Clinical trials: Respiration; Arrest
Cardiac Arrest
Monitoring of Intubation and Ventilation During Resuscitation
Airway control and ventilation is vital during cardiopulmonary resuscitation (CPR) in cardiac arrest. Endotracheal intubation is the gold standard for airway control, but several studies have shown high rates of unrecognized…
- Trial name
- NCT00204217
- Testing
- endotracheal intubation
- Where
- Norway
- Volunteers
- 15 people
- Sponsor
- University of Oslo
Respiratory Failure, Respiratory Insufficiency
Evaluating Safety and Efficacy of Umbulizer in Patients Requiring Intermittent Positive Pressure Ventilation
Randomized, control crossover study comparing Umbulizer's efficacy to traditional mechanical ventilators
- Conditions
- Respiratory Failure, Respiratory Insufficiency, Respiratory Arrest
- Trial name
- NCT04030208
- Testing
- Umbulizer, Traditional Mechanical Ventilator
- Where
- Pakistan
- Volunteers
- 24 people
- Sponsor
- Umbulizer LLC
Cardiac Arrest
Improving Cardiac Arrest Diagnostic Accuracy of Emergency Medical Dispatchers
The main goal of this project is to help 9-1-1 emergency medical dispatchers save the lives of more cardiac arrest victims. The investigators will develop teaching tools to help the dispatchers recognize abnormal breathing that…
- Trial name
- NCT01872325
- Testing
- Education
- Where
- Canada
- Volunteers
- 1,076 people
- Sponsor
- Ottawa Hospital Research Institute
Cardiac Arrest, Trauma
Pre-Hospital Advanced Airway Management in the Nordic Countries
Pre-Hospital Advanced Airway Management (PHAAM) is a potentially lifesaving intervention. A recent Danish multicentre single country study demonstrated a 99,7% incidence of successful anaesthesiologist pre-hospital endotracheal…
- Conditions
- Cardiac Arrest, Trauma, Traumatic Brain Injury, Hypoventilation
- Trial name
- PHAST (NCT02450071)
- Where
- Sweden
- Volunteers
- 2,028 people
- Sponsor
- Karolinska Institutet
Cardiac Arrest
Comparison of Scores for Early Brain Damage Assessment at Intensive Care Unit Admission After Cardiac Arrest
Even in patients with successful return of spontaneous circulation (ROSC), outcome after cardiac arrest remains poor. The overall in-hospital survival rate widely varies both worldwide and across communities, from 1 to 4 folds…
- Trial name
- AfterROSC2 (NCT05606809)
- Testing
- Calculation of early prognosis score
- Where
- 5 sites in France
- Volunteers
- 4,500 people
- Sponsor
- AfterROSC
Cardiogenic Shock, Cardiac Arrest
Outcome of Patients Treated With ECLS
Extracorporeal life support (ECLS), also called extracorporeal membrane oxygenation (ECMO), is an extracorporeal technique of providing effective circulatory and (or) respiratory failure, with a growing number of critically ill…
- Conditions
- Cardiogenic Shock, Cardiac Arrest, Heart Failure, Acute Respiratory Failure
- Trial name
- NCT04405817
- Testing
- ECMO
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Nanjing Medical University
Cardiac Arrest
Sustained Inflation and Chest Compression vs 3:1 C:V Ratio in Asphyxiated Newborns
Newborn infants who require cardiopulmonary resuscitation at birth receive chest compression using a 3-Compression to 1-Ventilation (3:1 C:V) ratio.
- Trial name
- SUR1VE-2 (NCT06577818)
- Testing
- CC+SI (Chest compression during sustained inflation), 3:1 C:V (3:1 Compression:Ventilation ratio)
- Where
- Canada
- Volunteers
- 554 people
- Sponsor
- University of Alberta
Cardiac Arrest, Post Cardiac Arrest Syndrome
Lung-cOnservative Liquid VEntilation for the Induction of Ultra-Rapid COOLing After Cardiac Arrest
Out-of-hospital cardiac arrest (OHCA) affects over 356,000 individuals annually in the United States, with fewer than 10% surviving to hospital discharge, mirroring statistics from Europe.
- Trial name
- OverCool (NCT06798818)
- Testing
- Ultra-rapid therapeutic hypothermia induction by total liquid ventilation
- Where
- France
- Volunteers
- 24 people
- Sponsor
- ORIXHA
Tonsillectomy Postoperative Adverse Events
Factors Predictive of Adverse Postoperative Outcomes in Children Undergoing Tonsillectomy
The purposes of the study are to identify 1) the patient (demographic and clinical) and health care system factors predictive of immediate and late postoperative adverse outcomes in children undergoing tonsillectomy.
- Trial name
- NCT01669993
- Where
- United States
- Volunteers
- 2,400 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Cardiac Arrest (CA), In-Hospital Cardiac Arrest
The Ventilation During In-hospital Cardiac Arrest Study
The goal of this prospective observational study is to learn how ventilation quality parameters during cardiopulmonary resuscitation (CPR) are associated with short-term survival following in-hospital cardiac arrest of adult…
- Conditions
- Cardiac Arrest (CA), In-Hospital Cardiac Arrest, Heart Arrest
- Trial name
- VENT-IHCA (NCT06809309)
- Testing
- Positive pressure ventilation during cardiopulmonary resuscitation
- Where
- 11 sites in Denmark, Norway
- Volunteers
- 900 people
- Sponsor
- University of Aarhus
Cardiopulmonary Arrest
Comparison of Ventilation With Bag-Valve-Mask, Laryngeal Tube S-D and Laryngeal Mask Airway Supreme
Inexperienced rescuers may encounter severe problems in an unconscious patient in opening and maintaining an upper airway patent.
