Clinical trials: Replacement, Knee
Total Knee Replacement, Post-operative Pain
Tapentadol vs Tramadol in Total Knee Arthroplasty
Compare the effectiveness of tapentadol and tramadol as part of a multimodal analgesia treatment for Total Knee Replacement (TKR).
- Conditions
- Total Knee Replacement, Post-operative Pain, Chronic Pain
- Trial name
- NCT06269770
- Testing
- Tapentadol, Tramadol
- Where
- Greece
- Volunteers
- 96 people
- Sponsor
- University of Thessaly
Osteoarthritis, Knee
All-Polyethylene Tibias in TKA: PS vs CS Implants
This is a randomized control trial where patients will be randomized to receive one of two types of total knee arthroplasty (TKA) all-polyethylene (AP) tibial components: cruciate retaining (CR) or posterior stabilized (PS).
- Trial name
- NCT03569670
- Testing
- Posterior stabilized all-polyethylene tibial component, Cruciate retaining all-polyethylene tibial component
- Where
- Canada
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Complications; Arthroplasty, Knee Injuries
Ultrasound-guided Adductor Canal Block for Total Knee Replacement
Total knee arthroplasty is associated with intense early postoperative pain. Fast track recovery programs including early therapy protocols and early hospital discharge are being implemented at various hospitals.
- Trial name
- NCT02100579
- Testing
- Bupivacaine, Preservative free normal saline
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Northwestern University
Osteoarthritis
A Study to Determine the Performance of the Press Fit Condylar (P.F.C.) Sigma RP-F Knee System
The purpose of this study is to evaluate if the P.F.C. Sigma RPF knee accommodates functional stability with a post-operative passive range of motion of greater than 125° of flexion and to demonstrate that the range of motion…
- Trial name
- NCT00761410
- Testing
- P.F.C. Sigma RP-F Total Knee Replacement
- Where
- 8 sites in India, Japan and 5 more
- Volunteers
- 170 people
- Sponsor
- DePuy International
Osteoarthritis, Knee
Comparison of Surgical Time and Efficiency of Total Knee Arthroplasty
This study is designed to compare the surgical efficiency of TruMatch® Personalized Solutions surgical technique compared to conventional surgical technique.
- Trial name
- NCT01301950
- Testing
- Custom Patient Instrumentation, Conventional Instruments
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- DePuy Orthopaedics
Osteoarthritis, Osteoarthritis (OA) of the Knee
Feasibility of Choose to Move Replacement Ready
Choose to Move (CTM) is a 3-month, choice-based health-promoting program for low active older adults being scaled-up across British Columbia (BC), Canada.
- Conditions
- Osteoarthritis, Osteoarthritis (OA) of the Knee, Osteoarthritis, Hip, Total Knee Arthroplasty; Total Hip Arthroplasty
- Trial name
- CTM-RR (NCT07069179)
- Testing
- Choose to Move Replacement Ready
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of British Columbia
Arthroplasty Replacement Knee, Knee Prosthesis
In Vivo Determination of 3D Patellofemoral Mechanics
This study will analyze the tibio-femoral and patellofemoral (motion) and mechanics (forces) of participants having a normal knee or a total knee arthroplasty (TKA) using one or two different (TKA) devices Low Contract Stress…
- Trial name
- Patella (NCT01290627)
- Testing
- Subjects implanted with DePuy LCS PS RP TKA, Subjects implanted with DePuy Sigma PS RP TKA
- Where
- 4 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The University of Tennessee, Knoxville
Prosthetic Joint Infection
Cost Of Failure Following Reimplantation After a 2-Stage Exchange Strategy For Hip Or Knee Prosthetic Joint Infection
This study concerns patients having had an infection on their prosthesis (hip, knee,..) and for whom a 2-step exchange of prosthesis has been done.
- Trial name
- NCT03612076
- Testing
- Global cost of management of PJI
- Where
- France
- Volunteers
- 115 people
- Sponsor
- Hospices Civils de Lyon
Knee Osteoarthritis
PARQVE Prior to Total Knee Replacement
Introduction: Elderly patients, the majority of the population submitted to total knee arthroplasty (TKA), have a lower capacity for adaptation to hospitalization and surgical stress.
- Trial name
- NCT04017858
- Testing
- Multiprofessional and educational Program prior to Total knee replacement TKA. (PARQVE TKA)., Patients will be submitted to total knee replacement.
- Where
- Brazil
- Volunteers
- 44 people
- Sponsor
- University of Sao Paulo General Hospital
Osteoarthritis, Knee
Prehab Intervention in Patients Awaiting Total Knee Arthroplasty (TKA)
The objectives of this study are to investigate the feasibility primarily and furthermore the effects of a four to eight-weeks program of a combined clinic- and home-based preoperative physical therapy (exercise training and…
- Trial name
- NCT05314985
- Testing
- Prehab intervention
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Balgrist University Hospital
Hip or Knee Replacement
Interest of High-dose Gentamicin Cement Associated With Clindamycin in Changes of Hip and Knee Prostheses
A hip or knee prosthesis can be cemented or not. The team of orthopedic surgeons from the CCOM (Centre de Chirurgie Orthopédique et de la Main) has been cementing all hip and knee prosthesis poses for many years using gentamycin…
- Trial name
- HKP (NCT06183606)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Strasbourg, France
Osteo Arthritis Knee, Total Knee Arthroplasty
Comparing Surgical and Economical Parameters of Total Knee Replacement.
Randomized study comparing surgical and economic parameter of Total Knee Arthroplasty performed using two different specific surgical techniques.
- Trial name
- NCT03427047
- Testing
- MyKnee with single use Efficiency Instrument, Stryker Navigational with conventional metal instruments
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Medacta USA
Self-Administered Versus Nurse Administered Pain Medication.
Patient Controlled Oral Analgesia for Postoperative Pain Management After Total Knee Replacement
Patient Centered Care (PCC) is "an approach that consciously adopts the patient's perspective...about what matters" (Gerteis, Edgeman, Levitan, Walker, Stokes, Cleary, Delbanco, 1993).
- Trial name
- NCT00221936
- Testing
- Self-administration or nurse administered medication
- Where
- 3 sites in Canada
- Volunteers
- 50 people
- Sponsor
- University Health Network, Toronto
Osteoarthritis of the Knee
Structured Treatment of Osteoarthritis of the Knee With or Without Total Knee Replacement
The purpose of this study is to test whether surgical insertion of total knee replacement provides further improvement in quality of life, pain and function in addition to an algorithm for systematic non-surgical treatment…
- Trial name
- MEDIC (NCT01410409)
- Testing
- Neuromuscular training (NEMEX-TJR), Paracetamol, Burana
- Where
- 3 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Northern Orthopaedic Division, Denmark
Total Knee Replacement
Pre-operative Radiological Measurement to Assess Femur Rotational Alignment
Purpose: This study outlines the benefits of the proximal tibia angle (PTA) in evaluation of the pre-operative individual condylar twist angle (CTA) in total knee arthroplasty.
- Trial name
- NCT02817737
- Where
- 2 sites in China
- Volunteers
- 33 people
- Sponsor
- Xi'an Honghui Hospital
Joint Replacement Surgery
The Effect of a Psychosensory Therapy
This is a prospective study looking at the impact of psychosensory therapy and how it can diminish pain and consumption of pain medications.
- Trial name
- NCT02765932
- Testing
- Dummy Movements, Psychosensory Therapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- NYU Langone Health
Knee Prosthesis
Study of Patients With Knee Prostheses Treated With Noninvasive Neuromodulation
It will consist of a randomized clinical trial with a control group. The sample will be distributed as homogeneously as possible into two groups, which will be randomly divided into a control group, to which the usual general…
- Trial name
- NCT06134999
- Testing
- Non-invasive Neuromodulation
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- University of Las Palmas de Gran Canaria
Surgery
Netflix Streaming Services in the Operating Room During Total Knee Replacement - a Feasibility Study
The purpose of this research study is to test the safety, tolerability, and effectiveness of watching streamed videos through virtual reality (VR) goggles during surgery.
- Trial name
- NCT04469881
- Testing
- VR
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Virginia Commonwealth University
Osteoarthritis
Comparison of the Tibiofemoral Rotational Alignment After Mobile and Fixed Bearing Total Knee Arthroplasty
The anatomic landmark for the anteroposterior (AP) axis of the proximal tibia and its variability was investigated in this study in order to determine whether a certain landmark could be employed as a reference axis for the…
- Trial name
- NCT01751334
- Testing
- total knee arthroplasty
- Volunteers
- 80 people
- Sponsor
- Seoul National University Hospital
Osteoarthritis
Overcoming TWEAK Signaling to Restore Muscle and Mobility After Joint Replacement
This single-blind, randomized, controlled trial is designed to test the effect of an intensive, 16 week exercise rehabilitation program (progressive resistance training + functional mobility training) vs.
- Trial name
- TWEAK (NCT02628795)
- Testing
- PRT + FM, Usual Care
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Alabama at Birmingham