Clinical trials: Renal Dysfunction
Overweight, Obesity
A Research Study Looking Into Blood Levels of NNC0174-0833 in People With Normal and Impaired Kidney Function
The study looks at the blood levels of a new study medicine in people with normal and impaired kidney function. Participants will get the study medicine called NNC0174-0833.
- Trial name
- NCT04209049
- Testing
- NNC0174-0833
- Where
- 2 sites in United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Renal Impairment
A Study to Evaluate the Pharmacokinetics, Safety, and Pharmacodynamics of Olpasiran in Participants With Normal Renal Function and Participants With Various Degrees of Renal Impairment
The primary objective of this study is to evaluate the pharmacokinetics (PK) of a single dose of olpasiran in participants with normal renal function and participants with various degrees of renal impairment.
- Trial name
- NCT05489614
- Testing
- Olpasiran
- Where
- 6 sites in United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Amgen
Renal Impairment
Safety and Pharmacokinetics of Fluzoparib in Healthy Subjects and Those With Impaired Kidney Function
The primary objective is to evaluate pharmacokinetics of Fluzoparib and its main metabolite in subjects with impaired kidney function in comparison with healthy subjects, to develop dose recommendations for patients with renal…
- Trial name
- NCT05032235
- Testing
- Fluzoparib
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Healthy, Respiratory Disease
A Clinical Study to Map the HLA Genomic Region in the Greek Population
The aim of GENESIS clinical study is to map the HLA genomic region in the Greek population and evaluate possible correlations with selected underlying diseases.
- Conditions
- Healthy, Respiratory Disease, Chronic Renal Failure, Cardiovascular Diseases
- Trial name
- GENESIS (NCT06227468)
- Where
- 8 sites in Greece
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Athens LifeTech Park
Cognitive Function, Preclinical, Chronic Kidney Diseases
Exercise Training and Cognitive Function in Kidney Disease
Chronic kidney disease (CKD), affects over 45% of all individuals over 70 years of age. Patients with moderate CKD have more than a two-fold increased risk of cognitive impairment than those without CKD; furthermore, as many as…
- Conditions
- Cognitive Function, Preclinical, Chronic Kidney Diseases, Older Adults
- Trial name
- NCT03197038
- Testing
- Partially supervised home-based walking exercise, Control
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Renal Insufficiency, Chronic, Kidney Diseases
Validation of New Markers of Glomerular Filtration Rate: Dota Gadolinium and Calcium EDTA (MultiGFR)
The purpose of this study is to validate in comparison to a reference method (inuline) two novel non-radioactive biomarkers for glomerular filtration rate (GFR) measurement in chronic-kidney disease (CKD) patients and in healthy…
- Trial name
- MultiGFR (NCT02286258)
- Testing
- Calcium EDTA, Gd-DOTA
- Where
- 4 sites in France
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Kidney Disease
Immunologic Abnormalities, Chronic Inflammation and Oxidative Stress in Chronic Kidney Disease
The common causes of mortality are late stages of chronic kidney disease, cardiovascular disease and infections, are associated with abnormalities of the immune system, an underlying state of chronic inflammation and oxidative…
- Trial name
- NCT00793806
- Testing
- Diffuse Optical Spectroscopy
- Where
- 3 sites in United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Acute Kidney Injury
Acute Normovolemic Hemodilution on Urine Neutrophil Gelatinase-associated Lipocalin Levels
Acute normovolemic hemodilution (ANH) is performed as a blood conservation technique during surgical procedures with high risk for significant blood loss.
- Trial name
- NCT05349292
- Testing
- ANH
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Renal Impairment, Healthy
A Study to Assess the Effects of Renal Impairment on the Pharmacokinetics, Safety, and Tolerability of Intranasally Administered Esketamine
The purpose of this study is to evaluate the pharmacokinetics of a single dose of intranasally administered esketamine in participants with impaired renal function when compared to participants with normal renal function.
- Trial name
- NCT02606084
- Testing
- Esketamine
- Where
- 2 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Intraoperative Hypotension, Jugular Veins
Internal Jugular Vein Ultrasound and Acute Kidney Injury After Abdominal Surgery
This observational study aims to learn whether changes in the internal jugular vein during anesthesia induction can help predict low blood pressure and kidney injury after surgery. The main questions it aims to answer are: 1.
