Clinical trials: Rejection Lung Transplant
Lung Transplant Reject, Bronchiolitis Obliterans
Mesenchymal Stem Cell Therapy for Lung Rejection
To assess the safety and feasibility of mesenchymal stem cells therapy in patients with transplant related bronchiolitis obliteran syndrome (BOS)
- Trial name
- NCT02181712
- Testing
- Mesenchymal stem cell 0.5, Mesenchymal stem cell 1.0
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Mayo Clinic
Lung Transplant Recipient, Donor Specific Antibodies
DSA Intragraft in Lung Transplantation: Diagnostic and Prognostic Value in Antibody Mediated Rejection
The diagnosis of AMR in lung transplant recipients is difficult and often comes too late, because of lack of standardized definition.
- Conditions
- Lung Transplant Recipient, Donor Specific Antibodies, Antibody Mediated Rejection
- Trial name
- NCT03702257
- Testing
- bronchoscopy.
- Where
- 5 sites in France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Strasbourg, France
Lung Transplantation, Graft Rejection
Immunologic Risk of Pregnancy in Women With Lung Transplantion : a National Multicentric Study
TRIGGER 1 is a previous study that evaluate the immunological risk of pregnancy in women with lung transplants in France, whose pregnancy has ended between January 1, 2012 and December 31, 2021.
- Conditions
- Lung Transplantation, Graft Rejection, Pregnancy
- Trial name
- TRIGGER-2 (NCT05689905)
- Testing
- HLA typing of the children
- Where
- 9 sites in France
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Lung Transplant Rejection
Multicenter Analysis of Efficacy and Outcomes of Extracorporeal Photopheresis as Treatment of Chronic Lung Allograft Dysfunction
Lung transplantation is an established therapy for end-stage lung disease such as chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, cystic fibrosis and pulmonary hypertension.
- Trial name
- NCT04792294
- Testing
- Extracorporeal photopheresis
- Volunteers
- 800 people
- Sponsor
- Medical University of Vienna
Lung Transplant Rejection
Adipose Derived Mesenchymal Cell Treatment in Lungtransplantation
To investigate safety of treatment with allogeneic adipose tissue-derived mesenchymal stromal cells (ASCs) in patients undergoing lung transplantation, to evaluate whether the treatment can reduce host immunological reaction…
- Trial name
- NCT04714801
- Testing
- adipose derived mesenchymal stromal cells, Saline
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Organizing Pneumonia, Lung Transplant Rejection
Organizing Pneumonia in Lung Transplant Recipients, a Restrospective Exploratory Study (OPIL-Study)
The aim of this study is to generate evidence regarding organizing pneumonia in lung transplant recipients.
- Trial name
- OPIL (NCT06203964)
- Testing
- No intervention
- Where
- Switzerland
- Volunteers
- 280 people
- Sponsor
- University of Zurich
Lung Transplant; Complications, Lung Transplant; Infection or Inflammation
Prospective Multicenter Research on Donor and Recipient Management Strategies to Improve Lung Transplant Outcomes
This project aims to collect detailed clinical data, blood samples, and patient-reported outcomes from 2,600 lung transplant candidates, donors, and recipients at Lung Transplant Centers.
- Conditions
- Lung Transplant; Complications, Lung Transplant; Infection or Inflammation, Lung Transplant Rejection, Lung Transplant Failure
- Trial name
- PROMISE (NCT06399302)
- Where
- 19 sites in United States, Canada
- Volunteers
- 2,600 people
- Sponsor
- Duke University
Lung Transplant Rejection, Lung Transplant Failure and Rejection
Comparison of Transbronchial Cryobiopsy and Forceps Biopsy in Lung Transplant Recipients
CLAD is defined as loss of lung function after other factors, particularly infections have been excluded. Readily accessible diagnostic procedures to detect acute cellular rejection at the earliest possible occasion is crucial…
- Trial name
- Kryo-LUTPL (NCT05006742)
- Testing
- CB study arm, FB-CB study arm
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- University of Zurich
Lung Transplantation
Can Immune Parameters Predict Acute and Chronic Rejection in Lung Recipients?
This study will evaluate the ability of lung transplant recipients to react to the transplanted organs. Previous research indicates that some immune tests can identify whether people are at risk for chronic rejection of…
- Trial name
- NCT00340951
- Where
- 2 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Lung Transplant Rejection
Cell-free DNA as a Biomarker After Lung Transplantation
The purpose of this investigation is to determine the association of the fraction of donor-derived cell-free DNA in plasma and lung fluid samples with acute rejection as proven by biopsy in lung transplant recipients.
