Clinical trials: Respiratory Physiological Phenomena
Obesity (BMI > 35), Sleeve Gastrectomy
Perioperative Respiratory Function in Sleeve Gastrectomy
This retrospective single-center cohort study aims to evaluate the effects of two intraoperative ventilation strategies on perioperative oxygenation and respiratory outcomes in obese patients undergoing laparoscopic sleeve…
- Conditions
- Obesity (BMI > 35), Sleeve Gastrectomy, Oxygenation, Peep Titration in Lung Protective Ventilation
- Trial name
- NCT07629102
- Testing
- PEEP 8 cmH2O + Recruitment Maneuvers, PEEP 5 cmH2O
- Where
- Turkey (Türkiye)
- Volunteers
- 53 people
- Sponsor
- Istanbul Saglik Bilimleri University
Asthma
Measuring Small-Airways Disease Improvement After Step-up to Extrafine TRIple or High-dose ICS/LABA in Patients Uncontrolled on Medium Dose ICS/LABA eXploring T2 Inflammation
The goal of this observational study is to investigate the change in small airway function through the R5-R19 index in oscillometry at 12 weeks in adults with asthma.
- Trial name
- MATRIX (NCT07372521)
- Volunteers
- 130 people
- Sponsor
- University Hospital, Ioannina
Oxygenation Index
Effects of Different Inhaled Oxygen Concentrations on Lung Function in Older Patients After Laparoscopic Gastrointestinal Surgery Under General Anesthesia
This was a multicenter, prospective, parallel-grouping, randomized controlled clinical study comparing low FiO2 (40%) and high FiO2 (80%) levels in older patients undergoing laparoscopic gastrointestinal surgery.
- Trial name
- NCT06359106
- Testing
- 80% Oxygen, 40% Oxygen
- Where
- 16 sites in China
- Volunteers
- 1,176 people
- Sponsor
- China Medical University, China
Asthma
The Correlations of FeNO, Blood Eosinophils and Lung Function in Well-controlled Asthma
In Asthma, the levels of exhaled FeNO is correlated to sputum eosinophils particularly in the patient with poor controlled asthma or severe asthma.
- Trial name
- NCT04454385
- Testing
- Patients with well controlled asthma
- Where
- Thailand
- Volunteers
- 84 people
- Sponsor
- Hat Yai Medical Education Center
Mechanical Ventilation
Transcutaneous Electrical Diaphragmatic Stimulation in PMV Patients
Muscle atrophy and diaphragm dysfunction are common with prolonged mechanical ventilation (PMV). Electrical stimulation has been shown to be beneficial in severe chronic heart failure and chronic obstructive pulmonary disease.
- Trial name
- NCT04281810
- Testing
- transcutaneous electric diaphragm stimulation
- Where
- Taiwan
- Volunteers
- 59 people
- Sponsor
- Chang Gung Memorial Hospital
Bronchiolitis Obliterans
Bronchial Inflammation in Patients With Bronchiolithis Obliterans
The investigators plan to study the variability of lung function parameters and bronchial inflammatory markers in 20 patients with bronchiolitis obliterans at the age of 6 to 25 years compared with an age- and sex-matched control…
- Trial name
- FRABO-02 (NCT01633385)
- Where
- Germany
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital
Healthy
Hemodynamic and Respiratory Function in Healthy Pregnant Women
This study looks at hemodynamic and respiratory function in healthy pregnant women; it is a longitudinal study.
- Trial name
- NCT00199693
- Where
- Norway
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
COPD, Postural; Defect
Spinal Structure and Mobility in Chronic Obstructive Pulmonary Disease
In recent studies with musculoskeletal system disorders in chronic respiratory patients, it has been reported that postural control is affected in COPD patients.
- Conditions
- COPD, Postural; Defect, Respiratory Function Impaired, Dyspnea
- Trial name
- NCT05021068
- Testing
- Postural Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 98 people
- Sponsor
- Izmir Katip Celebi University
Bronchiectasis Adult
Effect of Roflumilast on Quality of Life, Lung Function and Mucus Properties in Patients With Bronchiectasis
Although relatively common, bronchiectasis is considered an orphan disease as there is little evidence for adequate treatment, most of the therapeutic options are extrapolated from studies with patients with chronic obstructive…
- Trial name
- NCT03988816
- Testing
- Roflumilast
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo General Hospital
Obesity, Laparoscopic Gastric Bypass Surgery
CURES: The Effect of Deep Curarisation and Reversal With Sugammadex on Surgical Conditions and Perioperative Morbidity
The purpose of this study is to investigate if a deep neuromuscular block with a continuous infusion of rocuronium titrated to a post-tetanic count (PTC) of 1-2 responses combined with reversal of neuromuscular blockade with…
- Conditions
- Obesity, Laparoscopic Gastric Bypass Surgery, Surgical Conditions, Respiratory Function
- Trial name
- CURES (NCT01748643)
- Testing
- deep neuromuscular blockade with rocuronium, reversal with sugammadex, normal neuromuscular blockade reversal with rocuronium, reversal with neostigmine
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Ziekenhuis Oost-Limburg
COPD
Effect of Indacaterol on Inspiratory Capacity and Lung Function in Patients With COPD Versus Placebo and Formoterol
The purpose of this study is to assess the change in inspiratory capacity and lung function in patients with chronic obstructive pulmonary disease when treated with indacaterol compared to placebo and formoterol.
- Trial name
- NCT00422552
- Testing
- Indacaterol (QAB149)
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Novartis
Pulmonary Disease
Implemental Flutter Mucus Clearance Devices on Geriatric Lung Function
The purpose of this study is to evaluate the clinical outcome and safety of flutter mucus clearance devices in elders of gerocomium.
- Trial name
- NCT00881335
- Testing
- flutter mucus clearance device
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tongji University
Asthma, Chest Syndrome
Clinical Characteristics and Treatment of Chest Tightness Variant Asthma
Asthma, abbreviation for bronchial asthma, is one of the common chronic airways disease that threatens human health. Typical symptoms of asthma are recurrent wheezing, shortness of breath, chest tightness and cough, usually…
- Conditions
- Asthma, Chest Syndrome, Clinical Anxiety, Clinical Depression
- Trial name
- NCT04322422
- Testing
- Inhaled corticosteriod/long-acting beta-agonist plus Montelukast, Inhaled corticosteriod/long-acting beta-agonist only
- Where
- 33 sites in China
- Volunteers
- 300 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Asthma
Mechanism(s)of Airflow Limitation in Moderate-severe Persistent Asthma
The purpose of this study is to evaluate the site and mechanisms responsible for expiratory airflow limitation in chronic, treated, non-smoking, stable asthmatics with moderate to severe persistent expiratory airflow obstruction.
- Trial name
- NCT00576069
- Testing
- budesonide/formoterol, fluticasone/salmeterol, mometasone/formoterol
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Gelb, Arthur F., M.D.
Myotonic Dystrophy
Postural Spirometry Changes in Ambulatory Myotonic Dystrophy Patients
Myotonic dystrophy Type 1 (MD1, Steinert's disease), an autosomal dominant multisystem disease, is of the most common muscular dystrophies in adults, with a European prevalence of 3-15/100 000.
- Trial name
- NCT01242007
- Testing
- Supine spirometry
- Where
- France
- Volunteers
- 58 people
- Sponsor
- University of Nancy
Systemic Lupus Erythematosus
Respiratory Function, Physical Activity and Fatigue in SLE
Increasing awareness of possible pulmonary involvement in patients with systemic lupus erythematosus (SLE) will enable earlier diagnosis of the disease and minimize damage accumulation.
- Trial name
- NCT07193745
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Melis Usul
Sepsis, Respiratory Physiological Phenomena
Respiratory Variations for Predicting Fluid Responsiveness
Hypovolemia and acute circulatory failure affects more than 60% of patients hospitalized in intensive care or resuscitation. The volume expansion (VE) by fluid replacement therapy is the first treatment improve circulatory…
- Conditions
- Sepsis, Respiratory Physiological Phenomena, Circulatory Failure
- Trial name
- ReVaPreF (NCT03066362)
- Testing
- Echocardiography-Doppler
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Lille
Bronchiolitis Obliterans, Bone Marrow Transplantation
Effectiveness of Azithromycin Therapy in Improvement of Symptoms and Lung Function in Patients With Bronchiolitis Obliterans After Bone Marrow Transplantation
Bronchiolitis obliterans syndrome (BOS), an obstructive airway disease as a result of chronic rejection, is one of the major causes of morbidity and mortality in long-term survivors of allogeneic bone marrow transplantation…
- Trial name
- NCT00563251
- Testing
- Azithromycin
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Hospital Authority, Hong Kong
Cystic Fibrosis
Strength and Muscle Related Outcomes for Nutrition and Lung Function in CF
The goal of the study is to examine multiple markers of anthropometrics, body composition, sarcopenia and frailty and compare them to dual energy X-ray absorptiometry (DXA) output, which is considered the current clinical…
- Trial name
- NCT05639556
- Testing
- BMI and lean mass index from DXA, Anthropometric Measurements, Hand-grip strength
- Where
- 23 sites in United States
- Volunteers
- 300 people
- Sponsor
- Jaeb Center for Health Research
Pain, Hypoxia
Effects of Static Apnea at Low Lung Volume on Hypoalgesia, Cardiovascular Function and Respiratory Function
The aim of this randomized controlled study is to explore the hypoalgesic response of a 6 minutes of intermittent static apneas training session at low lung volume in healthy subjects; also, as secondary objectives, to analyze…
- Conditions
- Pain, Hypoxia, Hypercapnia, Apnea
- Trial name
- NCT06158256
- Testing
- Voluntary apnoea
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centro Universitario La Salle