Clinical trials: Respiratory Distress Syndrome, Adult
Acute Respiratory Distress Syndrome, COVID-19
Stellate Ganglion Block (SGB) for COVID-19 Acute Respiratory Distress Syndrome (ARDS)
The purpose of this study is to understand if it is safe and useful to perform SGB (Stellate Ganglion Block) in patients who have severe lung injury Acute Respiratory Distress Syndrome (ARDS) due to COVID-19 infection.
- Trial name
- NCT04402840
- Testing
- Stellate Ganglion Block
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- West Virginia University
Acute Respiratory Distress Syndrome
Safety and Effectiveness Assessment of the MakAir Artificial Ventilator
The objective of our study is to carry out an evaluation of the safety and the effectiveness of the use of the MakAir respirator as useful supplement in situation of shortage of technical devices of assistance to the mechanical…
- Trial name
- COVRESP (NCT04475185)
- Testing
- MakAir
- Where
- 2 sites in France
- Volunteers
- 4 people
- Sponsor
- Nantes University Hospital
Coronavirus Disease 2019 (COVID-19), Acute Lung Injury
Dociparstat for the Treatment of Severe COVID-19 in Adults at High Risk of Respiratory Failure
This was a randomized, double-blind, placebo-controlled Phase 2/3 study to evaluate the safety and efficacy of dociparstat sodium in adult patients with acute lung injury (ALI) due to Coronavirus Disease 2019 (COVID-19).
- Conditions
- Coronavirus Disease 2019 (COVID-19), Acute Lung Injury, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
- Trial name
- NCT04389840
- Testing
- Dociparstat sodium
- Where
- 12 sites in United States
- Volunteers
- 27 people
- Sponsor
- Jazz Pharmaceuticals
Emphysema, Acute Respiratory Distress Syndrome
Use of the Hattler Respiratory Assist Catheter in Severe Respiratory Failure
A new artificial lung device has been developed that potentially provides added support to mechanical ventilation for severely damaged lungs.
- Conditions
- Emphysema, Acute Respiratory Distress Syndrome, Chronic Obstructive Pulmonary Disease, Asthma
- Trial name
- NCT00288964
- Testing
- Hattler Respiratory Assist Catheter
- Where
- United Kingdom
- Sponsor
- Alung Technologies
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Tocilizumab for Patients With Cancer and COVID-19 Disease
This phase II expanded access trial will study how well tocilizumab works in reducing the serious symptoms including pneumonitis (severe acute respiratory distress) in patients with cancer and COVID-19.
- Conditions
- Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm, Pneumonia, Pneumonitis
- Trial name
- NCT04370834
- Testing
- Tocilizumab
- Where
- 5 sites in United States
- Volunteers
- 1 people
- Sponsor
- National Cancer Institute (NCI)
Acute Respiratory Distress Syndrome, Prone Position
Improvement of ARDS Ventilation-perfusion Matching by Prone Positioning Assessed by EIT
Acute Respiratory Distress Syndrome (ARDS) is a highly lethal disease with limited treatment options. In recent years, prone position ventilation has been shown to improve the mortality rate and lung injury of ARDS patients by…
- Conditions
- Acute Respiratory Distress Syndrome, Prone Position, Electrical Impedance Tomography
- Trial name
- NCT05765760
- Where
- China
- Volunteers
- 77 people
- Sponsor
- Beijing Chao Yang Hospital
Respiratory Distress Syndrome in Premature Infant
The Role of Circuit Flow During Mechanical Ventilation of Neonates
During neonatal mechanical ventilation inflating pressures, tidal volumes, and inflation and expiration times need to be set and adjusted to optimise oxygenation and carbon dioxide removal.
- Trial name
- E-Flow (NCT03306524)
- Testing
- SIPPV_VG_0_08, SIPPV_VG_0_16, SIPPV_VG_0_24
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
COVID-19, ARDS, Human
WeanINg From Mechanical Ventilation for ARDS CovId-19 Patients Guided by Combined Thoracic UltraSound.
The most feared complication of COVID-19 infection is the occurrence of an acute respiratory distress syndrome (ARDS) that requires ICU admission and prolonged mechanical ventilation in more than 2% of the affected patients.
