Clinical trials: Renal Injury, Acute
Arthroplasty, Replacement, Knee, Acute Kidney Injury
After Surgery Acute Renal Failure Incidence in Total Knee Arthroplasty With and Without Tourniquet
This study analize the incidence of acute renal failure after performing total knee arthroplasty with or without use of tourniquet limb cuff (half of patients for each group) in a randomized clinical trial
- Conditions
- Arthroplasty, Replacement, Knee, Acute Kidney Injury, Tourniquets, Knee Osteoarthritis
- Trial name
- NCT03795805
- Testing
- total knee arthroplasty, Tourniquet limb cuff, Intaarticular lidocain
- Where
- Mexico
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Instituto Mexicano del Seguro Social
Acute Kidney Injury, Acute Kidney Injury (AKI)
Hamburg Acute Kidney Injury Study (HAKIS)
The Hamburg Acute Kidney Injury Study (HAKIS) is a prospective observational cohort study aimed at investigating the mechanisms, risk factors, and clinical determinants of acute kidney injury (AKI) trajectories and consequences.
- Trial name
- HAKIS (NCT07338669)
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Acute Kidney Injury, The Changes of Plasma Creatinine
Short-Term Alpha Lipoic Acid Therapy for Prevention of Contrast-induced Acute Kidney Injury and Endothelial Dysfunction in Type 2 Diabetes
Contrast-induced acute kidney injury (CIAKI) is a major complication with adverse outcomes after contrast media injection. Although the risk of developing CIAKI is low in patients with normal renal function, it is dramatically…
- Conditions
- Acute Kidney Injury, The Changes of Plasma Creatinine, The Changes of Plasma Free Radicals, The Changes of Endothelium-dependent Arterial Dilation
- Trial name
- NCT01978405
- Testing
- Alpha lipoic acid
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xiang Guang-da
Kidney Failure, Acute, Critical Illness
Comparison of Femoral Versus Jugular Routes for Temporary Hemodialysis in Seriously Ill Patients
The purpose of this study is to determine whether a jugular route leads to a lower rate of complications as compared with a femoral route for catheterization in patients admitted in several intensive care units in France who…
- Trial name
- CATHEDIA (NCT00277888)
- Testing
- Femoral route for hemodialysis, Jugular route for hemodialysis
- Where
- 10 sites in France
- Volunteers
- 750 people
- Sponsor
- University Hospital, Caen
Anemia, Iron Deficiency, Acute Kidney Injury
Effect of Intravenous Iron Repletion on Renal Function in Patients With Iron Deficiency and Acute Kidney Injury
This clinical trial aims to carry out research on the effect on hemoglobin and renal function of intravenous administration of iron dextran as a repletion strategy in patients with iron deficiency anemia and acute kidney injury…
- Trial name
- NCT05960227
- Testing
- Iron dextran
- Where
- 2 sites in Mexico
- Volunteers
- 120 people
- Sponsor
- Hospital Civil de Guadalajara
Extracorporeal Membrane Oxygenation Complication
Estimation of Glomerular Filtration Flow in Patients of Resuscitation Under Extra-bodily Assistance
The aim of the study will be to evaluate the quality of the GFR estimate of the two estimation equations (CKD-EPI and Cockcroft's formula) against the measured clearance of creatinine, which can be performed routinely in…
- Trial name
- CREA-ECMO (NCT03525483)
- Testing
- Ultrasound for renal resistivity index measurement
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Toulouse
Acute Kidney Injury
Early Postoperative L-arginine and Acute Kidney Injury After Cardiac Surgery
Acute kidney injury (AKI) is common after cardiac surgery, yet effective protective strategies remain limited. L-arginine is the substrate for endogenous nitric oxide (NO) synthesis and may improve renal perfusion and endothelial…
- Trial name
- NCT07718373
- Testing
- L-arginine
- Volunteers
- 5,000 people
- Sponsor
- Xijing Hospital
Diuretic Toxicity, Acute Kidney Injury
Risk Factors and Machine Learning Model for Diuretics Related Acute Kidney Injury
Acute kidney injury (AKI) is a series of clinical syndromes in which serum creatinine (Scr) concentrations increase over a short period of time, or urine output decreases.
- Trial name
- NCT05527054
- Testing
- Diuretics
- Where
- China
- Volunteers
- 18,000 people
- Sponsor
- Qianfoshan Hospital
Acute Kidney Injury
Effects of Oral Protein Load on Kidney Function in Patients Undergoing Cardiac Surgery
Acute kidney injury (AKI) occurs in approximately one-third of patients undergoing cardiac surgery (CS), and represents one of the most significant negative predictors of patient outcome in this population.
- Trial name
- NCT03102541
- Testing
- None intervention
- Volunteers
- 214 people
- Sponsor
- University of Giessen
Acute Kidney Injury
A Study of the PK Interaction of CXA-10 With Pravastatin and Vytorin® in Healthy Males
This is an exploratory study in a small, well controlled group of healthy subjects to explore the effect of CXA-10 on pravastatin and Vytorin® (combination of simvastatin and ezetimibe).
