Clinical trials: Recurrent Implantation Failure
Repeated Implantation Failure
A Randomized Double Blind Comparison of Atosiban in Patients With RIF Undergoing IVF Treatment
This study intends to carry out a prospective, randomized, double blind and controlled study to compare the influence of Atosiban and placebo on uterine contraction frequency, endometrial blood flow perfusion, oxytocin and serum…
- Trial name
- NCT02893722
- Testing
- atosiban, 0.9% saline
- Volunteers
- 200 people
- Sponsor
- Shanghai First Maternity and Infant Hospital
Infertility
Platelet Rich Plasma for Patients With Recurrent Implantation Failure
Patients with recurrent implantation failure are among the most difficult patients to treat, with no proven standard treatment. Platelet rich plasma stimulates cellular processes involved in endometrial regeneration, and in a…
- Trial name
- NCT03379649
- Testing
- Platelet rich plasma
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Stanford University
Embryo Implantation
Effect of Dilatation and Curettage on the Endometrial Receptivity
Effect of dilatation and curettage on the endometrial receptivity and pregnancy outcome in patients with recurrent implantation failure
- Trial name
- NCT03485235
- Testing
- D&C, ICSI
- Where
- Egypt
- Volunteers
- 160 people
- Sponsor
- Ain Shams University
Repeated Implantation Failure
Atosiban Improves Implantation and Pregnancy Rates in Patients With Repeated Implantation Failure
Atosiban, administered at embryo transfer, can improve the implantation rate and the clinical pregnancy rate in patients with repeated implantation failure undergoing IVF-ET (in-vitro fertilization and embryo transfer).
- Trial name
- NCT01493440
- Testing
- atosiban
- Where
- Vietnam
- Volunteers
- 71 people
- Sponsor
- An Sinh Hospital
Sub-fertility, Recurrent Implantation Failure
The PIP Study - Pre- IVF Immune Profiling Study
Many IVF clinics offer testing for immune cells in the blood and endometrium as it has been suggested that abnormal levels of these cells can affect fertility or the chance of an IVF cycle working.
- Trial name
- PIP (NCT03660735)
- Where
- 2 sites in United Kingdom
- Volunteers
- 250 people
- Sponsor
- University of Oxford
Infertility, Female
Personalized FET in RIF Patients With Displaced Dating
The endometrium becomes receptive as a result of a series of timed hormonal events during the menstrual cycle. The exposure of the endometrium to progesterone after ovulation initiates morphological and functional alterations…
- Trial name
- NCT03910582
- Testing
- personalized frozen-thawed embryo transfer, routine frozen-thawed embryo transfer
- Volunteers
- 117 people
- Sponsor
- Reproductive & Genetic Hospital of CITIC-Xiangya
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
CoRDS, or the Coordination of Rare Diseases at Sanford, is based at Sanford Research in Sioux Falls, South Dakota. It provides researchers with a centralized, international patient registry for all rare diseases.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- 2 sites in United States, Australia
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Unexplained Infertility
Effect of Danazol on Endometrial αvβ3 Integrin Expression in Patients With Unexplained Recurrent Implantation Failure
This study investigates the presence of a possible link between treatment with danazol and expression of endometrial αvβ3 integrin which might allow tailoring of danazol treatment to the subset of repeated IVF/ET failure that…
- Trial name
- NCT03563664
- Testing
- Pre-treatment endometrial biopsy, Danazol, Post-treatment endometrial biopsy
- Where
- Egypt
- Volunteers
- 38 people
- Sponsor
- Ain Shams University
Recurrent Implantation Failure
Efficacy of a Non-Invasive Endometrial Receptivity Prediction Model Based on Peripheral Blood miRNA Signatures During the Peri-Implantation Period in Improving IVF Outcomes in Patients With Unexplained RIF
The goal of this clinical trial aims to investigate whether a non-invasive implantation window prediction model, constructed based on characteristic changes in peripheral blood miRNAs during the peri-implantation period, can…
- Trial name
- RIF (NCT07363018)
- Testing
- Non-invasive endometrial receptivity prediction model guides personalized embryo transfer for patients with recurrent implantation failure (RIF).
- Volunteers
- 546 people
- Sponsor
- Tang-Du Hospital
Repeated Implantation Failure
Intrauterine Injection of Human Chorionic Gonadotrophin and Pregnancy Rate in ICSI
Despite recent advances in clinical and laboratory techniques of Assisted Reproductive Technology (ART), the pregnancy rate remains around 30% per cycle.
- Trial name
- NCT03445910
- Testing
- Human chorionic gonadotropin
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Fertility Disorders
The Effect of Granulocyte Colony Stimulating Factor Versus Human Chorionic Gonadotropin in Females With a History of RIF
One hundred patients who suffered from recurrent implantation failure in intracytoplasmic sperm injection (ICSI) were allocated in the study.
- Trial name
- NCT04604054
- Testing
- Granulocyte Colony Stimulated Factor, Human Chorionic Gonadotropins
- Volunteers
- 100 people
- Sponsor
- Al-Azhar University
Subfertility
BAP-EB as a Predictive Tool for Endometrial Receptivity and Pregnancy Outcome of IVF Treatment
To determine the predictive value of attachment rate of human embryonic stem cells (hESC)-derived trophoblast spheroids (BAP-EB, embryo surrogate) onto endometrial epithelial cells (EEC) on success of IVF treatment and to use the…
- Trial name
- NCT02713854
- Testing
- endometrial biopsy
- Where
- China
- Volunteers
- 240 people
- Sponsor
- The University of Hong Kong
Pregnancy Complicated by Low Implantation
Intralipid Therapy for Recurrent Implantation Failure and Recurrent Miscarriages: Is it a Hope or Myth?A Randomized Clinical Trial
Both organ-specific and systemic autoimmunity are associated with an increased prevalence of recurrent miscarriage and reproductive failure, rendering the role of the maternal immunological system in fertility a key concept.
- Trial name
- ILRIFRM (NCT01679561)
- Testing
- intralipid
- Where
- Egypt
- Volunteers
- healthy volunteers welcome
- Sponsor
- Woman's Health University Hospital, Egypt
Recurrent Implantation Failure in Setting of Artifically Prepared Endometrium
Trial of Endometrial Scratch Prior to Frozen Embryo Transfer in Patients With Recurrent Implantation Failure
Patients with a history of recurrent implantation failure who are planning a frozen embryo transfer (FET) are enrolled into the program.
- Trial name
- NCT03157765
- Testing
- endometrial biopsy
- Volunteers
- healthy volunteers welcome
- Sponsor
- Brown Fertility
Subfertility
Effect of Intralipid Infusion in Patients With Recurrent Implantation Failure
The aim of present study is to evaluate the effect of intralipid 20% infusion, once between days 4 and 9 of the ovarian stimulation, and again within 7 days of a positive pregnancy test on clinical pregnancy rates in women with…
- Trial name
- NCT02865785
- Testing
- Intralipid 20%
- Where
- Egypt
- Volunteers
- 320 people
- Sponsor
- Ain Shams University
Recurrent Implantation Failure
Immunomodulatory Effects of Rapamycin on Pregnancy Rate of Patient With Recurrent Implantation Failure
Repeated implantation failure (RIF) is determined as failure to achieve pregnancy following at least 3 embryo transfers of high quality embryos in IVF cycles.
- Trial name
- NCT03161340
- Testing
- Rapamycin
- Where
- 2 sites in Iran
- Volunteers
- 121 people
- Sponsor
- Mehdi Yousefi
Infertility Implantation Failure
A Multicentre, Randomised, Double-blind, Placebo-controlled Proof of Concept Study to Compare the Efficacy and Safety of r-hLIF (Emfilermin) for Improving Embryo Implantation Following in Vitro Fertilization (IVF) and Embryo Transfer (ET) in Women With Recurrent Implantation Failure
The primary objective of the study was to provide further clinical and statistical evidence of the efficacy of r-hLIF, in comparison with placebo, administered during the luteal phase after IVF and ET for improving embryo…
- Trial name
- NCT00504608
- Testing
- Emfilermin, recombinant human leukemia inhibitory factor (r-hLIF)
- Volunteers
- 150 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Endometriosis, In Vitro Fertilization Implantation Failure
The In Vitro Fertilization - Lipiodol Uterine Bathing Effect Study
The hypothesis of this study is that Lipiodol uterine bathing improves the success rate of in vitro fertilization (IVF) for women with endometriosis or recurrent IVF implantation failure.
- Trial name
- NCT00894946
- Testing
- Lipiodol + IVF, IVF
- Where
- New Zealand
- Volunteers
- 350 people
- Sponsor
- University of Auckland, New Zealand
Recurrent Implantation Failure (RIF)
Management of Recurrent Implantation Failure
This is the first study to investigate, whether pregnancy and implantation rates would improve in patients with recurrent implantation failure (RIF), if all embryos were to be frozen and transferred in a consecutive natural cycle.
- Trial name
- RIF (NCT02681367)
- Testing
- Freeze all policy
- Volunteers
- 200 people
- Sponsor
- TopLab Company for ART Laboratories Consultation and Training
Unexplained Infertility, Recurrent Implantation Failure
Using Microfluidic Separation Sperm Selection for Unexplained Infertility and Reccurrent Implantation Failure
In order to increase the likelihood of achieving IVF-treated pregnancy, good quality embryo transfer is important. To get good quality embryos, good quality gametes are needed.
- Trial name
- NCT03355937
- Testing
- Sperm Chip
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Acibadem University