Clinical trials: Regression
Breast Biopsy
The Role of Pre-deployment Retraction in Decreasing Biopsy Clip Migration During Stereotactic Breast Biopsies
This will be a single-center prospective randomized control trial that is Institutional Review Board (IRB) approved. The study plans to enroll 250 female patients presenting to the University of Alabama at Birmingham (UAB) for…
- Trial name
- NCT04398537
- Testing
- 5mm retraction of clip deployment apparatus., No retraction of clip deployment apparatus.
- Where
- United States
- Volunteers
- 245 people
- Sponsor
- University of Alabama at Birmingham
Glaucoma
Partial Least Squares Regression Modelling for Glaucoma Detection
A partial least squares regression model for visual field testing among glaucoma patients will be developed. In addition, microperimetry will be compared to conventional perimetry and reproducibility will be assessed.
- Trial name
- NCT03365245
- Testing
- Microperimetry, automated visual field
- Where
- Austria
- Volunteers
- 19 people
- Sponsor
- Vienna Institute for Research in Ocular Surgery
Pain
Novel Technique for Botulinum Toxin Injection to Minimize Patient Discomfort
This single blinded randomized pilot study was performed on 21 Caucasian females to determine if injections through follicular openings were less painful than traditional injections for cosmetic botulinum toxin type A injections.
- Trial name
- NCT00628472
- Testing
- botulinum type a
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Hematopoietic and Lymphoid Cell Neoplasm, Metastatic Malignant Solid Neoplasm
Salvage Radiation Therapy in Treating Patients With Metastatic Cancer That Has Progressed After Systemic Immunotherapy
This phase II trial studies the side effects and best dose of radiation therapy and to see how well it works in treating patients with cancer that has spread to other places in the body (metastatic) or has increased in size after…
- Trial name
- NCT02710253
- Testing
- External Beam Radiation Therapy, Laboratory Biomarker Analysis, Stereotactic Body Radiation Therapy
- Where
- 5 sites in United States
- Volunteers
- 214 people
- Sponsor
- M.D. Anderson Cancer Center
Cervical Cancer
Decreasing Over Screening and Treatment of Cervical Precancers in Young Women
The goal of this study is to prevent over screening and over treatment of young women for cervical precancers, which can result in psychological distress and has been associated with future risk of premature deliveries.
- Trial name
- NCT02270021
- Testing
- Provider Mobile Application (ProvAPP), ProvAPP + Patient Educational Tool (Tab)
- Where
- 2 sites in United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Pain Management, Laparascopic Sleeve Gastrectomy
Ketamine for Shoulder Pain Following Laparoscopic Gastric Sleeve Surgery
Shoulder pain is a well-recognized complaint following laparoscopic surgery. It is underlying mechanism has various causes, therefore, modalities in management and prevention of this sort of pain are numerous with different…
- Trial name
- NCT07429916
- Testing
- Intraoperative ketamine
- Where
- Jordan
- Volunteers
- 50 people
- Sponsor
- King Abdullah University Hospital
Down Syndrome, Regression
Therapies for Down Syndrome Regression Disorder
Individuals with Down syndrome (DS) have an increased risk of numerous co-occurring conditions, including the neuropsychiatric condition known as Down Syndrome Regression Disorder (DSRD).
- Trial name
- NCT05662228
- Testing
- Lorazepam, Intravenous immunoglobulin (IVIG), Tofacitinib
- Where
- 2 sites in United States
- Volunteers
- 66 people
- Sponsor
- University of Colorado, Denver
Colonoscopy
Effectiveness of Stiffening Wire in Colonoscopy With Pre-Owned Colonoscopes
The study aims to determine whether a proprietary, FDA approved stiffening wire improves the efficiency of colonoscopy (that is, decreases the duration of the procedure) and/or enables complete visualization of the colon in a…
- Trial name
- NCT01115010
- Testing
- Colonoscope stiffening device
- Where
- Jamaica
- Volunteers
- 112 people
- Sponsor
- Cornwall Regional Hospital
Pregnancy Complications, Pregnancy, High Risk
Defining, Recognising and Escalating Maternal Early Deterioration (DREaMED)
Every year more than 700,000 women give birth in the United Kingdom. Of these at least 8700 nearly die - called a "near-miss", and 70 die. Many more women suffer harm, often with effects lasting for life.
