Clinical trials: Regression
Alcoholism
Acamprosate: Genes Associated With Response
In 2004, acamprosate was approved in the U.S. for abstinence maintenance, by decreasing craving, in alcoholic patients who have undergone detoxification.
- Trial name
- ACAM (NCT00662571)
- Testing
- acamprosate
- Where
- United States
- Volunteers
- 485 people
- Sponsor
- Mayo Clinic
Aortic Stenosis
Cardiac MRI for Severe Aortic Stenosis
This study will evaluate the importance of arterial stiffness and wave reflections as determinants of persistent left ventricular (LV) hypertrophy and fibrosis (assessed using cardiac magnetic resonance imaging [MRI]) after…
- Trial name
- NCT01638156
- Where
- 2 sites in United States
- Volunteers
- 39 people
- Sponsor
- American College of Radiology
Polypoidal Choroidal Vasculopathy
Interval of Disease Inactivity After Complete Polypoidal Regression in PCV Receiving Aflibercept
Polypoidal choroidal vasculopathy (PCV), a subtype of neovascular age-related macular degeneration (NV AMD), is an important cause of central visual loss, especially among Asian and African descendants.
- Trial name
- NCT04707027
- Testing
- Aflibercept Injection (2 mg/0.05 ml), Defer treatment
- Where
- Thailand
- Volunteers
- 80 people
- Sponsor
- Chiang Mai University
Liver Cirrhosis
Optimized Treatment and Regression of HBV-induced Compensated Liver Cirrhosis
Six hundreds patients with chronic hepatitis B clinically diagnosed as compensated liver cirrhosis are randomly assigned in a 1:1 ratio.
- Trial name
- NCT01943617
- Testing
- Entecavir, Thymosin-α
- Where
- 21 sites in China
- Volunteers
- 606 people
- Sponsor
- Beijing Friendship Hospital
Anesthesia, General
Muscle Relaxants and Laryngeal Local Anesthetics for Laryngeal Mask Airway Insertion Decreasing Propofol in Elderly
Laryngeal mask airway (LMA) is currently the most widely used supraglottic airway device with advantages of simple and fast placement, reduced anesthesia drug use, more stable hemodynamics, and less throat discomfort after…
- Trial name
- LMA (NCT05310110)
- Testing
- 10% lidocaine spray, Cisatracurium, Propofol
- Where
- Taiwan
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Proton Pump Inhibitor, Acute Kidney Injury
Risk Factors and Machine Learning Model for Proton Pump Inhibitor Related Acute Kidney Injury
Recent evidence concerns acute kidney injury (AKI) following proton pump inhibitor (PPI) application. Few actual studies have compared the incidence, risk factors, and predictive models of AKI associated with PPI.
- Trial name
- NCT05533619
- Testing
- Proton pump inhibitor
- Where
- China
- Volunteers
- 30,000 people
- Sponsor
- Qianfoshan Hospital
C.Surgical Procedure; Cardiac, Delirium
Decreasing the Incidence of Delirium After Cardiac Surgery
In critically ill surgical patients, delirium (confusion and disorientation) is extremely common and is associated with longer hospital length of stay, mortality, cost, and long term cognitive impairment.
- Trial name
- NCT02119806
- Testing
- Benzodiazepine, Fentanyl, Propofol
- Where
- United States
- Sponsor
- University of California, Los Angeles
Colorectal Cancer, Triple Negative Breast Cancer, NSCLC - Adenocarcinoma
A Study of PDR001 in Combination With CJM112, EGF816, Ilaris® (Canakinumab) or Mekinist® (Trametinib)
The purpose of this study was to combine the PDR001 checkpoint inhibitor with each of four agents with immunomodulatory activity to identify the doses and schedule for combination therapy and to preliminarily assess the safety…
- Trial name
- NCT02900664
- Testing
- PDR001, ACZ885, CJM112
- Where
- 23 sites in United States, Belgium and 7 more
- Volunteers
- 283 people
- Sponsor
- Novartis Pharmaceuticals
Bronchoscopy
This Study Will Evaluate the Effectiveness of a Simple Intervention Through a Classical Yankauer Oral Suction Tube, in Decreasing the Sedative Medication Doses Needed to Provide Effective Patient Sedation During Bronchoscopy, Along With Its Effect on Both Patient's and Bronchoscopist Satisfaction
The aim of this study is to evaluate the effectiveness of a simple intervention through a classical Yankauer oral suction tube, a device known to have a proven safety profile in multiple healthcare settings, in decreasing the…
- Trial name
- NCT06908109
- Testing
- Yankauer Suction Device, Bronchoscopy
- Volunteers
- 120 people
- Sponsor
- American University of Beirut Medical Center
Post Operative Pain, Cesarean Section Pain
Application of Transversus Abdominus Plain Block, Local Subcutaneous Injection and IV Nalbuphine
Approximately 1 in 5 women who undergo CS will experience severe acute postoperative pain. The severity of pain in the acute postoperative period is a significant predictor for the development of chronic pain, which occurs in…
- Trial name
- NCT05276206
- Testing
- NSAID , NALUFIN , local anesthetic andTAP Block
- Where
- Egypt
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Egymedicalpedia
Cervical Radiculopathy
Role of Nerve Mobilizations in Decreasing Pain and Disability Among Patients With Cervical Radiculopathy
Objective of the study is to find out the effectiveness of nerve mobilization in patients with cervical radiculopathy. It is a single blinded randomized controlled trial using non-probability convenient sampling.
- Trial name
- NCT04896749
- Testing
- Nerve mobilization, Conventional physical therapy
- Where
- Pakistan
- Volunteers
- 64 people
- Sponsor
- University of Lahore
HCC Patients After Curative Treatment With Low HBV Viral Load
Tenofovir Alafenamide(TAF) Reduces the Risk of Hepatocellular Carcinoma(HCC) Recurrence
Hepatocellular carcinoma(HCC) is prevalent in the hepatitis B virus(HBV) infection endemic areas. For early stage of HCC, surgical resection, radiofrequency ablation (RFA) or microwave ablation (MWA) are the main treatment…
- Trial name
- NCT04290936
- Testing
- Vemlidy® (Tenofovir Alafenamide; TAF)
- Where
- 4 sites in Taiwan
- Volunteers
- 402 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Infertility
Effect of Psychological Intervention on Drop-out Rates in IVF
The most common reason why insured In Vitro Fertilization (IVF) patients drop out of treatment is the distress caused by the treatment.
- Trial name
- NCT01318291
- Testing
- CCRI Group, Control
- Where
- United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Boston IVF
Pre Diabetes, Postpartum Disorder
Treatment to Regress to Normoglycemia in Women with a Recent History of GDM
The purpose of the study is to determine the efficacy of semaglutide 1mg (Ozempic®) to aid recently postpartum women with dysglycemia and a history of GDM to regress to normoglycemia; thereby filling a gap in efficacious…
- Trial name
- SWEET (NCT04873050)
- Testing
- Semaglutide Pen Injector [Ozempic]
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Woman's
Procedural Pain
Comparing Buzzy Device With Emla Cream in Needle Related Pain
This randomized controlled study will enroll the eligible patients to either the Buzzy device arm or to the EMLA cream arm as a standard therapy. This will be done with concealment; however, blinding will not be practical.
- Trial name
- NCT05354739
- Testing
- The vibration cold device (BUZZY)
- Where
- Qatar
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Hamad Medical Corporation
Scleroderma, Systemic
Thalidomide for Decreasing Collagen Biosynthesis in People With Progressive Systemic Sclerosis
Progressive systemic sclerosis (SSc) is an immune-based disease that causes abnormal connective tissue growth of the skin and internal organs. At this point, there are no effective therapies for treating SSc.
- Trial name
- NCT00418132
- Testing
- Thalidomide
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- NYU Langone Health
Low-Moderate Hypercholesterolemia
Clinical Trial to Demonstrate the Efficacy of a Dietary Supplement in Decreasing Cardiovascular Risk
This clinical trial seeks to verify the efficacy of a red rice yeast dietary supplement in the decrease of cardiovascular risk, by assessing variables related with cardiovascular risk as levels of cholesterol, triglycerides and…
- Trial name
- NCT03828006
- Testing
- Red Rice Yeast
- Where
- 3 sites in Spain
- Volunteers
- 100 people
- Sponsor
- Bioksan
Acute Coronary Syndrome, Air Pollution
Air Pollution Exposure on Acute Coronary Syndrome in Two Cohorts of Industrial and Non-industrial Areas
Background: There is a lack of data on the effect of air pollution on acute coronary syndrome (ACS) in industrial and non-industrial areas.
- Trial name
- NCT04539925
- Testing
- Acute coronary syndrome
- Where
- 2 sites in Poland
- Volunteers
- 9,046 people
- Sponsor
- Medical University of Silesia
Pain, Anxiety
Decreasing REcurrent Pain and Anxiety in Medical Procedures With a Pediatric Population: a Pilot Study
Children with injuries, including burns, experience severe pain intensity during medical procedures despite the increasing doses of analgesics.
- Conditions
- Pain, Anxiety, Burns, Child
- Trial name
- DREAM-P (NCT02977923)
- Testing
- VR distraction via Oculus Rift, Standard pharmacological treatment
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- St. Justine's Hospital
Loneliness, Anxiety
Is Signposting to Online Peer Support Helpful in Decreasing Loneliness in Parents of Children With Long-term Conditions and Disabilities?
The present study aims to evaluate whether signposting to online peer support will be associated with a significant decrease in self-reported loneliness for parents of children with long-term conditions and disabilities.
- Conditions
- Loneliness, Anxiety, Anxiety Disorder, Depression
- Trial name
- NCT05373121
- Testing
- Online Peer Support
- Where
- United Kingdom
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- University College, London