Clinical trials: Renal Perfusion
Healthy
Renal NCE-MRI in Healthy Volunteers
Non-contrast enhanced (NCE) structural MRI enables to investigate renal anatomy. Additional NCE-MR acquisition modalities (e.g. Diffusion Weighted Imaging (DWI), Blood Oxygenation Level Dependent (BOLD) MRI, Arterial Spin…
- Trial name
- NCT02618460
- Testing
- Non contrast-enhanced magnetic resonance imaging
- Where
- Italy
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Mario Negri Institute for Pharmacological Research
Healthy
Comparison of Extended Release Tacrolimus (Advagraf) and Cyclosporine A Microemulsion on Renal Function in Healthy Volunteers
The purpose of this study is to compare the effects of steady state tacrolimus vs. cyclosporine on renal pharmacodynamics in healthy volunteers.
- Trial name
- NCT00818194
- Testing
- extended release tacrolimus, cyclosporine A microemulsion
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Inc
Hypertension, Chronic Kidney Disease
Accuracy of 1.5 T Versus 3 T Magnetic Resonance Arterial Spin Labeling to Measure Renal Blood Flow
In this study we want to compare the accuracy of two methods to measure renal perfusion by MRI spin labelling technique: the first measurement done with the 1.5 T MRI versus the second one obtained with the 3.0 T MRI (Siemens MRI…
- Trial name
- NCT02746549
- Testing
- renal perfusion
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Renal Function Test, Urine Output, Lactate Level
Dopamine and Norepinephrine Infusion With Restricted Hydration
This study was designed to assess the effect of adding dopamine infusion in addition to restrictive hydration combined with noradrenaline infusion on intraoperative serum lactate levels as an indicator for tissue hypo perfusion…
- Trial name
- NCT03780686
- Testing
- Norepinephrine, dopamine
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Chronic Renal Failure, Healthy Controls
Gender Differences in Renal Functioning and Disease
The purpose of the GenderBOLD study is to shed light on the mechanisms responsible for women's lower susceptibility to developing and progressing chronic renal disease, using modern imaging techniques, and applying different…
- Trial name
- GenderBOLD (NCT04085094)
- Testing
- high-salt diet (V1) and low salt diet (V2), Contrast-enhanced ultrasound (CEUS), functional MRI
- Where
- Switzerland
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Kidneys
Cardio and Renovascular Effects of Isometric Exercise in the Healthy Human Measured by PET/CT and MRI
This randomized crossover study aims to validate measurements of renal perfusion in healthy males with PET/CT, using 15-oxygen labeled water as tracer, against the validated multiparametric MRI technique.
- Trial name
- NCT06555211
- Testing
- MRI, PET/CT
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Kidney Transplant Failure
Kidney Transplantation and Renal and Myocardial Perfusion
The cardiovascular morbidity and mortality is significantly higher in chronic kidney disease (CKD) patients, especially in dialysis patients, than in normal population.
- Trial name
- Transkidney (NCT02960802)
- Testing
- kidney transplantation
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Safe Volunteers, Kidney Transplant Recipients
Study of the Renal Perfusion in Healthy Volunteers and Renal Transplant Recipients During an Orthostatic Stress
Autonomic nervous system contributes to the regulation of renal blood flow, affected by upright posture. Kidney transplantation implies sympathetic denervation.
