Clinical trials: Respiratory Support
COVID-19
A Clinical Trial to Determine the Safety and Efficacy of HB-adMSCs to Provide Protection Against COVID-19
Hope Biosciences is conducting a research study of an investigational product called autologous adipose-derived mesenchymal stem cells (abbreviated as HB-adMSCs) to provide immune support against COVID-19.
- Trial name
- NCT04349631
- Testing
- HB-adMSCs
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Hope Biosciences Research Foundation
Atelectasis, Postoperative Pulmonary
Evaluation of the Effects of Different Ventilation Modes Used During Anesthesia Awakening on the Frequency of Postoperative Atelectasis
In our study, we aimed to detect atelectasis developing in patients undergoing surgery under general anesthesia using transthoracic lung ultrasonography and to investigate the effect of ventilation methods used during recovery…
- Trial name
- NCT06358027
- Testing
- lung ultrasound
- Volunteers
- 278 people, healthy volunteers welcome
- Sponsor
- Dokuz Eylul University
Acute Respiratory Failure, Mechanical Ventilation
A Study of Communication Between Clinicians, Patients, and Families in the Intensive Care Unit (ICU)
The purpose of this study is to investigate a specific approach to patient care called a time-limited trial (TLT). This approach is sometimes used for people who develop critical illness and are cared for in an intensive care…
- Conditions
- Acute Respiratory Failure, Mechanical Ventilation, Life-Supporting Treatments, Communication
- Trial name
- TIME (NCT06042621)
- Where
- 5 sites in United States
- Volunteers
- 7,818 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Mental Health Wellness 1, PTSD
Mental Health Outcomes in Healthcare Workers During COVID-19
An online survey will be sent to healthcare workers (HCWs) in acute care hospitals to explore a variety of risk factors for negative psychological outcomes and levels of anxiety, depression and post-traumatic stress symptoms…
- Conditions
- Mental Health Wellness 1, PTSD, Anxiety, Stress
- Trial name
- NCT04397848
- Where
- Canada
- Volunteers
- 3,852 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Healthy
A Physiological Study to Assess Awake Prone Positioning and Respiratory Support in Healthy Volunteers
Awake prone positioning (APP) has been proven to reduce the intubation rate for patients with COVID-19-induced hypoxemic respiratory failure.
- Trial name
- NCT05512585
- Testing
- awake prone positioning with advanced respiratory support (high-flow nasal cannula or continuous positive airway pressure)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Chronic Heart Failure, Diabetes Mellitus
Exploring Acceptance and Outcomes of an Online-based Self-management Support System in Chronic Illness
The aim of the USECARE project is to improve and test SENACA, an ICT-based self-management support system for chronically ill patients and informal caregivers. 60 end-users will be instructed to use SENACA for approx.
- Conditions
- Chronic Heart Failure, Diabetes Mellitus, Chronic Obstructive Pulmonary Disease, Special Orthopaedic Co-Morbidity After Hip/Knee Replacement
- Trial name
- USECARE (NCT02832739)
- Testing
- SENACA - ICT based self-management support system
- Where
- 2 sites in Israel, Norway
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assuta Medical Center
Pneumonia
Adaptation and Pilot Implementation of ePNa Clinical Decision Support for Utah Urgent Care Clinics
We plan to adapt an innovative, validated emergency department (ED) CDS tool based on consensus guidelines for pneumonia care (ePNa) to function in urgent care clinics (Instacares at Intermountain) and combine it seamlessly with…
- Trial name
- NCT04606849
- Testing
- Physician Survey, ePNa-CheXED
- Where
- 12 sites in United States
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Intermountain Health Care, Inc.
Stress Related Disorder
MIND-VR: Virtual Reality for COVID-19 Operators' Psychological Support
Since the COVID-19 pandemic began, several psychological support programs for health care workers have been implemented, especially group or individual counseling sessions delivered face-to-face or using phones and video…
- Trial name
- NCT04611399
- Testing
- VR for psychoeducation and relaxation, Control (CR)
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
SARS-CoV Infection, Corona Virus Infection
Microbiome Therapy in Covid-19 Primary Care Support
This double-blind, randomized, placebo-controlled study aims to investigate whether a throat spray containing probiotic bacteria (i.e.
