Clinical trials: Respiratory Inflammation
Critical Illness, Sepsis
Enteral Glutamine in Critical Illness
Glutamine is an amino acid which is rapidly depleted in critical illness. It is used as energy by cells that line the gut, vital for immune system function, and works as an anti-oxidant.
- Conditions
- Critical Illness, Sepsis, Respiratory Insufficiency
- Trial name
- NCT00318331
- Testing
- Glutamine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Christiana Care Health Services
Decrease of Inflammation of Adipose Tissue, Sleep Apnea Syndrome
Inflammation and Oxidative Stress of Adipose Tissue in Sleep Apnea Syndrome
The main objective of this study is to evaluate the decrease of inflammation of adipose tissue in obese and non-obese patients having a sleep apnea syndrome and treated or not by continuous positive airway pressure (cPAP).
- Trial name
- ADISAS (NCT01196845)
- Testing
- cPAP
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Grenoble
Sepsis, Respiratory Failure
The Effect of Intensive Insulin Therapy in the Surgical Critical Care Unit
We sought to determine if there is a benefit to using an insulin drip to control hyperglycemia in the surgical critical care unit for patients who undergo general and vascular surgery.
- Conditions
- Sepsis, Respiratory Failure, Renal Failure, Surgical Site Infection
- Trial name
- NCT00282594
- Testing
- Novolin R (human recombinant Insulin)
- Where
- United States
- Volunteers
- 317 people
- Sponsor
- Genesys
Respiratory Infections in Old Age, Bacteremia
Infectious Diseases in Aged Population
The increasing number of persons >65 years of age form a special population at risk for nosocomial and other health care-associated infections.
- Trial name
- AEQUI (NCT04825132)
- Testing
- Geriatric assessment tools
- Where
- 22 sites in France, Italy and 1 more
- Volunteers
- 521 people
- Sponsor
- University Hospital, Grenoble
Sepsis, Infective Endocarditis
Study of Leukocyte Immunophenotype and the Lipid Transport System as Predictive Biomarkers of Severe Bacterial Infections
Current study evaluates the relationship between cell immunity and lipid transport systems in patients with severe bacterial infections (on the model of pneumonia, infective endocarditis, sepsis) in order to develop new methods…
- Conditions
- Sepsis, Infective Endocarditis, Pneumonia, Bacterial
- Trial name
- NCT04178915
- Testing
- Bood leukocyte subsets, The cholesterol content of the cell membrane of T-cells and monocytes
- Where
- Belarus
- Volunteers
- 100 people
- Sponsor
- The Republican Research and Practical Center for Epidemiology and Microbiology
Bronchiectasis
Sputum Microbiota and the Association With Clinical Parameters in Steady-state, Acute Exacerbation and Convalescence of Bronchiectasis
Study 1 is a cross-sectional investigation. Patients with clinically stable bronchiectasis (symptoms, including cough frequency, sputum volume and purulence, within normal daily variations) will undergo baseline assessment…
- Trial name
- BISER-2 (NCT02315547)
- Testing
- Antibiotics
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Guangzhou Institute of Respiratory Disease
Allergic Rhinitis, Allergy
Pollutant Altered Allergic Responses
This study is designed to investigate whether exposure to particulate air pollution increases the allergic response to allergens.
- Trial name
- NCT00011440
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Asthma
A Phase IIA FF/VI Study to Measure FeNO in Asthmatic Patients.
For asthmatic subjects, a combination of inhaled corticosteroid (FF) and long-acting beta2 receptor agonist (VI) is recommended for use (once daily) and fraction of exhaled nitric oxide (FeNO) is a non-invasive airway…
- Trial name
- NCT02712047
- Testing
- Fluticasone furoate (FF) (100 mcg), Vilanterol (VI) (25 mcg)
- Where
- New Zealand
- Volunteers
- 28 people
- Sponsor
- GlaxoSmithKline
Sepsis, Renal Failure
The Prevention of Failure to Rescue Using Early Warning Scoring
The purpose of this study is to assess if, compared with standard paper-based systems, an automated Early Warning System (EWS) resident in a spot check patient monitor, can help to identify deteriorating patients.
- Conditions
- Sepsis, Renal Failure, Pulmonary Edema, Cardio-pulmonary Arrest
- Trial name
- VitalCare (NCT01197326)
- Testing
- use of the MP5 EWS patient monitor
- Where
- Australia
- Volunteers
- 414 people, healthy volunteers welcome
- Sponsor
- Philips Healthcare
COVID-19
The Safety & Efficacy of Imatinib for the Treatment of SARS-COV-2 Induced Pneumonia
A randomized controlled pilot study on the safety \& efficacy of imatinib for the treatment of patient with moderate to severe SARS-COV-2 induced pneumonia.