- Trial name
- ortho_rein (NCT02179411)
- Testing
- tilt test
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Kidney Injury, Acute, Perfusion Imaging
Validation of Renal Perfusion CEUS Against MRI, and Its Application in Acute Kidney Injury
The purposes of this study is 1. To establish the validity of CEUS to measure renal perfusion by comparing it against ASL-MRI in young and older healthy volunteers, and generate a normative dataset of CEUS measures of renal…
- Conditions
- Kidney Injury, Acute, Perfusion Imaging, Ultrasonography, Kidney Diseases
- Trial name
- NCT04181281
- Testing
- Contrast enhanced ultrasound, Arterial Spin Labelling -Magnetic Resonance Imaging
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Renal Cell Carcinoma
Non-Contrast Perfusion Using Arterial Spin Labeled MR Imaging for Assessment of Therapy Response in Metastatic Renal Cell Carcinoma
Magnetic Resonance Imaging (MRI) including Arterial Spin Labeling (ASL) will be performed before, during, and after the treatment, in a total of up to 6 MRI sessions until 7 months after the first session, or when progression is…
- Trial name
- NCT04831138
- Testing
- MRI with ASL, ASL-MRI
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Heart Failure With Reduced Ejection Fraction (HFrEF), Renal Impairment
AZD3427 Effects on Renal Perfusion in Heart Failure Patients With Reduced Ejection Fraction and Renal Impairment
The present study is designed to test the effect of AZD3427 on renal perfusion in participants with heart failure and reduced eGFR (30 to 90 mL/min/1.73m2).
- Trial name
- Re-PERFUSE (NCT06611423)
- Testing
- AZD3427, Dopamine, Radiolabelled ligand
- Where
- Sweden
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Ketosis, Ketonemia
Effects of Exogenous Ketosis on Renal Function, Renal Perfusion, and Sodium Excretory Capacity in Healthy Subjects
This is a randomized, placebo-controlled, double-blinded crossover design. Fifteen healthy subjects will be randomized to receive either ketone bodies (KE4) or placebo delivered by KetoneAid.
- Trial name
- KETO (NCT05980858)
- Testing
- Beta-hydroxybutyrate
- Where
- Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Gødstrup Hospital
Renal Effects
Renal Effects of Erythropoietin in Humans
Erythropoietin (EPO) is a glycoprotein produced mainly in the kidney. After its release to the bloodstream EPO binds to its receptor predominantly located within the bone marrow where erythropoiesis is stimulated.
- Trial name
- EPO 2012 (NCT01584921)
- Testing
- Erythropoietin (Epoetin-beta, NeoRecormon®)
- Where
- Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
The GLP-1-mediated Gut-kidney Axis
Acute Effects of GLP-1 on Renal Hemodynamics
This study investigates the hypothesis, that GLP-1's suppression of ANG II and natriuretic action increase medullary perfusion and decrease oxygen consumption, leading to higher tissue oxygenation.
- Trial name
- GLP1RRBF (NCT04337268)
- Testing
- Glucagon-Like Peptide 1, saline 0.9%
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Anesthesia, Intraocular Pressure
Intraocular Pressure, Optic Nerve Sheath Diameter and Optic Perfusion Pressure of Minimal Low and High-Flow Anesthesia
The aim of this clinical trial is to determine the effect of minimal low-flow versus high-flow anesthesia on intraocular pressure (IOP) by non-contact tonometry, optic nerve sheath diameter (ONSD) by USG and optic perfusion…
- Conditions
- Anesthesia, Intraocular Pressure, Nephrolithiasis
- Trial name
- NCT06684704
- Testing
- minimal and high flow anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Elazıg Fethi Sekin Sehir Hastanesi
Healthy
A Comparison of the Effects of Extended Release Tacrolimus (Advagraf®) vs. Immediate Release Tacrolimus (Prograf®) on Kidney Function in Healthy Male Volunteers
The purpose of the study is to evaluate the drug profiles (pharmacokinetics) and effects (pharmacodynamics) of Advagraf® and Prograf® on the kidneys.
- Trial name
- NCT01681134
- Testing
- Advagraf®, Prograf®
- Where
- Canada
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Canada, Inc.
Kidney Perfusion
Ultrasound for Perfusion in Neonates
The purpose of this study is to evaluate the effectiveness of renal ultrasound to check kidney perfusion in premature and/or very low birth weight babies.
- Trial name
- NCT00847951
- Testing
- 3D Ultrasound Imaging
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Michigan