Clinical trials: Respiratory Inflammation
Chronic Obstructive Pulmonary Disease (COPD)
Nitric Oxyde Concentration in Chronic Obstructive Pulmonary Disease Patients - SANOB Study
Among many other causes, Bronchial obstruction in Chronic Obstructive Pulmonary Disease (COPD) is also caused by inflammation of peripheral airways walls.
- Trial name
- SANOB (NCT01853787)
- Testing
- Formoterol Fumarate, Salmeterol
- Where
- 2 sites in Italy
- Volunteers
- 49 people
- Sponsor
- University of Milan
Rhinitis, Allergic, Seasonal, Seasonal Allergic Rhinitis
Trial With Rhinitic Patients Taking GSK256066 Versus Placebo In A Pollen Challenge Chamber
This study is in patients with seasonal allergic rhinitis(SAR)and will compare the effect versus placebo of repeat doses of intranasal GSK256066 using the Vienna Challenge Chamber.
- Trial name
- NCT00377728
- Testing
- GSK256066
- Where
- Austria
- Volunteers
- 44 people
- Sponsor
- GlaxoSmithKline
Long COVID
Effect of Red Beetroot Juice Intake in Adults With Long COVID-19
Red beetroot juice may have positive effects on multiple pathways involved in long COVID. The aim of this pilot study was to explore the impact of beetroot juice supplementation on physical function, gut microbiota, and systemic…
- Trial name
- NCT06535165
- Testing
- Red Beetroot Juice
- Where
- Italy
- Volunteers
- 31 people
- Sponsor
- Catholic University of the Sacred Heart
Premature Birth, Fragility
Wireless MicroPremVitals Button Sensor in the NICU
A wireless and miniaturized vital sign (ECG, SpO2, Skin Temperature) sensor system, MicroPremVitals Button Sensors was developed by the Dr.
- Conditions
- Premature Birth, Fragility, Apnea of Prematurity, Bradycardia Neonatal
- Trial name
- NCT07732257
- Testing
- Wireless MicroPremVitals Button Sensor System
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Brain Tumor, Metabolic Disturbance
Effect of Dexmedetomidine on Brain Homeostasis and Neurocognitive Outcome
Brain tumor surgery is commonly associated with different degrees of preoperative intracranial hypertension and surrounding tumor edema, elicited by tumor underlying pathophysiology.
- Conditions
- Brain Tumor, Metabolic Disturbance, Inflammatory Response, Oxygen Deficiency
- Trial name
- NCT04266665
- Testing
- Dexmedetomidine, Normal saline
- Where
- Greece
- Volunteers
- 56 people
- Sponsor
- Georgia Tsaousi
Pulmonary Disease, Chronic Obstructive
A Pilot Study of the Mechanism of Synergism Between FP and Salmeterol in Preventing COPD Exacerbations
The purpose of this study is to evaluate the blood and airway of subjects with mild to moderate COPD while undergoing standard treatment.
- Trial name
- NCT00116402
- Testing
- fluticasone and salmeterol
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Chicago
Healthcare-Associated Pneumonia, Sepsis
Trial of Antimicrobial Restraint in Presumed Pneumonia
The objective of this cluster-randomized crossover study is to determine the effect of delaying antimicrobial initiation until objective microbiologic data is obtained in patients with presumed ICU-acquired pneumonia without…
- Trial name
- TARPP (NCT04438187)
- Testing
- antimicrobial initiation
- Where
- United States
- Volunteers
- 186 people
- Sponsor
- University of Kansas Medical Center
Asthma
Determining the Optimal Adenosine Provocation Test
Asthma is a frequently occurring inflammatory lung disease that affects the whole bronchial tree including the small airways (<2mm).
- Trial name
- impact (NCT01610921)
- Testing
- Bronchial provocation test
- Where
- 2 sites in Netherlands
- Volunteers
- 11 people
- Sponsor
- University Medical Center Groningen
Allergic Rhinitis
Effect of Laser Acupuncture Alone or Combined With Pranayama Exercise on Inflammation in Allergic Rhinitis
Allergic rhinitis (AR) represents one of the most common global health problems with seriously increasing incidence over the last decades.The goal of the treatment of rhinitis is to prevent or reduce the symptoms through…
- Trial name
- NCT05553483
- Testing
- pranayama plus acupoint stimulation by laser, acupoint stimulation by laser
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Covid19, COVID-19 Lower Respiratory Infection
In-patient COVID-19 Study of Intranasal Foralumab
This is a Phase 2, randomized, placebo-controlled, double-blind, proof-of-concept study of intranasal foralumab in hospitalized subjects with severe COVID-19 and pulmonary inflammation.
