Clinical trials: Respiratory Distress Syndrome, Pediatric
Respiratory Distress Syndrome, Respiratory Distress Syndrome, Adult
Identifying PARDS Endotypes
Pediatric acute respiratory distress syndrome (PARDS) is a severe and diffuse lung injury that is a common cause of admission and mortality in the pediatric intensive care unit (PICU).
- Trial name
- NCT03539783
- Testing
- Respiratory epithelial cell brushing
- Where
- 2 sites in United States
- Volunteers
- 76 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Pediatric Respiratory Diseases, Bronchiolitis
Assessment of NeuroBOX and NeuroPAP in Infants.
Non-invasive ventilation (NIV, delivered via a mask or cannulas) permits to reduce the need for tracheal intubation in infants who needs a ventilatory support.
- Conditions
- Pediatric Respiratory Diseases, Bronchiolitis, Infant Respiratory Distress Syndrome
- Trial name
- NeuroPap2 (NCT03650478)
- Testing
- NeuroPAP ventilation (2h) and NeuroBox monitoring (23h), NeuroPAP ventilation (4h) and NeuroBox monitoring (25h)
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- St. Justine's Hospital
Acute Respiratory Distress Syndrome
Pediatric Acute Respiratory Distress Syndrome Ventilation Bundle
Mortality rates in children with pediatric acute respiratory distress syndrome (PARDS) are higher in Asia compared to other regions.
- Trial name
- NCT03504176
- Testing
- Ventilation bundle
- Where
- Singapore
- Volunteers
- 134 people
- Sponsor
- KK Women's and Children's Hospital
COVID, SARS-CoV-2
European/Euro-ELSO Survey on Adult and Neonatal/ Pediatric COVID-19 Patients in ECMO
In the last 10 years, severe acute respiratory infection (SARI) was responsible of multiple outbreaks putting a strain on the public health worldwide.
- Conditions
- COVID, SARS-CoV-2, ARDS, Human, Refractory Hypoxemia
- Trial name
- EuroECMO-COVID (NCT04366921)
- Where
- 97 sites in Austria, Belgium and 17 more
- Volunteers
- 150 people
- Sponsor
- Maastricht University Medical Center
Acute Respiratory Distress Syndrome, Acute Lung Injury
Efficacy and Safety of a Lung Recruitment Protocol in Children With Acute Lung Injury
Lung units which participate in gas exchange are known as 'recruited' lung. Patients with lung injury suffer from a proportion of units which do not participate in gas exchange (i.e.
- Trial name
- Recruitment (NCT00830284)
- Testing
- Recruitment maneuver
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Boston Children's Hospital
Acute Respiratory Failure, Pediatric Respiratory Distress Syndrome
Closed-loop Synchronization Versus Conventional Synchronization
A prior research indicated that asynchrony between the patient and ventilator occurred in 33 percent of 19,175 breaths, and was seen in every patient.
- Trial name
- CHESTSIPP (NCT05731024)
- Testing
- close-loop synchronization controller with SPONT mode, Conventional synchronization settings with SPONT mode
- Where
- 5 sites in Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Dr. Behcet Uz Children's Hospital
ARDS, Pediatric Respiratory Distress Syndrome
REcruitment MAneuvers and Mechanical Ventilation Guided by EIT in pARDS
There is evidence from randomized controlled trials in adult patients with Acute Respiratory Distress Syndrome (ARDS) suggesting that delivering small tidal volumes with adequate levels of Positive End-Expiratory Pressure (PEEP)…
- Conditions
- ARDS, Pediatric Respiratory Distress Syndrome, Respiratory Disease
- Trial name
- REMAV-EIT (NCT06067152)
- Testing
- EIT measurement, Staircase Recruitment Maneuvers with EIT guided and decremental PEEP trial, Setting of EIT-guided mechanical ventilation
- Where
- Italy
- Volunteers
- 13 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Ventilation Therapy; Complications, Ventilator-Induced Lung Injury
Clinical Decision Support Tool in PARDS Pilot Study
Previous clinical trials in adults with acute respiratory distress syndrome (ARDS) have demonstrated that ventilator management choices can improve Intensive Care Unit (ICU) mortality and shorten time on mechanical ventilation.
- Conditions
- Ventilation Therapy; Complications, Ventilator-Induced Lung Injury, Ards
- Trial name
- NCT04068012
- Testing
- Ventilator protocol
- Where
- 8 sites in United States, Canada and 1 more
- Volunteers
- 180 people
- Sponsor
- Children's Hospital Los Angeles
Pediatric Acute Respiratory Distress Syndrome (PARDS), Pediatric Respiratory Diseases
IPV and Lung Compliance in Invasively Ventilated Children
The goal of this observational study is to determine if Intrapulmonary Percussive Ventilation (IPV) improves lung compliance in children receiving conventional invasive mechanical ventilation.
- Conditions
- Pediatric Acute Respiratory Distress Syndrome (PARDS), Pediatric Respiratory Diseases, Lung Compliance
- Trial name
- NCT06836050
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northwell Health
ARDS
Establishment of a Early Risk Model of ECMO in Children With ARDS
The key problem in the treatment of ARDS is refractory hypoxemia. Extracorporeal Membrane Oxygenation (ECMO) is an extracorporeal oxygenation of venous blood to eliminate carbon dioxide and return to the body.
