Clinical trials: Regression
Cigarette Smoking-Related Carcinoma, Tobacco-Related Carcinoma
Broccoli Sprout/Broccoli Seed Extract Supplement in Decreasing Toxicity in Heavy Smokers
This randomized early phase I trial studies how well broccoli sprout/broccoli seed extract supplement works in decreasing toxicity in heavy smokers.
- Trial name
- NCT03402230
- Testing
- Broccoli Sprout/Broccoli Seed Extract Supplement, Laboratory Biomarker Analysis, Questionnaire Administration
- Where
- 2 sites in United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Ileostomy - Stoma
Efficacy of Ostom-i Alert System at Decreasing Dehydration Related Complications
The purpose of this study is to evaluate the efficacy of the Ostom-i device in decreasing readmission rates of subjects with new ileostomies in the first 30 days post-operatively.
- Trial name
- NCT02694757
- Testing
- Ostom-i device
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Massachusetts General Hospital
Alcohol Drinking, Cannabis Use
Developing and Testing an Online Intervention for Alcohol and Cannabis Misuse and Healthy Relationship Skills Among Young Adult Couples
The goal of this clinical trial is to develop and test a brief online intervention to reduce alcohol and cannabis misuse and improve healthy relationship skills among young adult couples.
- Conditions
- Alcohol Drinking, Cannabis Use, Couples
- Trial name
- NCT06422299
- Testing
- Online, couples-based intervention
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Washington
Endometrial Polyp
Endometrial Polyps Regression With Progesterone Therapy
This prospective randomized study will compare the regression rates of women managed with watch-and-wait approach and of those treated with 3 cycles of luteal 25mg subcutaneous progesterone from 18 to 25 days of menstrual cycle
- Trial name
- NCT03309709
- Testing
- subcutaneous progesterone
- Where
- 2 sites in Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Magna Graecia
Gastroesophageal Reflux Disease (GERD), Gastroesophageal Reflux (GER)
Development of Machine Learning Models to Predict Postoperative GERD Symptom Resolution After Laparoscopic Nissen Fundoplication
This study aims to develop machine learning models to predict postoperative gastroesophageal reflux symptom resolution after laparoscopic Nissen fundoplication using Elastic Net regression and synthetic minority oversampling…
- Trial name
- NCT06862037
- Testing
- Laparoscopic Nissen fundoplication
- Where
- South Korea
- Volunteers
- 112 people
- Sponsor
- Korea University Anam Hospital
Hyperandrogenism, Metabolic Cardiovascular Syndrome
Phlebotomy and Polycystic Ovary Syndrome
AIMS To study the effects of the decrease in iron tissue depots after scheduled bloodletting on insulin sensitivity, carbohydrate metabolism, classic and non-classic cardiovascular risk factors in patients with functional…
- Trial name
- NCT02460445
- Testing
- Phlebotomy, ethinylestradiol, Cyproterone Acetate
- Where
- Spain
- Volunteers
- 37 people
- Sponsor
- Manuel Luque Ramírez
Pulpitis, Nerve Block
Predicting Local Anesthetic Success in Symptomatic Irreversible Pulpitis: A Machine Learning Study
This study will develop and internally validate three machine learning models - logistic regression, random forest, and XGBoost - to predict local anesthetic (LA) success in patients undergoing endodontic treatment for…
- Conditions
- Pulpitis, Nerve Block, Anesthesia, Local
- Trial name
- LA-PREDICT-SIP (NCT07672678)
- Volunteers
- 4,390 people
- Sponsor
- Jamia Millia Islamia
Burnout, Professional, Occupational Stress
Factors Affecting Burnout in Physiotherapists in Turkey
This cross-sectional descriptive study aims to identify the demographic, occupational, organisational and individual psychological factors that predict burnout among physiotherapists working in active clinical practice in Turkey.
- Conditions
- Burnout, Professional, Occupational Stress, Psychological Resilience, Self Efficacy
- Trial name
- PT-BURNOUT-TR (NCT07722858)
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Sepsis
Regression Discontinuity Design to Evaluate of Drotrecogin Alpha Effectiveness
Many health care interventions and medications found to have benefits ("efficacy") in experimental, tightly-controlled, human research trials are later found to lack real-world health benefits ("effectiveness").
- Trial name
- NCT02843685
- Testing
- Drotrecogin alfa activated
- Where
- United States
- Volunteers
- 12,492 people
- Sponsor
- Boston Medical Center
Scoliosis; Juvenile, Scoliosis; Adolescence
Virtual Reality's Effect on Decreasing Pain and Subsequent Opioid Use in Pediatric Patients in the Post-Operative Period Following Scoliosis Repair
The goal of this study is to determine whether introducing VR in the immediate post-operative period following scoliosis repair can reduce perceived pain and stress in pediatric patients and in turn ultimately decrease opioid…
- Conditions
- Scoliosis; Juvenile, Scoliosis; Adolescence, Scoliosis
- Trial name
- NCT05888038
- Testing
- virtual reality
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Northwell Health
Procedural Complication
Examining Behaviors of Teachers of Invasive Bedside Procedures Using an Eye Tracking Device
Researchers are studying the behaviors in teachers of invasive bedside procedures to improve the safety of invasive bedside procedure in the Intensive Care Unit (ICU).
