Clinical trials: Rejection
Cytomegalovirus Infection, Renal Transplant Failure
Efficacy and Safety of Induction Strategies Combined With Low Tacrolimus Exposure in Kidney Transplant Recipients Receiving Everolimus or Sodium Mycophenolate
Despite the improvement of efficacy results with current immunosuppressive regimens (about 15% of incidence of acute rejection), the security schemes used do not show the same results.The most worldwide used regime is tacrolimus…
- Conditions
- Cytomegalovirus Infection, Renal Transplant Failure, Transplant; Complication, Rejection
- Trial name
- NCT01354301
- Testing
- Thymoglobulin, Everolimus, Basiliximabe
- Where
- Brazil
- Volunteers
- 300 people
- Sponsor
- Hospital do Rim e Hipertensão
Chronic Rejection in Lung Transplant, Cytokine Production in Bos Post Lung Transplant
Early Indicators of Chronic Rejection in Lung Transplant
The purpose of this research is to discover the different patterns of cytokine production in patients who may develop Bronchiolitis Obliterans Syndrome-0p (BOS-0p) which means ongoing rejection.
- Trial name
- BOS (NCT00449332)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Chicago
Chronic Rejection of Lung Transplant
Noninvasive Early Detection of Lung Allograft Dysfunction After Lung Transplantation With Multiple Breath Washout Test
Chronic rejection, more commonly called bronchiolitis obliterans syndrome (BOS), is the leading cause of death beyond the first year post lung transplantation.
- Trial name
- NCT05586906
- Testing
- Multiple Breath Washout (MBW) tests
- Where
- Switzerland
- Volunteers
- 90 people
- Sponsor
- University of Zurich
Heart Transplant Failure
Tacrolimus and Personalized Therapy to Prevent Acute Rejection Episodes
Heart transplant is the only effective treatment for people with advanced heart failure. Post-transplant pharmacological therapies are of fundamental importance for the survival of individuals after surgery: although considerable…
- Trial name
- NCT06338306
- Testing
- Tacrolimus（FK506）
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Graft Rejection, Kidney Disease
Monitoring for Tolerance to Kidney or Combined Kidney-Pancreas Transplants
This protocol facilitates the development of methods for determining whether transplant recipients have developed immune hyporesponsiveness or tolerance towards their allograft.
- Trial name
- NCT00001858
- Where
- United States
- Volunteers
- 294 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Kidney Transplantation, Kidney Allograft Biopsy
Study of Alloimmune Response in Humoral Rejection After Kidney Transplantation
We will study a prospective cohort including all kidney transplant recipients undergoing kidney graft biopsy in one kidney transplantation center, for a duration of 5 years.
- Conditions
- Kidney Transplantation, Kidney Allograft Biopsy, Humoral Rejection, Microvascular Inflammation
- Trial name
- RECITE (NCT05890430)
- Testing
- Blood draw, Urine draw
- Volunteers
- 570 people
- Sponsor
- University Hospital, Strasbourg, France
Kidney Transplant Rejection
The TOGETHER Project - Kidney RNA-seq Validation
The researchers are trying to develop a way to measure the risk of rejection through the validation of a blood test.
- Trial name
- TOGETHER (NCT03874299)
- Where
- 3 sites in United States
- Volunteers
- 302 people
- Sponsor
- Mayo Clinic
Lung Transplant; Complications, Chronic Kidney Diseases
Immunosuppressive Regimen on Changes in Renal Function and Transplant Rejection Rate in Patients With Lung Transplant
This retrospective single-center analyzes the impact of switch of immunosuppressive regimen on renal function and transplant rejection rate in patients with lung transplant.
- Trial name
- NCT03657004
- Where
- Germany
- Volunteers
- 145 people
- Sponsor
- University of Giessen
Kidney Failure, Kidney Diseases
Study Evaluating Sirolimus in the Treatment of Kidney Transplant
The aim of this study is to test whether withdrawal of calcineurin inhibitors, followed by treatment with sirolimus, may improve renal function in renal transplant recipients with chronic allograft nephropathy.
- Trial name
- NCT00282217
- Testing
- Sirolimus
- Where
- 13 sites in Spain
- Volunteers
- 100 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Kidney Transplant Rejection, Medication Adherence
Immunosuppressant Medication Dosed Daily After Kidney Transplant
Medication non-adherence is a major risk factor for graft dysfunction and graft loss among pediatric and adult transplant recipients.
- Trial name
- NCT04156204
- Testing
- Medication Event Monitoring System (MEMS), Once-Daily Tacrolimus extended release
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Colorado, Denver
Kidney Transplantation
Contrast-Enhanced Ultrasound for Kidney Transplant
Contrast-enhanced ultrasound (CEUS) is a promising non-invasive imaging tool that may aid in the early detection of kidney transplant complications, such as delayed graft function (DGF) and acute allograft rejection.
