Clinical trials: Renal Dysfunction
Renal Insufficiency, Chronic
Living With Chronic Kidney Disease Without Renal Replacement Therapy: Experience of Women of Childbearing Age
Chronic kidney disease (CKD) affects approximately 13% of the global population. This condition is often associated with comorbidities such as diabetes and hypertension.
- Trial name
- IMAJE (NCT07690202)
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Caen
Chronic Kidney Diseases
Aerobic Exercise in Patients With CKD
Patients with chronic kidney disease (CKD), especially those who are on dialysis, have a high prevalence of cardiovascular mortality and among the risk factors; inflammation and oxidative stress stand out.
- Trial name
- NCT04375553
- Testing
- Aerobic exercise
- Where
- Brazil
- Volunteers
- 32 people
- Sponsor
- Universidade Federal Fluminense
Red-Cell Aplasia, Pure
A Study to Observe the Number of Patients Who Develop Pure Red Cell Aplasia (PRCA, a Rare Form of Anemia) While Receiving Epoetin Alfa or Other Recombinant Erythropoietins
The purpose of this study is to record the number of participants with chronic renal disease who are receiving treatment with epoetin alfa or other recombinant erythropoietins who develop pure red cell aplasia (PRCA, a rare form…
- Trial name
- NCT00211029
- Volunteers
- 4,670 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
End Stage Renal Disease
Blood Flow Conditions and Sounds in AVFs
This is a prospective non-pharmacological interventional study aimed at investigating the relationship between the blood flow condition and the arteriovenous fistula (AVF) sound, with the ultimate aim of predicting the AVF…
- Trial name
- APOLLO (NCT06411353)
- Testing
- MRI acquisition, US examination
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Diabetic Kidney Disease, Diabetic Nephropathies
Patient-Derived Stem Cell Therapy for Diabetic Kidney Disease
The Researchers will assess the safety, tolerability, dosing effect, and early signals of efficacy of intra-arterially delivered autologous (from self) adipose (fat) tissue-derived mesenchymal stem/stromal cells (MSC) in patients…
- Conditions
- Diabetic Kidney Disease, Diabetic Nephropathies, Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
- Trial name
- NCT03840343
- Testing
- Autologous adipose-derived mesenchymal stem/stromal cells (MSC) Lower Dose, Autologous adipose-derived mesenchymal stem/stromal cells (MSC) Higher Dose
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Mayo Clinic
Pyelonephritis, Prognostic
Factors and Prognosis of Obstructive Pyelonephritis Patients
Acute obstructive pyelonephritis is a condition with a high risk of complications and may require admission to the intensive care unit.
- Trial name
- PYELO-OBS (NCT06299215)
- Where
- France
- Volunteers
- 575 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Kidney Injury
Nafamostat Efficacy and Safety in Critically Ill Patients(NICE)
Acute kidney injury (AKI) is a common and serious problem in critically ill patients, and is known to be an independent risk factor for mortality.
- Trial name
- NCT01486485
- Testing
- heparinized saline priming group, nafamostat infusion after heparinized saline priming
- Where
- 4 sites in South Korea
- Volunteers
- 160 people
- Sponsor
- Seoul National University Hospital
Systemic Sclerosis and Systemic Lupus Erythematous
Renal Assessment for Early Detection of Renal Impairment in Systemic Sclerosis and Systemic Lupus Erythematosus Patients
Evaluate renal resistive index in SSc and SLE patients for early detection of renal impairment. Evaluate renal multi-parametric MRI in SSc and SLE patients for early detection of renal impairment.
- Trial name
- NCT06287125
- Testing
- Renal multi-parametric MRI, Renal doppler ultrasound, Serum CD147
- Volunteers
- 95 people
- Sponsor
- Assiut University
Multiple Myeloma, Acute Kidney Injury
Effect of HFR-SUPRA in the Treatment of Multiple Myeloma-related Acute Kidney Injury
In patients with multiple myeloma-related acute kidney injury, compare the renal outcome of chemotherapy combined with HFR-SUPRA to chemotherapy combined with hemodialysis.
- Conditions
- Multiple Myeloma, Acute Kidney Injury, Hemodiafiltration With Ultrafiltrate Regeneration (HFR)
- Trial name
- NCT05429515
- Testing
- HFR-SUPRA, hemodialysis, Chemotherapy
- Volunteers
- 50 people
- Sponsor
- Peking Union Medical College Hospital
Gene Polymorphism, Edoxaban
Prospective Observational Association Between SLCO1B1 Gene Polymorphism and the Anti-factor Xa Activity of Edoxaban in Patients With Moderate to Severe Renal Insufficiency
1. To provide reference for clinical rational use of edoxaban; 2. Optimize the individualized dosing regimen of edoxaban.
