Clinical trials: Respiratory Distress Syndrome of Newborn
ARDS, Hypercapnic Respiratory Failure
Low-flow Extracorporeal Carbon Dioxide Removal in COVID-19-associated Acute Respiratory Distress Syndrome
The study aims to investigate the efficacy of extracorporeal CO2 removal for correction of hypercapnia in coronavirus disease 19 (COVID-19)-associated acute respiratory distress syndrome
- Conditions
- ARDS, Hypercapnic Respiratory Failure, AKI
- Trial name
- NCT04351906
- Testing
- ECCO2R
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University of Giessen
Critical Illness
Effect of Inhaled Nitric Oxide on Pulmonary Ventilation/Perfusion Ratio Assessed by EIT in Patients With ARDS
Electrical impedance tomography was used to monitor changes in pulmonary perfusion distribution and V/Q ratio before and after iNO in patients with acute respiratory distress syndrome to investigate the factors predicting iNO…
- Trial name
- NCT05873647
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Transesophageal Echocardiography, Acute Respiratory Distress Syndrome
Using TEE to Evaluate the Effect of Levosimendan on Patients With ARDS Associated With RVD During MV
Acute respiratory distress syndrome (ARDS) is often complicated by right ventricular dysfunction (RVD), Acute cor pulmonale is the most serious form of ARDS complicated with RVD.Levosimendan is indicated for short-term treatment…
- Conditions
- Transesophageal Echocardiography, Acute Respiratory Distress Syndrome, Right Ventricular Dysfunction
- Trial name
- NCT05768230
- Testing
- levosimendan, 5% glucose injection
- Where
- China
- Volunteers
- 58 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Cerebral Injuries, Acute Respiratory Distress Syndrome (ARDS)
Alveolar Recruitment Maneuvers, Intracerebral Hemodynamic and Oxygenation
This study aims to compare 2 alveolar recruitment maneuvers (ARM) in patients with cerebral injuries and acute respiratory distress syndrome (ARDS) in term of efficacy and tolerance.
- Trial name
- M'RHICO (NCT02574169)
- Testing
- alveolar recruitment maneuvers group 1, alveolar recruitment maneuvers group 2
- Where
- 5 sites in France
- Volunteers
- 18 people
- Sponsor
- University Hospital, Toulouse
Respiratory Distress Syndrome, Mechanical Ventilation
Mechanical Ventilation Strategy for Coronavirus Disease 2019 (COVID-19)
This is a prospective, randomized, single-center, open-label controlled trial, designed to compare the efficacy of two ventilation strategies (Low Tidal Volume and positive end-expiratory pressure (PEEP) based on the Acute…
- Conditions
- Respiratory Distress Syndrome, Mechanical Ventilation, SARS (Severe Acute Respiratory Syndrome)
- Trial name
- COVEN (NCT04497454)
- Testing
- EIT-Group, ARDSNet
- Where
- Brazil
- Volunteers
- 128 people
- Sponsor
- University of Sao Paulo General Hospital
Acute Respiratory Distress Syndrome Caused by COVID-19
Comparison of High Flow Nasal Cannula (HFNC), Face-mask Non-Invasive Ventilation (NIV) & Helmet NIV in COVID-19 ARDS Patients
Objective: To determine whether NIV delivered through helmet interface reduces intubation rate among patients with COVID-19 ARDS compared to face-mask NIV and HFNC.
- Trial name
- NIV COVID19 (NCT04715243)
- Testing
- High flow nasal cannula (HFNC), Helmet NIV, Face-mask NIV
- Where
- Oman
- Volunteers
- 161 people
- Sponsor
- Sultan Qaboos University
Respiratory Distress Syndrome (RDS), Bronchopulmonary Dysplasia (BPD)
Can Betamethasone Given After Birth Help Extremely Premature Babies Come Off Breathing Support Safely and Effectively?
The goal of this study is to determine if giving a steroid medication (specifically, betamethasone) after birth can help extremely premature babies (born before 28 weeks) come off breathing machines safely and reduce their risk…
- Trial name
- NCT07447739
- Testing
- Betamethasone
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Khang Nguyen
COVID, Severe Acute Respiratory Syndrome
LSALT Peptide vs. Placebo to Prevent ARDS and Acute Kidney Injury in Patients Infected With SARS-CoV-2 (COVID-19)
To evaluate the proportion of subjects alive and free of respiratory failure (e.g. need for non-invasive or invasive mechanical ventilation, high flow oxygen, or ECMO) and free of the need for continued renal replacement therapy…
- Conditions
- COVID, Severe Acute Respiratory Syndrome, Sars-CoV2, Acute Kidney Injury
- Trial name
- NCT04402957
- Testing
- LSALT peptide
- Where
- 7 sites in United States, Canada and 1 more
- Volunteers
- 61 people
- Sponsor
- Arch Biopartners Inc.
Infantile Respiratory Distress Syndrome, Ventilator Lung; Newborn
Automatic Oxygen Control (SPOC) in Preterm Infants
Single-center, randomised controlled, cross-over clinical trial in preterm infants born at gestational age below 34+1/7 weeks receiving supplemental oxygen and respiratory support (continous positive airway pressure (CPAP) or…
- Trial name
- optimalSPOC (NCT03785899)
- Testing
- SPOCnew, 8s SpO2 averaging, SPOCold
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- University Hospital Tuebingen
Acute Respiratory Distress Syndrome, Acute Cor Pulmonale
Transpulmonary Pressure in Right Ventricle Protection of ARDS
To compare the effect between mechanical ventilation strategy guided by transpulmonary pressure and tranditional lung protective ventilation strategy in acute respiratory distress syndrome for right ventricle protection.
