Clinical trials: Resolution
Acid Base Imbalance, Osmolality Disturbance
Heart-Lung Machine: Impact of the Priming Solution on Acid-Base Balance, Electrolytes and Outcome on Patients Undergoing Cardiac Surgery
Most cardiac surgery procedures requires the use of heart-lung machine. The heart-lung machine circuit needs to be filled with a fluid before connecting it to the patients circulation.
- Conditions
- Acid Base Imbalance, Osmolality Disturbance, Crystalloid Solutions, Electrolyte Changes
- Trial name
- PRIMEII (NCT07267546)
- Testing
- Ringer's Acetate 80, Plasmalyte, Ringer's Acetate no add
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Region Skane
Healthy
A Study of LY3074828 in Healthy Participants
The purpose of this study is to look at the amount of the study drug, LY3074828, that gets into the blood stream and how long it takes the body to get rid of LY3074828, when given as a solution formulation in different devices.
- Trial name
- NCT03456713
- Testing
- LY3074828
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Seborrheic Keratosis (SK)
Study of Safety, Tolerability and Effectiveness of A-101 in Subjects With Seborrheic Keratosis
Evaluate the safety, tolerability of A-101 when applied to seborrheic keratosis lesions on the back of subjects.
- Trial name
- NCT01986920
- Testing
- A-101 25%, A-101 32.5%, A-101 40%
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Aclaris Therapeutics, Inc.
Post Procedural Pain Management in Neonates
Comparison of Minimal Effective Dose of Sucrose for Pain Relief in Neonates After Minor Procedure
Type of Study: Randomized Controlled Trial Aim: To compare the effectiveness of two doses of sucrose solution for pain relief in neonates after minor procedures.
- Trial name
- NCT06446323
- Testing
- 0.2 ml dose of sucrose
- Where
- Pakistan
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Rawalpindi Medical College
Regional Anesthesia Morbidity, Pain, Acute
Understanding Rebound Pain After Regional Anesthesia Resolution in Healthy Volunteers
Regional anesthesia decreases postoperative pain scores and opioid consumption, and may prevent chronic pain after surgery in patients undergoing surgery.
- Conditions
- Regional Anesthesia Morbidity, Pain, Acute, Healthy
- Trial name
- NCT06005480
- Testing
- Mepivacaine
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Surgical Site Infection
Effect of Peritoneal Lavage With Clindamycin-gentamicin Solution on Postoperative Colorectal Cancer Infection in Elective Surgery
Intrabdominal antibiotic irrigation will reduce wound and intrabdominal infection.
- Trial name
- lavage (NCT01378832)
- Testing
- Intra-peritoneal antibiotic lavage
- Volunteers
- 102 people
- Sponsor
- Universidad Miguel Hernandez de Elche
Bronchitis
Crossover, Single Dose, Two-stage Bioequivalence Study of SCMC-Lys Salt 1.35 g Powder vs SCMC-Lys Salt 90 mg/mL Syrup
Objectives: The objectives of the study was to investigate the bioequivalence between two formulations containing S-carboxymethyl-L-cysteine L-lysine monohydrate salt (SCMC-lys) when administered as single oral dose in two…
- Trial name
- NCT02858193
- Testing
- SCMC-lys powder 1.35 g, Fluifort® syrup
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Dompé Farmaceutici S.p.A
Meconium Obstruction of Prematurity
Saline Enema Administration in Meconium Obstruction of Prematurity and Impact on the Resolution, Feeds, Microbiome, and Gut-brain Axis.
The goal of this clinical trial is to study the effect of twice-daily saline enema (SE) in the treatment obstruction of prematurity (MOP) in infants with the birth weight ≤1.25kg.