- Trial name
- NCT02911714
- Testing
- Lumason Contrast-Enhanced Ultrasound
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Utah
Liver Transplant Rejection
Cell Infusion Intraportal Autologous Bone Marrow Mononuclear as Enhancer of Liver Regeneration
This is a randomized controlled trial in which the safety and feasibility of cell therapy medicinal product shall be measured by comparing the variables of the response after treatment compared to baseline prior to…
- Trial name
- NCT01745731
- Testing
- Cell infusion intraportal mononuclear bone marrow autologous and portal embolization of the affected segments.
- Where
- Spain
- Volunteers
- 13 people
- Sponsor
- Andalusian Initiative for Advanced Therapies - Fundación Pública Andaluza Progreso y Salud
Kidney Transplant Rejection
Cellular Immunotherapy in Recipients of HLA-matched, Living Donor Kidney Transplants
The primary objective of this study is to demonstrate the safety and efficacy of cellular immunotherapy with MDR-101 for induction of functional immune tolerance in recipients of human leukocyte antigen (HLA)-matched, living…
- Trial name
- NCT03363945
- Testing
- MDR-101
- Where
- 19 sites in United States, Canada
- Volunteers
- 30 people
- Sponsor
- Medeor Therapeutics, Inc.
Lung Transplantation
Transbronchial Cryobiopsy in Lung Transplant Patients
Cryobiopsy has displaced the transbronchial biopsy (BTB) with forceps because it allows to obtain samples of more representative pulmonary parenchyma with more alveoli, less artifacts and a greater diagnostic yield.
- Trial name
- NCT03090594
- Testing
- Biopsy
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Kidney Disease, Kidney Failure
A Retrospective Multicenter Study to Determine 5-Year Clinical Outcomes in Subjects Previously Enrolled in the CTOT-01 Study
This study is a multicenter, non-randomized, retrospective study to collect long term (5 years post-transplant) clinical outcome data to test whether the results of the noninvasive immune monitoring test strategy performed in the…
- Conditions
- Kidney Disease, Kidney Failure, End Stage Renal Disease
- Trial name
- NCT01974999
- Where
- 7 sites in United States, Canada
- Volunteers
- 184 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Restrictive Chronic Lung Allograft Dysfunction, Lung Transplant Rejection
Pirfenidone for Restrictive Chronic Lung Allograft Dysfunction
Despite advances in lung transplantation, the median survival remains only 55% at 5 years. The main limitation to long term survival is the development of chronic lung allograft dysfunction.
- Trial name
- PIRCLAD (NCT03359863)
- Testing
- Pirfenidone
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of California, San Francisco
Influenza
Assess the Risk of Solid Organ Transplant Rejection Following Vaccination With Pandemrix™ in UK
This study aims to assess the risk of solid organ transplant (SOT) rejection following vaccination with Pandemrix™ and/ or seasonal influenza vaccination.
- Trial name
- NCT01715792
- Testing
- Data collection
- Where
- United Kingdom
- Volunteers
- 587 people
- Sponsor
- GlaxoSmithKline
Lung Transplant
Alveoscopy, Endoscopic Confocal Microscopy and Lung Rejection, Parenchymal Lung Diseases in Vivo
Lung transplantation is indicated when end-stage lung diseases no longer respond to available standard therapy, making life expectancy short and associated with disability.
- Trial name
- NCT01033201
- Testing
- Confocal imaging
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Mayo Clinic
End-stage Renal Failure, Graft Rejection
Standard Versus Prolonged-release Tacrolimus Monotherapy After Alemtuzumab Induction in Kidney Transplantation
The current anti-rejection drug regime for kidney transplant recipients in use at the West London Renal \& Transplant Centre (WLRaTC) consists of induction therapy with the very potent monoclonal antibody Campath 1-H…
- Trial name
- TAESR (NCT00807144)
- Testing
- Tacrolimus (Kidney transplant maintenance immunosuppression), Kidney transplant maintenance immunosuppression
- Where
- United Kingdom
- Volunteers
- 102 people
- Sponsor
- Imperial College Healthcare NHS Trust
Kidney Transplantation
OPERA Study: A Study of Two Dosing Regimens of CellCept (Mycophenolate Mofetil) in Kidney Transplant Patients.
This study will compare the incidence of acute clinical or subclinical rejection between immunosuppression with CellCept at a starting dose of 3mg po daily with therapeutic drug monitoring and standard immunosuppression with…
- Trial name
- NCT02005562
- Testing
- mycophenolate mofetil, anti-IL-2R, methylprednisolone
- Where
- 24 sites in France
- Volunteers
- 252 people
- Sponsor
- Hoffmann-La Roche