Clinical trials: Respiratory Distress Syndrome, Newborn
Intubation, Intubation Complications
A Stepped Wedge Cluster Randomised Trial Of Video Versus Direct Laryngoscopy For Intubation Of Newborn Infants
Many newborn babies have difficulty breathing. When babies need a lot of help, a doctor will intubate them - i.e. put a tube into their windpipe (trachea) - so that they can be given support with a breathing machine.
- Conditions
- Intubation, Intubation Complications, Infant, Newborn, Infant Respiratory Distress Syndrome
- Trial name
- NEU-VODE (NCT06757543)
- Testing
- Video laryngoscopy, Direct laryngoscopy with standard laryngoscope
- Where
- 17 sites in Croatia, Czechia and 8 more
- Volunteers
- 840 people
- Sponsor
- University College Dublin
SIRS, Cytokine Storm
Cytokine Hemoadsorption in ECMO Patients
Cytokine hemoadsorption is a novel therapy used to improve outcome in critically ill patients with a dysregulated cytokine response and hemodynamic instability.
- Conditions
- SIRS, Cytokine Storm, Cardiogenic Shock, Cardiac Arrest
- Trial name
- NCT04901338
- Where
- Slovenia
- Volunteers
- 25 people
- Sponsor
- University Medical Centre Ljubljana
Respiratory Distress Syndrome in Premature Infant
Comparison of Two Nasal Interface for CPAP in Preterm
Continuous distending airway pressure (CPAP) has gained popularity as a means to provide non-invasive respiratory support in neonates to reduce ventilator induced lung injury (VILI).
- Trial name
- NCT03212508
- Testing
- RAM cannula and Hudson prongs
- Volunteers
- 12 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Covid19, Post Traumatic Stress Disorder
Quality of Life After COVID-19 Related Acute respIratory Distress Syndrome Among ICU Survivors Patients in Italy: the ODISSEA Study.
Acute respiratory insufficiency is one of the principal causes of intensive care admission for COVID 19 positive patients. This may determine a variable mortality rate ranging from 25-30%.
- Conditions
- Covid19, Post Traumatic Stress Disorder, Quality of Life
- Trial name
- ODISSEA (NCT04860687)
- Where
- 8 sites in Italy
- Volunteers
- 309 people
- Sponsor
- Azienda Sanitaria-Universitaria Integrata di Udine
ARDS, Human, COVID
Senicapoc in COVID-19 Patients With Severe Respiratory Insufficiency
SARS-CoV-2, one of a family of human coronaviruses, was initially identified in December 2019 in Wuhan city. This new coronavirus causes a disease that has now been named COVID-19.
- Trial name
- COVIPOC (NCT04594668)
- Testing
- Senicapoc
- Where
- 4 sites in Denmark
- Volunteers
- 46 people
- Sponsor
- University of Aarhus
COVID-19, Organ Dysfunction Syndrome Sepsis
Mechanisms for Organ Dysfunction in Covid-19
The study aims to investigate organ dysfunction and biomarkers in patients with suspected or verified COVID-19 during intensive care at Uppsala University Hospital.
- Conditions
- COVID-19, Organ Dysfunction Syndrome Sepsis, Organ Dysfunction Syndrome, Multiple, Septic Shock
- Trial name
- UMODCOVID19 (NCT04316884)
- Where
- Sweden
- Volunteers
- 380 people
- Sponsor
- Uppsala University
Acute Respiratory Distress Syndrome
Early Versus Late Initiation of ECMO (Extracorporal Membrane Oxygenation) Trial (ELIEO-Trial)
This trial is a prospective randomized multicenter trial that assigns patients to either a treatment for Acute Respiratory Distress Syndrome (ARDS) with an Extracorporal Membrane Oxygenation (ECMO) immediately after admission to…
- Trial name
- ELIEO (NCT04208126)
- Testing
- ECMO
- Where
- Germany
- Volunteers
- 508 people
- Sponsor
- University Hospital Tuebingen
Acute Respiratory Distress Syndrome
Inflammation During ECMO Therapy and ECMO Weaning
The goal of this interventional clinical trial is to compare patients who undergo ECMO therapy for treatment of acute respiratory distress syndrome (ARDS) and a randomized into one of two possible weaning strategy groups.
- Trial name
- ECMOWean (NCT05640635)
- Testing
- Ventilator weaning first, ECMO weaning first
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University Hospital Tuebingen
Lung Injury, ARDS
Point-of-care Lung Ultrasound (POCUS)-Integrated Study of Admitted Patients With COVID-19
This study seeks to define the ultrasound profile of patients with COVID-19, and document the progression of these ultrasound findings to develop prognostication and clinical decision instruments that can help guide management of…
- Conditions
- Lung Injury, ARDS, Acute Cardiac Event, Covid19
- Trial name
- PIOS-COVID (NCT05228717)
- Testing
- Point of Care Ultrasound
- Where
- 4 sites in United States
- Volunteers
- 240 people
- Sponsor
- Olive View-UCLA Education & Research Institute
Respiratory Distress Syndrome in Premature Infant
Ventilator Weaning Outcome Between NIV-NAVA and Nasal CPAP (or IMV ) Modes in Premature Neonates
Premature neonates are prone to respiratory distress and need ventilator support because of the rapid breathing and large variations in respiratory patterns.
