Clinical trials: Reproductive Disorder, open to volunteers
Infertility, Infertility (IVF Patients)
Language Matters: Exploring the Impact of Language Concordance on Fertility Treatment Progression
Currently, patients presenting to the Fertility and Reproductive Medicine Center meet with an English-speaking provider and communicate through an interpreter, as none of the physicians speak Spanish.
- Conditions
- Infertility, Infertility (IVF Patients), Infertility Assisted Reproductive Technology, Ovulation Ind
- Trial name
- ImpaLa (NCT06636838)
- Testing
- Spanish-Speaking Provider
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Washington University School of Medicine
Hiv
Multi-product PrEP Delivery to Young Women Seeking Reproductive Health Services and Coverage of HIV Prevention
Following on the heels of large implementation science projects that participated in the launch of widespread daily oral PrEP availability, investigators will launch and study the integration of novel PrEP products - beginning…
- Trial name
- PrEMIA (NCT07076043)
- Testing
- Multiple Product PrEP Program, Routine Oral PrEP
- Where
- Kenya
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Anxiety, Assisted Reproductive Treatments
Virtual Reality for Anxiety Relief in Infertile Women
This study examines the impact of virtual reality (VR) applications on anxiety levels before and after embryo transfer procedures.
- Conditions
- Anxiety, Assisted Reproductive Treatments, Women, VR
- Trial name
- NCT07020975
- Testing
- VR Glasses
- Where
- Cyprus
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cyprus Aydin University
Heat Stress, Pregnancy
Indigenous Nutritional Supplements for Pregnancy to Improve Resilience in Environmental Heat
The purpose of this study is to learn whether a simple, traditional, and balanced meal made from local foods, eaten once a day during pregnancy, can help women in rural Pakistan stay healthier in hot weather and give birth to…
- Conditions
- Heat Stress, Pregnancy, Women of Reproductive Age, Nutrition Status
- Trial name
- INSPIRE (NCT07489664)
- Testing
- Indigenous Balanced Diet Arm
- Where
- Pakistan
- Volunteers
- 292 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Breast Cancer
Clinical and Biological Study of Early-onset Breast Cancer and the Influence of the Reproductive Cycle on the Aggressiveness of the Disease
The incidence of breast cancer is increasing, particularly among young women. Cancers in young women are associated with a poor prognosis. The causes remain poorly understood.
- Trial name
- ARTEMIS (NCT07601152)
- Testing
- No Intervention: Observational Cohort
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Institut Cancerologie de l'Ouest
Hypogonadotropic Hypogonadism
Kisspeptin Administration Subcutaneously to Patients With IHH
The goal of this study is to see whether kisspeptin, a naturally occurring hormone, can stimulate the release of other reproductive hormones in men and women with idiopathic hypogonadotropic hypogonadism (IHH).
- Trial name
- NCT05896293
- Testing
- kisspeptin 112-121, leuprolide acetate
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Stephanie B. Seminara, MD
ICSI, IVF
Dual Trigger VS HCG Trigger for Final Oocyte Maturation in Normal Responders
To compare the embryological and reproductive outcomes of dual trigger versus conventional hCG trigger for final oocyte maturation in normal responder patients undergoing ICSI cycles.
- Conditions
- ICSI, IVF, Normal Responders, Infertility Assisted Reproductive Technology
- Trial name
- DT-HCG-IVF (NCT07861399)
- Testing
- Dual trigger (human chorionic gonadotropin plus GnRH-agonist), hCG trigger
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Al-Azhar University
HIV Infection, Sexual and Reproductive Health
PrEPared to Choose (PtC) is an Implementation Study of the Delivery of Cabotegravir Long-acting, an Injectable Pre-exposure Prophylaxis (PrEP) Option for HIV Prevention. Injectable PrEP Will be Offered Alongside Oral and Vaginal Ring PrEP From Within a Real-world Context in Cape Town, South Africa.
The goal of this clinical trial is to offer adolescents and young people in Cape Town, South Africa different HIV pre-exposure prophylaxis (PrEP) products and describe how they use these products over an 18-month period.
- Trial name
- PtC (NCT06807736)
- Testing
- Cabotegravir long-acting, Tenofovir emtricitabine, Dapivirine containing vaginal ring
- Where
- South Africa
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Desmond Tutu HIV Foundation
Primary Ciliary Dyskinesia (PCD)
A Qualitative Study Investigating the Lived Experiences and Impact of Reproductive Issues in Adults With Primary Ciliary Dyskinesia
Study involving undertaking research interviews with adults who have primary ciliary dyskinesia in the UK about their views and experiences of fertility, pregnancy and parenthood
- Trial name
- NCT07357558
- Testing
- Interview only
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Environmental Enteric Dysfunction (EED), Malnutrition
The Maternal EED Study
Undernutrition among women of reproductive age is more common in South Asia than in any other region. In South Asia, the prevalence of maternal undernutrition varies between 10 and 40%.
- Conditions
- Environmental Enteric Dysfunction (EED), Malnutrition, Women of Reproductive Age, Gut Microbiota
- Trial name
- NCT05862363
- Testing
- Microbiota-directed balanced energy protein (MD-BEP), Ready-to-use supplementary food-balanced energy protein (RUSF-BEP), Esophagogastroduodenoscopy (EGD)
- Where
- Bangladesh
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Adenomyosis of Uterus
Nintedanib for Improving Reproductive Outcomes in Adenomyosis
This study aims to evaluate the effectiveness and safety of nintedanib, an antifibrotic drug, in improving live birth rates for infertile women with adenomyosis who have frozen embryos.
- Trial name
- NCT07162961
- Testing
- Nintedanib, Progesterone
- Volunteers
- 328 people
- Sponsor
- Sun Yat-sen University
Sexual Behavior, Adolescent Behavior
Evaluation of Parent Toolkit 2.0 (Morehouse Family Health Study)
Child Trends will conduct a randomized control trial evaluation of Parent Toolkit 2.0, an innovative intervention for parents and caregivers of middle and high school students.
- Conditions
- Sexual Behavior, Adolescent Behavior, Sexually Transmitted Diseases, Contraception Behavior
- Trial name
- NCT06579781
- Testing
- Morehouse Family Health Study's Parent Toolkit 2.0, Morehouse Family Health Study's General Health Guide
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Child Trends
PCOS (Polycystic Ovary Syndrome)
Symptoms of Polycystic Ovarian Syndrome Ameliorated by Keto-Adaptation Pilot
The SPARK- Pilot study (Symptoms of PCOS Ameliorated by Responses to Keto-adaptation) is a 12-week clinical trial at The Ohio State University designed to explore how different ways of achieving ketosis may improve reproductive…
- Trial name
- (SPARK-Pilot) (NCT07227363)
- Testing
- Ketogenic diet, Exogenous Ketone Supplement
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Ohio State University
Ovarian Neoplasms, Reproductive System Neoplasm
Reproductive Health Outcomes Among Young Women With Ovarian Neoplasms Following Surgery
This retrospective study aims to assess reproductive health outcomes including menstrual function, fertility potential, menopausal symptoms, sexual function, and quality of life in young women following surgical treatment for…
- Trial name
- NCT06777147
- Volunteers
- 120 people
- Sponsor
- Assiut University
Infertility, in Vitro Fertilization (IVF)
Use of Artificial Intelligence for Clinical Assessment of Assisted Reproductive Techniques and IVF Outcomes
The use of machine learning techniques using an artificial intelligence tool is proposed to analyze clinical data to predict best possible IVF/ART outcomes.
- Conditions
- Infertility, in Vitro Fertilization (IVF), ART
- Trial name
- AI in ART (NCT04255615)
- Testing
- AI to analyze 3 D ultrasound
- Where
- United States
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Reproductive Issues, Fertility Issues
Towards Optimal Fertility, Fathering and Fatherhood studY
This case-control study involving fertile and subfertile couples aims to identify male factors related to pregnancy likelihood, create a fertility index measure combining male and female factors to predict pregnancy likelihood…
- Trial name
- TOFFFY (NCT06293235)
- Testing
- Lifestyle and metabolic indicators
- Where
- Singapore
- Volunteers
- 960 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Nutritional Status, Nutrient Deficiency
Challenges in Achieving Adequate Dietary Status of Women
The aim of the study is to investigate the dietary habits of women of reproductive age (20-49 years). We aim to obtain epidemiological data on the intake and adequacy of key macronutrients and micronutrients, as well as to…
- Conditions
- Nutritional Status, Nutrient Deficiency, Micronutrient Deficiency, Vitamin D Deficiency
- Trial name
- NutriFem (NCT06745817)
- Testing
- Assessement of nutritional status, Dermis density and thickness, Skin elasticity
- Where
- 3 sites in Slovenia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Institute of Nutrition, Slovenia (Nutris)
Genetic Disorder, Infertility
Inherited Reproductive Disorders
Background: During puberty, children begin to develop into adults. Problems with the hormones released during puberty can affect the reproductive system. Some people have low hormone levels that severely delay or prevent puberty.
- Conditions
- Genetic Disorder, Infertility, Hypogonadism, Amenorrhea
- Trial name
- NCT01500447
- Where
- 2 sites in United States
- Volunteers
- 850 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Infertility Assisted Reproductive Technology, Infertility (IVF Patients)
Blastocyst AI Assisted Morphokinetics in ART
The goal of this observational study is to learn if embryo characteristics obtained via the recording of real-time embryo activity via 30-seconds video capture (e.g.: Embryo Morphokinetics) can correlate with known embryo outcome…
- Trial name
- AIM (NCT07611448)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Viable Biosciences
Endometriosis, Fertility
Reproductive Prognosis in Women Seeking Offspring After Medical or Surgical Therapy for Endometriosis
The study aims to compare the percentage of women with endometriosis who undergo PMA after medical vs surgical treatment and to describe conception patterns, pregnancy rates, and number of live vessels in women seeking offspring…
- Trial name
- SURGENDO (NCT07437742)
- Testing
- PMA
- Where
- Italy
- Volunteers
- 650 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico