Clinical trials: Respiratory Diaphragm
Inadequate; Pulmonary Ventilation, Newborn, Infant, Very Low Birth Weight
Nasal Noninvasive NAVA in the Very Low Birth Weight Infant
The purpose of this study is to determine if a new type of mechanical ventilation, or breathing machine (called neurally adjusted ventilatory assist or NAVA), will provide additional support to infants who were born prematurely.
- Trial name
- NCT01785563
- Testing
- Nasal NIV-NAVA
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Tarah T Colaizy
Surgery, Thoracic, Respiratory Diaphragm
Diaphragmatic Echography After Thoracic Surgery
The investigator evaluated diaphragmatic function in patients undergoing thoracic surgery. Diaphragmatic displacement was evaluated before surgery, 2 and 24 hours after surgery.
- Conditions
- Surgery, Thoracic, Respiratory Diaphragm, Complication, Postoperative
- Trial name
- OLVDD (NCT03347578)
- Testing
- Ultrasonography
- Volunteers
- 75 people
- Sponsor
- Università degli Studi di Ferrara
Respiratory Distress Syndrome, Premature Infants
Effects of Non-invasive Ventilation With Helium-oxygen Mixture in Premature Infants With Respiratory Distress Syndrome
The use of a mixture of helium with oxygen (heliox) as a breathing gas may be beneficial due to its unique physical properties, such as low density and high carbon dioxide (CO2) diffusion coefficient.
- Trial name
- NCT04404816
- Testing
- heliox
- Where
- Poland
- Volunteers
- 23 people
- Sponsor
- Poznan University of Medical Sciences
Mechanical Ventilation Complication, Diaphragm Injury
Respiratory Muscle Structure and Function in Mechanically Ventilated Patients and Long-term Outcomes
Air is normally pumped in and out of the lungs by the muscles that contribute to inhalation and exhalation, called the respiratory muscles.
- Conditions
- Mechanical Ventilation Complication, Diaphragm Injury, Lung Injury, Respiratory Insufficiency
- Trial name
- RESPIRE (NCT05857774)
- Testing
- Sonographic measurements, Physiological measurements, Biological measurements
- Where
- Canada
- Volunteers
- 230 people
- Sponsor
- University Health Network, Toronto
Pulmonary Disease, Chronic Obstructive
EVALUATION OF RESPIRATORY MECHANICS AND FUNCTIONALITY IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
To associate a lean mass, peripheral muscle strength, kinematic thoracic-abdominal, respiratory metabolic response, mobility and diaphragmatic thickness, verifying its relation with the obstruction level of COPD
- Trial name
- NCT03086590
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Universidade Federal de Pernambuco
Diaphragm Fatigue, Healthy
Inspiratory Resistive Loading and Diaphragm Fatigue
The aim of the study is to clarify whether specific loading of the inspiratory muscles induces contractile fatigue of the diaphragm muscle in healthy individuals and individuals with recurrent low back pain.
- Conditions
- Diaphragm Fatigue, Healthy, Low Back Pain
- Trial name
- NCT01505517
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Injuries, Spinal Cord
Diaphragm Pacing After Spinal Cord Injury
Respiratory dysfunction is the leading cause of death in individuals with spinal cord injuries (SCIs). Nearly one quarter of all SCI cases involve injury to the upper spinal cord segments which impairs neural activation of the…
- Trial name
- NCT02556125
- Testing
- Diaphragm pacing
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- University of Florida
Low Back Pain, Chronic Obstructive Pulmonary Disease
Nonspecific Low Back Pain in Association With Chronic Obstructive Pulmonary Disease
Introduction. Nonspecific low back pain (NSLBP) is a very prevalent medical condition, especially in subjects with chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT03227523
- Where
- Spain
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- University of Alcala
OSA
Ultrasonographic of Diaphragmatic Function in Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) is associated with altered respiratory mechanics, including diaphragmatic function. Ultrasonography provides a non-invasive tool to assess diaphragmatic structure and performance, which may correlate…
- Trial name
- NCT07370376
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Diaphragm Issues, Diaphragm; Paralysis, Due to Accidental Section of Phrenic Nerve During Procedure
A Chart Review to Evaluate the Safety and Efficacy of Phrenic Nerve Reconstruction for the Treatment of Diaphragmatic Paralysis
A retrospective chart review to evaluate the safety and efficacy of phrenic nerve reconstruction for diaphragmatic paralysis.