- Trial name
- NCT04710173
- Testing
- ECMO
- Where
- 3 sites in China
- Volunteers
- 95 people
- Sponsor
- Children's Hospital of Fudan University
Lung Injury, Extravascular Lung Water
Lung Ultrasound Score and Pediatric Intensive Care Outcomes (LUS-PICO)
Bedside lung ultrasonography helps to obtain reliable clinical information about lung aeration, that has been categorized by means of the so-called lung ultrasound score (LUS).
- Conditions
- Lung Injury, Extravascular Lung Water, Pulmonary Edema, Acute Respiratory Distress Syndrome
- Trial name
- LUS-PICO (NCT04660448)
- Testing
- Bedside lung ultrasound examination
- Where
- Spain
- Volunteers
- 650 people
- Sponsor
- Fundación para la Investigación Biosanitaria del Principado de Asturias
Acute Lung Injury
Driving Pressures in a Closed-loop and a Conventional Mechanical Ventilation Mode
In mechanically ventilated patients, driving pressure (ΔP) assess the strain applied to the respiratory system and is related to ICU mortality.
- Trial name
- NCT04541199
- Testing
- closed loop, conventional
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Dr. Behcet Uz Children's Hospital
Respiratory Failure
Closed-Loop O2 Use During Invasive Mechanical Ventilation Of Pediatric Patients
During mechanical ventilation (MV) hypoxemic or hyperoxemic events should be carefully monitored and a quick response should be provided by the caregiver at the bedside.
- Trial name
- CLOUDIMPP (NCT05714527)
- Testing
- Close-loop FiO2 controller, Conventional
- Where
- 4 sites in Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Dr. Behcet Uz Children's Hospital
Respiratory Failure, Respiratory Distress Syndrome
Ventilator Induced Diaphragm Dysfunction in Pediatric Critically Ill Patients (VIDD)
evaluation of diaphragmatic disfunction eventually occurred in pediatric patient undergoing mechanical ventilation therapy
- Conditions
- Respiratory Failure, Respiratory Distress Syndrome, Mechanical Ventilation Complication
- Trial name
- VIDD (NCT03768232)
- Testing
- ultrasound asessment
- Volunteers
- 80 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Respiratory Distress Syndrome
Feasibility Study of Aerosolized Surfaxin in the Prevention of Respiratory Distress Syndrome (RDS) in Premature Infants
To evaluate the feasibility, safety and tolerability of aerosolized lucinactant delivered by nasal continuous positive airway pressure (nCPAP) for the prevention of respiratory distress syndrome (RDS) in premature infants.
- Trial name
- NCT00807235
- Testing
- Aerosolized lucinactant
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Windtree Therapeutics
ARDS, Human, Respiratory Failure
Driving Pressure and Mortality: in the Pediatric Intensive Care Unit (PICU)
Respiratory failure is one of the most common causes of both hospitalization and mortality in patients in the pediatric intensive care unit (PICU).
- Trial name
- NCT04419376
- Testing
- driving pressure
- Where
- Turkey (Türkiye)
- Volunteers
- 116 people
- Sponsor
- Dr. Behcet Uz Children's Hospital
Pediatric Acute Respiratory Distress Syndrome
Post-discharge Outcomes of Pediatric Acute Respiratory Distress Syndrome
In this study, the investigators aim to better characterize the outcomes of pediatric acute respiratory distress syndrome (PARDS) survivors, to examine whether subgroups of children with PARDS can be identified, and to determine…
- Trial name
- PARDS (NCT03585582)
- Testing
- Prospective follow-up
- Where
- Canada
- Volunteers
- 77 people
- Sponsor
- St. Justine's Hospital
Pediatric Acute Respiratory Distress Syndrome (PARDS), Acute Respiratory Failure
Decremental Esophageal Catheter Filling Volume Titration For Transpulmonary Pressure Measurement
Mechanical ventilation is a critical intervention in the management of pediatric patients with respiratory distress. During this process, accurate measurement of transpulmonary pressure (PL) is essential to ensure the safety and…
- Conditions
- Pediatric Acute Respiratory Distress Syndrome (PARDS), Acute Respiratory Failure, Acute Respiratory Distress Syndrome
- Trial name
- DECFVTTPM (NCT06051292)
- Testing
- Fast method, Conventional method
- Where
- 4 sites in Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Dr. Behcet Uz Children's Hospital
Acute Respiratory Distress Syndrome (ARDS)
Trial of an Alternate Mode of Providing Artificial Breaths to Children With Very Severe Pneumonia
This study attempts to study a new ventilation mode in children with Acute respiratory distress syndrome (ARDS). Despite decades of research, no intervention has brought about a significant decrease in ARDS mortality.
- Trial name
- APRiCE (NCT02167698)
- Testing
- Airway Pressure Release Ventilation (APRV), Low-tidal volume ventilation, Methylprednisolone
- Where
- India
- Volunteers
- 52 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
ARDS (Acute Respiratory Distress Syndrome)
Comparative Analysis of Salivary and Bronchoalveolar Lavage IL-6 and TNF-α as Biomarkers in Pediatric Acute Respiratory Distress Syndrome
The aim of this study is to determine the degree of agreement in cytokines level measured through BAL and those measured through salivary glands excretion.
- Trial name
- NCT07380373
- Testing
- Bronchoscopy
- Where
- Egypt
- Volunteers
- 37 people
- Sponsor
- Ain Shams University