Clinical trials: Rejection
Lung Transplant Rejection
Adipose Derived Mesenchymal Cell Treatment in Lungtransplantation
To investigate safety of treatment with allogeneic adipose tissue-derived mesenchymal stromal cells (ASCs) in patients undergoing lung transplantation, to evaluate whether the treatment can reduce host immunological reaction…
- Trial name
- NCT04714801
- Testing
- adipose derived mesenchymal stromal cells, Saline
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Rejection, Graft Loss
Allogeneic Mesenchymal Stromal Cell Therapy in Renal Transplant Recipients
This study will test whether selected allogeneic bone marrow derived MSCs are safe by assessing the composite end point Biopsy Proven Acute Rejection (BPAR)/ graft loss at 12 months.
- Trial name
- Neptune (NCT02387151)
- Testing
- mesenchymal stromal cells
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Leiden University Medical Center
Disorder Related to Lung Transplantation, Bronchiolitis Obliterans
Aerosol Liposomal Cyclosporine for Chronic Rejection in Lung Transplant Recipients
This is a single-center pilot study to investigate the efficacy and safety of aerosolized liposomal cyclosporine A in the treatment of chronic rejection in lung transplant recipients with bronchiolitis obliterans syndrome (BOS).
- Conditions
- Disorder Related to Lung Transplantation, Bronchiolitis Obliterans, Decreased Immunologic Activity, Chronic Rejection of Lung Transplant
- Trial name
- NCT01650545
- Testing
- Liposomal aerosol cyclosporine, standard immune suppression, oral
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Maryland, Baltimore
Chronic Rejection of Lung Transplant
Advanced Immunoclinical Phenotyping of Rejection in Lung Transplant
Chronic allograft rejection of the transplanted lung (CLAD) is a major health issue in patients after lung transplant. This study is a registry-forming study with concurrent tissue banking from surveillance bronchoscopy in…
- Trial name
- NCT03697395
- Testing
- Lung transplant recipient without MRI imaging, Lung transplant recipient with MRI imaging
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- University of Virginia
Acute Rejection of Cardiac Transplant
Non-invasive Test for Acute Rejection Identification in Heart Transplanted Patients
Aim of the study is to test INNOGRAFT Heart Suite in a clinical setting, using a previously collected set of plasma samples from patients who underwent heart transplant and routinely or symptoms-based surveillance during the…
- Trial name
- INNOGRAFTRS001 (NCT04274712)
- Testing
- INNOGRAFT Heart Suite
- Where
- Italy
- Volunteers
- 72 people
- Sponsor
- Myway Gentics Srl
Cytomegalovirus Infections
Comparison of Oral Valganciclovir and Placebo for the Prevention of Cytomegalovirus (CMV) After Lung Transplantation
The study evaluated the efficacy and safety of a prolonged, continuous course of Valganciclovir (Valgan) in the prevention of CMV by comparing 3 months of Vaglanciclovir, the standard of care upon initiation of the study, to 12…
- Trial name
- Valgan (NCT00227370)
- Testing
- valganciclovir
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- Duke University
Graft Rejection
Urine Biomarker for Kidney Transplant Rejection
An adaptive sample collection to support biomarker evaluation for kidney transplant rejection.
- Trial name
- NCT05072951
- Testing
- Urine Biomarker for Kidney Transplant Rejection
- Volunteers
- 750 people
- Sponsor
- Exosome Diagnostics, Inc.
Kidney Transplantation
Extension Study Of Stage 1 Subjects Of Study A3921009 For The Prevention Of Acute Rejection In Kidney Transplant Patient
A new immunosuppressive drug, based on the inhibition of an important enzyme in the immune system called JAK3, is being developed by Pfizer to prevent transplant rejection.
- Trial name
- NCT00263328
- Testing
- Tacrolimus, CP-690,550
- Where
- 27 sites in United States
- Volunteers
- 46 people
- Sponsor
- Pfizer
Lung Transplant Rejection
Cell-free DNA as a Biomarker After Lung Transplantation
The purpose of this investigation is to determine the association of the fraction of donor-derived cell-free DNA in plasma and lung fluid samples with acute rejection as proven by biopsy in lung transplant recipients.
- Trial name
- NCT04271267
- Testing
- No Intervention
- Volunteers
- 126 people
- Sponsor
- Duke University
Cardiac Failure, Graft Rejection
OPtimal Adult Heart Transplant Immunosuppression With MicroRNA Levels
This study aims to develop and refine a microRNA (miR) biomarker panel that can be used to phenotype net immune state after heart transplantation using circulating miRs (associated with drug doses and levels).
