Clinical trials: Regression
Bile Duct Cancer, Biliary Cancer
Combination of Trametinib (MEK Inhibitor) and Hydroxychloroquine (HCQ) (Autophagy Inhibitor) in Patients With KRAS Mutation Refractory Bile Tract Carcinoma (BTC).
Background: Bile duct cancer is cancer of the slender tubes of the biliary tract. These tubes carry bile through the liver. Such cancer tumors often have an abnormal or mutated gene.
- Conditions
- Bile Duct Cancer, Biliary Cancer, Biliary Tract Neoplasms, Cholangiocarcinoma
- Trial name
- NCT04566133
- Testing
- Trametinib, Hydroxychloroquine
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- National Cancer Institute (NCI)
Cardiovascular Disease
Decreasing Dialysis Cardiovascular Risk: Daily Versus Longer Treatments
Given the known increased risk of heart disease in hemodialysis patients, this study aims to evaluate the change in both size and function of the heart by using cardiac magnetic resonance imaging (MRI) in patients undergoing…
- Trial name
- NCT00925483
- Testing
- dialysis
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Dallas VA Medical Center
Atherosclerosis, Diabetes
Strategies for Inflammation and Cardiovascular Disease (CVD) Prevention
The long-term goal of the proposed research is to identify and develop effective interventions to decrease persistent, low-level inflammation and risk of CVD.
- Trial name
- SICVDP (NCT02165228)
- Testing
- Mindfulness-based stress reduction, Nutrition Enhancement
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Montana State University
Hyperuricemia, Chronic Kidney Disease
The Effect of Uric Acid Decrement on Endothelial Function in Patients With Chronic Renal Failure
In this prospective study, the investigators aimed to evaluate the effects of improved hyperuricemia, a minor cardiovascular risk factor, on endothelial dysfunction in patients with chronic kidney disease.
- Trial name
- NCT00978653
- Testing
- allopurinol
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Istanbul University
Dehydration, Diverting Ileostomy, Loperamide
Use of Post Operative Loperamide in Colorectal Patients After Diverting Ileostomies
Dehydration post creation of a diverting ileostomy is a common and debilitating problem faced by patients undergoing ileal-anal pouch anastomoses for both inflammatory bowel disease and familial adenomatous polyposis (FAP)…
- Trial name
- NCT02263365
- Testing
- Loperamide
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Cedars-Sinai Medical Center
Food Selectivity
Effectiveness of the Just Right Challenge Food Club for Decreasing Food Selectivity and Increasing Mealtime Quality
This single subject study tested the effectiveness of the Just Right Challenge Food Club for decreasing food selectivity and increasing mealtime qualify for children with developmental disabilities.
- Trial name
- NCT03756844
- Testing
- Just Right Challenge Food Club
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Western Michigan University
Thyroid Cancer, Breast Cancer
Dexamethasone Reduces Postoperative Emesis by Decreasing PGF2α and LTC4 Levels
Hypothesis: Dexamethasone reduces postoperative emesis in thyroidectomy and mastectomy patients.
- Trial name
- NCT01811199
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Marmara University
Down Syndrome, Physical Inactivity
Decreasing Alzheimer's Risk Through oNline Choreographed Exercise - Down Syndrome
The investigators are assessing acceptability, appropriateness, and feasibility of an remote choreographed exercise intervention using validated scales alongside qualitative data among young adults with Down Syndrome.
- Trial name
- DANCE-DS (NCT06537648)
- Testing
- Decreasing Alzheimer's Risk Through oNline Choreographed Exercise - Down Syndrome Program
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Kansas Medical Center
Procedural Complication
Examining Behaviors of Teachers of Invasive Bedside Procedures Using an Eye Tracking Device
Researchers are studying the behaviors in teachers of invasive bedside procedures to improve the safety of invasive bedside procedure in the Intensive Care Unit (ICU).
- Trial name
- NCT04235790
- Testing
- Eye Tracking Device
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Acute Promyelocytic Leukemia With PML-RARA, t(15;17)
Simplified Patient Care Strategy in Decreasing Early Death in Patients With Acute Promyelocytic Leukemia
This clinical trial studies how well simplified patient care strategy works in decreasing early death in patients with acute promyelocytic leukemia.