- Trial name
- NCT04118400
- Testing
- NIV-NAVA, Nasal CPAP or NIMV mode
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Taipei Medical University Hospital
Acute Respiratory Syndrome Distress, Positive End-Expiratory Pressure
EIT-Guided PEEP Optimization in Trauma and Postoperative ARDS
Acute respiratory distress syndrome (ARDS) remains a serious and often fatal complication in patients following severe trauma or major surgery.
- Conditions
- Acute Respiratory Syndrome Distress, Positive End-Expiratory Pressure, Electrical Impedance Tomography, Trauma and Postoperative Pulmonary Insufficiency
- Trial name
- EIT-PEEP-SURG (NCT07313644)
- Testing
- EIT-giuded PEEP, Control
- Where
- Vietnam
- Volunteers
- 80 people
- Sponsor
- Nguyen Dang Thu
Acute Respiratory Distress Syndrome
The EVLW for Set the Positive End Expiratory Pressure (PEEP) in the Acute Respiratory Distress Syndrome (ARDS)
ARDS is a severe pathology with high mortality and morbidity.Actual ventilatory management is clear for the set of the tidal volume and for the survey of the plateau pressure for the patients who require mechanical ventilation.
- Trial name
- NCT00714987
- Volunteers
- 40 people
- Sponsor
- University Hospital, Strasbourg, France
ARDS, Human, COVID-19
Early Versus Late ECMO Therapy in COVID-19 Induced ARDS (ECMO-VID)
Experimental intervention: Insertion of Extracorporal Membrane Oxygenation (ECMO) within 24 hours of referral to an Intensive Care Unit.
- Trial name
- ECMO-VID (NCT04341285)
- Testing
- ECMO Implantation
- Where
- Germany
- Sponsor
- University Hospital Tuebingen
Acute Respiratory Distress Syndrome
The Effect of High Frequency Oscillation on Biological Markers of Lung Injury
Although mechanical ventilation is life saving, it is associated with a number of severe complications collectively referred to as ventilator induced lung injury (VILI).
- Trial name
- NCT00673517
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Unity Health Toronto
Mechanical Ventilation Complication, Respiratory Distress Syndrome in Premature Infant
Effect of Implementing Evidence Based Practices on Prevention of Associated Nasal Pressure Injuries Among Preterm Neonates With Non-Invasive Respiratory Support
This study aims to evaluate the effect of implementing evidence based practices on prevention of associated nasal pressure injuries among preterm neonates with non invasive respiratory support
- Trial name
- NCT06642285
- Testing
- Non Invasive Respiratory Support bundle
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
Acute Respiratory Distress Syndrome
Application Study of Individualized Mechanical Power Titration Strategy Based on PiCCO (Pulse Index Continuous Cardiac Output) Monitoring Parameters in ARDS Patients
Based on PiCCO combined with MP, the optimal mechanical power setting of the ventilator for ARDS patients in normal supine/prone position is determined to reduce the damage to lung function during mechanical ventilation.
- Trial name
- NCT07839234
- Testing
- Prone position ventilation
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Xiamen Hospital of Traditional Chinese Medicine
Respiratory Distress Syndrome, Adult
Changes in Refractory Acute Respiratory Distress Syndrome (ARDS) Patients Under High Frequency Oscillation-ventilation
The study is intended to evaluate the hemodynamic and the indexed extrapulmonary lung water (ELWI) changes in patients treated by high frequency oscillation-ventilation (HFO-V) for refractory acute respiratory distress syndrome…
- Trial name
- NCT01167621
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Respiratory Distress Syndrome
NHFOV Versus NCPAP to Prevent Exubation Failure
The purpose of the study is to assess whether nasal high frequency ventilation (NHFV) is superior to nasal continuous positive pressure (nCPAP) to prevent tracheal intubation and mechanical ventilation in preterm infants less…
- Trial name
- NCT01852916
- Testing
- CPAP, NHFOV
- Where
- 2 sites in Canada
- Volunteers
- 20 people
- Sponsor
- University of Manitoba
ARDS, COVID-19
ECMO for COVID-19 vs Influenza A H1N1 Associated ARDS
Objective: Veno-venous ECMO has been used as a rescue therapy for patients with severe ARDS associated to influenza A H1N1 and COVID19 viral pneumonia.
- Conditions
- ARDS, COVID-19, H1N1 Influenza
- Trial name
- InfluCOV_ECMO (NCT05080933)
- Where
- Italy
- Volunteers
- 308 people
- Sponsor
- University of Turin, Italy
Coronavirus Infection, Acute Respiratory Distress Syndrome
Pilot Study on Cytokine Filtration in COVID-19 ARDS
Background: There are no proven therapies for COVID-19 infection. COVID-19 infects the respiratory epithelium of the lower airways, causing widespread damage via cytopathic effects, resulting in severe inflammation and…
- Conditions
- Coronavirus Infection, Acute Respiratory Distress Syndrome, COVID
- Trial name
- CytokCOVID19 (NCT04361526)
- Testing
- Cytokine Adsorption
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Manuel Castellà
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