Clinical trials: Resection Margins
Breast Carcinoma, Prostate Cancer Surgery
High-resolution PET-CT Specimen Imaging for the Perioperative Visualization of Resection Margins
These are patients in whom a benign or malignant tumor was recorded requiring surgery. During that surgery, the surgeon will cut away the tumor as part of the treatment of the disease.
- Conditions
- Breast Carcinoma, Prostate Cancer Surgery, Thyroid Cancer, Parathyroid Adenomas
- Trial name
- NCT06835426
- Testing
- Single intravenous injection of the radiotracer, Imaging resected specimen using the high-resolution PET-CT specimen imager
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- Algemeen Ziekenhuis Maria Middelares
Pancreas, Adenocarcinoma
Prospective Evaluation of the Resection Margins and the Ganglionic Status Using a Quality Standard Resection for Adenocarcinoma of the Head of the Pancreas
This multicentric prospective study evaluates the role of the margins resection and the ganglionic status when using a quality standard for the resection of adenocarcinoma of the head of the pancreas.
- Trial name
- MRP (NCT00918853)
- Testing
- resection of adenocarcinoma of the head of the pancreas
- Where
- 20 sites in France
- Volunteers
- 156 people
- Sponsor
- Institut Paoli-Calmettes
Gastric Cancer, Molecular Imaging
Novel Humanized Ferritin-based NIR Fluorescent Molecular Probe for Identifying Tumor Margins in Gastric Tissue
Radical surgery remains the primary treatment for gastric cancer, but intraoperative tumor margin assessment relies on surgeons' visual inspection, limiting accuracy.
- Trial name
- NCT07276854
- Testing
- Diagnostic Test: ICG-FTn perfusion solution
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Rectal Cancer
Preoperative Prediction Model of Pathological Outcomes (Mesorectum Quality and Positive Circumferential Resection Margin) in Patients With Mid-low Rectal Cancer
Elaboration of a preoperative prediction model of the quality of the mesorectum and the involvement of the circumferential margin in patients with mid-low rectal cancer who undergo laparoscopic anterior rectal resection.
- Trial name
- PREMARE (NCT03107650)
- Testing
- Transanal total mesorectal excision of rectal cancer
- Where
- Spain
- Volunteers
- 323 people
- Sponsor
- Pere Planellas Giné
Skin Basal Cell Carcinoma
Effectiveness of Narrow Margins in Patients With Low-Risk Basal Cell Carcinoma Undergoing Surgery
This clinical trial studies the effectiveness of narrow margins in patients with low-risk basal cell carcinoma undergoing surgery to remove skin lesions on the face.
- Trial name
- NCT02579551
- Testing
- Therapeutic Conventional Surgery
- Where
- United States
- Volunteers
- 179 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Colonic Polyp, Colonic Sessile Serrated Lesion
The CARMA Technique Study
Colonoscopic removal of polyps is an important and well-established tool in the prevention of colorectal cancers. However, high polyp recurrence rates after endoscopic resection, with resultant development of interval cancers…
- Trial name
- NCT05099432
- Testing
- CARMA technique
- Where
- Australia
- Volunteers
- 60 people
- Sponsor
- Princess Alexandra Hospital, Brisbane, Australia
Endodontically Treated Teeth
Deep Margin Elevation Vs Crown Lengthening
The present clinical trial will be conducted to reject or accept the null hypothesis that in endodontically treated posterior teeth with deeply located proximal margins, will the Deep Margin Elevation will have better results…
- Trial name
- NCT05381298
- Testing
- Deep Margin Elevation using resin composite, Surgical Crown Lengthening
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Squamous Cell Carcinoma of Head and Neck, Basal Cell Carcinoma of Skin
Intraoperative Assessment of Surgical Margins Using Confocal Microscopy in Comparison With Reference Extemporaneous Examination
Study to evaluate the use of confocal microscopy for detecting resection margins in patients undergoing surgery for basal cell carcinoma of skin and squamous Cell Carcinoma of Head and Neck
- Trial name
- HISTOBLOC (NCT05935995)
- Testing
- microscopy confocal (Histolog Scanner)
- Where
- France
- Volunteers
- 42 people
- Sponsor
- Institut de Cancérologie de Lorraine
General Anesthesia Induction for Elective Surgery, Sono Guided Catheterization
Sonographic Safety Margins of Subclavian Vein: Effect of View and Arm Position
The purpose of this observational study is to evaluate and compare the anatomical safety margins of the subclavian vein using ultrasound.
- Trial name
- NCT07556770
- Testing
- Non-invasive sonographic observation
- Where
- South Korea
- Volunteers
- 55 people
- Sponsor
- Asan Medical Center
Soft Tissue Sarcoma of Members
Observation Versus Post-surgery Radiotherapy After Complete Exeresis in Soft Tissues Members Sarcoma
Soft tissue sarcomas represent less than 1% of malignant tumors in adults and sarcomas members represent 60% of them. These rare tumors involve complex multidisciplinary care better in centers having expertise.