- Trial name
- NCT03253848
- Testing
- Simplified Patient Care Strategy, Laboratory Biomarker Analysis
- Where
- 294 sites in United States, Puerto Rico
- Volunteers
- 202 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
ACL, Anterior Cruciate Ligament Injury
Decreasing Knee Injury Risk Factors With Neuromuscular Training
Anterior cruciate ligament (ACL) tears are disabling injuries that place a significant burden on the athlete. Roughly 80% of these injuries are linked to a noncontact mechanism, with more than 70% of them occurring while landing…
- Trial name
- NCT01433718
- Testing
- Neuromuscular and Resistance Training
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Ohio University
Liver Transplantation, Liver Diseases
Assessing Declined Liver Grafts With Normothermic Machine Perfusion to Reduce Transplant Waiting Time
The goal of this study is to find out if quality assessment by normothermic machine perfusion can be used to safely increase the number of usable donor livers, helping more people get transplants faster and with better results.
- Conditions
- Liver Transplantation, Liver Diseases, Surgery
- Trial name
- ExTra (NCT06874296)
- Testing
- Quality Assessment with Normothermic Machine Perfusion (NMP)
- Where
- 10 sites in Germany
- Volunteers
- 186 people
- Sponsor
- Charite University, Berlin, Germany
Crohn's Disease
A Crohn's Disease Diet to Reduce Symptoms of Crohn's Disease
A 16-week randomized, pilot study to determine if an elimination diet reduces symptoms of Crohn's disease. Sixty (60) adult patients (18-75 yrs) with a mild or moderate Crohn's Disease Activity Index (CDAI) of 150-450, will be…
- Trial name
- NCT01897090
- Testing
- Elimination Diet, Dietary Guidelines for Americans
- Where
- United States
- Sponsor
- Johns Hopkins University
Stress, Complete Psychological Check Up
Cognition and Health in Adolescents, Mindfulness as Prevention of Stress.
The purpose of this study is to determine whether mindfulness is useful as primary prevention for psychological health in highschool students, primarily related to stress, and whether mindfulness can improve cognitive function.
- Conditions
- Stress, Complete Psychological Check Up, Sleep, Cognition - Other
- Trial name
- CHAMPS (NCT01457222)
- Testing
- Mindfulness intervention, Music relaxation
- Where
- Sweden
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Region Skane
Endothelial Dysfunction
Effect of Different Methodologies on Variability of Brachial Artery Flow Mediated Dilation
Flow mediated dilation (FMD) of the brachial artery has been widely used as a non-invasive measure of endothelial function. FMD independently predicts future cardiovascular events and can be readily influenced by pharmacological…
- Trial name
- NCT01899937
- Where
- 4 sites in Italy, Netherlands
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Atherosclerosis, Diabetes Mellitus
TART - Troglitazone Atherosclerosis Regression Trial
The purpose of this study is to determine if troglitazone reduces the progression of early preintrusive carotid atherosclerosis in insulin-requiring diabetes patients.
- Trial name
- NCT00116545
- Testing
- troglitazone
- Where
- United States
- Volunteers
- 288 people
- Sponsor
- Parke-Davis
Head Injury Trauma, Traumatic Brain Injury, Mild
The PIONEER Comparative Effectiveness Study - Project 2
This is a pragmatic, open-label, multicenter, stepped-wedge, Type II hybrid effectiveness-implementation study. It is designed to evaluate both the comparative effectiveness and implementation feasibility of a…
- Trial name
- NCT07829107
- Testing
- Clinical pathway 1: Guidelines plus biomarkers, Clinical guidelines only
- Where
- 6 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- University of Michigan
Childhood Obesity, Hunger
School Breakfast Policy Initiative Study
The purpose of this study is to develop and evaluate the effects of a school breakfast policy initiative (SBPI) on the incidence of overweight and obesity as well as breakfast patterns (both inside and outside of school) among…
- Trial name
- SBPI (NCT01924130)
- Testing
- Classroom feeding, Nutrition education lessons, Social Marketing
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Temple University
Melanoma, Colon Cancer
Messenger RNA (mRNA)-Based, Personalized Cancer Vaccine Against Neoantigens Expressed by the Autologous Cancer
Background: Exome sequencing can identify certain gene mutations in a person's tumor. This can then be used to create cancer treatments.
- Conditions
- Melanoma, Colon Cancer, Gastrointestinal Cancer, Genitourinary Cancer
- Trial name
- NCT03480152
- Testing
- National Cancer Institute (NCI)-4650, a messenger ribonucleic acid (mRNA)-based, Personalized Cancer Vaccine
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Cancer Institute (NCI)
Myopia
Evaluation of the Efficacy in Decreasing Myopia Progression of the Proposed Ophthalmic Lens Prototypes
Evaluation of the efficacy in decreasing myopia progression of the proposed ophthalmic lens prototypes.
- Trial name
- NCT05250206
- Testing
- Myopia control lens
- Where
- Spain
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Indizen Optical Technologies, S.L.U.