Clinical trials: Respiratory Tract Disease
Pleural Effusion
Continuation Of a Study to Investigate the Effect of Thoracocentesis on Neural Respiratory Drive in Pleural Effusion
The aim of this study is to better understand the relationship between pleural effusions and breathlessness in patients with unilateral pleural effusions and breathlessness who require pleural fluid removal for its management.
- Trial name
- COSINE (NCT05945043)
- Testing
- Surface parasternal eletromyogram, Surface diaphragm electromyogram, Parasternal muscle ultrasound
- Where
- United Kingdom
- Volunteers
- 124 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Obstructive Sleep Apnea Syndrome
Narval CC Mandibular Repositioning Device in the Second-line Treatment of Severe Obstructive Sleep Apnea Hypopnea (OSAH)
The purpose of this study is to evaluate the long-term efficacy, tolerance and compliance of ORM Narval Mandibular Repositioning Device (MRD) as a second-line treatment for patients with severe Obstructive Sleep Apnea Hypopnea…
- Trial name
- ORCADES (NCT01326143)
- Testing
- ORM Narval MRD
- Where
- 26 sites in France
- Volunteers
- 360 people
- Sponsor
- ResMed
Non Small Cell Lung Cancer, Pulmonary Stereotactic Radiotherapy
Stereotactic Body Radiotherapy (SBRT) for Reirradiation of Inoperable Lung Lesions
Radiotherapy (radiation treatment) is often used to treat lung cancers and lung tumors that have spread from other cancers. It can be very effective, especially in early-stage lung cancer or when there are only a few tumor sites.
- Trial name
- NCT07401615
- Where
- 11 sites in Italy
- Volunteers
- 150 people
- Sponsor
- Istituto Clinico Humanitas
Hypercapnic Respiratory Failure
Use of TpCO2 (Transcutaneous CO2 Measurement) as PaCO2 Predictor During NIV in Case of Acute Hypercapnic Respiratory Failure
In patients suffering from hypercapnic respiratory failure and treated by non invasive ventilation (NIV), the interest of using transcutaneous CO2 measurement to evaluate PaCO2 and PaCO2 variation over time is unknown and will be…
- Trial name
- TpCO2-NIV (NCT01857635)
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University of Lausanne Hospitals
COVID-19
Clinical Study in the Treatment of Patients With Moderate Course of COVID-19
Study of safety, efficacy and pharmacokinetics, dose selection
- Trial name
- NCT04842435
- Testing
- COVID-globulin
- Where
- 21 sites in Russia
- Volunteers
- 376 people
- Sponsor
- Microgen
Hemoptysis
A Clinical Study to Evaluate the Efficacy and Safety of Hemocoagulase Injection
This is a multi-centre, randomised, double blind, placebo controlled clinical study which is designed to evaluate the efficacy and safety of hemocoagulase in the treatment of moderate to severe hemoptysis.
- Trial name
- NCT03270735
- Testing
- Snake venom thrombin (Treatment)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Lee's Pharmaceutical Limited
Asthma
Study to Compare PT007 to Placebo MDI and Open-Label Proventil® HFA in Adult and Adolescent Subjects With Asthma
This is a randomized, double-blind, single-dose, placebo-controlled, 5-period, 5-treatment, crossover, multi-center study to assess the bronchodilatory effect and safety of 2 dose levels of Albuterol Sulfate Pressurized…
- Trial name
- NCT03364608
- Testing
- AS MDI 90 μg, AS MDI 180 µg, Proventil 90 μg
- Where
- 10 sites in United States
- Volunteers
- 86 people
- Sponsor
- AstraZeneca
Asthma (Diagnosis) With Forward Head Posture
Comparative Effects of Posture Correction Exercises and Papworth Technique in Asthmatic Forward Head Posture
This study aims to evaluating and contrasting the effects of posture correction and papworth technique on dyspnea, chest expansion and quality of life in asthmatic patients with forward head.
- Trial name
- NCT07573904
- Testing
- papworth teachnique, posture correction exercises
- Where
- Pakistan
- Volunteers
- 38 people
- Sponsor
- Riphah International University
HIV Infections, COPD
Prevalence and Determinants of Chronic Obstructive Pulmonary Disease (COPD) in HIV+ Patients
The prevalence of COPD in HIV+ and AIDS patients is unknown. The pathophysiology of HIV infection and COPD might be of interest to both conditions.
- Trial name
- HIV&COPD (NCT00904384)
- Where
- Spain
- Volunteers
- 350 people
- Sponsor
- Cimera
Cystic Fibrosis
Skeletal Health and Bone Marrow Composition in Adolescents With Cystic Fibrosis
The investigators will be evaluating bone marrow composition via magnetic resonance imaging in adolescents diagnosed with cystic fibrosis (CF) compared to healthy, matched controls.
