Clinical trials: Resource-Limited Setting
Male Circumcision, HIV Prevention
Cohort Field Study to Assess the Safety and Efficacy of the PrePex Device for Non-Surgical Circumcision When Performed by Nurses
A range of observational and epidemiological studies have shown that the lifetime risk of HIV infection can be reduced by 70% through male circumcision.
- Trial name
- NCT01434628
- Testing
- PrePex™ device
- Where
- Rwanda
- Volunteers
- 590 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Rwanda
Cirrhosis of the Liver, Ascites
Ultrasound Assessment of Diaphragmatic Structure and Function in Patients With Liver Cirrhosis: A Point-of-Care Tool for Predicting Complications and Sarcopenia in Limited Resource Settings
The goal of this observational study is to learn how liver cirrhosis affects the diaphragm, the main muscle used for breathing, in adults.
- Conditions
- Cirrhosis of the Liver, Ascites, Pleural Effusion Disorder, Hepatocellular Carcinoma (HCC)
- Trial name
- NCT07667608
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Assiut University
Neonatal Resuscitation
Outcomes of Neonatal Resuscitation
The primary objective of this study is to describe mortality of newborns who received basic, advanced or no neonatal resuscitation immediately after birth at Shoklo Malaria Research Unit.
- Trial name
- NCT02840682
- Where
- Thailand
- Volunteers
- 15,073 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Cervical Intraepithelial Neoplasia
A Novel, Low-Cost, Handheld 3D Imaging System for Improved Screening for Cervical Neoplasia in Resource-Limited Settings
The purpose of this study is to evaluate the design and engineering of a new minimally invasive medical imaging device (CervImage™).
- Trial name
- CervImage (NCT06810427)
- Testing
- CervImage device
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Carilion Clinic
Healthy, Male Infertility
Expanding Fertility Care to Poor and Low Resourced Settings Study
The investigators currently lack an understanding of barriers to completing the male factor infertility evaluation. Furthermore, as the investigators continue to expand access to fertility treatment particularly within…
- Conditions
- Healthy, Male Infertility, Infertility, Male, Fertility Disorders
- Trial name
- EXPLORE (NCT05205733)
- Testing
- Mail-in semen analysis kit
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Acute Illness
Evaluation of the Basic Assessment of Severity of Illness in Children (BASIC) Scale
The purpose of this study is to assess whether the BASIC Scale--a simple, non-invasive clinical triage protocol--predicts severe illness, hospitalization or death among children under age five presenting for acute care in a rural…
- Trial name
- NCT01068574
- Testing
- BASIC Score (Observational)
- Where
- Rwanda
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
General Surgery, Costs and Cost Analysis
Evaluating the Impact of the National Health Insurance Scheme of Ghana on Surgical Care
Ghana, a Low-Middle Income Country (LMIC) situated in the heart of West Africa started a national health insurance scheme in 2003.The scheme was designed to provide a comprehensive benefit package inclusive of surgical care and…
- Trial name
- NCT03604458
- Where
- Ghana
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Resource-Limited Setting, Delphi Study
Consensus on Low-resource Setting Definition: An inteRnational Delphi sTudY (CLARITY-LRS)
The term "low-resource setting" (LRS) is widely used in global health and critical care, yet no universally accepted definition exists.
- Conditions
- Resource-Limited Setting, Delphi Study, Consensus, Critical Care
- Trial name
- CLARITY-LRS (NCT07826819)
- Where
- Bosnia and Herzegovina
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Clinical Centre of Republic of Srpska
Vomiting in Infants and/or Children, Acute Gastroenteritis
Ondansetron Versus Domperidone for Treating Vomiting in Acute Gastroenteritis in Children
Most of the trials conducted comparing ondansetron and domperidone have been conducted among children aged below 5 or 6 years of age while no study from Pakistan has compared efficacy of these antiemetic agents among children up…
- Trial name
- NCT05076461
- Testing
- Ondansetron
- Where
- Pakistan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Tehsil Headquarter Hospital
HIV
Comparing the PrePex™ Device to Surgical MC for Rapid Scale Up of MC in Resource Limited Setting
The protocol, approved by the Medical Research Council, was issued to assess the safety and efficacy of the non-surgical device for applying it to the national scale up of adult male circumcision in Zimbabwe
- Trial name
- NCT01956370
- Testing
- PrePex™ device for adult male circumcision, Surgical circumcision
- Where
- Zimbabwe
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Ministry of Health and Child Welfare, Zimbabwe
Global Health, Education
Can VAST Improve ACLS in Rwanda
Aim The purpose of this study is to determine if the addition of the VAST Course to technical resuscitation skills training enhances healthcare providers' resuscitation performance in a resource-limited setting.
