Clinical trials: Recurrence of Atrial Fibrillation
Atrial Fibrillation
Investigation of Substrates Associated With the Recurrence of Atrial Fibrillation After PV Cryoablation
The two main mechanisms for atrial fibrillation (AF) recurrence after cryoablation include Pulmonary vein (PV) reconnection and the presence of non-PV associated arrhythmic focuses.
- Trial name
- SubstrateAF (NCT03587181)
- Testing
- Cryoablation of the pulmonary veins and myocardial biopsy
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- National Research Center for Preventive Medicine
Atrial Fibrillation, Recurrence
Outcome of Overweight AF Patients Following Ablation With a Potential Weight Loss Medication ( GOAL-AF )
Atrial Fibrillation (AF) is the most common abnormal heart rhythm(arrhythmia) affecting about one in 40 people in England. Patients with AF often have symptoms ranging from palpitations and breathlessness, and a small number of…
- Conditions
- Atrial Fibrillation, Recurrence, Overweight and Obesity, Liraglutide
- Trial name
- GOAL-AF (NCT05221229)
- Testing
- Liraglutide plus upstream risk factors modification advice and consultation
- Where
- United Kingdom
- Volunteers
- 29 people
- Sponsor
- University Hospital Birmingham
Atrial Fibrillation, Atrial Fibrillation Recurrent
DIGITal mOnitoring afTer Af abLation
Recurrence of atrial fibrillation (AF) after a pulmonary vein isolation (PVI) procedure is frequent. Current follow up with Holter monitoring and electrocardiograms (ECG) during outpatient clinic consultations cover only short…
- Conditions
- Atrial Fibrillation, Atrial Fibrillation Recurrent, PVI
- Trial name
- DIGITOTAL (NCT05486364)
- Testing
- Digital Monitoring, Standard of care
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Ziekenhuis Oost-Limburg
Atrial Fibrillation (AF)
Acupuncture for Preventing Atrial Arrhythmia Recurrence After Ablation
This study aims to evaluate whether acupuncture can reduce the recurrence of atrial arrhythmias after catheter ablation in patients with persistent atrial fibrillation.
- Trial name
- NCT07487532
- Testing
- Electroacupuncture, Standard Medical Therapy
- Volunteers
- 120 people
- Sponsor
- Shanghai Zhongshan Hospital
Atrial Fibrillation
The Effect of Early Repeat Atrial Fibrillation (AF) Ablation on AF Recurrence
Atrial fibrillation (AF) is the commonest condition affecting the rhythm of the heart and causes an irregular and often rapid heartbeat.
- Trial name
- PRESSURE (NCT01942408)
- Testing
- Repeat PVI
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- Liverpool Heart and Chest Hospital NHS Foundation Trust
Atrial Fibrillation, Arterial Hypertension
Comparison of Redo PVI With vs. Without Renal Denervation for Recurrent AF After Initial PVI
The objective of this study is to compare the elimination of atrial fibrillation in patients with recurrent atrial fibrillation despite prior pulmonary vein isolation (PVI) when undergoing repeat PVI (control) vs repeat PVI plus…
- Trial name
- NCT01959997
- Testing
- Redo PVI, PVI + RDN
- Where
- 2 sites in United States, Russia
- Volunteers
- 60 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Atrial Fibrillation
Effect of Hydroxychloroquine on Atrial Fibrillation Recurrence
Atrial fibrillation is the most common arrhythmia in clinic. It can lead to heart failure or stroke, and has a high disability rate and mortality rate.
- Trial name
- NCT03592823
- Testing
- Hydroxychloroquine Sulfate 200 Mg Tablet
- Where
- China
- Volunteers
- 240 people
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Persistent and Long Lasting or Chronic Atrial Fibrillation, Atrial Fibrillation Ablation
SUbstrate Ablation in Persistent Atrial Fibrillation for Elimination of Recurrences (SUPAFER).
Antecedents: electrical isolation of pulmonary veins is the standard treatment for patients with atrial fibrillation. However, its efficacy is lower in persistent and chronic forms of this arrhythmia compared to paroxysmal atrial…
- Conditions
- Persistent and Long Lasting or Chronic Atrial Fibrillation, Atrial Fibrillation Ablation, Linear Left Atrial Ablation, Daily Transtelephonic Electrocardiogram
- Trial name
- SUPAFER (NCT06291506)
- Testing
- Radiofrequency ablation of heart atrial tissue.
- Where
- Spain
- Volunteers
- 176 people
- Sponsor
- Hospital Universitario La Paz
Atrial Fibrillation, Continuous Positive Airway Pressure
Clinical Study on the Effect of CPAP on AF Recurrence After Catheter Ablation in Patients with AF and OSA
Atrial fibrillation (AF) is the most common sustained arrhythmia in clinical practice, significantly increasing the risks of death, stroke, heart failure, cognitive impairment, and dementia, thus severely impacting patients'…
- Conditions
- Atrial Fibrillation, Continuous Positive Airway Pressure, Obstructive Sleep Apnea, Recurrence
- Trial name
- NCT06542263
- Testing
- CPAP
- Where
- China
- Volunteers
- 224 people
- Sponsor
- Second Affiliated Hospital of Soochow University
Atrial Fibrillation
Bursa Postgraduate Hospital Department of Cardiology
Ensuring and maintaining normal sinus rhythm is critical for reducing negative outcomes in patients with atrial fibrillation (AF).
