Clinical trials: Renal Insufficiency, Acute
Acute Kidney Failure
BNP (Nesiritide) vs. Placebo to Protect Kidney Function in Patients Undergoing Heart Bypass Surgery.
Use of BNP (nesiritide) vs placebo to help protect kidney function in patients undergoing heart bypass surgery.
- Trial name
- NCT00252200
- Testing
- Neseritide
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mayo Clinic
Acute Kidney Injury (Nontraumatic)
Effect of an Intervention to Prevent Acute Kidney Injury Versus Standard Care in High-risk Patients After Major Surgery
There is no specific therapy for acute kidney injury. It is presumed that supportive measures improve the care and outcome of patients with acute kidney injury.
- Trial name
- PrevProgAKI (NCT05275218)
- Testing
- Implementation of the KDIGO bundle)
- Where
- Germany
- Volunteers
- 480 people
- Sponsor
- University Hospital Muenster
COVID-19, Anxiety
Remote Psychological Intervention for COVID-19 Survivors With AKI and Caregivers (REPICOV-AKI)
The frequency of psychological conditions in recovered COVID-19 patients with Acute Kidney Injury (AKI) and their informal primary caregivers (IPC) is unknown; as well as the effects of psychological therapy in this population.
- Conditions
- COVID-19, Anxiety, Depressive Symptoms, Acute Kidney Injury
- Trial name
- REPICOV-AKI (NCT06522776)
- Testing
- Cognitive behavioral therapy
- Where
- Mexico
- Volunteers
- 98 people
- Sponsor
- Jesus Rivero, MD
Chronic Kidney Diseases, Diabetes Mellitus, Type 2
Effect of Acute Fructose Load in Human
The metabolism of the monosaccharide fructose is less controlled than the metabolism of glucose, which will result in the metabolic product uric acid.
- Trial name
- NCT03157960
- Testing
- Blueberry drink, Blueberry and pizza, Soft beverage
- Where
- Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Karolinska University Hospital
Acute Kidney Injury
Acute Kidney Outreach to Reduce Deterioration and Death (AKORDD)
The study pilots an outreach service for Acute kidney injury (AKI) patients, based on electronic alerts. Using the alerts we will contact the primary clinician caring for the patient with AKI in the Intervention group.
- Trial name
- AKORDD (NCT02398682)
- Testing
- Rapid diagnosis of AKI cause, Rapid treatment of AKI cause, Stopping 'nephrotoxic' drugs
- Where
- United Kingdom
- Volunteers
- 1,865 people
- Sponsor
- Heart of England NHS Trust
Cardiac Surgery, Acute Kidney Injury
Acute Normovolemic Hemodilution in Complex Cardiac Surgery
Postoperative bleeding in cardiac surgery is a frequent complication, and cardiac surgery utilizes 15-20% of the national blood supply. Packed red blood cells (pRBCs) are associated with worse short and long term outcomes.
- Conditions
- Cardiac Surgery, Acute Kidney Injury, Congenital Heart Disease, Aortic Surgery
- Trial name
- ANH (NCT05049590)
- Testing
- Acute normovolemic hemodilution (ANH)
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- University of California, Los Angeles
Intra-hospital Mortality, Epidemiological Study
Acute Kidney Injury in Non-Critical Care Setting: Elaboration and Validation of an In-hospital Death Prognosis Score
Acute renal failure (AKI) is defined by a deterioration of kidney function over a short period. This definition was clarified recently in order to allow homogenization and optimal comparison of patients in clinical studies by the…
- Trial name
- AKI-DPS (NCT04242615)
- Testing
- Prognostic score
- Volunteers
- 857 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Acute Kidney Injury (Nontraumatic)
Biomarkers of Acute Kidney Injury in Cardiac Surgery
Acute kidney injury (AKI) is the most common complication in patients after cardiac surgery. An usual estimation of risk for AKI is estimation of serum creatinine, which is unreliable indicator of AKI risk.
- Trial name
- AKIrisk (NCT03830450)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Nikola Bradic, MD
Acute Kidney Injury, Hepatorenal Syndrome
The Selective Cytopheretic Device (SCD) for Acute Kidney Injury (AKI) and Hepatorenal Syndrome (HRS) Type I
This research study is being done to learn what effect 7 days of treatment with the Selective Cytopheretic Device (SCD) will have on these white blood cells in the bloodstream of patients with hepatorenal syndrome and to learn…
- Trial name
- NCT04898010
- Testing
- Selective Cytopheretic Device
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Lenar Yessayan
Acute Kidney Injury, HIE
Theophylline Prophylaxis During Hypothermia to Limit Neonatal Nephron Damage
Acute kidney injury is a significant complication for infants who experience hypoxic ischemic encephalopathy, being associated with increased rates of death and prolonged hospitalization.