- Trial name
- DDI (NCT02547402)
- Testing
- CXA-10, pravastatin, Vytorin® (combination of simvastatin and ezetimibe)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Complexa, Inc.
Renal Neoplasm, Renal Injury
The Effect of Remote Ischemic Preconditioning on Kidney Function in Patients Undergoing Partial Nephrectomy
This study is intended to evaluate the renal protective effect of Remote Ischemic Preconditioning (RIPC) in patients undergoing partial nephrectomy.
- Trial name
- NCT03273751
- Testing
- Remote Ischemic Preconditioning
- Where
- South Korea
- Volunteers
- 86 people
- Sponsor
- Seoul National University Hospital
Acute Kidney Injury
Personalized Versus Standard Hydration for Prevention of CI-AKI: a Randomized Trial With Bioimpedance Analysis
The aim of this study was to evaluate, in patients with "lower fluid status" defined by bioimpedance analysis, whether two different protocol of IV isotonic saline infusion are associated with different volume expansion and…
- Trial name
- NCT02225431
- Testing
- sodium chloride infusion
- Where
- Italy
- Volunteers
- 296 people
- Sponsor
- Ospedale Misericordia e Dolce
Malaria, Sepsis
Optimal Fluid Management in Adult Severe Malaria
Optimal fluid therapy in severe falciparum malaria has not been well defined, especially in resource poor settings where access to mechanical ventilation is limited.
- Trial name
- DRIPICCO (NCT01936766)
- Where
- Bangladesh
- Volunteers
- 156 people
- Sponsor
- University of Oxford
Rhabdomyolysis, Acute Kidney Failure
Plasma Neutrophil Gelatinase Associated Lipocalin Levels During Emergency Management of Rhabdomyolysis
This research project consists of a prospective diagnostic study conducted on patients with clinical suspicion of rhabdomyolysis admitted to the emergency rooms of the University Hospitals of Nimes, Montpellier, Paris, Nice and…
- Trial name
- NCT01544231
- Testing
- Plasma NGAL level
- Where
- 5 sites in France
- Volunteers
- 197 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Hepato-Renal Syndrome
Nor-epinephrine Versus Midodrine/Octreotide in Patients With Hepatorenal Syndrome
Hepatorenal syndrome is a functional renal impairment occurring in cirrhotic patients . It develops secondary to splanchnic arterial vasodilatation which decreases the effective blood volume, activate the…
- Trial name
- NCT04522297
- Testing
- Midodrine/Octreotide, Nor-epinephrine
- Where
- Egypt
- Volunteers
- 91 people
- Sponsor
- National Hepatology & Tropical Medicine Research Institute
Acute Kidney Injury, Kidney Injury
Automated urIne Flow Detection to Reduce Errors and Nursing Workload
This study is an observational study which seeks to examine a) the accuracy of the Clarity Renal Monitoring System (Clarity RMS)® sensor kit at the bedside compared to manual urine output monitoring, b) total time/effort per…
- Trial name
- AiDe-RN (NCT03636113)
- Testing
- Clarity RMS Electronic Sensor
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Pittsburgh
Acute Kidney Injury
Regional COVID Epidemiology in England (RECEDE)
The COVID-19 pandemic has exposed the unwanted variation in outcomes as evidence by Public Health England's report on increased mortality in regions of the country.
- Trial name
- RECEDE (NCT04579562)
- Testing
- No intervention
- Volunteers
- 5,000 people
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
Post Operative Vasoplegic Syndrome, Acute Kidney Injury
POLECAT: Perioperative Delta Renin Concentration
We want to measure the amount of a hormone called renin in people's bodies before and after they have major abdominal surgery. We want to see if changes in renin levels are connected to problems with blood flow, unstable blood…
- Trial name
- POLECAT (NCT05942846)
- Volunteers
- 405 people
- Sponsor
- Royal Surrey County Hospital NHS Foundation Trust
COVID-19, Acute Kidney Injury
A Study of Cell Therapy in COVID-19 Subjects With Acute Kidney Injury Who Are Receiving Renal Replacement Therapy
The purpose of this study is to assess the safety and tolerability of the investigational product, SBI-101, in subjects with an infectious etiology of Acute Kidney Injury (AKI).
- Conditions
- COVID-19, Acute Kidney Injury, Sepsis
- Trial name
- NCT04445220
- Testing
- SBI-101
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Sentien Biotechnologies, Inc.
Sepsis, Septic Shock
Specific miRNAs in Sepsis and Nephrotoxic Antibiotic Treatment
Critically ill patients are prone to develop acute kidney injury due to sepsis itself and by administration of potentially nephrotoxic antibiotic treatment (vancomycin or gentamicin).
- Conditions
- Sepsis, Septic Shock, Acute Kidney Injury
- Trial name
- NCT04991376
- Testing
- Blood-specific miRNA levels
- Where
- Czechia
- Volunteers
- 53 people
- Sponsor
- University Hospital Ostrava
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