- Conditions
- Intraoperative Hypotension, Jugular Veins, Hypotension on Induction, General Anesthesia With Propofol
- Trial name
- PRO-JUGULAR (NCT07638306)
- Testing
- Internal Jugular Vein Ultrasound Assesment
- Where
- Romania
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Tîrgu Mureș Emergency Clinical County Hospital, Romania
Congestive Heart Failure, Diabetes
Study of the Effect on Clinical Outcomes Using Secure Text Messaging
In this study, the investigators will conduct a randomized, controlled trial to evaluate the impact of offering mobile secure text messaging on clinical outcomes.
- Conditions
- Congestive Heart Failure, Diabetes, Renal Failure, Copd
- Trial name
- NCT02568514
- Testing
- Secure text messaging
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Dyslipidemias, Children, Only
The Effect of Childhood Dyslipidemia on Endothelial and Renal Function
The aim of the study is to assess if abnormal lipid levels in childhood could cause early damage of the inner layer of the vessels, the endothelium.
- Conditions
- Dyslipidemias, Children, Only, Endothelial Dysfunction, Renal Dysfunction
- Trial name
- NCT03856476
- Where
- Greece
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Ioannina
Renal Insufficiency
Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Dabigatran Etexilate in Patients With and Without Renal Impairment
To assess the effect of different degrees of renal impairment on the pharmacokinetics and pharmacodynamics of dabigatran etexilate administered orally.
- Trial name
- NCT02182024
- Testing
- Dabigatran etexilate high dose, Dabigatran etexilate low dose
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Renal Impairment
Pharmacokinetic Study of AR882 in Subjects With Various Degrees of Renal Impairment
This is a 2-segment, multi-center, phase 1, open-label, study evaluating the pharmacokinetics and pharmacodynamics of AR882 in subjects with various degrees of renal impairment.
- Trial name
- NCT04646889
- Testing
- AR882 Single Dose, AR882 Multiple Dose
- Where
- 4 sites in United States, New Zealand
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Arthrosi Therapeutics
Cardiac Surgery With Cardiopulmonary Bypass, Complete Serum Phosphorus Measure
Serum Phosphatemia Predictive Marker for AKI Diagnosis After Cardiac Surgery
Cardiac surgery associated acute kidney injury is an independent factor of morbidity and mortality . Despite its delayed elevation, serum creatinine (Cr) remains the goal standard to diagnose AKI.
- Conditions
- Cardiac Surgery With Cardiopulmonary Bypass, Complete Serum Phosphorus Measure, Complete Serum Creatinine Measure
- Trial name
- PhosphoIRA (NCT02900313)
- Testing
- cardiac surgery
- Where
- France
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Renal Insufficiency
Effects of Creatine Supplementation on Renal Function
Creatine (CR) supplementation is commonly used by athletes. However, its effects on renal function remain controversial. The aim of this study was to evaluate the effects of creatine supplementation on renal function and…
- Trial name
- NCT00465140
- Testing
- creatine supplementation, aerobic exercise training
- Where
- Brazil
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Cardiovascular Diseases, Heart Diseases
The Jackson Heart Study of Cardiovascular Disease Among African Americans
This is a prospective study of the environmental and genetic factors that influence the development of cardiovascular disease (CVD) in African American adults.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Atherosclerosis, Coronary Disease
- Trial name
- JHS (NCT00005485)
- Where
- United States
- Volunteers
- 5,306 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
End Stage Renal Disease
Neuroimaging and End Stage Renal Disease
Brain impairment is one of the common complications of end-stage renal disease (ESRD). The patients always present with various cerebrovascular diseases, cognitive impairment and sensorimotor abnormalities, with morbidity over…
- Trial name
- NESRD (NCT03961724)
- Testing
- magnetic resonance image (MRI)
- Where
- China
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Renal Impairment
A Study to Evaluate the Pharmacokinetics of HSK21542 in Subjects With Renal Impairment
This is an open-label, single-dose study to evaluate the pharmacokinetics and safety of HSK21542 in subjects with mild, moderate and severe renal impairment compared to the matched control subjects with normal renal function.
- Trial name
- NCT05947097
- Testing
- HSK21542 Injection
- Where
- China
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Healthy Participants, Gastrointestinal Neoplasms
A Study to Investigate the Effects of Moderate or Severe Renal Impairment (RI) on Velzatinib
This study evaluates the effect of moderate and severe renal impairment on the pharmacokinetics (PK) of velzatinib compared with normal renal function.
- Trial name
- NCT07867171
- Testing
- Velzatinib
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
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