- Trial name
- OPTIMAL (NCT06939751)
- Where
- 6 sites in United States
- Volunteers
- 250 people
- Sponsor
- Northwestern University
Prophylaxis of Organ Rejection
Bioequivalency Study of Mycophenolate Mofetil 250 mg Capsules Under Fed Conditions
The objective of this study was to prove the bioequivalence of Mycophenolate Mofetil 250 mg Capsules under fed conditions.
- Trial name
- NCT00893919
- Testing
- mycophenolate mofetil
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Roxane Laboratories
Kidney Transplant Rejection, Kidney Transplantation
Observational Cohort Study Renal Transplantation University Hospitals Leuven
This observational cohort study aims to compile routinely collected clinical, histological and outcome data of kidney transplant recipients, to evaluate risk factors for post-transplant injury, phenotypes of injury, and impact on…
- Conditions
- Kidney Transplant Rejection, Kidney Transplantation, Kidney Transplant Failure
- Trial name
- NCT06505200
- Testing
- No intervention
- Where
- Belgium
- Volunteers
- 1,891 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Corneal Diseases
Functional Antigen Matching in Corneal Transplantation
Penetrating keratoplasty is one of the most commonly performed transplantation surgeries. Graft rejection is a major complication.
- Trial name
- FANCY (NCT00810472)
- Testing
- HLA Matching, Penetrating keratoplasty
- Where
- Germany
- Volunteers
- 650 people
- Sponsor
- University Hospital Freiburg
Major Depressive Disorder
Neuronal Responses to Social Feedback in Major Depressive Disorder
The overall goal of the proposed project is to investigate the neuronal pathways regulating the effects of social acceptance and rejection in healthy controls and patients with Major Depressive Disorder (MDD).
- Trial name
- NCT02180607
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Lung Transplant Rejection
A Study to Test How Effective Belumosudil Tablets Are for Treating Adult Participants With Chronic Lung Allograft Dysfunction
This double-blind, randomized, placebo-controlled, multinational, multicenter, parallel-group, Phase 3, 2-arm, study will investigate the efficacy and safety of belumosudil compared with placebo, both administered on top of…
- Trial name
- ROCKaspire (NCT06082037)
- Testing
- Belumosudil, Azithromycin
- Where
- 85 sites in United States, Australia and 18 more
- Volunteers
- 180 people
- Sponsor
- Sanofi
End Stage Kidney Disease, Immunological Tolerance
Delayed Immunological Tolerance in Patients With Well-functioning Pre-existing HLA-matched Kidney Transplants
The study seeks to determine if patients with a pre-existing, well-functioning kidney transplant from a HLA-identical living donor can be withdrawn from immunosuppressive medications without compromising allograft function…
- Conditions
- End Stage Kidney Disease, Immunological Tolerance, Kidney Transplant Failure and Rejection, Chronic Kidney Diseases
- Trial name
- NCT05525507
- Testing
- Conditioning and Stem cell infusion
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
End Stage Renal Disease, Renal Transplant
Evaluating Safety and Efficacy of TOL101 Induction Versus Anti-Thymocyte Globulin to Prevent Kidney Transplant Rejection
Induction therapy with antibodies is administered during transplant surgery and for a short period of time following transplant surgery in an effort to render the immune system less able to mount an initial rejection response.
- Trial name
- NCT01154387
- Testing
- Anti-Thymocyte Globulin, TOL101, Steroids
- Where
- 12 sites in United States
- Volunteers
- 85 people
- Sponsor
- Tolera Therapeutics, Inc
Antibody Mediated Rejection of Lung Transplant
A Phase 1 Clinical Trial of Siltuximab for the Treatment of Antibody-Mediated Rejection After Lung Transplantation
Antibody-mediated rejection after lung transplantation commonly results in allograft failure and death in spite of current therapeutic regimens.
- Trial name
- Siltux-AMR (NCT06990711)
- Testing
- Siltuximab
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Washington University School of Medicine
Kidney Rejection Transplant
Molecular Transcriptomics in Diagnosing Pediatric Kidney Transplant Rejection: the PANDA-Kids-ATLAS Study
Children with kidney failure have markedly increased mortality and face repeated transplantation over their lifetime due to limited allograft half-life (12-15 years).
- Trial name
- NCT07091214
- Where
- France
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Paris Translational Research Center for Organ Transplantation
Heart Transplant Failure and Rejection, Coronary Artery Disease
Percutaneous Coronary Intervention in Patients witH OrthotoPic hEart Transplantation: the PCI-HOPE a Multicenter Study.
This is a retrospective, multicenter, study including patients undergone to one or more percutaneous revascularization after OHT.
- Trial name
- PCI-HOPE (NCT03538509)
- Testing
- PCI and implantation drug eluting stent or bare metal stent
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Fabrizio D'Ascenzo