- Trial name
- NCT04271267
- Testing
- No Intervention
- Volunteers
- 126 people
- Sponsor
- Duke University
Covid19, Kidney Transplant; Complications
Multicenter CTS Pre-and Post-Transplantation Covid-19 Serum Studies
The Covid-19 Serum Study is a prospective case-control study in 1. kidney or liver transplanted patients being hospitalized due to an infection with Severe Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2) after…
- Conditions
- Covid19, Kidney Transplant; Complications, Kidney Transplant Failure and Rejection, Liver Transplant; Complications
- Trial name
- NCT04694573
- Where
- Germany
- Volunteers
- 600 people
- Sponsor
- Heidelberg University
Lung Transplantation
Transbronchial Cryobiopsy in Lung Transplant Patients
Cryobiopsy has displaced the transbronchial biopsy (BTB) with forceps because it allows to obtain samples of more representative pulmonary parenchyma with more alveoli, less artifacts and a greater diagnostic yield.
- Trial name
- NCT03090594
- Testing
- Biopsy
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Lung Transplant
Immuno-humoral Rejection Markers in Pulmonary Transplant
Open multicentric prospective study performed on pulmonary transplanted patients to detect the values of different diagnostic markers for immuno- humoral reaction and their roles in the humoral rejection for those patients.
- Trial name
- RHUM-TP (NCT01791166)
- Testing
- Blood test for detecting the circulatory anti-HLA antibodies by ELISA and LUMINEX tests
- Where
- France
- Volunteers
- 53 people
- Sponsor
- Hopital Foch
Lung Transplant Failure and Rejection, CLAD, Bronchiolitis Obliterans
Plasma and Radiologic Biomarkers of Response to ECP in Lung Transplant Recipients With CLAD
This study is for people who have had a lung transplant and developed a condition called chronic lung allograft dysfunction (CLAD), which is a type of chronic rejection.
- Conditions
- Lung Transplant Failure and Rejection, CLAD, Bronchiolitis Obliterans, Extracorporeal Photopheresis
- Trial name
- NCT07434869
- Where
- 3 sites in United States
- Volunteers
- 25 people
- Sponsor
- Brian Keller
Lung Transplant Rejection
The Role of Immune Checkpoints in Lung Transplant (ILTRA)
The goal of this observational study is to learn about rejection in lung transplantation. The main question it aims to answer is: what is the role of immune checkpoints in lung transplantation? Participants will describe pathways…
- Trial name
- ILTRA (NCT06302556)
- Testing
- Immune checkpoints analysis, Gene expression analysis
- Where
- 4 sites in Italy
- Volunteers
- 280 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Bronchiolitis Obliterans Syndrome
Correlation of Lung Biopsy, BAL, and High Resolution CT Scan in Lung Transplantation
A major source of graft failure and dysfunction in lung transplantation is known to be bronchiolitis obliterans (BO)and its clinical correlate called bronchiolitis obliterans syndrome(BOS).
- Trial name
- NCT00528853
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Chicago
Lung Transplant
Belumosudil to Block Chronic Lung Allograft Dysfunction (CLAD) in High Risk Lung Transplant Recipients
The purpose of this study is to see if taking the study drug, Belumosudil, for 52 weeks in addition to your usual care and medication, will prevent Chronic Lung Allograft Dysfunction (CLAD) in participants who have a lung biopsy…
- Trial name
- CLAD (NCT06476132)
- Testing
- Belumosudil
- Where
- 12 sites in United States, Canada
- Volunteers
- 234 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Cardiac Transplant Rejection, Lung Transplant Rejection
Genome Transplant Dynamics: Non-invasive Sequencing-based Diagnosis of Rejection
The purpose of this study is to determine whether shotgun sequencing technology, which can be used to detect donor DNA in recipient plasma, can be used as a rapid, accurate, non-invasive method to detect Acute Cellular Rejection…
- Trial name
- GTD (NCT01985412)
- Where
- 2 sites in United States
- Volunteers
- 65 people
- Sponsor
- Stanford University
Lung Transplantation, Chronic Lung Allograft Dysfunction
Lung Clearance Index and Lung Allograft Dysfunction
The aim of this project is to evaluate the ability of the lung clearance index (LCI) to detect early chronic lung allograft failure (CLAD) in adult lung transplant recipients over a period of 3 years.
- Conditions
- Lung Transplantation, Chronic Lung Allograft Dysfunction, Rejection Lung Transplant
- Trial name
- NCT03850002
- Testing
- Early detection of CLAD by Lung Clearance Index (LCI)
- Sponsor
- University of Zurich
Acute Rejection (AR) of Transplanted Kidney, Chronic Allograft Nephropathy (CAN)
Proteogenomic Monitoring and Assessment of Kidney Transplant Recipients
Chronic Allograft Nephropathy (CAN)/Interstitial fibrosis and Tubular Atrophy (IFTA) is responsible for most kidney transplant failures. CAN/IFTA on a 3 month kidney biopsy strongly predicts graft survival long term.
- Conditions
- Acute Rejection (AR) of Transplanted Kidney, Chronic Allograft Nephropathy (CAN), Interstitial Fibrosis (IF), Tubular Atrophy (TA)
- Trial name
- Mini-Kidney (NCT01531257)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Northwestern University