Clinical trials: Respiratory Acidosis
Ketosis, Hypoxia
Effect of Ketone Ester Supplementation on Hypoxic Tolerance
This WP specifically aims to elucidate the effects of IEK on hypoxic tolerance and the development and severity of AMS symptoms, blood and tissue oxygenation status, as well as sleep quality during an episode of acute exposure to…
- Trial name
- NCT05588427
- Testing
- Ketone ester
- Where
- Belgium
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Fibromyalgia, Respiratory Alkalosis and Metabolic Acidosis
Evaluation of Respiratory Function in Fibromyalgia
This study will evaluate respiratory function in people with fibromyalgia and whether or not breathing patterns in this patient group can be explained by stress, emotional or biomechanical variables.
- Conditions
- Fibromyalgia, Respiratory Alkalosis and Metabolic Acidosis, Chronic Hyperventilation
- Trial name
- NCT04098731
- Where
- Sweden
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Ketosis, Hypoxia
Intermittent Exogenous Ketosis (IEK) at High Altitude
Altitude-related hypoxia decreases human functional capacity, especially during exercise. Even with prolonged acclimatization, the physiological adaptations are insufficient to preserve exercise capacity, especially at higher…
- Trial name
- NCT06097754
- Testing
- Ketone ester
- Where
- 2 sites in Belgium, Slovenia
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Jozef Stefan Institute
Sepsis, Septic Shock
Determination of the Dissociation Constant (Ka) of Plasma and Whole Blood in Septic Patients
Alterations of acid-base equilibrium are very common in critically ill patients and understanding their pathophysiology can be important to improve clinical treatment.
- Conditions
- Sepsis, Septic Shock, Critical Illness, Respiratory Acidosis
- Trial name
- ENTERPRISE (NCT03966664)
- Testing
- In vitro determination the dissociation constant (Ka) and total amount of non-volatile buffers (Atot) in isolated plasma., In vitro determination the dissociation constant (Ka) and total amount of non-volatile buffers (Atot) in whole blood, Biomolecular analysis of plasma proteins.
- Where
- 2 sites in Czechia, Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Diabetic Ketoacidosis, Heart Disease, Ischemic
Effectiveness of Music Intervention on Anxiety and Physiological Responses in Critical Ill Patient
Music intervention is a non-pharmacological and effective intervention that can alleviate anxiety and agitation in patients undergoing weaning.
- Conditions
- Diabetic Ketoacidosis, Heart Disease, Ischemic, Stroke, GastroIntestinal Bleeding
- Trial name
- NCT04977011
- Testing
- relaxing music
- Where
- Taiwan
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Min-Sheng General Hospital
Mitochondrial Disorders, Mitochondrial Genetic Disorders
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)
The North American Mitochondrial Disease Consortium (NAMDC) maintains a patient contact registry and tissue biorepository for patients with mitochondrial disorders.
- Conditions
- Mitochondrial Disorders, Mitochondrial Genetic Disorders, Mitochondrial Diseases, Disorder of Mitochondrial Respiratory Chain Complexes
- Trial name
- NAMDC (NCT01694940)
- Where
- 17 sites in United States, Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Columbia University
Acid-Base Imbalance, Respiratory Acidosis
Non Carbonic Buffer Power of Critical Ill Patients With Sepsis
Alterations of acid-base equilibrium are very common in critically ill patients and understanding their pathophysiology can be important to improve clinical treatment.
- Conditions
- Acid-Base Imbalance, Respiratory Acidosis, Respiratory Alkalosis
- Trial name
- NCT03503214
- Testing
- In vitro determination of non-carbonic buffer power, Classic description of acid-base status
- Where
- Italy
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Hypoxia, Ketosis
Ketone Esters for Optimization of Cognitive Performance in Hypoxia
This study will investigate the effects of ketone ester drinks on cognitive performance in hypoxia.
- Trial name
- NCT03659825
- Testing
- Ketone Ester, Hypoxic exposure
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- HVMN Inc
Dyspnea, Lactic Acidosis
Effect of High Velocity/Hyperoxic Breathing Therapy on Blood Lactate Decline
The study will evaluate the impact of high velocity therapy (HVT) on reduction of work of breathing (as implied by breath frequency) and enhanced blood lactate decline during recovery from a Wingate-type Exercise test.
- Conditions
- Dyspnea, Lactic Acidosis, Muscle, Breathlessness
- Trial name
- NCT05984186
- Testing
- High Velocity Therapy
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Vapotherm, Inc.
Asthma
The Various Effects of Gaseous Albuterol on Serum Lactate
Empirical data from physician observation indicates an increase in serum lactate in acute asthmatic patients being treated with inhaled albuterol therapy.
- Trial name
- NCT02073747
- Testing
- Normal Saline, Albuterol
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University Medical Center of Southern Nevada
Work of Breathing
The Gas Mask: the Effects on Respiration!
Background: The gas mask is used to protect military and non-military subjects exposed to respiratory hazards (CBRN agents). The aim of the study was to evaluate the impact of the gas mask on respiratory patterns and indexes of…
- Trial name
- NCT02782936
- Testing
- measurement of the work of breathing, Gas mask
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Laval University
Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease
Clinical Stabilization of Hypercapnia: NIPPV v HVNI
This study will evaluate the ability of High Velocity Nasal Insufflation [HVNI] to effect ventilation and related physiologic responses in hypercapnic patients when compared to noninvasive positive pressure ventilation [NIPPV].
- Conditions
- Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease, Dyspnea, Hypercapnic Acidosis
- Trial name
- HYPERACT (NCT04709562)
- Testing
- High Velocity Nasal Insufflation (HVNI), Noninvasive Positive Pressure Ventilation (NIPPV)
- Where
- 7 sites in United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Vapotherm, Inc.
Ketosis, Hypoxia
The Effect of Butanediol Ingestion on Skeletal Muscle Angiogenesis in Hypoxia
This study specifically aims to elucidate the effects of intermittent exogenous ketosis (IEK) as well as hypoxia on muscular pro-angiogenic factors- after a 60-min HIIT bout in normoxia.
- Conditions
- Ketosis, Hypoxia, Angiogenesis
- Trial name
- NCT06472427
- Testing
- Normoxic recovery and ketones (NKE), Hypoxic recovery and ketones (HKE)
- Where
- Belgium
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Exercise, Hypoxia
Effect of Oral Ketone and Sodium Bicarbonate Administration During Endurance Exercise in Hypoxia
This study is investigating the effects of oral ketone and sodium bicarbonate administration on physiological and metabolic parameters during cycling endurance exercise in hypoxia.
- Trial name
- NCT04579770
- Testing
- Ketone ester, Sodium bicarbonate
- Where
- Belgium
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Jozef Stefan Institute
Ketosis, Hypoxia
Effect of Ketone Ester Supplementation on Sleep and Recovery in Hypoxia
This study specifically aims to elucidate the effects of IEK on sleep and recuperation in hypoxia, after training in normoxia. These conditions are in line with the widely applied live-high train-low strategy.
- Conditions
- Ketosis, Hypoxia, Sleep
- Trial name
- NCT06060093
- Testing
- Ketone ester
- Where
- Belgium
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Apnea, Ventilation Therapy; Complications
THRIVE Apneic Ventilation With Standardized Airway Management During General Anesthesia.
Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) denotes the use of high-flow humidified nasal oxygen system (for example Optiflow®) as an alternative ventilation modality for an anesthetized patient without…
- Conditions
- Apnea, Ventilation Therapy; Complications, Respiratory Acidosis
- Trial name
- NCT03797859
- Testing
- Apneic ventilation
- Where
- 2 sites in Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet