Clinical trials: Respiratory Muscle Blood Flow
Cystic Fibrosis
Blood Flow and Vascular Function in Cystic Fibrosis
Cystic fibrosis (CF) has many health consequences. A reduction in the ability to perform exercise in patients with CF is related to greater death rates, steeper decline in lung function, and more frequent lung infections.
- Trial name
- CF-FLOW (NCT02057458)
- Testing
- Sildenafil (Acute-1 hour), Sildenafil (Subchronic-4 weeks)
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Augusta University
Type 1 Diabetes
Inspiratory Muscle Strength Training in Adults With Type 1 Diabetes
Adults with type 1 diabetes have elevated cardiovascular disease risk, and systolic blood pressure is a leading modifiable contributor to that risk.
- Trial name
- NCT07859943
- Testing
- High-Resistance Inspiratory Muscle Strength Training
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Florida State University
Type 2 Diabetes
RESIST! Blood-flow Restriction Resistance Training for Improving Insulin Sensitivity in Type 2 Diabetes
The study aims to investigate the metabolic and cardiovascular effects of classical resistance training with high loads and blood-flow restricted training (BFRT) with low loads in individuals with type 2 diabetes over 12 weeks.
- Trial name
- RESIST (NCT04222231)
- Testing
- Blood-flow restriction resistance training, Classical resistance training
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- German Diabetes Center
Chronic Obstructive Pulmonary Disease (COPD), Blood Flow Restriction Training (BFRT)
Effects Of Low-Load Blood Flow Restriction Training Of The Upper Extremity In Patients With Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease (COPD) is characterized by persistent airflow limitation, progressive dyspnea, and peripheral muscle dysfunction, significantly impairing functional capacity and quality of life.
- Trial name
- NCT07469111
- Testing
- Low-Load Blood Flow Restriction Training (LL-BFRT) + Aerobic Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Inonu University
Intermittent Claudication
The Relationship Between Peripheral Arterial Disease and Mitochondrial Respiratory Capacity
Current evidence cannot explain the clinical features of peripheral arterial disease only from the principle of reduced blood flow.
- Trial name
- NCT02434783
- Where
- Norway
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Interstitial Lung Disease (ILD)
Acute Hemodynamic Responses to Blood Flow Restriction Aerobic Exercise in Interstitial Lung Disease
Interstitial lung diseases (ILD)impaired gas exchange and reduced lung elasticity lead to marked reductions in exercise capacity and decreased oxygen consumption due to circulatory limitations.
- Trial name
- NCT07315425
- Testing
- Blood flow restriction (BFR) low-intensity aerobic exercise training, Low-intensity aerobic exercise training
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Gazi University
Sarcopenia, Lung Neoplasms
Construction and Effect Evaluation of the Low Load Blood Flow Restriction Training Program for Lung Cancer Patients Complicated With Sarcopenia During Chemotherapy
The goal of this clinical trial is to verify the effectiveness and safety of the low load blood flow restriction training program.
- Trial name
- NCT06347965
- Testing
- Low load blood flow restriction training, Progressive resistance training group
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Xin Wang
Respiratory Muscle Blood Flow
Clinical Respiratory Evaluation Using Spectroscopy Trial
Respiratory muscles (the muscles used to breathe) need more blood (and oxygen) when their workload increases. It is difficult to measure respiratory muscle blood flow (RMBF) without invasive techniques.
- Trial name
- CREST (NCT01321411)
- Testing
- Near Infrared Spectroscopy
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of British Columbia
Control Condition, Pulmonary Disease (COPD), Chronic Obstructive
Acute Muscular and Vascular Responses to a Single Session of Exercise With BFR in COPD
Exercise training is a cornerstone of pulmonary rehabilitation (PR) in patients with chronic obstructive pulmonary disease (COPD). However, some patients derive limited benefits from conventional exercise programs.
- Conditions
- Control Condition, Pulmonary Disease (COPD), Chronic Obstructive, Blood Flow Restriction Training (BFRT)
- Trial name
- 2BFREE_aigu (NCT07668921)
- Testing
- Blood Flow Restriction, Standard exercise session
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Grenoble
Hypoxia, Altitude, Blood Flow Restriction
Effects of Low-Intensity Blood Flow Restriction Training in Normoxia and Hypoxia Conditions
One approach to significantly reducing resistance training intensity while maintaining effectiveness in muscle mass and strength development involves conducting training sessions under hypoxic conditions.