- Trial name
- NCT04422678
- Testing
- Imatinib Mesylate, Standard of Care
- Volunteers
- 30 people
- Sponsor
- Alexandria University
Sepsis, ARDS (Acute Respiratory Distress Syndrome)
Research on Risk Assessment and Early Warning Models for Adverse Clinical Outcomes in Critically Ill Patients
This is a medical research study that uses information from past patient hospital records. It focuses on three serious conditions that often affect critically ill patients: sepsis (a life-threatening body-wide infection), ARDS (a…
- Conditions
- Sepsis, ARDS (Acute Respiratory Distress Syndrome), AKI - Acute Kidney Injury
- Trial name
- NCT07317817
- Testing
- No intervention (Observational study)
- Where
- China
- Volunteers
- 55,940 people
- Sponsor
- Chongqing Medical University
Lung Neoplasm, Adult ALL
LUS to Assess Lung Injury After Lung Lobectomy
The purpose of the study is to assess whether lung ultrasound is able to detect lung injury after lung resection surgery.
- Conditions
- Lung Neoplasm, Adult ALL, Lung Injury, Lung Inflammation
- Trial name
- OPEN THORUS (NCT04755478)
- Testing
- Thoracotomy, VATS
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Hospital General Universitario de Valencia
Sepsis, ARDS
Multicenter Prospective Cohort of Sepsis and ARDS in China
This prospective, multicenter, observational cohort study enrolls 6,000 adults with sepsis and/or acute respiratory distress syndrome (ARDS) at multiple hospitals in China.
- Trial name
- NCT07863908
- Testing
- Surveys, 6-Minute Walk Test, Blood collection
- Where
- 24 sites in China
- Volunteers
- 6,000 people
- Sponsor
- Shanghai Zhongshan Hospital
Atopic Keratoconjunctivitis
An Efficacy and Safety Study of DFL24498 in the Treatment of AKC
This is a phase 3, multicenter, randomized, double-masked, parallel-group, vehicle-controlled study to evaluate the safety and efficacy of DFL24498 compared with vehicle ophthalmic solution, in participants with AKC.
- Trial name
- NCT07395232
- Testing
- DFL24498, Vehicle, dexamethasone sodium phosphate (DSP) ophthalmic solution
- Where
- 19 sites in United States, Italy and 1 more
- Volunteers
- 153 people
- Sponsor
- Dompé Farmaceutici S.p.A
Pulmonary Disease, Chronic Obstructive
Effects of Liraglutide in Chronic Obstructive Pulmonary Disease
The study is a 44 weeks, prospective, randomized, placebo-controlled, double-blinded, parallel group two-center trial. Forty patients are recruited among the outpatients of the chronic obstructive pulmonary disease (COPD) clinic…
- Trial name
- NCT03466021
- Testing
- Liraglutide
- Where
- 2 sites in Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Claus Bogh Juhl
Sepsis
Can Respiratory Rate Predict the Risk of Deterioration of Septic Patients
The primary objective is to determine if the trend in Respiratory Rate measurements provided by the device under investigation can be used to predict an increase in Sequential/Sepsis-related Organ Failure Assessment (SOFA) score.
- Trial name
- NCT03752047
- Where
- Denmark
- Volunteers
- 132 people
- Sponsor
- PMD Solutions
Bacteremia, Healthcare-associated Pneumonia
Randomized-controlled Trial (RCT) on Combination Antibiotic for Infections Caused by Gram-negative Bacteria
Background and rationale: Antimicrobial resistance is a global public health threat. An increasing number of Gram-negative bacteria isolates worldwide are resistant to virtually all antibiotics including carbapenems.
- Conditions
- Bacteremia, Healthcare-associated Pneumonia, Ventilator-associated Pneumonia
- Trial name
- XDR-GNB (NCT02134106)
- Testing
- Polymyxin B, Polymyxin B + Doripenem
- Where
- 2 sites in Singapore
- Sponsor
- Tan Tock Seng Hospital
Diabetic Ketoacidosis, Heart Disease, Ischemic
Effectiveness of Music Intervention on Anxiety and Physiological Responses in Critical Ill Patient
Music intervention is a non-pharmacological and effective intervention that can alleviate anxiety and agitation in patients undergoing weaning.
- Conditions
- Diabetic Ketoacidosis, Heart Disease, Ischemic, Stroke, GastroIntestinal Bleeding
- Trial name
- NCT04977011
- Testing
- relaxing music
- Where
- Taiwan
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Min-Sheng General Hospital
COPD
Evaluation Inhaled Corticosteroids on Exhaled Nitric Oxide Gas Exchange
To evaluate the role of inhaled corticosteroids to suppress nitric oxide gas exchange in stable patients with moderate-to-severe COPD who are current non-smokers and not on oral corticosteroids.
- Trial name
- NCT00568347
- Testing
- fluticasone 100mcg/ salmeterol 50mcg, fluticasone 250/salmeterol 50, salmeterol
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Arthur F Gelb MD
Congenital Diaphragmatic Hernia
Airway Inflammation in Congenital Diaphragmatic Hernia Patients
We propose to examine Congenital Diaphragmatic Hernia (CDH) patients for evidence of airway inflammation as a first step to characterize the reported bronchodilator responsiveness.
- Trial name
- NCT02453750
- Testing
- Hypersaline, Bronchodilator Response
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- The Hospital for Sick Children
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