Clinical trials: Respiratory Support
Respiratory Failure
Pressure Support Ventilation (PSV) Versus Neurally Adjusted Ventilator Assist (NAVA) During Acute Respiratory Failure (ARF)
Acute respiratory failure (ARF) is a life-threatening emergency which occurs due to impaired gas exchange. In the US, the number of hospitalisations owing to acute respiratory failure was 1,917,910 in the year 2009.(1) The…
- Trial name
- NCT03271671
- Testing
- NAVA during Non invasive ventilation, PSV during Non invasive ventilation
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Extracorporeal Circulation; Complications, Extracorporeal Membrane Oxygenation Complication
Definition and Management of Right Ventricular Injury in Adult Patients Receiving Extracorporeal Membrane Oxygenation
The aim of this study is to identify existing definitions and therapeutic approaches for acute right ventricular injury (RVI) in patients receiving extracorporeal membrane oxygenation (ECMO) for respiratory support.
- Conditions
- Extracorporeal Circulation; Complications, Extracorporeal Membrane Oxygenation Complication, Right Heart Failure, Right Ventricular Dysfunction
- Trial name
- NCT05948332
- Testing
- Delphi Rounds to generate consensus opinions among Experts
- Where
- United Arab Emirates
- Volunteers
- 52 people
- Sponsor
- Prashant Nasa
Lung Diseases
AI in PRImary Care Spirometry Pathways for Diagnosis of Lung Disease (APRIL)
To investigate the feasibility of performing a future real-world randomised controlled trial to determine the clinical effectiveness of ArtiQ.Spiro in supporting diagnostic performance of primary care staff in the interpretation…
- Trial name
- APRIL (NCT05865249)
- Testing
- Spirometry decision support software (ArtiQ.Spiro)
- Where
- 2 sites in United Kingdom
- Volunteers
- 63 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
COVID-19
Acalabrutinib Study With Best Supportive Care in Participants Hospitalized With COVID-19
Study D822FC00005 will investigate the Phamacokinetics, Safety and tolerability of Acalabrutinib suspension when delivered via a nasogastric tube and co-administered with a Proton Pump Inhibitor, in the treatment of COVID-19.
- Trial name
- NCT04497948
- Testing
- Acalabrutinib
- Where
- 4 sites in Brazil
- Volunteers
- 9 people
- Sponsor
- Acerta Pharma BV
COVID-19, Respiratory Failure With Hypoxia
Elmo Respiratory Support Project - COVID-19
The number of COVID-19 cases has been growing exponentially, so that the industrialized economies are facing a significant shortage in the number of ventilators available to meet the demands imposed by the disease.
- Trial name
- NCT04470258
- Testing
- ELMO PROJECT AT COVID-19: STUDY IN HUMANS, ELMO PROJECT AT COVID-19: PROOF OF CONCEPT AND USABILITY
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Escola de Saúde Pública do Ceará
Positive-Pressure Respirations, Respiratory Failure
Inferior Vena Cava Indexes in Positive Pressure Supports
Collapsibility (CI-IVC), distensibility (dIVC) and delta (ΔIVC) indices, which are dynamic measures of inferior vena cava (IVC) diameter, are used to assess the intravascular volume status in critically ill patients.
- Trial name
- NCT03452046
- Testing
- IVC diametres
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Tepecik Training and Research Hospital
Wellness, Burnout, Caregiver
Evaluating the Impact of Resource Navigators to Support LTC and RH Staff During and Beyond COVID-19
The goal of this clinical trial is to test how well resource navigators help long-term care and retirement home staff access the various health and wellness resources available to them and the effects that this has on their…
- Conditions
- Wellness, Burnout, Caregiver, Burnout, Professional, COVID-19
- Trial name
- NCT05677997
- Testing
- Intervention
- Where
- Canada
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Spinal Cord Injuries, Cerebral Palsy
Mobile Health Self-Management and Support System for Chronic and Complex Health Conditions
This study will assess the benefits of using mobile health system designed for individuals with chronic and complex health conditions (such as those with Spinal Cord Injury,Cerebral Palsy, Spina Bifida, and Traumatic Brain…
- Conditions
- Spinal Cord Injuries, Cerebral Palsy, Spinal Dysraphism, Brain Injuries
- Trial name
- NCT02592291
- Testing
- MHealth
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
COVID-19 Pandemic
A Coping and Resilience Intervention in Adolescents
The primary purpose of this study is to assess the feasibility and acceptability of a coping and resilience intervention for adolescents in school settings named CERIA, in the post-coronavirus disease 2019 or COVID-19 era.
- Trial name
- CERIA (NCT05830188)
- Testing
- Coping and Resilience Intervention for Adolescents, Printing materials of Coping and Resilience Intervention for Adolescents
- Where
- Indonesia
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
COPD
Singing for Wellness: Is Singing a Useful Way of Supporting People in South Devon to Self-manage Aspects of Their COPD
The aim of this study is to explore whether singing is a useful way of supporting people in South Devon to self manage aspects of their COPD and associated social isolation.
