Clinical trials: Resistant Hypertension
Healthy, Overweight and Obesity
Strategies To OPpose Sugars With Non-nutritive Sweeteners Or Water (STOP Sugars NOW) Trial
Health authorities recommend a reduction in added sugars from sugar-sweetened beverages (SSBs) due to risk of obesity and diabetes. As a sugar-reduction strategy, finding the ideal SSB replacement is of the utmost importance.
- Conditions
- Healthy, Overweight and Obesity, Metabolic Syndrome, PreDiabetes
- Trial name
- NCT03543644
- Testing
- Sugar-sweetened beverage (SSB), Non-nutritive sweetened beverages (NSB), Water
- Where
- Canada
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Hypertension, Obesity
Pleiotropic Effects of Azilsartan Medoxomil Over Insulin Resistance in Obese, Diabetic and Hypertensive Patients
The goal of this study is to build a mathematical model to explain the effect of two doses of azilsartan (40 and 80 mg) upon metabolic (insulin resistance, glucose) and inflammatory parameters (cytokines) in function of…
- Conditions
- Hypertension, Obesity, Type 2 Diabetes Mellitus
- Trial name
- NCT02235519
- Testing
- Azilsartan 40 mg., Azilsartan 80 mg
- Where
- Mexico
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Hospital General de México Dr. Eduardo Liceaga
Metabolic Syndrome, Menopause
Effects of L-citrulline Supplementation on Vascular Function in Metabolic Syndrome
The objective of this project is to provide evidence that L-Citrulline (CIT) supplementation can improve vascular function in the fasted and acute hyperglycemia conditions in middle-aged and older women with metabolic syndrome.
- Trial name
- NCT06025357
- Testing
- L-Citrulline supplementation
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Hypertension
Unilateral and Bilateral Resistance Training in Hypertension
Hypertension is associated with autonomic nervous system dysfunction, reduced muscle strength, and impaired functional capacity, all of which contribute to increased cardiovascular risk and decreased quality of life.
- Trial name
- NCT07751445
- Testing
- Unilateral Resistance Training, Bilateral Resistance Training
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Postmenopausal, Hypertension
Cardiovascular Adaptations to Resistance Exercise: Effect of Set Configuration on Postmenopausal Women
The main purpose of this project is to analyze the effect of set configuration of resistance exercise on cardiovascular responses and adaptations of postmenopausal women.
- Trial name
- CARE (NCT05544357)
- Testing
- Short set configuration resistance training, Long set configuration resistance training
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidade da Coruña
Hypertension
Spironolactone Versus Amiloride as an Add on Agent in Resistant Hypertension
Joint National Committee 7 (JNC-7) defines resistant hypertension as a persistent elevation of blood pressure (BP) above goal - ≥ 140/90 mm Hg for the general hypertensive population or ≥ 130/80 mm Hg for persons with diabetes…
- Trial name
- NCT00709137
- Testing
- spironolactone, amiloride
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- VA Salt Lake City Health Care System
Atherosclerosis, Congestive Heart Failure
Dallas Heart Study 2: Return Clinic Visit for the Dallas Heart Study Cohort
The Dallas Heart Study (DHS-1) is a large, multi-ethnic, population-based epidemiological study designed to identify determinants of atherosclerotic heart disease (ASHD) in a representative United States (US) urban environment.
- Conditions
- Atherosclerosis, Congestive Heart Failure, Left Ventricular Hypertrophy, Diabetes Mellitus
- Trial name
- NCT00344903
- Where
- United States
- Volunteers
- 3,400 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Insulin Resistance, Metabolic Syndrome X
MARIS Study; Mediterranean Approach to Reduce Insulin-Resistance Study
Background: During the 1990s, the prevalence of the metabolic syndrome in the Netherlands ranged from 3% in women of 20-39 yrs to at least 33% in men 55 yrs and older and it is expected to increasing.
- Conditions
- Insulin Resistance, Metabolic Syndrome X, Dyslipidemia, Hypertension
- Trial name
- NCT00405197
- Testing
- Isocaloric diet high in MUFA or Mediterranean diet
- Where
- 2 sites in Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Hypertension
Neural Mechanism of Aldosterone-induced Insulin Resistance
Patients with high aldosterone hormone have higher blood glucose than normal people. This study is being done to understand how aldosterone hormone affects the nerve activity that controls blood flow in the muscles and blood…
- Trial name
- NCT02102243
- Testing
- DEFINITY® infusion, Human Recombinant Regular Insulin infusion, Dextrose infusion
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Wanpen Vongpatanasin
Hypertension, Resistant to Conventional Therapy
Effect of Renal Sympathetic Denervation on Resistant Hypertension and Cardiovascular Hemodynamic in Comparison to Intensive Medical Therapy Utilizing Impedance Cardiography
The purpose of this study is to demonstrate that Renal Sympathetic Denervation (RDN) improves the control of blood pressure (BP) in patients with treatment-resistant hypertension, as compared to intensive medical therapy (IMT)…
- Trial name
- OsloRDN (NCT01673516)
- Testing
- The SymplicityTM Renal Denervation System, The HOTMAN® System
- Where
- Norway
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Glucose Intolerance, Hyperinsulinemia
Health Effects of Liposuction in Overweight Women With Elevated Insulin Levels, Impaired Glucose Tolerance and/or Type 2 Diabetes
This study is for women who have already decided to undergo liposuction at Georgetown University Medical Center in Washington, D.C.
- Conditions
- Glucose Intolerance, Hyperinsulinemia, Diabetes Mellitus, Non Insulin Dependent, Obesity
- Trial name
- NCT00005760
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)