- Conditions
- COVID-19, ARDS, Human, Mechanical Ventilation
- Trial name
- INVICTUS (NCT04372680)
- Testing
- CTUS examination
- Where
- 2 sites in France
- Volunteers
- 89 people
- Sponsor
- University Hospital, Toulouse
Respiratory Distress Syndrome in Premature Infant, Surfactant
Clinical RD (Respiratory Distress) Score for Objective Decision Making for Surfactant Therapy
To develop a comprehensive 'Clinical RD score' for decision making for administration of Surfactant in respiratory distress syndrome in preterm infants with gestation of 26 0/7 - 34 6/7 weeks and to assess the validity of this…
- Conditions
- Respiratory Distress Syndrome in Premature Infant, Surfactant, CPAP
- Trial name
- NCT03273764
- Where
- India
- Volunteers
- 209 people
- Sponsor
- Lady Hardinge Medical College
Neonatal Respiratory Distress Syndrome, Intubation, Intratracheal
Chest Physiotherapy Technique Increasing Inspiratory Flow on Weaning From Non Invasive Ventilation
The main objective is to show by a randomised controled therapeutic trial comparing in two parallel open arms ( 50 infants x 2 = 100 infants) that the technique IIF decreases the duration of non invasive respiratory support in…
- Trial name
- KVNI (NCT02041676)
- Testing
- Chest physiotherapy, Usual surveillance
- Where
- France
- Volunteers
- 101 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Lung Injury, Acute
SB-681323 IV for Subjects at Risk of Acute Lung Injury or ARDS
This is an early phase (Phase IIa), randomized, double-blind, parallel group, multi-centre study for subjects with trauma (physical injury) who are at risk for developing Acute Lung Injury (ALI) or Acute Respiratory Distress…
- Trial name
- NCT00996840
- Testing
- SB-681323 Intravenous 3mg, SB-681323 Intravenous 7.5 mg, SB-681323 Intravenous 7.5mg
- Where
- 6 sites in United States
- Volunteers
- 77 people
- Sponsor
- GlaxoSmithKline
Respiratory Distress Syndrome, Adult
Evaluating Health Outcomes and QOL After ALI Among Participants of the ALTA, OMEGA, EDEN, and SAILS ARDS Network Trials
Acute lung injury (ALI) is a severe lung condition that causes respiratory failure. The ARDS Network (ARDSNet) is a National Heart, Lung, and Blood Institute-sponsored network that is focused on improving treatments for people…
- Trial name
- ALTOS (NCT00719446)
- Where
- 6 sites in United States
- Volunteers
- 922 people
- Sponsor
- Johns Hopkins University
COVID-19 Acute Respiratory Distress Syndrome
Prone Positioning and R/I Ratio in COVID-19 Patients With ARDS (SyDRAC-DV)
The purpose of this study is to determine the efects of prone positioning on the recruitment- to-inflation ratio in COVID-19 patients with acute respiratory distress syndrome.
- Trial name
- SyDRAC-DV (NCT05360862)
- Testing
- Prone positioning session
- Where
- France
- Volunteers
- 92 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
ARDS, ARDS, Human
Effects of Sevoflurane on Extravascular Lung Water and Pulmonary Vascular Permeability in Patients With ARDS
The study will investigate the effects of inhaled sedation with sevoflurane using the AnaConDa device on extravascular lung water index (EVLWi) and the pulmonary vascular permeability index (PVPI) in patients with moderate to…
- Trial name
- NCT04530188
- Testing
- Sevoflurane, Propofol
- Volunteers
- 68 people
- Sponsor
- Bicetre Hospital
Covid-19
Mesenchymal Stem Cell Therapy for SARS-CoV-2-related Acute Respiratory Distress Syndrome
Acute Respiratory Distress Syndrome (ARDS) is the major cause of death in the COVID-19 pandemic. In this trial, the safety and efficacy of Mesenchymal Stem Cells (MSC) for the treatment of ARDS in COVID-19 patients will be…
- Trial name
- NCT04366063
- Testing
- Cell therapy protocol 1, Cell therapy protocol 2
- Where
- Iran
- Volunteers
- 60 people
- Sponsor
- Royan Institute
Acute Respiratory Distress Syndrome
Comparison of Different PEEP Strategies in Moderate-to-Severe ARDS Based on Various Bedside Assessment Tools
Many patients admitted to the intensive care unit (ICU) for a severe lung disease called acute respiratory distress syndrome (ARDS) require mechanical ventilation and positive end-expiratory pressure (PEEP) to improve their…
- Trial name
- OPTI-PEEP (NCT07741916)
- Testing
- Ventilation at different levels of PEP including a test involving a gradual decrease in PEP.
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Prematurity, Respiratory Distress Syndrome, Newborn
Infantile NO Replenishment as a New Therapeutic Possibility
Case-control study of inhaled Nitric Oxide (iNO) treatment of full-term and preterm infants. The main objective of this study is to investigate the association between premature birth and its later comorbidities (neuroendocrine…
- Trial name
- miniNO (NCT04914806)
- Where
- 3 sites in France, Greece and 1 more
- Volunteers
- 240 people
- Sponsor
- National and Kapodistrian University of Athens
Acute Lung Injury, Acute Respiratory Distress Syndrome
Epidemiologic Multicenter Study on Mechanical Ventilation Management in Children With Acute Lung Injury
PALIVE 1 is an observational multicenter study on mechanical ventilation strategies used in children with an acute lung injury (ALI).
- Trial name
- PALIVE1 (NCT00521625)
- Where
- 58 sites in United States, Austria and 10 more
- Sponsor
- St. Justine's Hospital
Acute Respiratory Distress Syndrome
Assessment of Occult Lung Stress During Lung Protective Mechanical Ventilation
The present study will utilize esophageal manometry to measure the presence and magnitude of persistent patient effort during lung protective ventilation, allowing identification and mitigation of occult lung stress.
- Trial name
- NCT05675696
- Testing
- Esophageal Catheter
- Where
- United States
- Sponsor
- NYU Langone Health
Respiratory Distress Syndrome
A Multicenter, Randomized, Open Label Trial of a New Animal Extracted Surfactant to Treat RDS in Preterm Infants
The purpose of this study is to determine the efficacy and safety of the new pulmonary surfactant produced by Butantan Institute among premature infants with gestational age below 34 weeks with RDS, comparing to the pulmonary…
- Trial name
- NCT02305160
- Testing
- Butantan, Control
- Where
- 30 sites in Brazil
- Volunteers
- 327 people
- Sponsor
- University of Sao Paulo
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