- Trial name
- NCT01452867
- Testing
- Bag-Valve-Mask-Ventilation (Ambu Facemask), Laryngeal Mask (Laryngeal Mask Airway Supreme), Laryngeal Tube (Laryngeal Tube LT-S-D (VBM))
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Krankenhaus Bruneck
Out-of-hospital Cardiac Arrest (OHCA)
Ventilation Performance and Feedback Simulation Trial
The study "Understanding the Effect of Feedback on Ventilation Performance of Rescuers in a Simulation Trial" will address treatments administered by Emergency Medical Services (EMS) during cardiopulmonary resuscitation (CPR) in…
- Trial name
- VENT-SIM (NCT07352709)
- Testing
- Real-time feedback
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Texas Southwestern Medical Center
Cardiac Arrest
Optimizing Ventilation to Improve Survival From Out-of-hospital Cardiac Arrest: the OPTIVO Randomized Controlled Trial
When the heart stops pumping during cardiac arrest, cardiopulmonary resuscitation (CPR) is used to continue pushing blood and providing oxygen to vital organs.
- Trial name
- OPTIVO (NCT07479836)
- Testing
- Low Volume Ventilation, High Volume Ventilation
- Where
- Canada
- Volunteers
- 1,656 people
- Sponsor
- Sunnybrook Health Sciences Centre
Critical Illness, Sepsis
Pancreatic Exocrine Insufficiency and Pancreatic Enzyme Supplementation in Critically Ill Adult Patients
Malnutrition is a frequent problem in critically ill patients that is associated with detrimental clinical outcomes. To provide adequate nutritional support, current studies focused mostly on the choice of delivery timing…
- Conditions
- Critical Illness, Sepsis, Diabetes, Cardiac Arrest
- Trial name
- NCT01753024
- Testing
- Enteral nutrition (EN)
- Where
- 2 sites in China
- Volunteers
- 362 people
- Sponsor
- Shanghai 10th People's Hospital
Indication of Orotracheal Intubation, Cardio Respiratory Arrest
Comparative Evaluation of the McGrath Videolaryngoscope and the Direct Laryngoscopy for Tracheal Intubation in the Prehospital Setting
In the prehospital setting, the risk of difficult intubation and life-threatening complications is increased under particular conditions due to the environment or the frequent instability of patients.
- Conditions
- Indication of Orotracheal Intubation, Cardio Respiratory Arrest, Respiratory Failure, Neurological Failure
- Trial name
- AMAC (NCT04930419)
- Testing
- Videolaryngoscopy group, Direct laryngoscopy group
- Volunteers
- 150 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Out-Of-Hospital Cardiac Arrest, Trauma
AI to Improve Data From Danish Cardiac Arrest Registry
Out-of-hospital cardiac arrest is a leading cause of death worldwide and patient outcome vary substantially throughout regions suggesting further evaluation and potential for improvement.When focussing on subgroups of OHCA, data…
- Conditions
- Out-Of-Hospital Cardiac Arrest, Trauma, Drug Overdose, Electrocution
- Trial name
- NCT05308303
- Where
- Denmark
- Volunteers
- 31,200 people
- Sponsor
- Prehospital Center, Region Zealand
Cardiac Arrest
Intra-Arrest-Ventilation in Human Cadavers
The study investigates the influence of non-synchronized bag-device-ventilation and intermittent positive pressure ventilation (IPPV), as recommended in the current resuscitation guidelines of the European Resuscitation Concil…
- Trial name
- NCT06306898
- Testing
- Endotracheal Intubation, Laryngeal tube, Laryngeal mask
- Where
- Germany
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Gerrit Jansen
Cardiac Arrest
The Impact of Real Time Ventilation Feedback on Ventilation Rate and Tidal Volume During Cardiac Arrest.
During out-of-hospital cardiopulmonary resuscitation, patient are first ventilated without ventilation feedback (but with a flowsensor connected), hereafter patients are ventilated with the use of ventilation feedback.
- Trial name
- NCT06528704
- Testing
- Ventilation feedback device
- Where
- 2 sites in Belgium
- Volunteers
- 100 people
- Sponsor
- University Hospital, Ghent
Out-Of-Hospital Cardiac Arrest
Ventilation Monitoring in OHCA
This is a before-and-after study examining the impact of real-time ventilation monitoring during out-of-hospital cardiac arrest.
- Trial name
- NCT04988906
- Testing
- Zoll Accuvent Ventilation Monitor
- Where
- Canada
- Volunteers
- 412 people
- Sponsor
- Sunnybrook Health Sciences Centre
Cardiac Arrest (CA), Out-of-hospital Cardiac Arrest (OHCA)
The Application of Positive End-Expiratory Pressure in Out-of-Hospital Cardiac Arrest: The Lazarus-PEEP Trial.
The goal of this clinical trial is to learn whether using Positive End-Expiratory Pressure (PEEP) during cardiopulmonary resuscitation (CPR) improves outcomes for adults who experience out-of-hospital cardiac arrest, a condition…
- Conditions
- Cardiac Arrest (CA), Out-of-hospital Cardiac Arrest (OHCA), Positive End-expiratory Pressure (PEEP), Ventilation During Resuscitation
- Trial name
- Lazarus-PEEP (NCT06939335)
- Testing
- Disposable PEEP Valve set at 5 cm H20., Controle
- Where
- 7 sites in Belgium, France
- Volunteers
- 132 people
- Sponsor
- University Hospital, Ghent