Clinical trials: Respiratory Aspiration
Respiratory Distress Syndrome, Positive-Pressure Respiration
Personalized Ventilation Based on Ventilation-perfusion Mismatch and Lung Recruitability
This observational study will explore the effects of PEEP and position on regional lung ventilation-perfusion mismatch by electrical impedance tomography (EIT) in moderate-to-severe ARDS patients with different lung…
- Conditions
- Respiratory Distress Syndrome, Positive-Pressure Respiration, Mechanical Ventilation
- Trial name
- NCT06430554
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Zhongda Hospital
Ventilation, ARDS
Respiratory Knowledge Portal Computer and Phone Application to Improve Quality of Mechanical Ventilation by Reducing the Number of Ventilator Associated Events, Injury Created by the Ventilator and Unsafe Setting of Alarms.
Ventilator associated events (VAE) is a quality metric defined by 48 hours of stability followed by 48 hours of escalation of ventilator settings within the ICU.
- Conditions
- Ventilation, ARDS, Respiratory Failure, Mechanical Ventilation
- Trial name
- NCT06737432
- Testing
- RKP Monitoring Software
- Where
- United States
- Volunteers
- 875 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Altered Mental Status, Sepsis
Pre-hospital Ventilation Clinical Study
This study will collect and characterize ventilator use during patient care with a ZOLL 731 Series ventilator in a pre-hospital setting.
- Conditions
- Altered Mental Status, Sepsis, Heart Failure, Hemorrhage
- Trial name
- NCT05604430
- Testing
- 731 Series Ventilator
- Where
- 5 sites in United States
- Volunteers
- 500 people
- Sponsor
- Zoll Medical Corporation
All-cause Mortality, Quality of Life
PRophylaxis Against Early VENTilator-associated Infections in Acute Brain Injury
This research is about whether treatment with a commonly used antibiotic can prevent infections in airway and lungs and improves the chance of surviving, if it is given soon after patients commence mechanical ventilation when…
- Conditions
- All-cause Mortality, Quality of Life, Disability, Intellectual, Neurological Disorder
- Trial name
- PREVENT-NEURO (NCT06819592)
- Testing
- Ceftriaxone 2g diluted in >200ml 0.9%sodium chloride
- Where
- 29 sites in Australia, Canada and 1 more
- Volunteers
- 3,300 people
- Sponsor
- The George Institute
Pain and Diaphragmatic Dysfunction After Shoulder Arthroscopy
Effect of Optimal Biological Volume Bupivacaine Liposome Interscalene Brachial Plexus Block on Postoperative Analgesia After Shoulder Arthroscopy
This study aims to evaluate whether 15ml/75mg low-dose bupivacaine liposome is non-inferior to 15ml/133mg standard-dose bupivacaine liposome for postoperative analgesia in interscalene brachial plexus block during arthroscopic…
- Trial name
- NCT07792044
- Testing
- OBV bupivacaine liposome group, Standard dose bupivacaine liposome group
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Affiliated Hospital of Jiaxing University
VA-ECMO
Optimizing Breathing and Blood Flow in Patients Treated With VA ECMO
The aim of this study is to characterize ventilation/perfusion (V/Q) matching in adult patients receiving peripheral VA ECMO support while on mechanical ventilation, and to evaluate the impact of PEEP titration guided by…
- Trial name
- ECMO-VP (NCT07141524)
- Testing
- Physiology measurements
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Beth Israel Deaconess Medical Center
Chronic Neck Pain, Healthy (Controls)
Accessory Inspiratory Muscles in Chronic Neck Pain
This cross-sectional case-control study aims to investigate the ultrasonographic structural and functional characteristics of accessory inspiratory muscles in individuals with chronic non-specific neck pain and compare them with…
- Trial name
- AIM-CNP (NCT07782099)
- Testing
- Diaphragm Ultrasonography, Anterior Scalene Muscle Ultrasonography, Upper Trapezius Muscle Ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Kocaeli Sağlık ve Teknoloji Üniversitesi
Cardiac Arrest (CA)
Does Increasing the Compression Pause From 3 to 5 Seconds in Mechanical Compression Devices Increase Ventilation Success Rate and Return of Spontaneous Circulation?
To give chest compressions during cardiopulmonary resuscitation (CPR), mechanical chest compression devices can be used. During synchronous 30:2 CPR, the standard setting on these devices leave an automated 3-second chest…
- Trial name
- LUCASVP (NCT06824961)
- Testing
- 5-second ventilation pause duration during mechanical CPR, 3-second ventilation pause duration during mechanical CPR
- Where
- 2 sites in Netherlands
- Volunteers
- 692 people
- Sponsor
- Amsterdam UMC, location VUmc
Blood Pressure Monitoring, Home, Hypertension
Implementation Strategies for Self-Measured Blood Pressure Monitoring in Racially and Ethnically Diverse Populations
This clinical trial aims to assess the impact of patient-focused and clinical-focused implementation strategies on blood pressure control.
- Trial name
- INSPIRED (NCT06871462)
- Testing
- BP monitor use training and app training, Online patient portal enrollment and training, SMS reminders to take blood pressure
- Where
- United States
- Volunteers
- 330 people
- Sponsor
- University of California, San Francisco
Parkinson Disease, Parkinsonism
Cross-System Effects of Acute Intermittent Hypercapnia-Based Interventions in PD
Parkinsonism impairs upper airway and axial motor control, leading to disordered breathing, reduced speech volume, and ineffective cough. Symptoms are poorly addressed by current therapies.
