Clinical trials: Respiratory Function, open to volunteers
Obstructive Sleep Apnea, Down Syndrome (Trisomy 21)
Effects of a Pacifier on Obstructive Sleep Apnea and Its Repercussions in Infants With Down Syndrome
Obstructive Sleep Apnea (OSA) is characterised by repetitive collapse of the upper airway during sleep, inducing breathing disturbances that can result in oxygen desaturation and frequent arousals.
- Trial name
- TET21 (NCT07658053)
- Testing
- CURAPROX pacifier use, Pacifier diary, Polysomnography (PSG) to explore OSA
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Hospices Civils de Lyon
COPD
Prospective Dynamic Cohort Study of Phenotypic Profiles in Patients With Chronic Obstructive Pulmonary Disease
This prospective, multicenter, real-world observational cohort study will describe phenotypic profiles, patient characteristics, and treatments in adults with stable chronic obstructive pulmonary disease (COPD).
- Trial name
- COPD-BPCO 2 (NCT07627763)
- Testing
- Routine care / no study-specific intervention
- Where
- 7 sites in France
- Volunteers
- 500 people
- Sponsor
- Initiatives Bronchopneumopathie Chronique Obstructive (BPCO)
Acute Respiratory Distress Syndrome ARDS
Driving Pressure-guided Tidal Volume Ventilation in the Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome (ARDS) is associated with high mortality, some of which can be attributed to ventilator-induced lung injury (VILI) when artificial ventilation is not customized to the severity of lung injury.
- Trial name
- DRIVENT (NCT06322758)
- Testing
- Tidal volume customization in the acute respiratory distress syndrome
- Volunteers
- 750 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Surgeries Undergoing General Anesthesia
Impact of Intraoperative Oxygenation Practices on Patient Outcomes
This multicenter, cluster-randomized, cluster-crossover clinical trial evaluates the impact of three intraoperative FiO2 (Fraction of Inspired Oxygen) oxygenation strategies-lower (FiO₂ 0.21-0.40), intermediate (FiO₂ 0.40-0.80)…
- Trial name
- IntraOp Ox (NCT07224243)
- Testing
- Lower FiO2, Intermediate FiO2, Higher FiO2
- Where
- 4 sites in United States
- Volunteers
- 54,000 people
- Sponsor
- Frederic T Billings IV
DIAPHRAGM -Ultrasound -Weaning -Mechanical Ventilation
Diaphragm Training Ultrasound
Common neurological indications of intubation and initiation of mechanical ventilation (MV) include ischemic and hemorrhagic stroke, neurotrauma, and intracranial hemorrhage.
- Trial name
- DiaphUS (NCT04186325)
- Testing
- DIAPHRAGMATIC exercising
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Mansoura University
Respiratory Monitoring, Thoracic Surgery
AirGo™ Respiratory Monitoring in Lung Resection
Patients undergoing lung resection surgery may experience changes in respiratory function during the perioperative period. Current monitoring methods provide important clinical information but are often limited to specific time…
- Conditions
- Respiratory Monitoring, Thoracic Surgery, Lung Resection Surgery, Respiratory Function
- Trial name
- NCT07838025
- Testing
- AirGoTM system
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Obstructive Sleep Apnea (OSA), Mild Cognitive Impairment (MCI)
CPAP Randomized Controlled Trial
The overall goal of this randomized controlled trial is to test the hypothesis that in older adults with mild cognitive impairment (MCI) and previously untreated obstructive sleep apnea (OSA), 4 months of web-based sleep…
- Conditions
- Obstructive Sleep Apnea (OSA), Mild Cognitive Impairment (MCI), Cognitive Decline Prevention in Pre-frail Older Adults
- Trial name
- NCT06773416
- Testing
- CPAP Therapy Combined with Web-Based Sleep Education for Cognitive and Sleep Health, Delayed CPAP Therapy Combined with Web-Based Sleep Education for Cognitive and Sleep Health
- Where
- Canada
- Volunteers
- 206 people
- Sponsor
- Sunnybrook Health Sciences Centre
the Elderly, Respiratory Disorders
Effects of Pulmonary Rehabilitation in Salt Chambers on Functional Efficiency, Respiratory Parameters, and Blood Rheology in Elderly With Respiratory Diseases.