- Trial name
- NCT04360642
- Testing
- singing
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- Torbay and South Devon NHS Foundation Trust
Carcinoma, Non-Small-Cell Lung
A Randomized Trial to Study the Safety and Efficacy of EGF Cancer Vaccination in Late-stage (IIIB/IV) Non-small Cell Lung Cancer Patients
The vaccine contains humanized recombinant antigen (Epithelial Growth Factor) and an adjuvant. The antibodies induced by vaccination will react with circulating EGF leading to removal of EGF from the circulation.
- Trial name
- NSCLC (NCT01444118)
- Testing
- Therapeutic EGF Vaccine (Cyclophosphamide and the recombinant human rEGF-P64K/Montanide ISA 51 vaccine)
- Where
- United Kingdom
- Sponsor
- Bioven Europe
Hypoxia
Clinical Validation of Vital-PICASO for Predicting Hypoxia Within 24 Hours in General Ward Inpatients
The purpose of this retrospective study is to evaluate the clinical performance of Vital-PICASO, an artificial intelligence-based biological signal analysis software designed to predict the risk of hypoxia within 24 hours using…
- Trial name
- NCT07742813
- Where
- South Korea
- Volunteers
- 2,250 people
- Sponsor
- Huinno AIM
Respiratory Failure
Comparative Effects on Diaphragmatic Electrical Activity and Respiratory Pattern of Various Levels of Assistance
Exploration of the effects on diaphragmatic electrical activity (EMG) and on respiratory pattern of various level of assistance delivered by the ventilator in intubated spontaneously breathing patients in pressure support (PS)…
- Trial name
- NCT01248845
- Testing
- Titration of various level of assistance
- Where
- Switzerland
- Volunteers
- 2 people
- Sponsor
- Prof. Philippe Jolliet
AKI, Renal Replacement Therapy
Hyperoxia vs Normoxia During Cardiopulmonary Bypass
This single-center randomized controlled pilot trial evaluates the effects of intraoperative hyperoxia compared with normoxia during cardiopulmonary bypass (CPB) in adult patients undergoing elective cardiac surgery.
- Conditions
- AKI, Renal Replacement Therapy, NGAL, Arrythmia
- Trial name
- IPEROXIA (NCT07510672)
- Testing
- Hyperoxia group, Normoxia group (control)
- Where
- Italy
- Volunteers
- 104 people
- Sponsor
- University of Padova
Asthma
GeoAsma: Pilot and Evaluation of a Clinical Decision Support System and a Mobile App for the Management of Asthma Patients.
GeoAsma is a study for the definition, validation and evaluation of predictive models on the influence of the environment on asthmatic patients in Andalusia.
- Trial name
- GeoAsma (NCT05639101)
- Testing
- Clinical Decission support system management & mobile App Intervention Group
- Where
- Spain
- Volunteers
- 214 people
- Sponsor
- Hospital Universitario Virgen Macarena
Lung Cancer
Pathways, a Hope Intervention to Support Personal Goal Pursuit, Mental Health, and Quality of Life During Advanced Lung Cancer Treatment
This study will compare the effects of a brief supportive intervention, called Pathways, against enhanced usual care on the mental health and quality of life of people undergoing treatment for advanced lung cancer.
- Trial name
- NCT06047301
- Testing
- Pathways, Enhanced Usual Care
- Where
- United States
- Volunteers
- 234 people
- Sponsor
- Laurie McLouth
Neuroregulation of Breathing
Effects of Abnormal Respiratory Mechanics and Assisted Mechanical Ventilation on Neuro-regulation of Respiration
Due to recent technological improvements, it is now possible to record the electrical activity of the diaphragm (Eadi), a direct expression of the central nervous system respiratory center activity.
- Trial name
- RegAIN (NCT01818219)
- Testing
- Records of EADI derived parameters
- Where
- France
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
COVID-19
CONFIDENT: Supporting Long-term Care Workers During COVID-19
The CONFIDENT Study is an online three-arm randomized trial that aims to help long-term care workers in the United States feel more confident about the Coronavirus Disease 2019 (COVID-19) vaccines.
- Trial name
- NCT05168800
- Testing
- Dialogue-Based Webinar, Social Media Website, Enhanced Usual Practice
- Where
- United States
- Volunteers
- 2,634 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Preterm Birth
Effect of Early Use of Caffeine Citrate in Preterm Neonates
This work is designed to study the effect of the early use of caffeine citrate in preterm neonates who need respiratory support on morbidity and short term neonatal outcome.
- Trial name
- NCT04001712
- Testing
- Caffeine Citrate
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- Ain Shams University
Quality of Health Care, Pulmonary Embolism
Strategies for Suspected Pulmonary Embolism in Emergency Departments
Aims: 1) To evaluate the effectiveness of two interventions aimed at improving the management of patients with suspected pulmonary embolism: Written guidelines and Computer-Assisted Decision Support (CADS).
- Trial name
- NCT00188032
- Testing
- Computer-Assisted diagnostic Decision Support, written diagnostic guidelines, electronic therapeutic reminders
- Where
- 20 sites in France
- Volunteers
- 1,331 people
- Sponsor
- University Hospital, Angers