- Trial name
- NCT05629832
- Testing
- mechanical ventilation strategy guided by transpulmonary pressure
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Beijing Chao Yang Hospital
Acute Lung Injury, Acute Respiratory Distress Syndrome (ARDS)
Using Human Menstrual Blood Cells to Treat Acute Lung Injury Caused by H7N9 Bird Flu Virus Infection
The purpose of this study is to determine whether human menstrual blood-derived stem cells are effective in the treatment of infection of H7N9 virus caused acute lung injury.
- Conditions
- Acute Lung Injury, Acute Respiratory Distress Syndrome (ARDS), Multiple Organ Failure
- Trial name
- NCT02095444
- Testing
- Menstrual blood stem cells
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- S-Evans Biosciences Co., Ltd.
Bronchopulmonary Dysplasia, Lung Diseases
High Frequency Ventilation in Premature Infants (HIFI)
To compare the efficacy and safety of high frequency ventilation (HFV) with that of standard, mechanical ventilation in premature infants of less than 2000 grams.
- Conditions
- Bronchopulmonary Dysplasia, Lung Diseases, Respiratory Distress Syndrome
- Trial name
- NCT00000567
- Testing
- high-frequency ventilation
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
ARDS (Acute Respiratory Distress Syndrome)
BALance: ARDS Deconvolution by Bronchoalveolar Lavage Multiomics and Radiomics
Acute respiratory distress syndrome (ARDS) is a major contributor to ICU mortality and is characterised by hypoxaemia and pulmonary oedema.
- Trial name
- BALance (NCT07633366)
- Testing
- sampling blood, Lavage with physiologic saline solution
- Where
- Austria
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Respiratory Distress Syndrome,Adult, Acute Lung Injury
Effect of Enteral Nutrition Support for Critically Ill Patients
To determine whether specialized enteral nutrition support can improve oxygenation status in critically ill patients with acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) comparing to a standard enteral…
- Trial name
- NCT01464853
- Testing
- Enteral nutrition with fatty acids, Standard Enteral Nutrition
- Where
- 9 sites in Russia
- Volunteers
- 84 people
- Sponsor
- Abbott Nutrition
Premature Lungs, Respiratory Distress Syndrome
Early Caffeine and LISA Compared to Caffeine and CPAP in Preterm Infants
This study is being conducted to determine whether prophylactic administration of surfactant by the Less Invasive Surfactant Administration (LISA) method reduces the need for mechanical ventilation in the first 72 hours of life…
- Conditions
- Premature Lungs, Respiratory Distress Syndrome, Surfactant Deficiency Syndrome Neonatal
- Trial name
- CaLI (NCT04209946)
- Testing
- Less Invasive Surfactant Administration LISA, Continuous Positive Airway Pressure CPAP
- Where
- 3 sites in United States
- Volunteers
- 180 people
- Sponsor
- Sharp HealthCare
Acute Respiratory Distress Syndrome, Mechanical Ventilation Complication
Early Diagnosis of ARDS in Mechanically Ventilated Patient Using LUS Score in Comparison With CT
The aim of this study is to assess accuracy of Lung ultrasound score for early diagnosis of acute respiratory distress syndrome in patients who expected to be mechanically ventilated more than 24 hour in comparison with computed…
- Conditions
- Acute Respiratory Distress Syndrome, Mechanical Ventilation Complication, Computed Tomography
- Trial name
- NCT06971042
- Testing
- Lung Ultrasound
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Tanta University
Respiratory Distress Syndrome, Adult, Gastrointestinal Hemorrhage
INR-Triggered Transfusion In GI Bleeders From ER
Transfusion-related acute lung injury (TRALI) is the most common cause of transfusion-related morbidity and mortality in the United States.
- Conditions
- Respiratory Distress Syndrome, Adult, Gastrointestinal Hemorrhage, Liver Diseases, Transfusion Related Lung Injury
- Trial name
- I-TRIGER (NCT01461889)
- Testing
- Transfuse plasma to High INR target, Transfuse plasma to Low INR target
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Colorado, Denver
Respiratory Distress Syndrome
Effects of Flow Magnitude on Cardiorespiratory Stability During Nasal High Flow Therapy in Preterm Infants
Premature babies often need help breathing for a longer period of time. Traditionally, this is done with a breathing aid called NCPAP (nasal continuous positive airway pressure).
- Trial name
- MASTER (NCT05908227)
- Testing
- NHF high, NHF low, NCPAP
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 150 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Acute Respiratory Distress Syndrome
Effect of Spontaneous Breathing in APRV Mode on Respiratory Physiology of ARDS Patients
This is a single-center, prospective, randomized, three-period crossover physiological study in adult patients with moderate-to-severe acute respiratory distress syndrome (ARDS, PaO₂/FiO₂ ≤150 mmHg).
- Trial name
- SBA-APRV (NCT07798154)
- Testing
- APRV ventilation with low-level spontaneous breathing, APRV ventilation with high-level spontaneous breathing, APRV ventilation with fully suppressed spontaneous breathing
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Preterm Infants, Respiratory Distress Syndrome (Neonatal)
Pressure Targeting During High Flow Therapy in Premature Infants
The goal of this study is to see if a new approach to breathing support ('Pressure Targeted High Flow') is as effective as standard of care ('Continuous Positive Airway Pressure') in prematurely born infants.
- Conditions
- Preterm Infants, Respiratory Distress Syndrome (Neonatal), BPD - Bronchopulmonary Dysplasia
- Trial name
- NeoMATCH (NCT07418502)
- Testing
- Pressure Targeted High Flow, CPAP
- Where
- 2 sites in United States
- Volunteers
- 78 people
- Sponsor
- University of Texas at Austin
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