- Trial name
- NCT05231967
- Testing
- Cardioversion
- Volunteers
- 120 people
- Sponsor
- Bursa Postgraduate Hospital
Atrial Fibrillation, Paroxysmal or Persistent
The SAFE Prospective Registry
Secretoneurin (SN) is a neuropeptide from the chromogranin family that influences intracellular calcium handling. SN suppresses calcium leakage from the sarcoplasmic reticulum through the ryanodine receptor.
- Trial name
- NCT05794464
- Testing
- Catheter ablation and/or electrical cardioversion
- Where
- Czechia
- Volunteers
- 60 people
- Sponsor
- University Hospital Ostrava
Atrial Fibrillation
Usefulness of Markers to Predict Recurrence of Atrial Fibrillation After Radiofrequency Catheter Ablation
Catheter ablation using radiofrequency is a new therapeutic tool to treat atrial fibrillation with a higher success rate than medical therapy (80% versus less than 50% respectively).
- Trial name
- NCT00315068
- Where
- Switzerland
- Volunteers
- 180 people
- Sponsor
- University Hospital, Geneva
Atrial Fibrillation (AF)
Discontinuation of Anticoagulations After Successful Catheter Ablation of Atrial Fibrillation
The DESTINATION Study investigates whether anticoagulation therapy is necessary after successful catheter ablation (CA) for atrial fibrillation (AF).
- Trial name
- DESTINATION (NCT06615596)
- Testing
- discontinue anticoagulation therapy, Anticoagulant drugs, Catheter Ablation
- Where
- 12 sites in United States, China
- Volunteers
- 3,160 people
- Sponsor
- China National Center for Cardiovascular Diseases
Atrial Fibrillation, Recurrence
Stepwise Approach Versus Linear Ablation in Patients With Recurrence of Persistent Atrial Fibrillation
Catheter ablation of persistent atrial fibrillation (AF) remains a challenging procedure. Even in experienced centres, repeat interventions are necessary in up to 70 of patients to achieve sinus rhythm at a long-term follow-up.
- Trial name
- REDO-AF (NCT01229475)
- Testing
- Ablation with stepwise approach, Linear ablation
- Where
- Germany
- Volunteers
- 130 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Persistent Atrial Fibrillation, Paroxysmal Atrial Fibrillation
A Feasibility Study to Evaluate the Effect of Concomitant Renal Denervation and Cardiac Ablation on AF Recurrence
The purpose of this post market clinical investigation is to complete preliminary evaluation on whether or not concomitant renal denervation with the EnligHTN™ Renal Denervation System and cardiac ablation will result in improved…
- Conditions
- Persistent Atrial Fibrillation, Paroxysmal Atrial Fibrillation, Hypertension
- Trial name
- RDN+AF (NCT01907828)
- Testing
- Renal Artery Ablation, Cardiac Ablation
- Where
- 2 sites in Germany
- Volunteers
- 61 people
- Sponsor
- Abbott Medical Devices
Long Standing Persistent Atrial Fibrillation
Remote Monitoring of AF Recurrence Using mHealth Technology
Atrial fibrillation (AF) is the most common arrhythmia worldwide. It carries a significant health burden, conferring on sufferers a reduction in quality of life, risk of significant morbidities such as stroke and heart failure…
- Trial name
- REMOTE-AF (NCT05037136)
- Where
- United Kingdom
- Volunteers
- 35 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Atrial Fibrillation (AF), Atrial Fibrillation Ablation Procedure
Efficacy and Safety of a Voltage-Guided Stepwise Strategy for Pulmonary Vein Isolation
The goal of this clinical trial is to learn if a voltage-guided stepwise pulmonary vein isolation (PVI) strategy can achieve effective PVI while potentially reducing lesion delivery, compared with conventional circumferential…
- Conditions
- Atrial Fibrillation (AF), Atrial Fibrillation Ablation Procedure, Atrial Tachyarrhythmia Recurrence, Esophageal Thermal Injury
- Trial name
- VoS-PVI (NCT07354737)
- Testing
- Radiofrequency ablation catheter system
- Where
- South Korea
- Volunteers
- 130 people
- Sponsor
- Ajou University School of Medicine
Atrial Fibrillation
Nifedipine vs Telmisartan on Prevention of Atrial Fibrillation (AF) Recurrence in Hypertensive Patients With AF
Different lowing blood pressure strategies have a different clinical efficacies. Blocking the angiotensin II type 1 receptor (Telmisartan) reduces the incidence of episodes of atrial fibrillation in hypertensive patients with…
- Trial name
- NCT01435161
- Testing
- Nifedipine,, Telmisartan
- Where
- China
- Volunteers
- 160 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation
Inflammatory and Endothelial Function Response, and Arrhythmia Recurrence Following Catheter Ablation for Atrial Fibrillation
Current international guidelines recommend a three-month blanking period after pulmonary vein isolation (PVI) for atrial fibrillation (AF).
- Trial name
- NCT04269785
- Testing
- Cryoballoon ablation, Radiofrequency ablation
- Sponsor
- Karan Saraf
Persistent Atrial Fibrillation
Epicardial Approach in Recurred Atrial Fibrillation
We aimed to assess the benefit of epicardial mapping and ablation in patients with recurred atrial tachyarrhythmias after single procedure for atrial fibrillation.
- Trial name
- EPIREAF (NCT02979847)
- Testing
- hybrid approach, conventional endocardial approach
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Korea University Anam Hospital