- Conditions
- Covid19, COVID-19 Lower Respiratory Infection, COVID-19 Respiratory Infection
- Trial name
- NCT04983446
- Testing
- Foralumab
- Sponsor
- Tiziana Life Sciences LTD
PICS
Impact of Persistent Inflammation-Immunosuppression-Catabolism Syndrome (PICS) on the Respiratory Physiology in Patients With Prolonged Mechanical Ventilation
Past research on PICS has mainly focused on the predictability and prognosis of PICS occurrence in ICU patients. Still, there is currently insufficient research on the role of PICS in the care setting of patients who have…
- Trial name
- NCT07002710
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taiwan University Hospital
Exercise Induced Asthma
Study of Airway Inflammation in Relation to Exercise in Elite Athletes
High school elite training programs are today more and more under development in several 'elite sport schools' in Belgium, in order to select and train future elite athletes already at young age.
- Trial name
- NCT01942096
- Where
- Belgium
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Acute Respiratory Distress Syndrome, Inflammation
Dexmedetomidine to Improve Outcomes of ARDS in Critical Care COVID-19 Patients
A continuous infusion of Dexmedetomidine (DEX) will be administered to 80 patients admitted to Critical Care because of signs of Respiratory Insufficiency requiring non-invasive ventilation.
- Conditions
- Acute Respiratory Distress Syndrome, Inflammation, Dexmedetomidine, Cytokine Storm
- Trial name
- COVID-DEX (NCT04358627)
- Testing
- Dexmedetomidine Injectable Product
- Volunteers
- 80 people
- Sponsor
- Hospital Clinic of Barcelona
Hospital Acquired Pneumonia, Ventilator-Associated Pneumonia
Hospital-acquired Pneumonia in Intensive Care Unit
hospital-acquired pneumonia are a common disease in intensive care unit. The prevention, the diagnosis and the treatment of hospital acquired pneumonia are a frequent challenge.
- Conditions
- Hospital Acquired Pneumonia, Ventilator-Associated Pneumonia, Sepsis, Pneumonia
- Trial name
- PNEUMOCARE (NCT03348579)
- Testing
- Guidelines publication and application, Targeted experience feedback
- Where
- France
- Volunteers
- 1,850 people
- Sponsor
- Nantes University Hospital
Inflammation, Vasculitis
Steroids and Methotrexate to Treat Systemic Vasculitis
This study will evaluate the safety and effectiveness of prednisone and methotrexate in treating severe Wegener's granulomatosis and other systemic vasculitides.
- Conditions
- Inflammation, Vasculitis, Wegener's Granulomatosis
- Trial name
- NCT00001256
- Testing
- prednisone and methotrexate
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Parapneumonic Effusion, Empyema, Pleural
Treatment of Complicated Parapneumonic Effusion With Fibrinolytic Therapy Versus VATs Decortication
This study aims to standardize the treatment of pleural space (parapneumonic) infections by comparing the difference in outcomes between 2 methods of treatment: early VATS (Video Assisted Thorascopic Surgery) decortication versus…
- Conditions
- Parapneumonic Effusion, Empyema, Pleural, Coagulopathy
- Trial name
- NCT03583931
- Testing
- VATS Decortication, Fibrinolytic Therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Denver Health and Hospital Authority
Acute Respiratory Distress Syndrome, Septic Shock
Organ-substituting Technologies in the Treatment of Heart and Pulmonary Failure
The implementation of this project will improve the effectiveness of surgical treatment and reduce the level of complications and mortality among patients with heart failure and heart failure in the terminal stage.
- Conditions
- Acute Respiratory Distress Syndrome, Septic Shock, Sepsis
- Trial name
- OST (NCT05042622)
- Testing
- Cytokine adsorber filter, Extracorporeal hemoperfusion cartridge
- Where
- Kazakhstan
- Volunteers
- 90 people
- Sponsor
- National Research Center for Cardiac Surgery, Kazakhstan
Pulmonary Sarcoidosis
Efficacy and Safety of Intravenous Efzofitimod in Patients With Pulmonary Sarcoidosis
This is a multicenter, randomized, double-blind, placebo-controlled, study comparing the efficacy and safety of intravenous (IV) efzofitimod 3 mg/kg and 5 mg/kg versus placebo after 48 weeks of treatment.
- Trial name
- NCT05415137
- Testing
- Efzofitimod 3 mg/kg, Efzofitimod 5 mg/kg
- Where
- 91 sites in United States, Brazil and 7 more
- Volunteers
- 268 people
- Sponsor
- aTyr Pharma, Inc.
Signs and Symptoms, Respiratory
Improved Patient Safety Through Continuous Bi-channel RR and SpO2 Monitoring With Masimo Patient SafetyNet
The investigator intend to perform an observational study, by adding Respiratory Rate monitoring to an already existing Patient SafetyNet system with SpO2 (Oxygen Saturation) and PR (Pulse Rate) monitoring.
- Trial name
- SafetyNet (NCT03043911)
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Baylor Research Institute
Coronavirus Infections, Pneumonia, Viral
Colchicine Counteracting Inflammation in COVID-19 Pneumonia
Cytokines and chemokines are thought to play an important role in immunity and immunopathology during virus infections [3]. Patients with severe COVID-19 have higher serum levels of pro-inflammatory cytokines (TNF-α, IL-1 and…
- Trial name
- ColCOVID-19 (NCT04322565)
- Testing
- Colchicine
- Where
- Italy
- Volunteers
- 193 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Parma
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.