- Trial name
- NCT00870701
- Testing
- Radiotherapy, absence of radiotherapy
- Where
- 18 sites in France
- Volunteers
- 77 people
- Sponsor
- Institut Claudius Regaud
Endoscopic Recurrence Rate, After Ileocolic Crohn 's Disease Surgery
Mesenteric Surgical Margin for Crohn's Disease Endoscopic Recurrence
Despite significant advancements in the treatment of Crohn's disease (CD), approximately 50% of patients undergo surgical intervention within ten years of diagnosis.
- Trial name
- NCT06241170
- Testing
- mesentery-guided resection margin, traditional resection margin
- Where
- China
- Volunteers
- 172 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Cancer, Solid Malignant Tumors
High-Resolution PET-CT Imaging for Surgical Margin Visualization
Imaging will be exploratory and be used intraoperatively. There have been no discovered risks associated with the device to be used in this study, and none are anticipated given the diagnostic and non-invasive, 'ex vivo' nature…
- Conditions
- Cancer, Solid Malignant Tumors, SCC - Squamous Cell Carcinoma, HNSCC
- Trial name
- NCT06915454
- Testing
- Intra-op PET/CT Specimen Scanner
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Rectal Cancer Patients, Rectal Cancer Stage
Study of Intramural Spread Pattern in Low Rectal Cancer.
The purpose of this study is to study the law of intramural diffusion of low rectal cancer in different stages, and to explore the relationship between intramural diffusion of low rectal cancer and the distal resection margin…
- Trial name
- NCT07202169
- Where
- China
- Volunteers
- 106 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
HCC - Hepatocellular Carcinoma
Defining the Ablative Dose for Y-90 TARE
This study is being done to help doctors improve how they treat liver tumors that cannot be removed by surgery or treated with standard ablation techniques.
- Trial name
- MARGIN (NCT07586046)
- Testing
- Yttrium-90 Radiation Segmentectomy (Y90 RS) using glass microspheres
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northwestern University
Breast Cancer
A Study Comparing ex Vivo MRI Versus Radiography of Breast Specimens
Radiography of breast specimens is currently the only radiological procedure used to verify removal of microcalcifications and presence of tumor-free margins after breast surgical resection.
- Trial name
- NCT01869335
- Testing
- radiography, MRI (magnetic resonance imaging)
- Where
- Italy
- Volunteers
- 260 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Non-Small Cell Lung Cancer
Factors Determine the Feasibility and Surgical Margin Quality of Sublobar Resection for Non-small Cell Lung Cancer?
Sublobar resection (SR) has been recognized as non-inferior to lobectomy for small-sized non-small cell lung cancer (NSCLC). This study aimed to systematically identify the potential factors influencing the feasibility and…
- Trial name
- NCT07005401
- Where
- China
- Volunteers
- 1,064 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Adenoma Colon Polyp
Evaluating Adenoma Recurrence After Endoscopic Mucosal Resection With Margin Marking or Post Treatment With Snare Tip Soft Coagulation
Non-inferiority trial comparing the recurrence rate of adenomas in non-pedunculated colonic lesions following endoscopic mucosal resection with margin marking (EMR-MM) and endoscopic mucosal resection with thermal margin ablation…
- Trial name
- ERADICATE (NCT06476145)
- Where
- United States
- Volunteers
- 342 people
- Sponsor
- AdventHealth
Adaptive Radiotherapy, Stereotactic Body Radiotherapy
Elimination of PTV Margins Based on Online Adaptive Stereotactic Radiotherapy for Early-stage Non-small Cell Lung Cancer or Pulmonary Oligometastases
This study aims to explore the safety and efficacy of eliminating the PTV (planning target volume) margins based on online adaptive stereotactic radiotherapy for patients with early-stage non-small cell lung cancer (NSCLC) or…
- Conditions
- Adaptive Radiotherapy, Stereotactic Body Radiotherapy, Non-small Cell Lung Cancer, Lung Oligometastases
- Trial name
- NCT06542159
- Testing
- Online adaptive SBRT, Conventional SBRT
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Sun Yat-sen University
Clinical Stage IA Cutaneous Melanoma AJCC v8, Clinical Stage IB Cutaneous Melanoma AJCC v8
Narrow Excision Versus Wide Excision for the Treatment of Adults With Invasive Cutaneous Melanoma, ICEMAN Trial
This clinical trial compares the effect of a narrow surgical excision (removal) to a wide excision for the treatment of adults with invasive cutaneous melanoma.
- Trial name
- NCT06673095
- Testing
- Biospecimen Collection, Excision, Survey Administration
- Where
- 5 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- OHSU Knight Cancer Institute
Breast Cancer
A Novel Optical Spectral Imaging System for Imaging Breast Tumor Margins
The goal of this research is to further develop novel optical assay systems for intra operative assessment of tumor margins in partial mastectomy or mastectomy specimens.
- Trial name
- NCT01372631
- Testing
- miniature spectral imaging system, Bench-top optical spectrometer, High resolution microendoscope
- Where
- 2 sites in United States
- Volunteers
- 218 people
- Sponsor
- Duke University