Clinical trials: Respiratory Allergy
Asthma
Pilot Study of Pioglitazone for the Treatment of Moderate to Severe Asthma in Obese Asthmatics
Asthmatics who are significantly overweight tend to have more severe symptoms, more flare ups, and are more likely to have poorly-controlled asthma when compared to other asthmatics.
- Trial name
- GLITZ Asthma (NCT00634036)
- Testing
- pioglitazone
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- Fernando Holguin
Asthma, Chronic Obstructive Pulmonary Disease
Towards Restoring the Physiological Inhibition of Airway Narrowing in Asthma
Asthma and COPD are characterized by airway narrowing. The most potent, physiological mechanism leading to bronchodilation is taking a deep inspiration.
- Trial name
- NCT00279136
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Asthma
A Study of MK0359 in Patients With Chronic Asthma (0359-013)
A study to test the effect of MK0359 in lessening the symptoms of asthma as compared to placebo.
- Trial name
- NCT00482898
- Testing
- MK0359
- Volunteers
- 56 people
- Sponsor
- Merck Sharp & Dohme LLC
Allergic Rhinitis, Urticaria
PK Comparisons of Bepotastine Besilate 10 mg and Bepotastine Salicylate 9.64 mg
To compare the relative bioavailability and pharmacokinetic characteristics of a newly developed bepotastine formulation, bepotastine salicylate, with a conventional formulation, bepotastine besilate, in healthy subjects with a…
- Conditions
- Allergic Rhinitis, Urticaria, Pruritus
- Trial name
- NCT01897428
- Testing
- Test-Bepotastine salicylate 9.64 mg, Reference-bepotastine besilate 10 mg
- Where
- South Korea
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Korea University Anam Hospital
Alopecia Areata, Alopecia Totalis
The Epidemiology, Management and Comorbidities in Alopecia Areata in Czech Republic
The study series consists of three studies with the aim to assess the incidence, prevalence, risk factors, comorbidities and management of patients with alopecia areata in Czech Republic based on the patients and registry of a…
- Conditions
- Alopecia Areata, Alopecia Totalis, Alopecia Universalis, Alopecia Areata (& Ophiasis)
- Trial name
- NCT05098600
- Testing
- Exposure of interest
- Where
- Czechia
- Volunteers
- 123 people
- Sponsor
- Faculty Hospital Kralovske Vinohrady
Bronchial Asthma
Study on the Safety and Efficacy of PA9159 Inhalation Aerosol for the Treatment of Adult Bronchial Asthma
PA9159 is a highly potent novel corticosteroid. The purpose of this study is to evaluate the safety, efficacy and characteristics of population pharmacokinetics of multiple dosing of PA9159 Inhaler in patients with bronchial…
- Trial name
- NCT07324707
- Testing
- PA9159 Metered-Dose Inhaler, 120 μg per day for 28 days, Fluticasone Propionate Inhaled Aerosol 200 μg per day for 28 days
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Anhui Palo Alto Pharmaceuticals, Inc.
Asthma
Asthma Exacerbations and Vascular Function
Although asthma is a disease of the airways, research is now showing that asthmatics are more likely to develop cardiovascular disease (CVD) compared to non-asthmatics.
- Trial name
- NCT02630511
- Testing
- Mannitol, Methacholine, Rest
- Where
- Canada
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Asthma, Healthy
Effects of Allergen Inhalation on Adenosine Receptor Expression in Sputum and Peripheral Blood
The purpose of this study is to determine whether asthmatics have different adenosine receptor expression profiles than healthy controls.
- Trial name
- NCT00116311
- Testing
- allergen inhalation, withdrawal of medication, sputum induction
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Groningen Research Institute for Asthma and COPD
Pollen Allergy
Identification of Allergen-reactive Antibodies in the Blood of Pollen Allergic Patients
The project examines the hypothesis that monoclonal allergen-neutralizing antibodies can be recombinantly produced from B lymphocytes isolated from pollen allergic patients.
- Trial name
- NCT03727399
- Testing
- blood withdrawal
- Where
- Switzerland
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Mabylon AG
Asthma in Children, Dysbiosis
Respiratory Dysbiosis in Preschool Children with Asthma: Predictive of a Severe Form
The prevalence of asthma in preschool children is between 11 and12%. Inhaled corticosteroid therapy is the main therapy used, however this treatment seems insufficiently effective in some children.
- Trial name
- DREAM (NCT05192499)
- Testing
- Stool test, Blood test, Induced sputum
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Brest
Self Efficacy, Asthma
The Effect of Online Peer and Adult Education Given to Adolescents With Allergic Asthma
Objectives: To examine the effect of interactive online education given by peers or adults on anxiety, self-efficacy, quality of life, and disease knowledge and management in adolescents with allergic asthma in the 10-14 age…
- Conditions
- Self Efficacy, Asthma, Asthma in Children
- Trial name
- NCT06045312
- Testing
- education
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people
- Sponsor
- Aydin Adnan Menderes University
Bronchial Asthma
Role of Herbs in the Management of Asthma
The aim of this trial is to study the effect of a polyherbal capsule containing four herbs: Inula racemosa, Ocimum sanctum, Terminalia Belerica and Piperum longum in the treatment of bronchial asthma.
