Clinical trials: Replacement, Knee
Knee Osteoarthritis, Knee Rheumatism
Does Adding an Additional Numbing Medication Injection in the Thigh Help With Pain Control After Knee Replacement Surgery?
One common anesthetic that is performed for total knee replacement surgery is spinal anesthesia with an adductor canal regional block, which involves injecting numbing medication in the thigh region for pain control after…
- Trial name
- NCT03326999
- Testing
- Obturator nerve regional block, Adductor canal regional block, Saline
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Total Knee Replacement
Evaluation of Patellar Crepitus Following Total Knee Arthroplasty
Analyze clinical data for a group of subjects implanted with a new surgical device designed to reduce the incidence of patellar crepitus following PCL-substituting TKA and compare that to a control group of subjects implanted…
- Trial name
- NCT01340144
- Volunteers
- 1,250 people
- Sponsor
- Colorado Joint Replacement
Knee Arthritis
The Assessment of Patient Specific Instrumentation for Unicompartmental Knee Replacement
Patient-specific instrumentation guides have previously been used to improving surgical accuracy and ease of implantation during Total Knee Replacement but have received less attention for implanting Unicompartmental Knee…
- Trial name
- NCT02748096
- Testing
- Patient Specific Instrumentation, Conventional Instrumentation
- Volunteers
- 45 people
- Sponsor
- Oxford University Hospitals NHS Trust
Arthroplasty, Replacement, Knee
Fast Track Total Knee Arthroplasty: Local Infiltration Analgesia vs Femoral Nerve Block
The objective of this study is to determine whether either a femoral nerve block (FNB) or local infiltration analgesia (LIA) is a better anesthetic technique to achieve optimal functional outcome after one year in patients…
- Trial name
- NCT01966263
- Testing
- LIA of the posterior capsule of the knee, LIA of the anterior capsule of the knee, LIA of the subcutaneous tissue of the knee
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- Sint Maartenskliniek
Total Knee Replacement Surgery
Comparison of 3 Techniques for Ultrasound-guided Femoral Nerve Catheter Insertion
This is a randomized study which will compare three femoral nerve catheter insertion techniques. Subjects will be randomized into one of thee groups, Group 1: ultrasound guided femoral nerve catheter using a stimulation needle…
- Trial name
- NCT00927368
- Testing
- ultrasound guidance alone, ultrasound guidance and needle stimulation, ultrasound guidance and catheter stimulation
- Where
- United States
- Volunteers
- 453 people
- Sponsor
- The Cleveland Clinic
PAIN
Effect of Oral Pregabalin on Spinal Neurotransmitters in Patients Undergoing Knee Replacement
This study involves research. Pregabalin is a Food and Drug Administration (FDA) medication approved in the United States for the treatment of nerve pain related to diabetes and post-herpetic neuralgia "shingles", and for…
- Trial name
- NCT00729690
- Testing
- Pregabalin
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Asokumar Buvanendran
Osteoarthritis
The Use of Evicel to Reduce Blood Loss in Total Knee Replacement Surgery
Application of "Evicel" hemostatic matrix during operation for unilateral total knee replacement surgery (TKA) will result in decreased bleeding and postoperative drain output, a reduction in transfusion requirements, and less…
- Trial name
- NCT01235715
- Testing
- Evicel fibrin sealant
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Hospital for Special Surgery, New York
Arthroplasty, Replacement, Thromboembolism
Pradaxa (Dabigatran Etexilate) 150 mg/q.d. in Patients With Moderate Renal Impairment After Hip or Knee Replacement Surgery
An observational cohort study on safety and efficacy to generate additional data on the benefit/risk profile of the 150 mg dose of Pradaxa in patients with renal impairment
- Trial name
- NCT00847301
- Where
- 53 sites in Austria, France and 5 more
- Volunteers
- 472 people
- Sponsor
- Boehringer Ingelheim
Venous Thromboembolism
Study to Assess the Safety and Efficacy of SelK2 to Prevent Blood Clots in Patients Undergoing Total Knee Replacement
The main purpose of this study is to determine if an investigational medication called SelK2 works in preventing a condition called "venous thromboembolism" (VTE) in patients having a total knee replacement.
- Trial name
- COURSE (NCT03812328)
- Testing
- SelK2, Enoxaparin
- Where
- 21 sites in Bulgaria, Latvia and 3 more
- Volunteers
- 207 people
- Sponsor
- Tetherex Pharmaceuticals Corporation
Arthroplasty, Replacement, Knee, Arthroplasty, Replacement, Hip
Tranexamic Acid Dosing for Major Joint Replacement Surgery
Over 1.7 million hip and knee replacements are performed every year worldwide. These surgeries are associated with high blood loss and transfusion rates. In older patients, the high blood loss can result in postoperative anemia.
- Trial name
- TXA-Dosing (NCT05075200)
- Testing
- Tranexamic acid
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- Sunnybrook Health Sciences Centre
Sleep Apnea, Obstructive
Prevalence of Sleep Apnea in Patients Presenting for Hip or Knee Replacement Surgery
The study hypothesis is that the prevalence of obstructive sleep apnea in patients presenting for total knee or total hip arthroplasty is higher than generally suspected.
- Trial name
- NCT00874822
- Where
- United States
- Volunteers
- 216 people
- Sponsor
- University of Nebraska
Osteoarthritis, Knee, Osteoarthritis, Hip
Liposomal Bupivacaine Versus Standard Analgesia in Total Joint Arthroplasty (TJA)
The purpose of this study is to determine whether liposomal bupivacaine is effective in the management of pain following total joint arthroplasty, as compared to standard of care analgesia.
- Conditions
- Osteoarthritis, Knee, Osteoarthritis, Hip, Osteoarthritis, Shoulder
- Trial name
- NCT02197273
- Testing
- Liposomal bupivacaine, Standard of care analgesia
- Where
- United States
- Volunteers
- 211 people
- Sponsor
- OhioHealth
Arthroplasty, Replacement, Knee
Combination of Peripheral Nerve Block and DepoDur in Total Knee Joint Replacement
The investigators hypothesize that patients who receive a femoral catheter with low dose epidural Depodur will experience comparable or superior pain relief than those who receive both femoral and sciatic catheters.
- Trial name
- NCT00895531
- Testing
- Depodur, sciatic nerve block
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Louisville
Arthroplasty, Replacement, Knee
Triathlon Total Stabilizer (TS) Outcomes Study
This study will be a prospective, non-randomized evaluation of the change between preoperative and postoperative outcomes for those receiving the Triathlon® TS Total Knee System for a revision knee operation.
- Trial name
- NCT00958789
- Testing
- Triathlon TS Knee System
- Where
- 12 sites in United States
- Volunteers
- 180 people
- Sponsor
- Stryker Orthopaedics
Degenerative Joint Disease, Osteoarthritis
PEAK PlasmaBlade 4.0 Versus Traditional Electrosurgery in Total Knee Replacement.
The objective of this clinical study is to evaluate the operative performance of the PEAK PlasmaBlade 4.0 during total knee replacement; to monitor and record post-operative pain, activity level, narcotic consumption, adverse…
- Trial name
- PRECISE (NCT01081886)
- Testing
- PEAK PlasmaBlade 4.0, Traditional Electrosurgery with scalpel
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Medtronic Surgical Technologies
Knee Injuries
Evaluation of Patient Reported Outcomes (PRO) After Total Knee Arthroplasty (TKA) Under Spinal Anesthesia
The purpose of this study will be to evaluate and compare patients undergoing total knee arthroplasty (TKA) with sensor guidance versus that of a standard technique.
- Trial name
- NCT03053453
- Testing
- Spinal Surgery, Verasense Knee System device
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- NYU Langone Health
Pain, Total Knee Replacement
Predicting, Understanding and Speeding Recovery After TKA
The objective of this research study is to better understand patterns of recovery after Total Knee Arthroplasty (TKA) amd Total Hip Replacement (THA).
- Conditions
- Pain, Total Knee Replacement, Total Hip Replacement
- Trial name
- NCT02685735
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- Wake Forest University Health Sciences
Tourniquets, Knee Arthroplasty, Total
Tourniquet Pressure in Primary Total Knee Arthroplasty
This proposed novel randomized control trial (RCT) seeks to address this gap in TKA protocol by gaining a better understanding of the relationship between tourniquet pressure and time, and intraoperative performance and…
- Conditions
- Tourniquets, Knee Arthroplasty, Total, Knee Replacement, Total
- Trial name
- NCT02830087
- Testing
- Tourniquet Cuff Pressure
- Where
- 2 sites in United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Osteoarthritis
Single-use Efficiency Instruments With Patient Specific Technique (MyKnee®) Versus Traditional Metal Instruments With Conventional Surgical Technique
To compare economic factors and the rate of adverse events between two types of instrumentation used for total knee replacement: Single-use Efficiency Instruments with Patient Specific Technique (MyKnee®) Traditional Metal…
- Trial name
- NCT03148379
- Testing
- Customized patient instruments, Traditional Metal Instruments
- Where
- 5 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Medacta USA
Total Knee Replacement, Primary Knee Arthroplasty
Postoperative Knee Strength Following Total Knee Replacement: A Double-Blinded Randomized Comparison Study
Major surgery involving the knee is often associated with severe postoperative pain. Postoperative pain control remains a significant contributor to delayed recovery and length of hospital stay.
- Trial name
- NCT01620047
- Testing
- Fentanyl, Ropivacaine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of South Florida