Clinical trials: Regulatory T Cell Function
Rheumatoid Arthritis, Swelling Joint
Characterization of Regulatory T Lymphocytes in the Synovial Fluid of Patients Affected by Rheumatoid Arthritis.
In rheumatoid arthritis (RA) the clinical response to anti-TNFα is related to an increase in the number or in the function of Treg lymphocytes in the peripheral blood of patients.
- Conditions
- Rheumatoid Arthritis, Swelling Joint, Joint Fluid, Characterization of Regulatory T Lymphocytes
- Trial name
- CATERLIS (NCT03293667)
- Testing
- Exploratory synovial fluid analysis
- Where
- France
- Volunteers
- 19 people
- Sponsor
- University Hospital, Montpellier
Conjunctivitis, Allergic
Treg Effector Function and Th2/Treg Ratio in Allergic Conjunctivitis: Effect of Desensitization Therapy
This study aims to evaluate the effector function and expression of TIGIT and PD-1 on Tregs, as well as the Th2/Treg ratio, in patients with allergic conjunctivitis with and without desensitization therapy, compared to healthy…
- Trial name
- INMUNOREG (NCT07171307)
- Where
- Mexico
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Toxic Epidermal Necrolysis
Evaluating the Effect of Isotretinoin in Regulatory T-cell Function in Adverse Cutaneous Drug Eruptions (ACDEs): A Pilot Study
The purpose of this study is to determine whether isotretinoin is helpful in treating patients with an adverse cutaneous drug eruption known as toxic epidermal necrolysis (TEN).
- Trial name
- NCT02795143
- Testing
- Isotretinoin
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Delayed Graft Function
Role of T Helper 17 and Regulatory T Cells in Delayed Graft Function
Delayed graft function (DGF) increases risk of acute rejection after kidney transplantation (KTx). Interleukin-6, which is produced in DGF, is critical in directing naive T helper cells differentiation towards T helper 17 (Th17)…
- Trial name
- NCT01232816
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Chronic Migraine
Suppressive Functions of Regulatory T Cells in Migraine
Migraine is a frequent, disabling condition, of great social and economical impact worldwide. This condition is more frequent in women and subjects with autoimmune and/or inflammatory diseases.
- Trial name
- SIIM-reg (NCT07067112)
- Testing
- Blood sampling, questionnaire and phone call
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Sleep Apnea Syndromes
The Number and Function of Regular T Cell in Patients With Obstructive Sleep Apnea
To compare the number and function of regular T cell of patients with obstructive sleep apnea (OSA) versus that of age-, gender- and BMI (body mass index)-matched controls
- Trial name
- NCT02342028
- Testing
- OSA
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Hepatocellular Carcinoma
Enumeration and Function Analysis of Treg Cells in Peripheral Blood of HCC Patients Before and After Ablation Therapy
The purpose of this study is to determine the enumeration and function changes of regulatory t cells in peripheral blood of hepatocellular carcinoma patients before and 1 week, 4 weeks after ablation therapy.
- Trial name
- NCT01668381
- Testing
- radiofrequency ablation
- Where
- China
- Volunteers
- 20 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Prostate Cancer
T-reg Function Changes: a Novel Immune Regulatory Effect Underlying Benefit of Statin Use on Lethal Prostate Cancer
This study will evaluate whether simvastatin reduces intraprostatic immunosuppressive microenvironment through YAP-mediated T-reg dysfunction, and increases intraprostatic anti-tumor immune response in men recently diagnosed with…
- Trial name
- NCT05586360
- Testing
- Simvastatin 40mg
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Medical University of South Carolina
Cat Allergy, Cat Hypersensitivity
A Randomized Prospective Clinical Trial of Fel d 1 Peptide Immunotherapy
The goal of this study is to identify changes in cells that are related to the treatment with Cat-PAD (ToleroMune Cat).
- Trial name
- NCT02311413
- Testing
- Cat-PAD
- Where
- Canada
- Volunteers
- 39 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Graves' Disease
Function of Regulatory T Cells Improved by Dexamethasone in Graves' Patients
Antithyroid drugs is the first choice treatment of Graves' disease in China and Europe. However,the relapse rate is very high (40-60%) after therapy withdrawal, and many patients need further treatment.