- Trial name
- NCT04235790
- Testing
- Eye Tracking Device
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Hyperlipidemia
The Effects of Atorvastatin on Vulnerable Plaques in Untreated Dyslipidemic Patients.
Inflammation is important in the both pathogenesis and outcome of atherosclerosis. Plaques containing numerous inflammatory cells, particular macrophages, have a high risk of rupture.We hypothesize that statin-induced plaque…
- Trial name
- NCT00172419
- Testing
- Atorvastatin
- Where
- Taiwan
- Volunteers
- 43 people
- Sponsor
- National Taiwan University Hospital
Hypertension, Left Ventricular Hypertrophy
Aliskiren in Combination With Losartan Compared to Losartan on the Regression of Left Ventricular Hypertrophy in Overweight Patients With Essential Hypertension
To compare the efficacy and safety of aliskiren in combination with losartan compared to losartan on the regression of the increased size of the left ventricle in overweight patients with high blood pressure.
- Conditions
- Hypertension, Left Ventricular Hypertrophy, Overweight
- Trial name
- ALLAY (NCT00219141)
- Testing
- Aliskiren 150/300 mg, Losartan 50/100 mg
- Where
- 9 sites in United States, Argentina and 7 more
- Volunteers
- 460 people
- Sponsor
- Novartis Pharmaceuticals
Endothelial Dysfunction
Effect of Different Methodologies on Variability of Brachial Artery Flow Mediated Dilation
Flow mediated dilation (FMD) of the brachial artery has been widely used as a non-invasive measure of endothelial function. FMD independently predicts future cardiovascular events and can be readily influenced by pharmacological…
- Trial name
- NCT01899937
- Where
- 4 sites in Italy, Netherlands
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Bleeding During Myomectomy
Rectal Misoprostol Versus Sublingual Misoprostol Prior to Myomectomy
the aim of the study is To compare the effectiveness of rectally administered prostaglandin E1 synthetic analogue (misoprostol) 400 microgram versus sublingually administered misoprostol before myomectomy to decrease blood loss…
- Trial name
- RM-SLM (NCT02716142)
- Testing
- rectal misoprostol, sublingual misoprostol
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Assiut University
Papillomavirus Infections
Clinical Effectiveness of PAPILOCARE® in Regression of Cervix HPV Cytological Abnormalities (PAPILOBS GR).
The present study is a multicenter, open, non-interventional, prospective observational clinical study for the evaluation of the effectiveness of Papilocare® (medical device with CE mark) in the regression of cervix cytological…
- Trial name
- PAPILOBSGR (NCT06399341)
- Testing
- Papilocare vaginal gel
- Where
- 4 sites in Greece
- Volunteers
- 524 people
- Sponsor
- Elpen Pharmaceutical Co. Inc.
Postoperative Pain
Combination of Preoperative Gabapentin and TAP Blocks in Decreasing Postoperative Pain
There is an increasing trend on decreasing narcotic use and maximizing efficiency in the perioperative care. There are no studies that have compared a TAP block versus a TAP block plus gabapentin for laparoscopic procures.This…
- Trial name
- NCT02927405
- Testing
- Gabapentin, TAP Block
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- State University of New York - Downstate Medical Center
Pulmonary Resection
Measurement of the Distance Between the Corresponding Anatomical Landmarks in the Thoracic Cavity and the Incisors
Patients who agree to receive pneumonectomy will be arranged to measure the distance from the incisors to the corresponding anatomical landmarks, including the cardia, the inferior pulmonary vein, the carina, the azygos vein, the…
- Trial name
- NCT03720405
- Where
- China
- Volunteers
- 520 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Hemodialysis Complication
UFH is the Most Used Anticoagulant in Hemodialysis, Decreasing the Risk of Clot Formation in the Circuit.
The objective of this study was to verify the clinical non-inferiority of the pharmacodynamic effects and the safety of use of the drug Heptar® manufactured by Eurofarma Laboratory, compared to the drug Liquemine®, manufactured…
- Trial name
- HEPIRC (NCT05148377)
- Testing
- Liquaemin, Heptar
- Volunteers
- 128 people
- Sponsor
- Eurofarma Laboratorios S.A.
Head and Neck Cancer
Contrast Between Traditional Regression Model and AI in Predicting Prolonged Stay Stay After Head and Neck Tumors
This experiment is an observational study of cohort. By establishing a cohort of patients with head and neck tumors transferred to ICU after surgery, investigators compared the prediction effect of AI and the traditional…
- Trial name
- NCT06570486
- Where
- China
- Volunteers
- 700 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University