- Conditions
- Gene Polymorphism, Edoxaban, Renal Insufficiency
- Trial name
- NCT06431789
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Yi Han
End Stage Renal Disease
An Extension to Assess the Effect of Expanded Dialysis on Patient Reported Symptoms Using LEVIL
Investigators know that many patients who are on dialysis suffer from burden of unwanted symptoms, which can affect quality of life.
- Trial name
- NCT06032208
- Testing
- Theranova Dialyzer
- Where
- 4 sites in Canada
- Volunteers
- 100 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Chronic Kidney Disease
Assessing Novel Methods of Improving Patient Education of Nutrition
The relationship between elevated phosphorus levels and morbidity and mortality in patients with chronic kidney disease (CKD) is well recognized, and dietary phosphorus restriction is a mainstay of phosphate management.
- Trial name
- NCT00394576
- Testing
- Internet-based nutrition module along with usual care, usual care
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of Wisconsin, Madison
ESRD, Diabetes
IMPENDIA- PEN VS Dianeal Only Improved Metabolic Control In Diabetic CAPD and APD Patients
Primary Objective: To demonstrate that use of glucose sparing prescriptions (PEN vs Dianeal only) in diabetic (Type 1 and Type 2) Continuous Ambulatory Peritoneal Dialysis (CAPD) and Automated Peritoneal Dialysis (APD)patients…
- Conditions
- ESRD, Diabetes, CAPD, APD
- Trial name
- Impendia (NCT00567489)
- Testing
- Physioneal, Dianeal, Extraneal
- Where
- 19 sites in Hong Kong, Russia and 3 more
- Volunteers
- 137 people
- Sponsor
- Vantive Health LLC
Chronic Kidney Disease (Stages 4 and 5), Peritoneal Dialysis (PD)
Probiotic and Prebiotic Supplementation in Peritoneal Dialysis Patients
The goal of this clinical trial is to learn if synbiotics work to lower inflammation in adults with chronic kidney disease who are on peritoneal dialysis.
- Trial name
- NCT07694791
- Testing
- Synbiotic
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Chronic Kidney Disease
Pharmacokinetics of Verinurad and Allopurinol in Combination With Cyclosporine and Rifampicin in Healthy Volunteers
This Phase 1 study aims to quantify the effects of cyclosporine, a broad transporter inhibitor, and rifampicin, an OATP1B1/3 inhibitor, on verinurad pharmacokinetics (PK).
- Trial name
- NCT04532918
- Testing
- Verinurad, Allopurinol, Cyclosporine
- Where
- Germany
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Acute Kidney Injury, Acute Kidney Injury (AKI)
COordiNated CommuNication, Education, and Care Transitions After Acute Kidney Injury (CONNECT-AKI)
The goal of this clinical trial is to learn whether different ways of providing information and follow-up support after acute kidney injury, also called AKI, can improve care transitions for adults being discharged from the…
- Trial name
- CONNECT-AKI (NCT07626268)
- Testing
- AKI Discharge Summary Template, Chat-Based Educational Messaging Program
- Where
- 2 sites in United States
- Volunteers
- 160 people
- Sponsor
- Northwell Health
Renal Insufficiency, Chronic, Iron-Deficiency Anemia
Study With Oral Ferric Maltol for the Treatment of Iron Deficiency Anemia in Subjects With Chronic Kidney Disease
To evaluate the efficacy of oral ferric maltol compared with placebo in the treatment of IDA in subjects with CKD
- Trial name
- AEGIS-CKD (NCT02968368)
- Testing
- Ferric maltol
- Where
- 27 sites in United States
- Volunteers
- 167 people
- Sponsor
- Shield Therapeutics
Aortic Aneurysm, Abdominal, Aortic Diseases
Haemodynamic Response to Aortic Surgery
Open elective abdominal aortic surgery is a high risk procedure involving clamping of the aorta. Indications include abdominal aortic aneurysm (AAA) or aortic occlusive disease (AOD) causing lower limb ischaemia.
- Conditions
- Aortic Aneurysm, Abdominal, Aortic Diseases, Acute Kidney Injury
- Trial name
- NCT01704391
- Where
- Denmark
- Volunteers
- 18 people
- Sponsor
- Sygehus Lillebaelt
End Stage Renal Disease
HeRO Vascular Access Device Post Market Procedural Survey Protocol
Post market observational survey of a vascular access device for access-challenged patients. Data collection efforts focused on patient medical and access history and implant procedure results.
- Trial name
- PPS (NCT00889291)
- Volunteers
- 77 people
- Sponsor
- Merit Medical Systems, Inc.
Cardiac Surgery
Individualized Blood Pressure Management in Patients Undergoing Cardiac Surgery
This pilot randomized-controlled study will determine the feasibility of large study comparing individualized versus standard blood pressure (BP) management in patients undergoing cardiac surgery under cardiopulmonary bypass…
- Trial name
- PRECISE (NCT03784690)
- Testing
- Individualized intraoperative BP management, Standard intraoperative BP management
- Where
- Russia
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
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