- Conditions
- Global Health, Education, Resuscitation
- Trial name
- NCT05278884
- Testing
- Advanced Cardiac Life Support Training, Vital Anesthesia Simulation Training
- Where
- Rwanda
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Male Circumcision
Randomized Trial Comparing PrePex Day 7 Foreskin Removal Procedure (FRP) to a Day 0 PrePex FRP .
A Prospective, Randomized, Open Label Trial Comparing PrePex™ Day 7 (FRP) to a PrePex Day 0 FRP of Male Circumcision in Resource Limited Settings.
- Trial name
- NCT03223532
- Testing
- PrePex Day 7 FRP, PrePex Day 0 FRP
- Where
- Kenya
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Nyanza Reproductive Health Society
HIV
Comparing the PrePex™ Device to Surgical Circumcision for Rapid Scale Up of Male Circumcision in Resource Limited Setting
The World Health Organization and UNAIDS cite that male circumcision can reduce the lifetime risk of HIV infection by 60% in high risk areas such as Sub Saharan Africa.
- Trial name
- NCT01284088
- Testing
- PrePex™ device for adult male circumcision, Surgical circumcision
- Where
- Rwanda
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Rwanda
Iron-deficiency, Iron Deficiency Anemia
Iron Fish for Dominican Republic (DR) Infants
This study evaluates the feasibility of cooking with an iron ingot, Lucky Iron Fish™ (LIF), and evaluate the natural history of hemoglobins and iron status among infants of families using this iron ingot in a population with a…
- Trial name
- NCT03606993
- Testing
- Lucky Iron Fish (TM) - An iron ingot that is a Cooking supplement
- Where
- Dominican Republic
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Penicillin Allergy
Evaluating the Feasibility of High-volume, Low-risk Penicillin Allergy De-labelling to Maximise Efficiency in a Resource-limited Setting
Plenty of studies have now established the safety of low-risk penicillin allergy de-labelling, but few have addressed how to organise de-labelling at the clinic level.
- Trial name
- De-Label Me (NCT06532448)
- Testing
- Single dose low-risk penicillin challenge
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Jaundice, Serum Bilirubin
A Study to Evaluate a New Jaundice Stick Test
This is an observational prospective study. The main purpose is to evaluate the stability of the Bilistick system in a humid and hot climate compared to the quantitative test for serum bilirubin (SBR) measurement currently used…
- Trial name
- Bilistick (NCT02926131)
- Testing
- Blood sampling
- Where
- Thailand
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Iron Deficiency Anemia, Anemia
Iron Fish in Dominican Republic (DR) Children
The objective of the study is to assess the acceptability, feasibility, and barriers to Lucky Iron Fish™ (LIF) utilization among families with young children in a Latin American community with a high prevalence of iron deficiency…
- Conditions
- Iron Deficiency Anemia, Anemia, Iron-deficiency
- Trial name
- NCT03199235
- Testing
- Lucky Iron Fish, enhanced standard of care
- Where
- Dominican Republic
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Cancer Palliative Care
R21 India Pal-Care Evaluation
The goal of this pragmatic clinical trial is to test and evaluate a home-based palliative care intervention for utilizing community health workers to facilitate the delivery of palliative care to cancer patients in rural India.
- Trial name
- NCT04972630
- Testing
- Pal-Care, Control-Usual Care
- Where
- India
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Trauma, Trauma Injury
Deploying Emergency Bystander Internet Training
The primary aim of this study is to evaluate the efficacy of a massive open online course (MOOC) for training lay first responders in sub-Saharan Africa.
- Trial name
- DEBIT (NCT05909917)
- Testing
- Half-Day First Responder Training
- Where
- 4 sites in Kenya, Nigeria and 2 more
- Volunteers
- 658 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Maternal Death, Maternal Morbidity
BetterBirth: A Trial of the WHO Safe Childbirth Checklist Program
The purpose of this study is to measure the impact of a checklist-based childbirth safety program (the WHO Safe Childbirth Checklist Program) on reduction of severe maternal, fetal, and newborn harm in institutional deliveries in…
- Conditions
- Maternal Death, Maternal Morbidity, Stillbirth, Neonatal Death
- Trial name
- BetterBirth (NCT02148952)
- Testing
- WHO Safe Childbirth Checklist Program
- Where
- India
- Volunteers
- 157,689 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)