Clinical trials: Respiratory Failure With Hypoxia
Hypoxic Respiratory Failure
Effect of FAST HUGS WITH ICU Approach on Length of Intensive Care Unit Stay in Patients With Hypoxic Respiratory Failure
This study will investigate the effect of the FAST HUGS WITH ICU approach on the length of stay in the intensive care unit in patients with hypoxic respiratory failure.
- Trial name
- NCT06901050
- Testing
- FAST HUGS WITH ICU approach
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Muş Alparslan University
Persistent Fetal Circulation Syndrome, Hypertension, Pulmonary, of Newborn, Persistent
Early iNO for Oxidative Stress, Vascular Tone and Inflammation in Babies With Hypoxic Respiratory Failure
The investigators in this study are concerned about the harmful effects of oxygen exposure in newborn infants, particularly at high concentrations.
- Conditions
- Persistent Fetal Circulation Syndrome, Hypertension, Pulmonary, of Newborn, Persistent, Persistent Pulmonary Hypertension of Newborn
- Trial name
- NCT01891500
- Testing
- Inhaled nitric oxide, Nitrogen Gas, Crossover iNO
- Where
- United States
- Sponsor
- University of Florida
Heart Failure, Systolic
Hypoxic Conditioning in Heart Failure
Heart failure impairs quality of life and exercise capacity, despite an optimal medical therapy. Alternative methods, like hypoxic conditioning coupled to exercise training, must be explored and describe
- Trial name
- hypoxheart (NCT03537079)
- Testing
- hypoxia air
- Where
- France
- Volunteers
- 14 people
- Sponsor
- University Hospital, Grenoble
PPHN, Persistent Pulmonary Hypertension of the Newborn
Study To Investigate Safety And Efficacy Of Sildenafil In The Newborns With Persistent Pulmonary Hypertension (PPHN)
Sildenafil is efficacious in newborns with persistent pulmonary hypertension and its use will reduce the need for inhaled nitric oxide.
- Conditions
- PPHN, Persistent Pulmonary Hypertension of the Newborn, Hypoxic Respiratory Failure
- Trial name
- NCT01069861
- Testing
- sildanefil
- Where
- United Kingdom
- Volunteers
- 4 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Pulmonary Hypertension, Hypoxic Respiratory Failure
Inhaled Nitric Oxide for the Treatment of Neonatal Hypoxic Respiratory Failure With Pulmonary Hypertension
This is a prospective, open-label, single-arm, multicenter Phase IV clinical study to evaluate the safety of INOmax for the treatment of hypoxic respiratory failure with pulmonary hypertension in newborns (≥ 34 weeks gestational…
- Trial name
- INOFTTONHRFWPH (NCT07099144)
- Testing
- Inhaled nitric oxide (NO)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Lee's Pharmaceutical Limited
Covid19, Hypoxemic Respiratory Failure
Automatic Oxygen Titration With O2matic® to Patients Admitted With COVID-19 and Hypoxemic Respiratory Failure
Patients with coronavirus disease (COVID-19) and pneumonitis often have hypoxemic respiratory failure and a need of supplementary oxygen.
- Conditions
- Covid19, Hypoxemic Respiratory Failure, Hypoxemia
- Trial name
- O2matic-COVI (NCT04565106)
- Testing
- Closed-loop control of oxygen supplementation by O2matic
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- Hvidovre University Hospital
Chronic Heart Failure, Oxygen Deficiency
Oxygen Therapy in Patients With Chronic Heart Failure With Reduced Ejection Fraction
The purpose of this study is to assess patients with chronic heart failure and moderate-severe ventricular dysfunction (left ventricular ejection fraction (FEVE) <40%) with nocturnal desaturation (mean Oxygen saturation (SatO2)…
- Trial name
- ROXIC (NCT05913739)
- Testing
- Oxygen Therapy
- Where
- Spain
- Volunteers
- 1 people
- Sponsor
- Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta
Hypoxia, Respiratory Failure With Hypoxia
Finger Pulse Oximeters in Hosptial Setting
Pulse oximetry is a well-established, non-invasive measurement tool used to estimate arterial oxygen saturation. The accuracy of these cheap, readily available finger pulse oximeters has not been robustly assessed in a clinical…
- Trial name
- NCT06994663
- Volunteers
- 100 people
- Sponsor
- Barts & The London NHS Trust
Respiratory Failure, Hypoxemia
NIV-FOB, HFNC-FOB- Comparison of Methods
The aim of the study is to asses safety and indications and contraindications for performing bronchofiberocopy (FB) with respiratory support methods, i.e. non-invasive ventilation (NIV) and high flow nasal oxygen therapy (HFNO).
- Conditions
- Respiratory Failure, Hypoxemia, Hypoxemic Respiratory Failure
- Trial name
- NIRA (NCT05655026)
- Testing
- NIV, HFNO
- Where
- Poland
- Volunteers
- 300 people
- Sponsor
- Medical University of Silesia
Acute Respiratory Failure With Hypoxia
NAVA Helmet in Pediatric Respiratory Failure
Neurally Adjusted Ventilatory Assist (NAVA) is a new form of partial support wherein the machine applies positive pressure throughout inspiration in proportion to the electrical activity of the diaphragm (EAdi), Because…
- Trial name
- NCT02050217
- Testing
- Neurally Adjusted Ventilatory Assist
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Respiratory Failure With Hypoxia
Helmet Noninvasive Ventilation vs. High-flow Nasal Cannula in Moderate-to-severe Acute Hypoxemic Respiratory Failure
Helmet noninvasive ventilation and high-flow nasal cannula are novel tools for the first-line treatment of acute hypoxemic respiratory failure.
- Trial name
- HENIVOTpilot (NCT04502576)
- Testing
- Noninvasive respiratory support
- Where
- 5 sites in Italy
- Volunteers
- 110 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Pulmonary Embolism (Diagnosis), Respiratory Failure With Hypoxia
Screening for Pulmonary Embolism Using Single-channel Electrocardiogram
It is a prospective, controlled, single-center, observational, non-randomized study. The study is planned to include at least 500 patients 18 years old and older (300 patients in the training sample and 200 patients in the test…
- Conditions
- Pulmonary Embolism (Diagnosis), Respiratory Failure With Hypoxia, Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- NCT07412418
- Where
- Russia
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- I.M. Sechenov First Moscow State Medical University
PPHN, Hypoxic Respiratory Failure
Predictors of Inhaled Nitric Oxide Responsiveness in Patients With PPHN
To identify biochemical, clinical, or genetic biomarkers that may predict responsiveness to iNO in neonates with PPHN/HRF. The primary outcome will be identification of any biomarker(s) associated with response to iNO therapy.
- Trial name
- PINOR (NCT06043635)
- Sponsor
- Nationwide Children's Hospital
Treatment Failure, Lethargy
RCT of Efficacy of Amoxicillin Over Ampicillin on Severe Pneumonia
Burden: Pneumonia remains the leading infectious cause of death accounting for 920,000 children under five around the world. This means a loss of over 2,500 child lives every day, or over 100 every hour.
- Conditions
- Treatment Failure, Lethargy, Altered Mental Status, Convulsion, Non-Epileptic
- Trial name
- NCT03369093
- Testing
- Amoxicillin
- Where
- Bangladesh
- Volunteers
- 308 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Pulmonary Hypertension, Familial Persistent, of the Newborn
A Study To Evaluate Safety And Efficacy Of IV Sildenafil In The Treatment Of Neonates With Persistent Pulmonary Hypertension Of The Newborn
This study will evaluate whether IV sildenafil can reduce the time on inhaled nitric oxide treatment and reduce the failure rate of available treatments for persistent pulmonary hypertension of the newborn.
- Trial name
- NCT01720524
- Testing
- iv sildenafil
- Where
- 42 sites in United States, Belgium and 10 more
- Volunteers
- 59 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Apgar; 0-3 at 1 Minute, Metabolic Acidosis
Autologous Stem Cells in Newborns With Oxygen Deprivation
The purpose of this study is to determine whether the plasticity of autologous intravenous application of cord blood stem cells would improve the clinical course of asphyxiated newborns.
- Conditions
- Apgar; 0-3 at 1 Minute, Metabolic Acidosis, Hypoxia, Brain, Multiple Organ Failure
- Trial name
- NCT01506258
- Testing
- Application of Stem Cells, Observation
- Where
- Mexico
- Volunteers
- 20 people
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Lung Disease, Hypoxemia
Inhaled Nitric Oxide in Neonates With Elevated A-a DO2 Gradients Not Requiring Mechanical Ventilation
The purpose of this pilot study is to evaluate whether administration of nitric oxide (NO)gas by oxygen hood at 20 ppm significantly increases PaO2, as compared to placebo gas (oxygen), within one hour of initiation and with no…
- Conditions
- Lung Disease, Hypoxemia, Respiratory Acidosis
- Trial name
- NCT00041548
- Testing
- nitric oxide for inhalation, Oxygen
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Mallinckrodt
COPD Exacerbation, Hypoxia
Automated Oxygen Delivery by O2matic to Patients Admitted With an Exacerbation in COPD
The aim of the study is to examine if automated oxygen delivery with O2matic is better than manually controlled oxygen therapy for patients admitted to hospital with an exacerbation in Chronic Obstructive Pulmonary Disease…
- Conditions
- COPD Exacerbation, Hypoxia, Hyperoxia, Respiratory Failure
- Trial name
- O2MATIC (NCT03464695)
- Testing
- O2matic
- Where
- 2 sites in Denmark
- Volunteers
- 20 people
- Sponsor
- Hvidovre University Hospital
Severe Pneumonia
Feasibility and Acceptability Followed by Effectiveness of bCPAP for Treatment of Children Aged 1-59 Months With Severe Pneumonia in Ethiopia
Principal Investigator: Mohammod Jobayer Chisti Research Protocol Title: Feasibility and Acceptability Followed by Effectiveness of Bubble Continuous Positive Airway Pressure (bCPAP) for Treatment of Children aged 1-59 months…
- Trial name
- NCT03870243
- Testing
- Bubble CPAP, Low flow oxygen
- Where
- Bangladesh
- Volunteers
- 1,240 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Hypoxemic Respiratory Failure
Correlation of Peak Tidal Inspiratory Flow Measured Before and After Extubation in Adult Patients With Hypoxemia
In this study, patients who are ready for extubation and indicated for high-flow nasal cannula therapy after extubation will be enrolled, the investigators would measure the patient peak tidal inspiratory flow (PTIF) pre and post…
- Trial name
- NCT04971148
- Testing
- HFNC flow set at patient peak tidal inspiratory flow, HFNC flow set at 1.33 times of patient peak tidal inspiratory flow, HFNC flow set at 1.67 times of patient peak tidal inspiratory flow
- Where
- 2 sites in United States, Spain
- Volunteers
- 5 people
- Sponsor
- Rush University Medical Center