumab in treating patients with solid tumors that have spread to other places in the body and usually cannot be cured or controlled with treatment, that…
- Conditions
- Adult Solid Neoplasm, Bladder Carcinoma, Colon Carcinoma, Estrogen Receptor Negative
- Trial name
- NCT02432963
- Testing
- Laboratory Biomarker Analysis, Modified Vaccinia Virus Ankara Vaccine Expressing p53, Pembrolizumab
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- City of Hope Medical Center
Rectal Cancer
Flexible Colonoscope Assisted Hybrid Transanal Total Mesorectal Resection (taTME)
The investigators propose to use flexible endoscopy combined with transanal total mesorectal resection to further reduce anal injury.
- Trial name
- NCT06380855
- Testing
- Flexible colonoscope assisted hybrid transanal total mesorectal resection
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Sun Yat-sen University
Transanal Endoscopic Microsurgery (TEM)
Quality of Life After Transanal Endoscopic Microsurgery (TEM)
This is a observational cohort study to determine the influence of Transanal endoscopic microsurgery (TEM) on patients Quality of Life
- Trial name
- QoLTEM (NCT03675243)
- Testing
- sphincterometry
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- State Scientific Centre of Coloproctology, Russian Federation
Anal Cancer, Locally Advanced Squamous Cell Carcinoma
Circulating Biomarkers in Patients With Anal Cancer Treated With Induction Chemotherapy
To investigate the prognostic and predictive value of plasma HPV (pHPV) prior, during and after induction chemotherapy (ICT) in locally advanced squamous cell carcinoma of the anus (SCCA) or synchronous metastatic SCCA patients…
- Conditions
- Anal Cancer, Locally Advanced Squamous Cell Carcinoma, Oligometastatic Disease, Circulating Tumor Cell
- Trial name
- NCT05233540
- Where
- 3 sites in Denmark
- Volunteers
- 60 people
- Sponsor
- Aarhus University Hospital
Colorectal Cancer
Fluorouracil and Leucovorin With or Without Irinotecan in Treating Patients With Metastatic Colorectal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known whether fluorouracil and leucovorin plus irinotecan is more effective than fluorouracil…
- Trial name
- NCT00004885
- Testing
- FOLFIRI regimen, fluorouracil, irinotecan hydrochloride
- Where
- 57 sites in Austria, Belgium and 7 more
- Volunteers
- 430 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
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