Clinical trials: Respiratory Inflammation
Cystic Fibrosis
Intestine-lung Axis of Cystic Fibrosis Patients Treated With the Combination Elexacaftor/Tezacaftor/Ivacaftor
Cystic fibrosis is a systemic disease, which affects in particular the respiratory and digestive systems of patients, sites of chronic inflammation.
- Trial name
- KAF-BIOTA (NCT05937815)
- Testing
- Sample collection
- Where
- 15 sites in France
- Volunteers
- 253 people
- Sponsor
- University Hospital, Bordeaux
Gastroenteritis, Bronchiolitis
Isotonic Versus Hypotonic Fluid for Maintenance IV Therapy
Hyponatremia associated with administration of hypotonic intravenous (IV) fluids may have serious complications. It has recently been suggested that isotonic saline may be a more appropriate choice of maintenance IV fluid.
- Conditions
- Gastroenteritis, Bronchiolitis, Sepsis, Urinary Tract Infection
- Trial name
- NCT00457873
- Testing
- 0.9% saline in 5% dextrose (intravenous), 0.45% saline in 5% dextrose (intravenous)
- Where
- Canada
- Volunteers
- 38 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Sepsis, Mechanical Ventilation
Respiratory Muscle Dysfunction in Critically Ill Patients
Respiratory muscle dysfunction in critically ill patients is associated with elevated morbidity, including prolonged weaning from mechanical ventilation.
- Trial name
- NCT01104857
- Testing
- diaphragm muscle biopsy
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- University Medical Center Nijmegen
Hyperactivity, Chronic Rhinosinusitis (Diagnosis)
Prevalence of Nasal Hyperreactivity in Chronic Upper Airway Inflammation
Rhinitis, or inflammation of the nasal mucosa, can present with nasal obstruction, nasal discharge, itch or sneezing. If the sinusal mucosa is involved as well, it is called rhinosinusitis and facial pain or loss of smell is…
- Conditions
- Hyperactivity, Chronic Rhinosinusitis (Diagnosis), Chronic Rhinitis, Upper Respiratory Disease
- Trial name
- NCT03893227
- Testing
- Questionnaire
- Where
- Belgium
- Volunteers
- 756 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Acute Respiratory Failure, Encephalopathy
Novel Arm Restraint For Critically Ill Patients To Reduce Immobility, Sedation, Agitation and Cognitive Impairment
This study evaluates a novel arm restraint compared with traditional soft wrist restraints in older critically ill patients. The primary outcome is upper extremity mobility measured by actigraphy, and secondary outcomes include…
- Conditions
- Acute Respiratory Failure, Encephalopathy, ARDS, Sepsis
- Trial name
- NCT04067622
- Testing
- Exersides
- Where
- 3 sites in United States
- Volunteers
- 58 people
- Sponsor
- University of Vermont
Rhinitis, Allergic, Seasonal, Seasonal Allergic Rhinitis
Trial With Allergic Rhinitis Patients Taking GSK256066 Versus Placebo In A Pollen Challenge Chamber
This study is in patients with seasonal allergic rhinitis (SAR) and will compare the effect versus placebo of repeat doses of intranasal GSK256066 using the Vienna Challenge Chamber.
- Trial name
- NCT00430157
- Testing
- GSK256066
- Where
- Austria
- Volunteers
- 45 people
- Sponsor
- GlaxoSmithKline
Inflammatory Response, Symptoms and Signs
CANDLE - A Study of Acute Health Effects of Exposure to Particles Generated by Candles
INTRODUCTION: Particle contamination is suggested to have substantial negative effects on health, with candles emitting huge amount of particles, thus being one of the largest contributors to indoor air pollution.
- Trial name
- NCT04864600
- Testing
- Candle C, Candle 1
- Where
- Denmark
- Volunteers
- 17 people
- Sponsor
- University of Aarhus
Pneumonia, Bacterial
Study Evaluating Streptococcus Pneumoniae Serotype Carriage Rate for Nasopharyngeal Carriage in Filipino Children
Evaluation of the carriage rate of Streptococcus pneumoniae in the nasopharynx of healthy children and the carriage rate and distribution of Streptococcus pneumoniae serotypes
- Trial name
- NCT00724828
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Rheumatoid Arthritis, Ankylosing Spondylitis
PatientSpot Formerly Known as ArthritisPower
Patient Power is a patient research network and database (registry) to collect prospective information about demographics, self-reported diagnoses and medications, and willingness to participate in research from participants with…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Fibromyalgia, Gout
- Trial name
- NCT03840928
- Where
- United States
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- Global Healthy Living Foundation
Bronchiectasis
Cardiovascular Comorbidities and Bronchiectasis
Bronchiectasis have multiple etiologies but share a similar bronchial injury associated with inflammation, which leads to a progressive lung deterioration.
- Trial name
- BRONCOCA (NCT02804971)
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Allergic Rhinitis
Effects of Hypertonic Saline Solution (NACL 3%+NAHCO3) on Nasal Inflammation in Children With AR. RinASol- Pilot Study
The main objective of RinASol project is to assess in patients with seasonal Allergic Rhinitis the effect of hypertonic saline solution NACL 3%+NAHCO3 vs the effect of standard saline solution on nasal inflammation by means of…
- Trial name
- RinASol (NCT02729012)
- Testing
- hypertonic saline solution (NACL 3%+NAHCO3), Saline Solution (NACL 0,9%)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Stefania La Grutta, MD
Asthma
The Effect of Asthma on Systemic Inflammation, Oxidative Stress and Cardiovascular Morbidity
Asthma is a chronic airway inflammation which involves the interplay of different types of inflammatory cells and cytokines in the airway.
- Trial name
- NCT00957281
- Where
- 4 sites in Hong Kong
- Volunteers
- 748 people
- Sponsor
- The University of Hong Kong
Asthma, Chronic Rhinosinusitis
Analysis of Inflammation and Microbiome in Patients With Sinusitis and Asthma
This is a cross-sectional, non-interventional study, consisting of three study arms, (1) Full Characterization (AIMS-Full), (2) Surgery Arm (AIMS-OR), and (3) Mucus Collection (AIMS-M).
- Trial name
- AIMS (NCT02548598)
- Testing
- Endoscopic sinus surgery
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of California, San Francisco
Pneumonia, Necrotizing, Lung Abscess
Complicated Pneumonia (CP) in Children in South-East Europe
This retrospective observational study aims to evaluate clinical course of complicated community acquired pneumonia in children, particularly focusing on necrotizing pneumonia cases, as well as determination of etiological agents…
- Conditions
- Pneumonia, Necrotizing, Lung Abscess, Empyema, Pleural
- Trial name
- CP (NCT06657898)
- Where
- Serbia
- Volunteers
- 300 people
- Sponsor
- Aleksandar Sovtic
Asthma, Inflammation
Effect of Fasting and Refeeding on T-cell Fate
Background: Researchers want to better understand the body s immune response to calorie restriction. To do this, they are asking healthy volunteers to fast for 24 hours.
- Trial name
- NCT02719899
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
COVID-19 Acute Respiratory Distress Syndrome, Cytokine Release Syndrome
Safety and Effectiveness of Cyclosporin in the Management of COVID19 ARDS Patients in Alexandria University Hospital
The study to evaluate the effect of cyclosporine ( IL2 inhibitor and antiviral) verse standard care treatment on decrease ADRS, hyper inflammation, hypercytokinemia, and the mortality rate
- Conditions
- COVID-19 Acute Respiratory Distress Syndrome, Cytokine Release Syndrome, Pulmonary Fibrosis
- Trial name
- NCT04979884
- Testing
- cyclosporine
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Alexandria University
Lung Disease, Inflammation
Study of Biologic Materials From the Mediastinal Lymph Nodes From Patients With Lung Disease.
The purpose of this protocol is to obtain biologic materials from the mediastinal lymph nodes from patients with lung disease and mediastinal lymph node involvement in order to: (1) develop a better understanding of the cause and…
- Conditions
- Lung Disease, Inflammation, Lung Cancer, Sarcoidosis
- Trial name
- NCT02168036
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Weill Medical College of Cornell University
Asthma
Influence of Diesel Exhaust Particles (DEP) With and Without Organic Compounds on the Allergic Inflammation in Asthmatic Subjects
The primary objective of this study is to elucidate the effects of Diesel particles on the allergic inflammation in the airways of asthmatic patients.
- Trial name
- NCT00773487
- Testing
- Bonchoscopy
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- Fraunhofer-Institute of Toxicology and Experimental Medicine
Bronchial Asthma
A Study to Assess the Efficacy of Inhaled Corticosteroid (ICS) Therapy in Moderate-Severe Bronchial Asthma
The purpose of this study is to investigate/assess the treatment of moderate to severe asthmatics with inhaled corticosteroid.
- Trial name
- NCT00411567
- Testing
- inhaled corticosteroid therapy
- Where
- Germany
- Volunteers
- 26 people
- Sponsor
- Novartis
Shock
GapCO2 and Respiratory Rate in Patients Under Volume Mechanical Ventilation
As an approximate of the difference between venous-to-arterial CO2 tension (∆PCO2), ∆PCO2 is proportional to CO2 production and inversely related to cardiac output (Fick equation).
- Trial name
- gapCO2 (NCT02867943)
- Testing
- Effects of respiratory rate on gapCO2
- Volunteers
- 28 people
- Sponsor
- 105 Hospital of Chinese People's Liberation Army
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