- Conditions
- Diaphragm Issues, Diaphragm; Paralysis, Due to Accidental Section of Phrenic Nerve During Procedure, Breath Shortness, Diaphragmatic Paralysis
- Trial name
- NCT06257589
- Where
- 2 sites in United States
- Volunteers
- 700 people
- Sponsor
- Advanced Reconstructive Surgery Alliance
Respiratory Failure, Neuromuscular Disorder
Regional Distribution of Ventilation to Assess Respiratory Muscle Dysfunction
The aim of this study is to better discriminate respiratory muscle dysfunction by comparing the measurements of thoracoabdominal motion obtained by an optoelectronic recording and the conventional tests of respiratory muscle…
- Conditions
- Respiratory Failure, Neuromuscular Disorder, Diaphragmatic Paralysis
- Trial name
- DREM (NCT01569217)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
Postoperative Pulmonary Complications
Influence of Neostigmine vs. Sugammadex on PORC and PPCs by Ultrasonography
This trial aims to compare the incidence of postoperative residual curarisation (PORC) and postoperative pulmonary complications (PPCs) in the SUG and NEO group by means of diaphragm ultrasonography and LUS, so as to conclude…
- Trial name
- NCT05040490
- Testing
- sugammadex as reversal drugs
- Volunteers
- 414 people
- Sponsor
- Peking Union Medical College Hospital
Ventilation Therapy; Complications, Diaphragm Disease
Real-time Effort Driven VENTilator Management
This study is a Phase II controlled clinical trial that will obtain comprehensive, serial assessments of respiratory muscle strength and architecture to understand the evolution of ventilator-induced respiratory muscle weakness…
- Conditions
- Ventilation Therapy; Complications, Diaphragm Disease, Pediatric Respiratory Diseases
- Trial name
- REDvent (NCT03266016)
- Testing
- Computerized Ventilator Protocol, Esophageal Manometry, Respiratory Inductance Plethysmography (RIP)
- Where
- United States
- Volunteers
- 248 people
- Sponsor
- Children's Hospital Los Angeles
Frailty Syndrome, Respiratory Muscle Weakness
Longitudinal Ultrasound Assessment of Diaphragmatic and Respiratory Muscle Function Following Respiratory Muscle Training in Frail Older Adults
This study aims to evaluate the effects of an 8-week inspiratory muscle training program on diaphragmatic and respiratory muscle function in frail older adults aged 80 years and above.
- Conditions
- Frailty Syndrome, Respiratory Muscle Weakness, Age-Related Frailty, Geriatric Health
- Trial name
- IMT-1 (NCT07258615)
- Testing
- Inspiratory Muscle Training
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Universidad Francisco de Vitoria
Diaphragm Kinetics, Sarcopenia
Diaphragm Kinetics Following Hepatic Resection
Sarcopenia is associated with reduced pulmonary function in healthy adults, as well as with increased risk of pneumonia following abdominal surgery.
- Conditions
- Diaphragm Kinetics, Sarcopenia, Muscle Wasting, Liver Resection
- Trial name
- NCT04889235
- Testing
- Major liver resection
- Where
- Germany
- Volunteers
- 44 people
- Sponsor
- RWTH Aachen University
Cystic Fibrosis
Relationship of Skeletal Muscle Thickness, Strength, and Diaphragm Function in Adults With CF
31 CF patients and 23 healthy sex and age-matched volunteers were enrolled. All subjects underwent pulmonary function tests, 6-minute walking tests.
- Trial name
- NCT04892485
- Where
- Turkey (Türkiye)
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Marmara University
Diaphragm Injury
Laparoscopy Versus Clinical Follow up to Detect Diaphragm Injury
Title: A randomized prospective study comparing non operative management with laparoscopic treatment in patients with a diaphragm injury following left thoracoabdominal stab wounds.
- Trial name
- NCT01044550
- Testing
- Laparoscopy, Clinical follow up
- Where
- South Africa
- Volunteers
- 66 people
- Sponsor
- University of Cape Town
Muscular Atrophy, Sensitivity Training Groups
Effects of Inspiratory Muscle Training in Elders
Aging causes anatomical and physiological changes in the respiratory system and respiratory muscle strength with decline in its maximum function.
- Conditions
- Muscular Atrophy, Sensitivity Training Groups, Aging
- Trial name
- NCT01791010
- Testing
- Inspiratory muscle training
- Where
- Brazil
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Pernambuco
COPD, Mechanical Ventilation
Doxapram Administration on Diaphragmatic Excursion in Mechanically Ventilated Patients With Chronic Obstructive Pulmonary Disease Undergoing Spontaneous Breathing Trial
Researchers aim to evaluate the impact of doxapram administration on diaphragmatic excursion in chronic obstructive pulmonary disease (COPD) patients undergoing spontaneous breathing trial
- Conditions
- COPD, Mechanical Ventilation, Weaning From Mechanical Ventilation
- Trial name
- NCT07022704
- Testing
- Doxapram
- Where
- Egypt
- Volunteers
- 35 people
- Sponsor
- Cairo University
Preterm Birth, Mechanical Ventilation Complication
Optimal High CPAP Pressures in Preterm Neonates Post-extubation
Use of continuous positive airway pressure (CPAP) in preterm neonates has traditionally been limited to between 5-8 cmH2O. In recent years, use of CPAP pressures ≥9 cmH2O is becoming more common in neonates with evolving chronic…
- Conditions
- Preterm Birth, Mechanical Ventilation Complication, Respiratory Distress Syndrome, Newborn
- Trial name
- NCT05230485
- Testing
- CPAP level
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- McMaster Children's Hospital