The aim of the study is to assess the impact of the rehabilitation and treatment stay at the underground Health Resort of the 'Wieliczka' Salt Mine in Wieliczka on the functional capacity, respiratory parameters, and rheological…
- Trial name
- PRSC-FERPBR (NCT06951633)
- Testing
- Subterranean, pulmonary rehabilitation
- Where
- Poland
- Volunteers
- 33 people
- Sponsor
- University School of Physical Education, Krakow, Poland
Cardiopulmonary Failure, Myocardial Infarction (MI)
COR-INSIGHT: Optimizing Cardiovascular and Cardiopulmonary Outcomes with AI-Driven Multiplexed Indications Using COR ECG Wearable
The COR-INSIGHT trial aims to evaluate the effectiveness of Peerbridge COR advanced ambulatory ECG wearables (COR 1.0 and COR 2.0) in accurately and non-invasively detecting cardiovascular and cardiopulmonary conditions using…
- Conditions
- Cardiopulmonary Failure, Myocardial Infarction (MI), Heart Decompensation, Heart Failure
- Trial name
- COR-INSIGHT (NCT06763549)
- Testing
- SUBPROTOCOL A, SUBPROTOCOL B, SUBPROTOCOL C
- Where
- United States
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Peerbridge Health, Inc
Acute Respiratory Distress Syndrome (ARDS)
COMPARISON OF LUNG RECRUITABILITY ASSESSMENT BY HYSTERESIS RATIO AND RECRUITMENT-TO-INFLATION RATIO, AND PEEP TITRATION IN ARDS.
This multicenter, single-blind physiological study aims to compare two bedside methods for assessing lung recruitability in mechanically ventilated patients with acute respiratory distress syndrome (ARDS): the…
- Trial name
- PV-TOOL (NCT07713420)
- Testing
- Physiological lung recruitability assessment and PEEP titration protocol
- Volunteers
- 30 people
- Sponsor
- Oriol Roca
Asthma
Ventilation and Perfusion in Asthmatics
Assess regional changes to perfusion and ventilation from inhaled corticosteroid (ICS) and Fast-acting beta-antagonist (FABA) among adult asthmatics using radiographically derived estimates of regional ventilation…
- Trial name
- NCT07426458
- Testing
- Albuterol Sulfate, Albuterol-Budesonide
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Miami
Myocardial Infarction (MI)
Can Wearable Technology be Used to Predict Exercise Intensity
There is a knowledge gap in the literature around using watts to measure exercise intensity in walking and running, this is largely due to new technological developments.
- Trial name
- (CWTPEI) (NCT06871943)
- Testing
- Incremental Shuttle Walk Tests
- Volunteers
- 24 people
- Sponsor
- Keele University
Sleep Apnea, Obstructive, Bariatric Surgery
Effect of CPAP Versus APAP in Patients With Obesity Undergoing Bariatric Surgery Protocol
Introduction Obstructive sleep apnea (OSA) is a common disorder in obese patients, especially those undergoing bariatric surgery.
- Conditions
- Sleep Apnea, Obstructive, Bariatric Surgery, Obesity, Treatment Adherence and Compliance
- Trial name
- ObesAOS (NCT07001215)
- Testing
- In the intervention group, patients will be treated with auto-adjusting APAP, providing variable pressures throughout the sleep hours., CPAP
- Where
- Spain
- Volunteers
- 104 people
- Sponsor
- Hospital Universitario Ramon y Cajal
Obstructive Sleep Apnea of Adult, Hypoxia, Brain
Cerebral Blood Flow and Ventilatory Responses During Sleep in Normoxia and Intermittent Hypoxia
A prospective double blind, placebo-controlled, randomized cross-over trial to evaluate the effect of lowering cerebral blood flow on the ventilatory chemoreflexes (acute hypoxic and hypercapnic ventilatory responses).