- Trial name
- NCT01534169
- Testing
- Dexamethasone
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Xiao-Ming Mao
Healthy
Impact of Propionic Acid on Regulatory T Cell Function in Healthy Adults ( Pro-Health)
Pro-Health is a single-center, double-blind, randomized and placebo-controlled intervention study in healthy adults. The investigators address the effect of a dietary food supplementation of propionic acid on the immune system…
- Trial name
- Pro-Health (NCT06198374)
- Testing
- Sodium propionate
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
KIDNEY TRANSPLANTATION
Effect of Thymoglobulin Versus Basiliximab on Regulatory T Cell Function in Live Donor Kidney Transplant Recipients
This study aims to study the effects that two standard of care immunosuppression induction regimens have on regulatory T cells (Treg) in live donor renal transplant recipients.
- Trial name
- TReg Kidney (NCT02730715)
- Testing
- Basiliximab, Thymoglobulin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pennsylvania
Multiple Sclerosis
Vitamin D3 Supplementation and the T Cell Compartment in Multiple Sclerosis (MS)
In patients with Relapsing Remitting Multiple Sclerosis (RRMS), the investigators observed a positive correlation between regulatory T cell (Treg) function and vitamin D status.
- Trial name
- NCT00940719
- Testing
- vitamin D3
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Maastricht University Medical Center
Asthma, Regulatory T Cell Function
Oral Contraceptives and Asthma Control
Asthma is a chronic inflammatory disorder of the airways affecting approximately 15 million individuals in the U.S. The rate of asthma exacerbations among women is twice that of men after adolescence, and a large proportion of…
- Trial name
- NCT00662051
- Where
- United States
- Sponsor
- University of Kentucky
Sepsis, Immune System Disorder
The Th17/Treg Cells and IL-23/IL-17 Axis and Early Enteral Nutrition in Sepsis
The investigators aim to evaluate the roles of Th17/Treg cells and IL-23/IL-17 axis in the mechanisms of early enteral nutrition (EEN) correcting immune imbalance of sepsis by means of improving the intestinal flora disturbance.
- Conditions
- Sepsis, Immune System Disorder, Enteral Feeding
- Trial name
- NCT03385850
- Testing
- enteral nutrition
- Where
- China
- Volunteers
- 53 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Multiple Sclerosis
Mechanistic Study of Ocrevus
The purpose of this study is to investigate the immune cell and other factor changes with Ocrevus in Multiple Sclerosis (MS) patients. Researchers will recruit 35 participants for this study.
- Trial name
- NCT04459988
- Testing
- Ocrelizumab
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Atherosclerosis, Chronic Kidney Disease
Vitamin D Supplementation in CKD - Vascular Function, Structure and Immune Regulation
A pilot study to assess feasibility of methods of an observer-blinded randomised controlled trial of the effect of vitamin D supplementation in Chronic Kidney Disease and low vitamin D levels on markers of vascular function (Flow…
- Trial name
- NCT04380467
- Testing
- Vitamin D (cholecalciferol)
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- St George's, University of London
Allergic Asthma, Allergic Rhinitis
Study of the Frequency and of the Regulatory Function of Positive T Lymphocytes Dual CD4CD8aa (DP8a) Specific to a Bacteria of the Intestinal Microbiota (Faecalibacterium Prausnitzii) in Atopic Dermatitis, Asthma and Allergic Rhinitis
The prevalence of allergic diseases (atopic dermatitis, asthma, rhinitis, conjunctivitis and food allergy) has increased dramatically in industrialized countries over the last 20-30 years.
- Conditions
- Allergic Asthma, Allergic Rhinitis, Atopic Dermatitis
- Trial name
- Prévall-DP (NCT02908360)
- Testing
- double positive T cells (CD4 + / CD8 +) to the specific peripheral blood of F prauznitzii analyse
- Where
- France
- Volunteers
- 56 people
- Sponsor
- Nantes University Hospital
Relapse Remitting Multiple Sclerosis
Deficient T Regulatory Cell (Treg) Function in Patients With Relapsing Remitting Multiple Sclerosis
The purpose of this research is to find out how the T regulatory (Treg) cells control autoimmune response in multiple sclerosis.
- Trial name
- NCT04857489
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Acute Rejection of Renal Transplant, Graft Failure
Dd-cfDNA and Treg in Prediction of Kidney Transplant Acute Rejection
Acute rejection after kidney transplantation should ideally be diagnosed prior to immunologic injury in a non-invasive fashion in order to improve long-term graft function.
- Trial name
- NCT05084768
- Testing
- Donor-derived cell-free DNA
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Loma Linda University