- Trial name
- NCT07674264
- Testing
- Acute intermittent hypercapnic hypoxia (AIHH), Acute intermittent hypercapnic normoxia (AIHN)
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- University of Florida
Primary Dysmenorrhea
Chinese Herbal Sachet Inhalation for Primary Dysmenorrhea in Female College Students
Primary dysmenorrhea (painful menstrual periods without an underlying disease) is very common in female college students and can affect sleep, mood, study and daily life.
- Trial name
- NCT07778849
- Testing
- Traditional Chinese herbal sachet (aromatic inhalation)
- Where
- China
- Volunteers
- 82 people
- Sponsor
- Macao Polytechnic University
Mechanical Ventilation, Critical Care, Intensive Care
Use of Connected Glasses to Help the Communication of Non Temporarily Speaking Patients in Intensive Care Unit : a Pilot Study
Hospitalization in an intensive care unit (ICU) is accompanied by major physical and emotional stress for patients, a source of discomfort and a risk factor for post-resuscitation syndrome.
- Conditions
- Mechanical Ventilation, Critical Care, Intensive Care, Artificial Respiration, Communication Aids
- Trial name
- CASTOR-REA (NCT07776795)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Comparison of Hemodynamics and Respiratory Function Between Ciprofol and Propofol in Elderly Patients Undergoing Non-intubated General Anesthesia
Comparison of Hemodynamics and Respiratory Function Between Ciprofol and Propofol in Elderly Patients Undergoing Non-intubated General Anesthesia
At the initiation of induction for non-intubated general anesthesia, ciprofol or propofol will be administered intravenously at a rate of 10 mL/min.
- Trial name
- NCT07670923
- Testing
- Propofol Injection, Ciprofol Injection
- Where
- China
- Volunteers
- 108 people
- Sponsor
- General Hospital of Ningxia Medical University
Muscle Aches, Stress
Telerehabilitation-Based Yoga Versus Yoga-Pranayama in University Students
This study will compare two online exercise programs for university students: yoga alone and yoga combined with breathing exercises called pranayama.
- Conditions
- Muscle Aches, Stress, Neck Disorders, Students
- Trial name
- NCT07770139
- Testing
- Yoga-Pranayama, Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Istanbul Gelisim University
Ventilator Weaning, Airway Extubation
Can a Pain Monitor Predict When Postoperative Intensive Care Unit Patients Are Ready to Breathe on Their Own? A Pilot Study
The goal of this observational study is to learn if a chest monitor that tracks heart rhythm can help predict whether adults on a breathing machine after surgery will be able to breathe on their own once the breathing tube is…
- Conditions
- Ventilator Weaning, Airway Extubation, Respiration, Artificial
- Trial name
- NCT07771101
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Hospital
Bronchopulmonary Dysplasia
Early Predictors of Bronchopulmonary Dysplasia in Extremely Preterm Infants
Bronchopulmonary dysplasia (BPD) remains one of the most common complications in extremely preterm infants despite advances in neonatal intensive care.
- Trial name
- EPIRESP (NCT07771387)
- Where
- Austria
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Administrative Staff, Upper Cross Syndrome
Comparative Effects of Stabilization Exercises and Corrective Exercises in Administrative Staff With Upper Cross Syndrome
This study compares two types of rehabilitation strategies' - the stabilization exercises and the corrective exercises - to improve pain, respiratory function, and postural alignment in administrative staff with upper cross…
- Conditions
- Administrative Staff, Upper Cross Syndrome, Forward Head Posture, Computer Workers
- Trial name
- SE vs CE (NCT07766070)
- Testing
- Stabilization Exercises, Corrective Exercises
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- University of Faisalabad
Type 1 Diabetes Mellitus
INHALE-1st: Afrezza® For Youth With Newly-Diagnosed Type 1 Diabetes
INHALE-1st is a Phase 2, single-arm, multi-center, clinical study evaluating the safety and efficacy of Afrezza in combination with subcutaneously-injected basal insulin (BI) for youth 6 to <18 years old with newly diagnosed…
- Trial name
- INHALE-1st (NCT07224321)
- Testing
- Technosphere Insulin, Basal insulin
- Where
- 10 sites in United States
- Volunteers
- 100 people
- Sponsor
- Mannkind Corporation
Mild Cognitive Impairment (MCI)
Safety Assessment of H2 Inhalation in Patients With Mild Cognitive Impairment
An open-label, one-arm, single-center clinical study tested safety and efficacy of one hour daily dosage of H2 gas in a form of inhalation.
- Trial name
- HYDRO-MCI (NCT07757542)
- Testing
- Molecular hydrogen inhalation
- Where
- Czechia
- Volunteers
- 34 people
- Sponsor
- University of Ostrava
Respiratory Insufficiency
Neurally Adjusted Ventilatory Assist (NAVA) in NonInvasive Ventilation (NIV)
Main hypothesis is that Neurally Adjusted Ventilatory Assist (NAVA) allows asynchrony reduction in non invasive ventilation (NIV) in comparison with reference Pressure Support (PSV) mode.
- Trial name
- NCT01426178
- Testing
- Neurally Adjusted Ventilatory Assist in Non Invasive Ventilation (Device)
- Where
- France
- Volunteers
- 17 people
- Sponsor
- University Hospital, Clermont-Ferrand