Clinical trials: Renal Replacement Therapies
Acute Renal Failure
Fenoldopam and Acute Renal Failure
Patients undergoing cardiac surgery could develop postoperative acute renal failure requiring renal replacement therapy. Fenoldopam, already used for patients with hypertensive emergencies, could improve renal function in…
- Trial name
- FENO HSR (NCT00621790)
- Testing
- fenoldopam
- Where
- 19 sites in Italy
- Volunteers
- 667 people
- Sponsor
- Università Vita-Salute San Raffaele
Acute Kidney Injury (AKI)
Mitochondrial Health and Hemodynamic Instability Related to Renal Replacement Therapy in Critically Ill Patients
Renal replacement therapy is a life-saving treatment for patients who have sudden and severe kidney failure. However, some of these patients blood pressure who receive this treatment could become unstable, thus resulting in more…
- Trial name
- MitoHIRRT (NCT05264285)
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Ottawa Hospital Research Institute
Critical Illness, Multi Organ Failure
Parathyroid Hormone Kinetics During CRRT
The objective of this study is to assess the parathyroid hormone serum concentrations and kinetics in critically ill patients admitted to the intensive care unit due to multi-organ failure and undergoing citrate anticoagulation…
- Conditions
- Critical Illness, Multi Organ Failure, Renal Failure, Circulatory Failure
- Trial name
- NCT03873675
- Testing
- parathyroid hormone
- Where
- 3 sites in Poland
- Volunteers
- 30 people
- Sponsor
- Uniwersytecki Szpital Kliniczny w Opolu
Acute Kidney Failure
Hannover Dialysis Outcome Study
Mortality rates of patients with acute kidney injury in the intensive care unit have changed little over the past few decades despite significant advances in supportive care.
- Trial name
- HAND-OUT (NCT00529139)
- Testing
- Standard extended dialysis, Intensified extended dialysis
- Where
- Germany
- Volunteers
- 157 people
- Sponsor
- Hannover Medical School
Liver Failure, Acute Kidney Disease
Intraoperative Dialysis in Liver Transplantation
Patient with liver failure waiting for liver transplantation are often hospitalized and commonly supported in an intensive care unit prior to surgery.
- Conditions
- Liver Failure, Acute Kidney Disease, Multi-organ Failure
- Trial name
- INCEPTION (NCT01575015)
- Testing
- Continuous renal replacement therapy (CRRT), Standard intraoperative support
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- University of Alberta
Continuous Renal Replacement Therapy
CRRTNet Registry- A Prospective Observational Registry
An observational registry to monitor the outcome of CRRT in adults with acute kidney injury.
- Trial name
- CRRT (NCT02034448)
- Testing
- Continuous Renal Replacement Therapy
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- AKI Critical Care Research Foundation
Burns, Sepsis
The Impact of Continuous Renal Replacement Therapy on the Outcomes of Burn Patients With Early Phase of Sepsis
The purpose of this study is to determine if early application of CRRT will result in an improvement of clinical outcomes of burn patients during the early phase of sepsis
- Trial name
- CRRT (NCT01501097)
- Testing
- Continuous Renal Replacement Therapy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Southwest Hospital, China
Acute Liver Failure
To Evaluate the Safety and Efficacy of Preemptive Administration of Continuous Renal Replacement Therapy in Patients With Acute Liver Failure With Cerebral Edema
In this prospective randomized controlled trial, investigator aim to evaluate the impact of early initiation of CRRT on outcomes in patients with acute liver failure with cerebral edema and hyperammonemia in improving cerebral…
- Trial name
- NCT04991259
- Testing
- Continuous Renal Replacement Therapy (CRRT), Standard Medical Treatment
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Acute Renal Failure, Infection
Anidulafungin During Continuous Venovenous Hemofiltration (CVVHF)
The purpose of this trial is to study the pharmacokinetics of anidulafungin during continuous venovenous hemofiltration. Background: Anidulafungin is a cyclic lipopeptide antifungal agent of the echinocandin class.
- Trial name
- NCT00892359
- Testing
- Anidulafungin
- Where
- Austria
- Volunteers
- 10 people
- Sponsor
- Medical University of Vienna
Covid-19, SARS
Tocilizumab vs CRRT in Management of Cytokine Release Syndrome (CRS) in COVID-19
Some patients infected with the COVID-19 can develop uncontrolled immune response, leading to potentially life-threatening damage to lung tissue. Tocilizumab was first approved by the U.S.
- Conditions
- Covid-19, SARS, Cytokine Storm, Cytokine Release Syndrome
- Trial name
- TACOS (NCT04306705)
- Testing
- Tocilizumab, Standard of care, Continuous renal replacement therapy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Tongji Hospital
Critical Illness, Acute Kidney Injury
Continuous Renal Replacement Therapy Circuit Lifespan in Intensive Care Patients
The goal of this retrospective observational study is to evaluate how long continuous renal replacement therapy (CRRT) circuits remain in use in adult intensive care unit patients and to describe how CRRT pressure measurements…
- Trial name
- NCT07842562
- Testing
- Archived CRRT Device Log Data
- Where
- Turkey (Türkiye)
- Volunteers
- 162 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Acute Kidney Injury, COVID-19
Incidence of Acute Kidney Injury in Covid-19
Acute kidney injury (AKI) in Covid-19 patients is a topic that receives little attention in the literature, although being important in clinical practice in the ICU, particularly in Oman.
- Conditions
- Acute Kidney Injury, COVID-19, Critically Ill
- Trial name
- COVIDAKI (NCT05467956)
- Testing
- Covid-19
- Where
- Oman
- Volunteers
- 286 people
- Sponsor
- Sultan Qaboos University
Acute Kidney Injury
Renal Replacement Therapy and In-Hospital Mortality Incidence in Cardiac Surgery Associated Acute Kidney Injury
The goal of this study is to analyse the relation of severe acute kidney injury post cardiac surgery which characterised by the need of renal replacement therapy, with in-hospital postoperative mortality incidence.
- Trial name
- NCT06091982
- Testing
- Renal Replacement Therapy (RRT)
- Where
- Indonesia
- Volunteers
- 1,113 people
- Sponsor
- National Cardiovascular Center Harapan Kita Hospital Indonesia
Sepsis
Normal Saline Versus Ringer's Lactate for Initial Fluid Resuscitation in Sepsis
This clinical trial aims to determine if the type of intravenous fluid used for initial resuscitation affects the short-term outcomes of adult patients with sepsis who are treated in the emergency department.
- Trial name
- NCT07240701
- Testing
- Ringer's Lactate, Normal Saline (0.9% Sodium Chloride)
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- Egemen Yildiz
Acute Pancreatitis
Early High-volume Continuous Veno-venous Hemofiltration for Patients With Severe Acute Pancreatitis
The purpose of this study is to determine the effect and safety of early high-volume continuous veno-venous hemofiltration for patients with severe acute pancreatitis.
- Trial name
- EHVCVVHSAP (NCT01595672)
- Testing
- AN69 hemofilter, conventional treatments
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Air Force Military Medical University, China
Infection During Renal Replacement Therapy, Critically Ill
Ceftaroline Pharmacokinetics in Continuous Renal Replacement Therapy
Dosing of ceftaroline in patients with chronic kidney disease is defined, but there is no data on pharmacokinetics and pharmacodynamics of the drug in patients receiving continuous renal replacement therapy (CRRT).
- Trial name
- NCT04152694
- Testing
- Ceftaroline levels in CRRT
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Maryland, Baltimore
Optimal Intensity of Renal Replacement Therapy on Sepsis Patients
Effect of the Intensity of Continuous Renal Replacement Therapy
In patients with sepsis and AKI, increasing the intensity of renal replacement therapy from 50 mL/kg/h (HVHF) to 85 mL/kg/h (EHVHF)will increase the survival at 28 days and 90 days.
- Trial name
- NCT01251081
- Testing
- extra high volume hemofiltration, high volume hemofiltration
- Where
- China
- Volunteers
- 280 people
- Sponsor
- Zhejiang University
Acute Kidney Injury, Fluid Overload
Volume Removal Intolerance During Net Ultrafiltration in Acute Kidney Injury Patients
Acute kidney injury (AKI) is common in critically ill patients and is frequently associated with fluid overload, which can worsen clinical outcomes.
- Conditions
- Acute Kidney Injury, Fluid Overload, Fluid Overload in Dialysis Patients, Critical Illness
- Trial name
- VINKO (NCT07643597)
- Where
- 10 sites in Brazil, Chile and 5 more
- Volunteers
- 128 people
- Sponsor
- Hospital Las Higueras
Kidney Failure
Clearance and Pharmacokinetics of Antibiotics in Renal Replacement Therapy
This is an observational study that evaluates the dialysis clearance and pharmacokinetics of antibiotics with different protein-bound levels in patients receiving renal replacement therapy.
- Trial name
- NCT03714789
- Testing
- Blood and spent dialysate collection
- Where
- China
- Volunteers
- 19 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Acute Renal Failure
Continuous Venovenous Hemofiltration Versus Continuous Venovenuous Hemodialysis
Acute kidney injury is often treated with the use of continuous renal replacement therapy. Two commonly used treatments are continuous venvenous hemofiltration (CVVH)and continuous venovenous hemodialysis (CVVHD).
- Trial name
- NCT01062984
- Testing
- Continuous Venovenous Hemofiltration (CVVH), Continuous Venovenous Hemodialysis (CVVHD)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Chicago