- Trial name
- TheoPHyLNNe (NCT05853601)
- Testing
- Single Dose Theophylline, Repeat Dose Theophylline
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Medical College of Wisconsin
Acute Kidney Injury
Biomarker Rule in/Out in Patients With Acute Diseases for Validation of AKI (BRAVA) Acute Kidney Injury
The presence or development of AKI impacts on outcomes in patients presenting with acute conditions to the ED. As a result, treating physicians are often concerned with the risk of AKI and take such risk in consideration when…
- Trial name
- BRAVA (NCT03754023)
- Testing
- Urine-TIMP-IGFBP7 biomarker for AKI
- Where
- 5 sites in Australia, India and 3 more
- Volunteers
- 818 people
- Sponsor
- GREAT Network Italy
Acute Kidney Injury
The Use of Renal Guard System in Patients Undergoing CRT Implantation
The purpose of this study is to determine whether the use of RenalGuard system which creates high urine output with fluid balancing may prevent contrast induced nephropathy in patient undergoing cardiac resynchronization therapy…
- Trial name
- NCT01936142
- Testing
- Use of RenalGuard
- Where
- Israel
- Sponsor
- Tel-Aviv Sourasky Medical Center
Coronary Artery Disease, Acute Kidney Injury
Endothelial Glycocalyx Damage in Acute Kidney Injury
Abstract Significance: Cardiac surgery-associated acute kidney injury (CSA-AKI) is common and has serious immediate and long-term sequelae.
- Trial name
- NCT05471583
- Testing
- Main group
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- King's College London
Malaria, Sepsis
Optimal Fluid Management in Adult Severe Malaria
Optimal fluid therapy in severe falciparum malaria has not been well defined, especially in resource poor settings where access to mechanical ventilation is limited.
- Trial name
- DRIPICCO (NCT01936766)
- Where
- Bangladesh
- Volunteers
- 156 people
- Sponsor
- University of Oxford
Kidney Failure, Acute, Critical Illness
Comparison of Femoral Versus Jugular Routes for Temporary Hemodialysis in Seriously Ill Patients
The purpose of this study is to determine whether a jugular route leads to a lower rate of complications as compared with a femoral route for catheterization in patients admitted in several intensive care units in France who…
- Trial name
- CATHEDIA (NCT00277888)
- Testing
- Femoral route for hemodialysis, Jugular route for hemodialysis
- Where
- 10 sites in France
- Volunteers
- 750 people
- Sponsor
- University Hospital, Caen
Acute Kidney Injury
Differential Adaptation of Renal Function in Intense Physical Exercise
In recent years there has been a significant increase in the number of participants in high intensity and duration sports events.
- Trial name
- NCT04929418
- Testing
- 10 km continuous running, 1.5 km continuous swimming
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hospital Clínico Universitario de Valladolid
Acute Kidney Injury
Renal Arterial Resistive Index for Differential Diagnosis of Acute Kidney Injury
early differential diagnosis of anticipated acute kidney injury via ultrasound renal resistive index calculation
- Trial name
- NCT05409690
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Ankara Diskapi Training and Research Hospital
Cytomegalovirus Retinitis, Acute Renal Failure
Pharmacokinetics of Cidofovir During Continuous Venovenous Hemofiltration
Cidofovir is an acyclic nucleotide analog with broad-spectrum antiviral activity against herpesviruses. Its potency in inhibiting HCMV has been shown in conventional in vitro studies.
- Trial name
- NCT01866397
- Testing
- Cidofovir pharmacokinetics
- Where
- Austria
- Volunteers
- 1 people
- Sponsor
- Medical University of Vienna
Postoperative Acute Kidney Injury, Intraoperative Hypotension
Impact of Intraoperative Blood Pressure Components on Postoperative AKI: A Phenotype-Stratified Analysis
Postoperative acute kidney injury (AKI) is a serious complication often linked to low blood pressure during surgery. This study aims to better protect patients' kidneys by personalizing how blood pressure is managed during an…
- Trial name
- NCT07156474
- Where
- China
- Volunteers
- 44,504 people
- Sponsor
- Lanyue Zhu
End Stage Renal Disease, Reperfusion Injury
Intra-graft Coagulation Events in Clinical Renal Transplantation and Delayed Graft Function
The purpose of this study is to investigate local activation of the coagulation system in the kidney graft during organ preservation and during early reperfusion in adult kidney transplantation.
- Conditions
- End Stage Renal Disease, Reperfusion Injury, Delayed Graft Function, Kidney Transplantation
- Trial name
- KTX (NCT02568696)
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- Helsinki University Central Hospital
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