- Conditions
- Obstructive Sleep Apnea of Adult, Hypoxia, Brain, Sleep Apnea, Sleep Disorder
- Trial name
- NCT03255408
- Testing
- Drug Lowering Cerebral Blood Flow (CBF) and Normoxia Sleep, Drug Lowering CBF and Intermittent Hypoxia Sleep
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Transfusion-Related Acute Lung Injury, ARDS, Human
Comparison of the Proteome in ICU Patients in Search for TRALI Biomarkers: A Case-control Study Using Both Retrospective and Prospective Samples
Transfusion-related acute lung injury (TRALI) is a severe complication of blood transfusions. After a transfusion, TRALI develops in 0.08-15% of cases depending on the characteristics of the studied population.
- Trial name
- CURIE (NCT06444750)
- Testing
- Blood sample collection
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Premature Birth, Asthma in Children
Post-Vent, the Sequelae: Personalized Prognostic Modeling for Consequences of Neonatal Intermittent Hypoxemia in Preterm Infants at Pre-School Age
Despite improved survival of extremely premature infants in recent decades, neonatal intensive care unit (NICU) graduates are diagnosed with asthma, sleep disordered breathing (SDB) in childhood, and neurodevelopmental…
- Conditions
- Premature Birth, Asthma in Children, Sleep-Disordered Breathing, Neurodevelopmental Disorders
- Trial name
- NCT05336890
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Weaning Invasive Mechanical Ventilation, Weaning-induced Pulmonary Edema
Ultrasound Evaluation of Cardiac Function During Spontaneous Breathing Trials
The goal of this clinical trial is to evaluate the evolution of a cardiac ultrasound index (E/E') during 3 spontaneous breathing trials in Intensive Care Unit (ICU) adults (over 18 years) patients at risk for weaning failure.
- Conditions
- Weaning Invasive Mechanical Ventilation, Weaning-induced Pulmonary Edema, Weaning Failure of Mechanical Ventilation, Spontaneous Breathing Test
- Trial name
- ATARI (NCT06923267)
- Testing
- No Pressure Support No Positive End Expiratory Pressure Spontaneous Breathing Trial, Pressure Support Spontaneous Breathing trial, Humidified High Flow Spontaneous Breathing Trial
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Respiratory Insufficiency, Circulatory Failure
Comparing Anticoagulation Strategies Using UFH, Argatroban and LMWH for ECMO Support
A three-arm randomized controlled non-inferiority pilot study comparing anticoagulation strategies using unfractionated heparin, argatroban and enoxaparin for extracorporeal membrane oxygenation support conducted as an…
- Conditions
- Respiratory Insufficiency, Circulatory Failure, Thromboembolism, Bleeding
- Trial name
- CASUAL-ECMO (NCT06442267)
- Testing
- Enoxaparin Injectable Solution, Argatroban, 1 Mg/mL Intravenous Solution, Unfractionated heparin
- Where
- Austria
- Volunteers
- 90 people
- Sponsor
- Medical University of Vienna
Post-Acute COVID-19 Syndrome
Exercise Training Using an App on Physical Cardiovascular Function Individuals With Post-covid-19 Syndrome
The aim of this study is to assess the effect of a physical exercise program via a mobile application on functional parameters in individuals with post-COVID-19 syndrome.
- Trial name
- Recovery (NCT06168006)
- Testing
- Exercise, Control
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Nove de Julho
Respiratory Distress Syndrome, Mechanical Ventilation Complication
Nebulized Furosemide, Heparin, Hypertonic Saline in Mechanically Ventilated Acute Respiratory Distress Syndrome Adult Patients
There are no specific drugs or therapies available to directly treat/prevent ARDS. Mechanical ventilation with an aim to minimize Ventilator Induced Lung Injury (VILI) and management of refractory hypoxemia are the keystones in…
- Trial name
- NCT07286409
- Testing
- nebulization
- Where
- Egypt
- Volunteers
- 344 people
- Sponsor
- Tanta University
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