- Conditions
- Hypoxia, Altitude, Blood Flow Restriction, Resistance Training
- Trial name
- NCT06171841
- Testing
- low-intensity resistance training, high-intensity resistance training, low-intensity resistance training combined with blood flow restriction
- Where
- Poland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Jerzy Kukuczka Academy of Physical Education in Katowice
Dyspnea
Patient Dyspnea Under Veno-arterial Extracorporeal Circulation
Rationale: Patients with severe heart failure increasingly benefit from extracorporeal circulatory assistance (Extracorporeal Membrane Oxygenation - ECMO) that completely replaces the function of the heart and is in addition to…
- Trial name
- DYSCO2 (NCT04815330)
- Testing
- increment sweep gas flow, non-invasive ventilation
- Where
- France
- Volunteers
- 19 people
- Sponsor
- Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil
Emphysema or COPD
Improve Muscle Weakness in Patient With COPD
This randomized controlled trial investigated the effects of combining aerobic exercise with blood flow restriction (BFR) training in patients with emphysematous chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT07649850
- Testing
- Aerobic Exercise Combined with Blood Flow Restriction, Aerobic exercise
- Sponsor
- Al-Zaytoonah University of Jordan
Pulmonary Arterial Hypertension
Peripheral Muscle Microcirculation and Exercise-induced Blood Flow Distribution in Pulmonary Arterial Hypertension
Pulmonary artery hypertension (PAH) is a rare, severe disease, characterized by a progressive increase in pulmonary vascular resistance ultimately leading to right ventricular (RV) failure and premature death.
- Trial name
- NCT01520493
- Testing
- Submaximal exercises
- Where
- 2 sites in Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Laval University
Asthma
Acute Airway Vascular Smooth Muscle Effects of Inhaled Budesonide
Glucocorticosteroids recently have been shown to have non-genomic actions that are plasma membrane-mediated and do not require gene transcription and translation.
- Trial name
- NCT01219738
- Testing
- Budesonide 360ug, Budesonide 720ug, Budesonide 1440ug
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Miami
Age Problem
Relationship Between Respiratory Muscle Strenght, Peripheral Muscle Blood Flow and Gait Speed in the Elderly
The pourpose of this study is to verify if have relationship between respiratory muscle strenght, peripheral muscle blood flow and gait speed in the elderly.
- Trial name
- NCT04559659
- Testing
- Respiratory muscle strength
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hospital Israelita Albert Einstein
Cardiac Surgery With Extracorporeal Circulation, Thoracic Surgery
Evaluation of the Prognostic Value of Preoperative Quadriceps and Respiratory Muscle Thickness by Ultrasound Measurement in Cardiac and Thoracic Surgery Patients
Cardiac and thoracic surgery are major procedures. In order to estimate the operative risk, many scores have been developed, including the Euroscore 2 in cardiac surgery.
- Trial name
- MUSCA (NCT05412095)
- Testing
- Ultrasound of the abdominal wall muscles, Ultrasound quadricipital, Ultrasound of the diaphragm
- Where
- France
- Volunteers
- 301 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Chronic Obstructive Pulmonary Disease, Acute Exacerbation of COPD
Effect of Blood Flow Restriction Resistance Exercises in COPDAE In-patient Rehabilitation
This is a randomised controlled trial of the blood flow restriction resistance exercise (BFR-RE) for early rehabilitation of chronic obstructive pulmonary disease acute exacerbation (COPDAE) in the Haven of Hope Hospital.
- Trial name
- NCT04448236
- Testing
- Blood flow restriction resistance exercise
- Where
- Hong Kong
- Volunteers
- 53 people
- Sponsor
- Hospital Authority, Hong Kong
Asthma
Interactive Acute Smooth Muscle Effects of Salmeterol and Fluticasone in the Airway
The addition of an inhaled long-acting beta-adrenergic agonist to an inhaled glucocorticosteroid improves disease control in persistent asthma.
- Trial name
- NCT01231230
- Testing
- fluticasone, Salmeterol, fluticasone/salmeterol
- Volunteers
- 14 people
- Sponsor
- University of Miami
COPD, Muscle Weakness
Low-load Blood Flow Restriction Training in COPD
Peripheral muscle weakness is a predominant problem in patients with COPD and treated using exercise training in pulmonary rehabilitation.
- Trial name
- LL-BFRT COPD (NCT04151771)
- Testing
- Low-load blood flow restriction training, Usual outpatient pulmonary rehabilitation
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University of Zurich