- Trial name
- MiCel (NCT04793997)
- Testing
- Microbiome spray
- Where
- Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Nurse-led Supportive Care
Effects of Nurse-led Supportive Care Programme on Caregiver Burden and Resilience of Family Caregivers
Lung cancer is the leading cause of cancer-related deaths worldwide, with a mortality rate of 18%. The prognosis of lung cancer is progressive and devastating, which may cause patients to experience problems during the treatment…
- Trial name
- NCT06204289
- Testing
- Nurse-led Supportive Care Programme
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Izmir Bakircay University
Lung Disease
Spirometry Interpretation Performance of Primary Care Clinicians With/Without AI Software
To evaluate whether an artificial intelligence decision support software (ArtiQ.Spiro) improves the diagnostic accuracy of spirometry interpreted by primary care clinicians, as measured by Clinician Diagnostic Accuracy (vs…
- Trial name
- SPIRO-AID (NCT05933694)
- Testing
- Artificial Intelligence-powered Spirometry Interpretation Report
- Where
- United Kingdom
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Asthma
Using Computers to Assist in the Treatment of Asthma in a Pediatric Setting
This study seeks to improve physician adherence to four recommendations of the NHLBI asthma treatment guidelines: 1. Improve case detection of asthma among patients with pulmonary symptoms, 2.
- Trial name
- NCT01312805
- Testing
- CHICA Asthma Module, CHICA Control
- Where
- United States
- Volunteers
- 2,098 people, healthy volunteers welcome
- Sponsor
- Indiana University
Covid19, Intellectual Disability
Supporting the Health and Well-being of Children With Intellectual and Developmental Disability During COVID-19 Pandemic
The primary goal of this project is to identify the best messaging and implementation strategies to maximize SARS-CoV-2 testing for children with intellectual and developmental disabilities (IDD) and their teachers to help ensure…
- Conditions
- Covid19, Intellectual Disability, Developmental Disability, Child Development Disorder
- Trial name
- NCT04565509
- Testing
- Standard Messaging, Enhanced Messaging, COVID-19 Testing
- Where
- 3 sites in United States
- Volunteers
- 1,143 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Respiratory Distress Syndrome, Newborn, Respiratory Distress Syndrome in Premature Infant
Predicting the Need for Prolonged Respiratory Support in Neonates Delivered in a Lower-Level NICU Setting
The purpose of this study is to analyze the gastric fluid aspirated from the stomachs of neonates receiving routine post-delivery care to predict the need for prolonged respiratory support (>6 hours of life).
- Conditions
- Respiratory Distress Syndrome, Newborn, Respiratory Distress Syndrome in Premature Infant, Transient Tachypnea of the Newborn, Meconium Aspiration Syndrome
- Trial name
- NCT07344714
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Healthy
Inspiratory Support Improves Preoxygenation in Healthy Subjects
Preoxygenation optimizes oxygen content in the functional residual capacity (FRC). Adequate preoxygenation is defined by an expiratory oxygen fraction (FEO2) > 90%.
- Trial name
- NCT00922753
- Testing
- VS, AI-4/PEEP-4, AI-6/PEEP-4
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maisonneuve-Rosemont Hospital
Dementia, Cancer
Using Community Health Workers to Support Rural Care Partners of Seriously Ill Older Veterans
The investigators aim to support care partner's well-being and satisfaction with VA care and decrease their work burden by offering extra support from a trained Community Health Worker who will help connect the care partner to…
- Conditions
- Dementia, Cancer, Renal Disease, Obstructive Pulmonary Disease
- Trial name
- PATH (NCT06963970)
- Testing
- Remote Community Health Worker support
- Where
- United States
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Lung Cancer
Rapid Absorbance-based Detection of Inner Cheek Cell Abnormalities Using Light Spectroscopy for Risk Evaluation of Lung Cancer to Enable Critical Decision Support in Targeted Patient Populations
Overview Sierra Medical is at the forefront of early detection of lung cancer by creating AIR-DS, a non-invasive early detection test.
- Trial name
- RADICAL-REACT (NCT07051044)
- Testing
- AIR-DS
- Where
- 2 sites in United Kingdom
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Sierra Medical Ltd.
Adolescent Behavior, Sleep Disturbance
Personalized Approach To Habits - Sleep
Two arm study, intervention and control, to explore the impact of an app to help high risk teens with asthma improve their sleep
- Conditions
- Adolescent Behavior, Sleep Disturbance, Asthma in Children, Knowledge, Attitudes, Practice
- Trial name
- PATH-S (NCT07029919)
- Testing
- PATH-S app
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- KDH Research & Communication
COVID-19
Direct Income SupporT and Advice Negating Spread of Epidemic COVID-19: a Randomized Controlled Trial
This is a clinical trial of a cash transfer on symptoms consistent with COVID-19 and adherence to physical distancing guidance.
- Trial name
- DISTANSE COVID (NCT04359264)
- Testing
- Cash transfer
- Where
- 2 sites in Canada
- Volunteers
- 392 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
COVID-19, Myocarditis
Support for the Resumption of Training of High-level Athletes Post-epidemic COVID-19
As of March 2020, COVID-19 has become a global pandemic, halting athletic competition worldwide. Reports from China show a high prevalence of cardiac involvement in patients with severe SARS-CoV-2 infection.
- Trial name
- ASCCOVID19 (NCT04936503)
- Testing
- Resting electrocardiogram, Stress test, Cardiac echocardiography
- Where
- 21 sites in France
- Volunteers
- 984 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux