Clinical trials: Reflux
Mitral Valve (MV) Regurgitation
A Prospective, Multicenter, Single-Arm Study to Support the Clinical Evidence Base for MRace as a Treatment Option for FMR Patients With Complex M-TEER Anatomies (AU)
A pilot study to evaluate the safety and performance of the MRace System to treat severe mitral regurgitation and to gather data on its performance thereby providing guidance for future clinical development.
- Trial name
- ACCESS-MR (AU) (NCT07757698)
- Testing
- Transcatheter mitral valve repair
- Volunteers
- 15 people
- Sponsor
- Polares Medical SA
Mitral Valve (MV) Regurgitation
A Prospective, Multicenter, Single-Arm Study to Support the Clinical Evidence Base for MRace as a Treatment Option for FMR Patients With Complex M-TEER Anatomies (DE)
A pilot study to evaluate the safety and performance of the MRace System to treat severe mitral regurgitation and to gather data on its performance thereby providing guidance for future clinical development.
- Trial name
- ACCESS-MR (DE) (NCT07757776)
- Testing
- Transcatheter mitral valve repair (MRace Implant and Delivery System)
- Volunteers
- 20 people
- Sponsor
- Polares Medical SA
GERD, Hiatal Hernia
Antireflux Surgery Without Preoperative Esophageal Manometry
The goal of this clinical trial is to learn if people can safely skip a test called esophageal manometry before surgery for acid reflux (gastroesophageal reflux disease, or GERD) or a hiatal hernia.
- Conditions
- GERD, Hiatal Hernia, Heartburn, Paraesophageal Hernia
- Trial name
- NOMA (NCT07659080)
- Testing
- Preoperative workup without high-resolution esophageal manometry, Standard preoperative workup with high-resolution esophageal manometry
- Where
- 2 sites in United States, Canada
- Volunteers
- 96 people
- Sponsor
- McMaster University
Reflux Esophagitis
A Prospective Cohort Study on Endoscopic Features of Upper Gastrointestinal Tract at High Altitude (Zaduo County)
To prospectively enroll participants undergoing gastroscopy at Zaduo County People's Hospital and perform paired analyses with matched cases from Jilin Province.
- Trial name
- NCT07755384
- Testing
- Sedated gastroscopy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Jilin University
Gastroesophageal Reflux Disease, Hiatal Hernia
Registry of Outcomes From AntiReflux Surgery
Prospective registry comparing outcomes after laparoscopic treatment of gastroesophageal reflux disease and hiatal hernia.
- Trial name
- ROARS (NCT02923362)
- Testing
- Laparoscopic Fundoplication, LINX Antireflux
- Where
- 19 sites in United States
- Volunteers
- 1,941 people
- Sponsor
- The Heartburn Foundation
Gastroesophageal Reflux Disease (GERD)
One-year Clinical Outcomes of Endoscopic Cardia Banding Plication for Refractory Gastroesophageal Reflux Disease After Laparoscopic Sleeve Gastrectomy
This single-center retrospective cohort study was conducted at the Center for Bariatric and Metabolic Surgery, China-Japan Friendship Hospital, Beijing, China, and is reported in accordance with the STROBE guidelines for…
- Trial name
- NCT07749352
- Testing
- endoscopic cardia banding plication
- Where
- China
- Volunteers
- 47 people
- Sponsor
- China-Japan Friendship Hospital
Gastroesophageal Reflux Disease
A Retrospective Analysis of Patients With Gastroesophageal Reflux Disease Based on a Prospective Clinical Dataset
This retrospective, observational cohort study aimed to establish a comprehensive research cohort utilizing a large-scale prospective clinical registry.
- Trial name
- NCT07749989
- Testing
- Clinical Data Collection
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Beijing Friendship Hospital
Laryngomalacia
Assessing the Role of Proton Pump Inhibitors in Reducing Aspiration Incidence in Pediatric Laryngomalacia Cases
Laryngomalacia is the most common congenital laryngeal anomaly in children and is frequently associated with aspiration. This randomized controlled study aims to assess the role of proton pump inhibitor (PPI) therapy in reducing…
- Trial name
- NCT07750379
- Testing
- PPI, vitamin D, feeding instruction
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Minia University
Gastroesophageal Reflux Esophagitis
Mobile Application for Gastroesophageal Reflux Disease
Gastroesophageal reflux disease (GERD) is a chronic condition with frequent symptom recurrence that may negatively affect sleep quality and quality of life.
- Trial name
- NCT07744815
- Testing
- Study Mobile Application, Standard Education
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Fooyin University
Esophageal Motility Disorders, Gastric Motor Dysfunction
Gastrointestinal Dysmotility on Aspiration Risk
The hypothesis of this study is that esophageal and gastric dysmotility increase the risk of developing aspiration-associated symptoms in children with neurologic impairment.
- Conditions
- Esophageal Motility Disorders, Gastric Motor Dysfunction, Aspiration Pneumonia, Gastro Esophageal Reflux
- Trial name
- NCT05455359
- Testing
- Prucalopride, Famotidine
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Boston Children's Hospital
Obesity & Overweight, Gastroesophageal Reflux (GERD)
Transit Bipartition After Sleeve Gastrectomy
This prospective, single-center study will evaluate adults undergoing revisional conversion from sleeve gastrectomy to intestinal transit bipartition.
- Conditions
- Obesity & Overweight, Gastroesophageal Reflux (GERD), Weight Recurrence, Bariatric Surgery
- Trial name
- BTT-SLEEVE (NCT07728682)
- Testing
- Conversion to Intestinal Transit Bipartition
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Hospital das Clínicas de Ribeirão Preto
Gastroesophageal Reflux Disease (GERD)
A Study to Check the Safety of Dexlansoprazole and Learn if it Can Treat Symptomatic Nonerosive Gastroesophageal Reflux Disease in Children 2 to 11 Years Old
Gastroesophageal reflux disease (GERD) is caused by food or acid coming up from the stomach into the esophagus, repeatedly. The esophagus is the tube that carries food and liquids from the mouth to the stomach.
- Trial name
- NCT02616302
- Testing
- Dexlansoprazole
- Where
- 18 sites in United States, Canada and 3 more
- Volunteers
- 71 people
- Sponsor
- Takeda
Maintenance of Healed Erosive Gastroesophageal Reflux Disease (ERD)
Phase 3 Study of JP-1366: Efficacy and Safety of JP-1366 as Maintenance Therapy in Subjects With Healed Erosive Esophagitis
This study aims to evaluate the Efficacy and Safety of JP-1366 as Maintenance Therapy in Subjects with Healed Erosive Esophagitis
- Trial name
- NCT07732075
- Testing
- JP-1366 10 mg, Lansoprazole 15mg
- Volunteers
- 384 people
- Sponsor
- Onconic Therapeutics Inc.
Gastroesophageal Reflux
Multi-Center Study of Panosyl-Isomaltooligosaccharides Adjunctive to PPI Therapy to Treat GERD
This study will be conducted as a multi-center, randomized, double-blind, placebo-controlled trial to evaluate the effect of MHS-1031 on heartburn-free days in subjects with GERD-related heartburn symptoms.
- Trial name
- NCT05556824
- Testing
- MHS-1031
- Where
- 18 sites in United States
- Volunteers
- 255 people
- Sponsor
- Microbiome Health Sciences
Gerd, Eosinophilic Esophagitis
Utility of Mucosal Impedance Device in Chronic Esophageal Disorders:
Background \& Significance Chronic benign esophageal disorders such as Gastroesophageal reflux disease (GERD) and eosinophilic esophagitis are common gastrointestinal disorders affecting nearly 20% and 0.1% of the population…
- Trial name
- NCT07227506
- Testing
- MuVI Esophageal mucosal impedance testing
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Gastro Esophageal Reflux
Endoscopic Classification of Fundoplication Integrity Predicts Pathologic Reflux
This single-center, two-phase cohort study aimed to develop and validate a simple endoscopic classification of fundoplication integrity after anti-reflux surgery (ARS - Nissen or Toupet fundoplication).
- Trial name
- NCT07722663
- Where
- Italy
- Volunteers
- 153 people
- Sponsor
- IRCCS Policlinico S. Donato
Gastro Esophageal Reflux Disorder
Safety, PK, and PD Comparison of UI059 and UIC202201 in Healthy Volunteers
A randomized, open-label, multiple-dose, crossover phase 1 clinical trial to compare and evaluate the safety, pharmacokinetics and pharmacodynamics characteristics after oral administration of UI059 and UIC202201 in healthy adult…
- Trial name
- NCT07727629
- Testing
- UI059, UIC202201
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Korea United Pharm. Inc.
Mitral Valve Regurgitation
Early Feasibility Study of the Neovasc Tiara™ Mitral Valve System
The purpose of this study is to evaluate the safety and initial performance of the Neovasc Tiara Mitral Transcatheter Heart Valve with the Tiara Transapical Delivery System.
- Trial name
- TIARA-I (NCT02276547)
- Testing
- Mitral valve replacement
- Where
- 10 sites in United States, Belgium and 1 more
- Volunteers
- 27 people
- Sponsor
- Shockwave Medical, Inc.
Mitral Valve (MV) Regurgitation
Transventricular Off-pump Mitral Valve Repair
The purpose of this study is to assess the safety and effectiveness (usefulness) of an investigational technique used to repair the mitral valve for patients with mitral regurgitation due to a defective valve leaflet.
- Trial name
- TRANSOM (NCT07726173)
- Testing
- TRANSOM
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- Johns Hopkins University
Gastroesophageal Reflux Disease (GERD), Reflux, Gastroesophageal
An Investigation of the EndoStim® Lower Esophageal Sphincter (LES) Stimulation System for the Treatment of Reflux
The purpose of this investigation is to demonstrate the safety and effectiveness of Lower Esophageal Sphincter (LES) Stimulation System in treating gastroesophageal reflux disease (GERD).
- Conditions
- Gastroesophageal Reflux Disease (GERD), Reflux, Gastroesophageal, Gastroesophageal Reflux, Acid Reflux
- Trial name
- NCT02749071
- Testing
- Laparoscopic implantation surgery with or without crural repair, EndoStim stimulation for first six months of study, EndoStim stimulation from Month 6 thru end of study
- Where
- 21 sites in United States, Belgium and 2 more
- Volunteers
- 161 people
- Sponsor
- EndoStim Inc.