Clinical trials: Regression
Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma
D2 Gastrectomy With or Without Para-Aortic Lymph Node Dissection After Chemoimmunotherapy for Gastric Cancer
Some patients with gastric cancer have enlarged para-aortic lymph nodes, also called No. 16 lymph nodes, at diagnosis. After standard chemoimmunotherapy, these lymph nodes may shrink to less than 10 mm on imaging, but it is…
- Trial name
- PAN-SELECT (NCT07912606)
- Testing
- Gastrectomy with D2 lymphadenectomy plus para-aortic lymph node dissection, Gastrectomy with standard D2 lymphadenectomy
- Where
- China
- Volunteers
- 32 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Brain Injuries, Craniocerebral Trauma
DASH After TBI Study: Decreasing Adrenergic or Sympathetic Hyperactivity After Traumatic Brain Injury
The investigators intend to determine the effect of adrenergic blockade on 1) short-term physiology, behavior, and cognition and 2) long-term neuropsychological outcomes after severe Traumatic Brain Injury (TBI).
- Conditions
- Brain Injuries, Craniocerebral Trauma, Trauma, Nervous System, Traumatic Brain Injury
- Trial name
- NCT01322048
- Testing
- IV Propranolol and Per Tube Clonidine
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Vanderbilt University
Bleeding, Surgical Blood Loss
Decreasing Postoperative Blood Loss by Topical vs. Intravenous Tranexamic Acid in Open Cardiac Surgery
The aim is to conduct a double-blinded single-centre randomized controlled clinical trial of application of topical dose of tranexamic acid (TA) versus the usual intravenous TA in patients undergoing cardiac surgery at the…
- Trial name
- DEPOSITION (NCT03376061)
- Testing
- Tranexamic Acid
- Where
- Canada
- Volunteers
- 97 people
- Sponsor
- Population Health Research Institute
Appendix Carcinoma, Colon Carcinoma
Oral Cryotherapy Plus Acupressure and Acupuncture Versus Oral Cryotherapy for Decreasing Chemotherapy-Induced Peripheral Neuropathy From Oxaliplatin-Based Chemotherapy in Patients With Gastrointestinal Cancer
This phase II trial investigates how well oral cryotherapy plus acupressure and acupuncture compared with oral cryotherapy alone work in decreasing chemotherapy-induced peripheral neuropathy in patients with gastrointestinal…
- Conditions
- Appendix Carcinoma, Colon Carcinoma, Esophageal Carcinoma, Gastric Carcinoma
- Trial name
- NCT04505553
- Testing
- Acupuncture Therapy, Acupressure Therapy, Oral Cryotherapy
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- University of Washington
Gastric Cancer, Gastric Adenocarcinoma
MalnutritiOn Assessment With biOelectrical impedaNce Analysis in gastRic Cancer patIentS Undergoing Multimodal trEatment
The aim of this single-arm prospective, multicenter, cross-sectional study is to evaluate the nutritional status and body composition on tumor regression grade with bioelectrical impedance analysis in gastric cancer patients…
- Conditions
- Gastric Cancer, Gastric Adenocarcinoma, Malnutrition, Cachexia
- Trial name
- MOONRISE (NCT05723718)
- Testing
- Observational Survey
- Where
- Poland
- Volunteers
- 125 people
- Sponsor
- Medical University of Lublin
Acute Respiratory Infection
Decreasing Antibiotic Prescribing in Acute Respiratory Infections Through Nurse Driven Clinical Decision Support
This study evaluates the effects of a novel integrated clinical prediction tool on antibiotic prescription patterns of nurses for acute respiratory infections (ARIs).
- Trial name
- NCT04255303
- Testing
- Integrated clinical prediction rule (iCPR) system (iCPR)
- Where
- 3 sites in United States
- Volunteers
- 347 people
- Sponsor
- NYU Langone Health
Dental Anxiety, Local Anesthesia
Lavender vs Bitter Orange Aromatherapy to Reduce Anxiety and Pain in Pediatric Local Anesthesia
This randomized controlled clinical trial aims to evaluate and compare the effectiveness of lavender essential oil and bitter orange essential oil aromatherapy in reducing dental anxiety and pain in children during the…
- Trial name
- NCT07367594
- Testing
- Lavender essential oil in the inhaler, Bitter Orange essential oil in the inhaler
- Where
- Egypt
- Volunteers
- 26 people
- Sponsor
- October University for Modern Sciences and Arts
Down Syndrome
A Double-blind, Placebo-controlled Comparative Study and Open-label Extension Study to Confirm the Efficacy and Safety of E2020 in Subjects With Down Syndrome Having Regression Symptoms and Disabled Activities of Daily Living.
The purpose of this double-blind, placebo-controlled, comparative study and open-label extension study is to confirm the efficacy and safety of E2020 in subjects with Down syndrome having regression symptoms and disabled…
- Trial name
- NCT02094053
- Testing
- E2020-Donepezil hydrochloride
- Where
- 10 sites in Japan
- Volunteers
- 36 people
- Sponsor
- Eisai Co., Ltd.