- Trial name
- NCT02918487
- Testing
- Polyherbal
- Where
- India
- Volunteers
- 38 people
- Sponsor
- Composite Interceptive Med Science
Maxillary Sinusitis
Microarray Analysis of Sinus Samples From Patients With and Without Chronic Rhinosinusitis
Mucosal biopsies, endoscopically-guided brush samples of mucus, and a saline lavage taken from the maxillary sinuses of ten CRS patients undergoing sinus surgery are analyzed using three microarrays in order to detect bacteria…
- Trial name
- NCT00683371
- Testing
- Specimen collection
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Asthma (Diagnosis), COPD (Chronic Obstructive Pulmonary Disease)
Quantitative Chest CT and Multi-Omics to Distinguish Asthma From COPD and Predict Treatment Response
This study aims to improve the diagnosis and treatment prediction of asthma and chronic obstructive pulmonary disease (COPD) by combining quantitative chest computed tomography (CT) imaging with multi-omics data.
- Trial name
- CTOMICS (NCT07602192)
- Where
- 2 sites in South Korea
- Volunteers
- 200 people
- Sponsor
- Korea University Guro Hospital
Asthma
Optimization of Inhaled Corticosteroid Treatment in Adult Patients With Asthma Guided by Exhaled NO Measurement at Home
To compare the clinical outcome (effectiveness) of single inhaled corticosteroid (ICS) controller treatment guided by exhaled NO measurement made at home with usual care asthma management with regard to asthma control (primary…
- Trial name
- OCTAGEN (NCT01783132)
- Testing
- NIOX MINO
- Where
- Sweden
- Volunteers
- 142 people
- Sponsor
- Orion Corporation, Orion Pharma
Depression, Asthma
Antidepressant Treatment at an Inner City Asthma Clinic
Asthma is common with an increasing prevalence and mortality especially in low-income and minority populations. The course of asthma appears to be influenced by mood and emotions.
- Trial name
- NCT01324700
- Testing
- High severity group: Escitalopram, Low severity group: Escitalopram
- Where
- United States
- Volunteers
- 139 people
- Sponsor
- University of Texas Southwestern Medical Center
SARS CoV 2 Infection, Respiratory Syncytial Virus (RSV)
Transplacental Transmission of RSV (TTRSV)
Aim 1: To study transplacental transmission of Respiratory Syncytial Virus (RSV) and how this is moderated by other maternal infections during pregnancy Aim 2: To test maternal blood for presence of RSV-specific immunoglobulins…
- Conditions
- SARS CoV 2 Infection, Respiratory Syncytial Virus (RSV), Bronchiolitis, Asthma
- Trial name
- NCT05443607
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Tulane University
Hypertension, Diabetes Mellitus
Generative AI for Medication Counselling and Adherence in Community Pharmacies
Medication counseling within community pharmacies is crucial for managing chronic diseases, yet significant challenges regarding correctness and completeness remain in Jordan.
- Conditions
- Hypertension, Diabetes Mellitus, Dyslipidemias, Cardiovascular Diseases
- Trial name
- NCT07649577
- Testing
- pharmacist-supervised AI-assisted medication counseling
- Where
- Jordan
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- University of Petra
Eczema, Asthma
The PEBBLES Study - Testing a Strategy for Preventing Eczema and Food Allergy in High Risk Infants
This is a phase III, single blind (outcome assessor is blinded), randomised controlled multicentre trial of the effect of EpiCeram emollient for improving and maintaining skin barrier function and reducing incidence of eczema and…
- Conditions
- Eczema, Asthma, Allergy;Food
- Trial name
- PEBBLES (NCT03667651)
- Testing
- EpiCeram
- Where
- 4 sites in Australia
- Volunteers
- 760 people, healthy volunteers welcome
- Sponsor
- University of Melbourne
Allergic Rhinitis With Asthma
Efficacy and Safety of Yiqi Wenyang Sanhan Formula Combined With Acupoint Application in Patients With Combined Allergic Rhinitis and Asthma Syndrome During Remission and Yang-Deficiency Syndrome
Allergic rhinitis-asthma syndrome is a clinical comorbid condition involving both upper and lower airway allergic inflammation, reflecting the concept of "one airway, one inflammatory response." Epidemiological studies have…
- Trial name
- NCT07540351
- Testing
- Yiqi Wenyang Sanhan Formula Combined with Acupoint Application
- Volunteers
- 188 people
- Sponsor
- Beijing Daxing District Hospital of Integrated Chinese and Western Medicine
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