- Trial name
- NCT06216704
- Testing
- Magnetic resonance relaxometry, Magnetic resonance spectroscopy, Blood Draw
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Pulmonary Disease, Chronic Obstructive, Respiratory Insufficiency
A Comparison of Three Nutritional Assessment Methods Predicting Prognosis in COPD With Respiratory Failure
This is a retrospective study of patients diagnosed with chronic obstructive pulmonary disease (COPD) with respiratory failure and admitted in West China Hospital during January 2014 to March 2016 by review of medical records.
- Trial name
- NCT02942784
- Where
- China
- Volunteers
- 750 people
- Sponsor
- West China Hospital
Lung Cancer
S0119: Combination Chemotherapy in Treating Patients With Extensive-Stage Small Cell Lung Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00030433
- Testing
- gemcitabine hydrochloride, irinotecan hydrochloride
- Where
- 102 sites in United States
- Volunteers
- 85 people
- Sponsor
- SWOG Cancer Research Network
Graft-Versus-Host Disease
Experience of Having Chronic Graft-Versus-Host Disease
Primary Objectives: 1. To explore the experience of chronic graft-versus-host disease (cGVHD) following allogeneic blood or marrow transplantation from the perspective of the patient and the patient's primary family caregiver. 2.
- Trial name
- NCT00353106
- Testing
- Interview, Questionnaire
- Where
- 2 sites in United States
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Non Small Cell Lung Cancer
Pembrolizumab and Itacitinib (INCB039110) for Non-Small Cell Lung Cancer
This is a single center, single arm phase 2 study to establish the safety and efficacy of itacitinib (also known as INCB039110) administered in combination with pembrolizumab in patients with metastatic PD-L1 positive non-small…
- Trial name
- NCT03425006
- Testing
- Itacitinib, Pembrolizumab
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Pennsylvania
Ventilator-Induced Lung Injury
Pressure Support Ventilation During Laparoscopic and Abdominal Robotic Surgery.
This study is a single-center, blind, prospective, randomized, controlled trial of pressure support ventilation (PSVpro) versus pressure control ventilation - volume guaranteed (PCV - VG) during laparoscopic and robotic abdominal…
- Trial name
- NCT04815733
- Testing
- Mandatory ventilation, pressure support ventilation
- Where
- Russia
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Moscow Clinical Scientific Center
Hematologic Disease
Early Application of CPAP in Hematologic
The purpose of this study is to evaluate the use of CPAP in the prevention of acute respiratory failure in neutropenic ( or hematologic malignancy ) patients .CPAP applied preventively in hematological patients with high risk of…
- Trial name
- HEMOCPAP (NCT00507533)
- Testing
- Continuous positive airway pressure
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Turin, Italy
Non-Small Cell Lung Cancer
A Multinational, Randomized, Open-Label Study of Custirsen In Patients With Advanced or Metastatic (Stage IV) Non-Small Cell Lung Cancer
The primary objective of the study is to compare overall survival of participants randomized to receiving custirsen in combination with docetaxel with participants randomized to receive docetaxel alone.
- Trial name
- ENSPIRIT (NCT01630733)
- Testing
- Custirsen, Docetaxel
- Where
- 78 sites in United States, Australia and 12 more
- Volunteers
- 664 people
- Sponsor
- Achieve Life Sciences
HER2-expressing Cancers
A Dose Finding Study of ZW49 in Patients With HER2-Positive Cancers
This is a first-in-human, Phase 1, multicenter, open-label, dose-escalation study to establish the maximum-tolerated dose (MTD) or recommended dosage (RD) of ZW49, the investigational agent under study, and to assess the safety…
- Trial name
- NCT03821233
- Testing
- ZW49
- Where
- 16 sites in United States, Australia and 2 more
- Volunteers
- 112 people
- Sponsor
- Zymeworks BC Inc.
Myocardial Disease
Cardiovascular Events for a Long Time End of COVID 19 Infection
In the follow-up of partecipants with Covid-19 infection, persistence of cardiovascular symptoms is common. Studies on the acute phase of Covid-19 infection have demonstrated a significant prevalence of acute myocardial damage…
- Trial name
- LONGCOVIDWP3 (NCT05729152)
- Testing
- Sample blood
- Where
- 2 sites in Italy
- Volunteers
- 240 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Respiratory Distress Syndrome, Newborn, Premature Birth
Prophylactic Minimally Invasive Surfactant Evaluation
The purpose of this study is to explore the question: Does prophylactic administration of exogenous surfactant in the delivery room, using a minimally-invasive technique, improve outcome in preterm infants 22-29 weeks' gestation…
- Trial name
- PreProMISe (NCT06007547)
- Testing
- Poractant Alfa
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.