- Trial name
- DREaMED (NCT06560931)
- Where
- United Kingdom
- Volunteers
- 459,160 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Colorectal Cancer, Non-small Cell Lung Carcinoma (Adenocarcinoma), Triple Negative Breast Cancer, Renal Cell Carcinoma
A Study of PDR001 in Combination With LCL161, Everolimus or Panobinostat
The purpose of this study was to combine the PDR001 checkpoint inhibitor with several agents with immunomodulatory activity to identify the doses and schedule for combination therapy and to preliminarily assess the safety…
- Trial name
- NCT02890069
- Testing
- PDR001, LCL161, Everolimus
- Where
- 25 sites in United States, Germany and 5 more
- Volunteers
- 298 people
- Sponsor
- Novartis Pharmaceuticals
Pain
Improving Pain Management and Decreasing LOS After Total Hip Arthroplasty (THA) and Total Knee Arthroplasty (TKA)
This two arm, patient blinded, randomized, post market clinical trial in a single orthopedic hospital will determine whether there is improved pain management and decreased length of stay when comparing standard of care pain…
- Trial name
- NCT05307341
- Testing
- sufentanil
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- More Foundation
Type 2 Diabetes, Non-alcoholic Fatty Liver Disease
A 24 Week, Multicenter, Prospective, Open-labeled, Single-arm, Exploratory Phase 4 Clinical Trial to Evaluate the Safety and Efficacy of Lobeglitazone in Decreasing Intrahepatic Fat Contents in Type 2 Diabetes With NAFLD
Lobeglitazone is highly selective peroxisome proliferator-activated receptor-gamma agonist that decreases insulin resistance in the periphery and liver resulting in increased insulin-dependent glucose disposal and decreased…
- Trial name
- NCT02285205
- Testing
- Oral administration of Lobeglitazone
- Where
- South Korea
- Volunteers
- 38 people
- Sponsor
- Yonsei University
Age Problem
Home Accidents Among Turkish Older Men and Women
Background: Home accidents are a significant public health issue in developed and developing countries. The present study aims to identify the factors associated with home accidents among older individuals in Türkiye.
- Trial name
- NCT06514872
- Testing
- prevalance and determinants of home accidents
- Where
- Turkey (Türkiye)
- Volunteers
- 8,225 people
- Sponsor
- Ataturk University
Tuberculous Lymphadenitis, Cervical
Steroids vs Placebo in Treatment of Tuberculous Lymphadenitis
This study will be conducted as a single blinded randomized control trial. The goal of this clinical trial is to learn about the role of low dose steroids in the resolution of tuberculous lymphadenitis.
- Trial name
- NCT06236152
- Testing
- Ferrous sulfate, Deltacortril
- Where
- Pakistan
- Volunteers
- 140 people
- Sponsor
- Fahad Javed Awan
Burnout, Professional, Occupational Stress
Factors Affecting Burnout in Physiotherapists in Turkey
This cross-sectional descriptive study aims to identify the demographic, occupational, organisational and individual psychological factors that predict burnout among physiotherapists working in active clinical practice in Turkey.
- Conditions
- Burnout, Professional, Occupational Stress, Psychological Resilience, Self Efficacy
- Trial name
- PT-BURNOUT-TR (NCT07722858)
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Atherosclerosis
Oxford Niaspan Study: Effects of Niaspan on Atherosclerosis and Endothelial Function
AIM 1 will test the hypothesis that elevation of high-density lipoprotein (HDL) through treatment with Niaspan will accelerate the regression of atherosclerotic plaque in patients with established atherosclerosis.
- Trial name
- NCT00232531
- Testing
- Niaspan
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- University of Oxford
Coronary Arterial Disease (CAD), Vulnerable Coronary Plaques
Ticin Pilot Study: Sirolimus-Eluting Balloon for Stabilization and Regression of Non-Obstructive Coronary Plaques.
The goal of this pilot clinical trial is to evaluate the use of the Selution SLR sirolimus-eluting balloon, in addition to guideline-directed medical therapy (GDMT), for the preventive treatment of non-flow-limiting vulnerable…
- Conditions
- Coronary Arterial Disease (CAD), Vulnerable Coronary Plaques, Multivessel Coronary Artery Disease, Coronary Vessel
- Trial name
- NCT06928883
- Testing
- Sirolimus drug eluting ballooon therapy, Optimal guidelines-directed medical therapies (GDMT)
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- Cardiocentro Ticino
Anxiety, Preoperative Anxiety
Comparing the Effect of Melatonin, Diazepam, and Placebo on Decreasing the Level of Anxiety Preoperatively
The goal of this clinical trial is to compare the effect of melatonin, diazepam, and placebo on the level of anxiety in patients undergoing surgery.
- Trial name
- NCT06103188
- Testing
- Diazepam, Melatonin
- Where
- Jordan
- Volunteers
- 87 people
- Sponsor
- University of Jordan
Anesthesia, Pain
Decreasing the Invasiveness of Ultrasound Guided Caudal Block: A Comparison Between 22-gauge and 27-guage Needles
Ultrasound (US) has facilitated the use of caudal block in children and visualization of the needle during insertion. This prospective clinical trial study compares between two different sizes of the used needles, in terms of…
- Conditions
- Anesthesia, Pain, Caudal Block, Pediatric Anesthesia
- Trial name
- NCT04691531
- Testing
- The use of classical Gauge 22 needle, The use of classical Gauge 27 needle
- Where
- Jordan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Jordan
Malaria, Anemia
Intermittent Preventive Treatment With Antimalarials in Kenyan Infants
The purpose of the study is to see whether antimalarial drugs administered at the time of routine infant vaccinations prevents malaria and anemia in the first year of life.
- Trial name
- NCT00111163
- Testing
- sulfadoxine-pyrimethamine with artesunate, amodiaquine with artesunate, chlorproguanil-dapsone
- Where
- Kenya
- Volunteers
- 1,516 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention