Clinical trials: Replacement, Total Knee
Osteoarthritis, Femoral Head Necrosis
Donepezil Attenuate Postoperative Cognitive Dysfunction
Postoperative cognitive dysfunction (POCD) occurs mainly in aged patients. POCD may increase the mortality and morbidity. However, the mechanism of POCD is not clear yet and no effective therapy method was proved.
- Conditions
- Osteoarthritis, Femoral Head Necrosis, Rheumatoid Arthritis
- Trial name
- DAPOCD (NCT02927522)
- Testing
- Donepezil
- Where
- China
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Arthritis Knee, Pain, Postoperative
Exparel Use in Adductor Canal Block After Total Knee Arthroplasty
Exparel has been shown to have better pain control compared to previously used infiltration agents, including bupivacaine, while having a minor side effect profile.
- Conditions
- Arthritis Knee, Pain, Postoperative, Opioid Use
- Trial name
- NCT04910165
- Testing
- Exparel, Ropivacaine
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- St. Luke's Hospital, Pennsylvania
Knee Osteoarthritis
Cemented vs Cementless TKA
The purpose of this study is to compare cemented and cementless versions of the Triathlon total knee arthroplasty/replacement (TKA) in terms of clinical outcomes, perioperative course, and outcome scores including function and…
- Trial name
- NCT03683992
- Testing
- Triathlon total knee system
- Where
- United States
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Postoperative Bleeding
Tranexamic Acid Use on Pain, Mobility and Bleeding Following Total Hip and Total Knee Arthroplasty
Tranexamic acid (TXA) is an anti-fibrinolytic agent developed in the 1960s that has been safely used to reduce blood loss, transfusion rates and bleeding-associated mortality in trauma, obstetrics and orthopedic surgery…
- Trial name
- TXA (NCT06208267)
- Testing
- Tranexamic acid
- Where
- Canada
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- St. Mary's Research Center, Canada
Osteoarthritis, Knee
Does Electrocautery Increase Postoperative Pain in Primary Total Knee Arthroplasty
Total knee arthroplasty (TKA) is a successful treatment for end-stage osteoarthritis of the knee. The main advantages of TKA are to relieve the pain of the knee, improve the knee function, restore lower limb alignment, and…
- Trial name
- NCT06239038
- Testing
- total knee arthroplasty
- Where
- Thailand
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Police General Hospital, Thailand
Postoperative Delirium, Postoperative Pain, Acute
Postoperative Delirium and Analgesia in Elderly Patients
This study aims to evaluate the effects of different postoperative analgesic approaches on postoperative delirium in elderly patients undergoing total knee arthroplasty.
- Trial name
- NCT07849517
- Testing
- adductor canal block and biFes block including bupivacain, Periarticular infiltration
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Arthroplasty, Knee Replacement, Musculoskeletal Disorder
Changes in Quadriceps Muscular Activity in Patients After Total Knee Arthroplasty Compared to Healty Subjects
During Total Knee Arthroplasty (TKA), joint undergo considerable stress, which causes neuromuscular activation deficits of the quadriceps femoris muscle.The aim of the study is to investigate differences in quadriceps…
- Trial name
- NCT04152538
- Testing
- not intervention but investigation
- Where
- Italy
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas
Unilateral Primary Osteoarthritis of Knee
Bone Mineral Density Changes Under Two Tibial Components in Total Knee Arthroplasty
Osteoarthritis is a progressive disease afflicting to two thirds of Americans. Today, an estimated 43 million individuals have arthritis. By 2020, more than 59.4 million Americans will be affected by the disease.
- Trial name
- NCT01764984
- Testing
- Total knee arthroplasty
- Where
- 3 sites in Canada
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Knee Pain, Chronic Osteoarthritis
ROSA Robot Used in Total Knee Replacement Post Market Study
This is a prospective, multicenter clinical study designed to facilitate the collection and evaluation of workflow efficiency, patient pain and function, and adverse event data.
- Conditions
- Knee Pain, Chronic Osteoarthritis, Avascular Necrosis of the Femoral Condyle, Moderate Varus, Valgus or Flexion Deformities
- Trial name
- NCT03969654
- Testing
- PERSONA Total Knee, Vanguard Total Knee, NexGen Total Knee
- Where
- 5 sites in United States
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- Zimmer Biomet
TKA Outcomes
Exploring the Benefits of a 3D Patient-specific Alignment in Total Knee Arthroplasty
General Aim: to explore the iKA in TKA related to clinical, biomechanical, and functional outcomes.
- Trial name
- iKA (NCT07367802)
- Testing
- iKA
- Where
- Belgium
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Degenerative Joint Disease of Knee, Osteoarthritis
A Randomized Controlled Trial for Partial Knee Arthroplasty
This is a prospective, multi-center, two-arm, randomized, controlled post-market study to evaluate and compare the clinical accuracy of component placement in robotic-assisted UKA and that of traditional methods.
- Conditions
- Degenerative Joint Disease of Knee, Osteoarthritis, Traumatic Arthritis, Varus Deformity
- Trial name
- NCT05037734
- Testing
- Persona Partial Knee System
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Zimmer Biomet
Osteoarthritis, Knee
Parabens Flocculation on the Anti Inflammatory Effects of Corticosteroid Injections for Total Knee Arthroplasty
The purpose of this study is to identify whether corticosteroid use with anesthetics containing preservatives (parabens) reduces clinical effectiveness of the anti-inflammatory agent Up to 100 patients, both male and female…
- Trial name
- 5160373 (NCT03445611)
- Testing
- corticosteroid solution with lidocaine containing parabens., corticosteroid solution with lidocaine containing no paraben
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Loma Linda University
Quality Of Recovery
Effect of Preoperative Oral Carbohydrate Loading on Elderly Patient Quality of Recovery in Total Knee Arthroplasty
This prospective randomized controlled study will be aimed to evaluate the effect of preoperative oral carbohydrate loading on the elderly patient's quality of recovery and satisfaction in undergoing knee arthroplasty (TKA)…
- Trial name
- NCT05582356
- Testing
- Carbohydrate group (Group OC)
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Karaman Training and Research Hospital
Postoperative Pain
Effects of Oral Tranexamic Acid Following Total Knee Arthroplasty
The primary purpose of this study is to evaluate postoperative pain. Secondary outcomes evaluated in this study will include range of motion (ROM), opioid consumption, and ambulation.
- Trial name
- NCT06479161
- Testing
- Tranexamic acid
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Matthew Grosso, MD
Knee Arthritis
Telemedicine in Total Knee Arthroplasty Using Wearable Technology
Subjectivity, cost-effectiveness, and inconsistent reporting limit monitoring after total knee arthroplasty (TKA). This prospective study leverages machine learning wearable technology to remotely monitor patients before and…
- Trial name
- NCT03406455
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Knee Injuries, Knee Osteoarthritis
Blood-Flow Restriction Exercise Following a Knee Replacement
This study will determine the safety and efficacy of using blood-flow restriction exercise enhancement (B-FREE) to overcome persistent quadriceps muscle weakness that occurs following a total knee replacement (TKR).
- Conditions
- Knee Injuries, Knee Osteoarthritis, Knee Arthritis
- Trial name
- NCT04018638
- Testing
- B-FREE
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Michigan Technological University
Knee Osteoarthritis
Comparison of Floseal® and Tranexamic Acid on Bleeding Control After Total Knee Arthroplasty
The total knee arthroplasty (TKA) is a well established option for the treatment of osteoarthritis in this joint. Nevertheless, there are still some concerns related to the peri-operative management of elderly patients…
- Trial name
- NCT02152917
- Testing
- Tranexamic acid, Floseal®
- Where
- Brazil
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Pain, Postoperative
Combination Effects of Pregabalin and Dexmedetomidine on Postoperative Pain
Pregabalin and dexmedetomidine have been introduced to manage postoperative pain. The present study aimed to evaluate the effect of the combination of two drugs on pain relief in patients undergoing total knee or hip arthroplasty…
- Trial name
- NCT03512574
- Testing
- Pregabalin, Dexmedetomidine, Pregabalin and dexmedetomidine
- Where
- South Korea
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Wonkwang University Hospital
Knee Osteoarthritis
Effectiveness of Contemporary Knee Arthroplasty in Working-age Patients
The aim of our study was to assess the effectiveness of contemporary knee arthroplasty in working-age patients (< 65 years) by conducting a prospective cohort study with 2-year follow up.
- Trial name
- NCT03233620
- Testing
- Knee arthroplasty
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Coxa, Hospital for Joint Replacement