Rosacea
Assess the Ability of MetroGel 1% to Deliver Moisture to Facial Skin After a Single Application
This eight-hour kinetic regression clinical study was conducted to assess the ability of MetroGel® 1% to deliver moisture to facial skin after a single application.
- Trial name
- NCT00436527
- Testing
- Metronidazole gel 1%
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Galderma R&D
Psychological Distress, Secondary Trauma
Feasibility of SOLAR Group Program Among MHPSS Workers After the Earthquake
The goal of this intervention program is to provide the feasibility of a culturally adapted version of the SOLAR program among mental health and psychosocial support (MHPSS) workers who provide psychological or psychosocial…
- Conditions
- Psychological Distress, Secondary Trauma, Depression, Anxiety
- Trial name
- NCT06231927
- Testing
- The Skills for Life Adjustment and Resilience (SOLAR) program
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Koç University
Coronary Artery Disease
ApoA-I Synthesis Stimulation and Intravascular Ultrasound for Coronary Atheroma Regression Evaluation
This study is designed to characterize the early effects of ApoA-I synthesis with RVX000222 on coronary atherosclerotic disease when administered to patients with coronary artery disease and have a low HDL-C level, as assessed by…
- Trial name
- ASSURE I (NCT01067820)
- Testing
- RVX000222
- Where
- 58 sites in Argentina, Belgium and 6 more
- Volunteers
- 324 people
- Sponsor
- Resverlogix Corp
Gestational Trophoblastic Disease
Letrozole as a Prophylaxis From GTN for Complete Mole Patients
Prophylactic use of aromatase inhibitor is effective in decreasing the incidence of Gestational Trophoblastic Neoplasia (GTN) in patients with complete hydatidiform mole (CHM)
- Trial name
- NCT05203562
- Testing
- Suction evacuation, Letrozole tablets
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Zagazig University
Liver Cirrhosis
Optimized Treatment and Regression of HBV-induced Compensated Liver Cirrhosis
Six hundreds patients with chronic hepatitis B clinically diagnosed as compensated liver cirrhosis are randomly assigned in a 1:1 ratio.
- Trial name
- NCT01943617
- Testing
- Entecavir, Thymosin-α
- Where
- 21 sites in China
- Volunteers
- 606 people
- Sponsor
- Beijing Friendship Hospital
Vitamin B 12 Deficiency
Cobalamin Status in Young Children With Developmental Delay
During fetal life and infancy, an adequate cobalamin status is important for normal growth and central nervous system development.
- Trial name
- NCT00710138
- Testing
- Hydroxycobalamin (Vitamin B12 Depot, Nycomed Pharma)
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- Haukeland University Hospital
Gastric Cancer
Using Radiomics to Predict Neoadjuvant Chemotherapy Efficacy
Neoadjuvant chemotherapy (NC) is an important treatment for advanced gastric cancer (AGC). However, tools that effectively predict the efficacy of NC before treatment are lacking.
- Trial name
- NCT05465512
- Testing
- response to neoadjuvant chemotherapy
- Where
- China
- Volunteers
- 193 people
- Sponsor
- Fujian Medical University
Blood Alcohol Concentration, Drunk Driving
Community-based Partnership's Efficacy in Decreasing Injury Rates At Night in Dallas, TX
According to the Centers for Disease Control and Prevention (CDC), "88,000 people die every year due to alcohol-related issues including homicide, sexual assault, intimate partner violence, and suicide".
- Trial name
- NCT06695416
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Methodist Health System
Cesarean Section Complications
Role of Drain in Decreasing Postoperative Complications
postoperative complications are common after cesarean section
- Trial name
- NCT04287933
- Testing
- Drain insertion
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Aljazeera Hospital
Colorectal Cancer, Triple Negative Breast Cancer, NSCLC - Adenocarcinoma
A Study of PDR001 in Combination With CJM112, EGF816, Ilaris® (Canakinumab) or Mekinist® (Trametinib)
The purpose of this study was to combine the PDR001 checkpoint inhibitor with each of four agents with immunomodulatory activity to identify the doses and schedule for combination therapy and to preliminarily assess the safety…
- Trial name
- NCT02900664
- Testing
- PDR001, ACZ885, CJM112
- Where
- 23 sites in United States, Belgium and 7 more
- Volunteers
- 283 people
- Sponsor
- Novartis Pharmaceuticals
Acute Coronary Syndromes
Effect of rHDL on Atherosclerosis - Safety and Efficacy: THE ERASE TRIAL
Currently available therapies to treat Acute Coronary Syndromes(ACS) have several limitations including; the relatively long treatment duration required before apparent significant benefit; the inability to achieve reversal of…
- Trial name
- NCT00225719
- Testing
- rHDL
- Where
- Canada
- Volunteers
- 180 people
- Sponsor
- CSL Limited
Concussion (Diagnosis)
Nature as Medicine for the Healing Brain: Utilization of a Nature-based Exposure Intervention for Decreasing Concussion Recovery Timeline and Symptom Load
The overall goal of this research is to provide pilot data that informs and drives a larger scale research project, incorporating multiple contemporary measurement modalities, to understand the utility and pathological mechanisms…
- Trial name
- NCT07642739
- Testing
- Nature-based Guided Awareness Group, Standard Guided Awareness Group
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Penn State University