- Trial name
- NCT06048614
- Testing
- Saline Enema (SE), Glycerin Suppository
- Where
- 2 sites in Singapore
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Dry Eye Disease
Efficacy Study of Ecabet Ophthalmic Solution in Dry Eye Disease
Efficacy study of ecabet ophthalmic solution in dry eye disease
- Trial name
- NCT00667004
- Testing
- ecabet ophthalmic solution
- Where
- United States
- Volunteers
- 183 people
- Sponsor
- Bausch & Lomb Incorporated
Bacterial Infections, Eye Infections
Study of AzaSite (Azithromycin) Versus Vigamox in the Conjunctiva of Healthy Volunteers
The purpose of this study is to evaluate the drug concentrations of AzaSite™ compared to Vigamox at various time points in conjunctiva tissue of healthy volunteers
- Trial name
- NCT00564447
- Testing
- Azithromycin, Moxifloxacin
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Diabetes Mellitus, Pancreas Transplantation
Histidine-Tryptophane-Ketoglutarate (HTK) vs University of Wisconsin (UW) Perfusion in Clinical Pancreas Transplantation
Graft preservation in clinical pancreas transplantation is based on hypothermia achieved by topic cooling and cold in situ flushing using special perfusion solutions designed to attenuate the effects of ischemia/reperfusion and…
- Trial name
- NCT00737880
- Testing
- Organ perfusion during pancreas procurement
- Where
- 4 sites in Austria, Belgium and 1 more
- Volunteers
- 68 people
- Sponsor
- Medical University Innsbruck
Chronic Rhinosinusitis, Cystic Fibrosis
Efficacy of Nasal Irrigation With Respimer® Netiflow® vs Saline Among Patients With Cystic Fibrosis and Chronic Rhinosinusitis
Prospective, randomized, cross-over, multicenter, trial comparing the efficacy and tolerability of nasal irrigation with Respimer® mineral salts solution versus saline solution both administered with Respimer® Netiflow® medical…
- Trial name
- Respire (NCT03145051)
- Testing
- Saline solution, Respimer Netiflow
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Laboratoire de la Mer
Cystic Fibrosis in Adults, Chronic Colonization With Pseudomonas Aeruginosa
Detection of Reductions in Cystic Fibrosis Airway Inflammation While Using Aztreonam Lysine Solution
In cystic fibrosis, there is a critical need for better predictors of treatment response. The investigators have identified a panel of white blood cell biomarkers which can be directly measured as a blood test in subjects with…
- Trial name
- NCT01736839
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- National Jewish Health
Colonoscopy
Amitiza® Plus GoLYTELY® (PEG) Versus Placebo Plus GoLYTELY® for Outpatient Colonoscopy Preparation
The primary objective is to compare the effectiveness and tolerance of the medication named lubiprostone plus a large volume liquid laxative versus placebo which is a look alike medication that has no effect such as a sugar pill…
- Trial name
- PEG (NCT00645801)
- Testing
- lubiprostone (Amitiza)
- Where
- 3 sites in United States
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
NSCLC (Non-small Cell Lung Cancer)
Oral Paclitaxel Solution With Immunotherapy and Concurrent SBRT as Neoadjuvant Treatment for Older Adults With NSCLC
his multicenter, open-label, single-arm phase I/II trial will evaluate the safety, tolerability, and preliminary efficacy of oral paclitaxel solution combined with an immune checkpoint inhibitor and concurrent stereotactic body…
- Trial name
- NCT07754812
- Testing
- Oral Paclitaxel Solution, PD-1/PD-L1 inhibitor, Stereotactic Body Radiotherapy (SBRT)
- Where
- 5 sites in China
- Volunteers
- 78 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Acute Pre and Post Operative Pain
Acute Pain Assessment Using Facial Expression Analysis
Managing pain, which affects 20-50% of the population, is a major issue in daily clinical practice. Evaluation of pain intensity is essential to adapt treatment but as it mainly relies on self-report, this assessment is difficult…
- Trial name
- DEF-I (NCT03957967)
- Testing
- video taken
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Cervical Cancer, Cervical Intraepithelial Neoplasia
CASUS: Validation for Detection of Precursor Lesions
The goal of the overall CASUS project is to develop the first fully molecular integrated cervical cancer screening approach, based on first-void urine as an easily accessible and non-invasive source of biomarkers.
- Conditions
- Cervical Cancer, Cervical Intraepithelial Neoplasia, Human Papilloma Virus, HPV-Related Cervical Carcinoma
- Trial name
- CASUS-WP4 (NCT04530201)
- Testing
- Colli-Pee Small Volumes (10 mL) device
- Where
- 3 sites in Belgium
- Volunteers
- 332 people
- Sponsor
- Universiteit Antwerpen
Wound of Skin
Safety and Performance of SWIS in Superficial Wounds
This is an open, evaluator blinded, intra-comparative, randomized, non-inferiority investigation prior to CE mark to confirm safety and performance of the SWIS device when used as intended, i.e.
- Trial name
- NCT04771819
- Testing
- SWIS
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- SoftOx Solutions AS
Colonic Neoplasms
Yoga and Bolus Lukewarm Saline as Rapid Colonoscopy Preparation
A quality colonoscopy examination remains as the gold standard for colorectal cancer screening, but effective large bowel cleansing prior to colonoscopy is still not achieved in all cases that undergo the procedure.
- Trial name
- NCT01547130
- Testing
- Normal (0.9%) saline, HalfLytely
- Where
- United States
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- Arya, Vijaypal, M.D., P.C.
Keratoconjunctivitis Sicca
A Safety and Efficacy Study of Tavilermide (MIM-D3) Ophthalmic Solution for the Treatment of Dry Eye
The purpose of this study is to assess the safety and efficacy of Tavilermide Ophthalmic Solution compared with Placebo Ophthalmic Solution in treating the signs and symptoms of dry eye.
- Trial name
- NCT02634853
- Testing
- 1% Tavilermide Ophthalmic Solution
- Where
- 2 sites in United States
- Volunteers
- 429 people
- Sponsor
- Mimetogen Pharmaceuticals USA, Inc.
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