Clinical trials: Respiratory Tract Infection
Influenza
Single-blind, Dose-ranging Study of Novel Swine Influenza Virus Vaccine in Japanese Adult Subjects
This study is to identify the preferred vaccine dosage (of antigen and adjuvant) and schedule (one or two administrations) of the cell-derived H1N1sw monovalent vaccine in healthy adults based on EMEA/CHMP criteria, and safety \&…
- Trial name
- NCT00996138
- Testing
- Adjuvanted cell-derived, inactivated novel swine origin A/H1N1 monovalent subunit influenza virus vaccine
- Where
- Japan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Novartis Vaccines
Covid19, Olfactory Dysfunction
Dysfunction of Olfaction After COVID-19 Infection: Morphological and Histomolecular Investigation
Investigation of the mechanisms of persistent SARS-CoV-2 associated olfactory dysfunction (OD) in patients with well-documented olfactory function.
- Trial name
- DysOSMIC (NCT06482138)
- Testing
- Biopsy and Cytobrush
- Where
- 7 sites in Belgium, Germany and 1 more
- Volunteers
- 240 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Absenteeism, Diarrhea
Evaluation of the Dubai Cares WASH in School Initiative
This study will use longitudinal data collection to quantify the impact of a school-based water, sanitation and hygiene (WASH) program in Mali, West Africa, on pupil absenteeism, diarrheal illness, and respiratory illness.
- Conditions
- Absenteeism, Diarrhea, Respiratory Tract Infections
- Trial name
- NCT01787058
- Testing
- Dubai Cares beneficiary
- Where
- Mali
- Volunteers
- 10,308 people, healthy volunteers welcome
- Sponsor
- Emory University
Common Cold
Acetylsalicylic Acid Combined With Pseudoephedrine in Common Cold
The purpose of the study is to determine the effectiveness of an acetylsalicylic acid (aspirin) pseudoephedrine combination for the treatment of pain and congestion symptoms compared to the effectiveness of the individual…
- Trial name
- NCT00963443
- Testing
- Acetylsalicylic Acid (Aspirin, BAYE4465), Pseudoephedrine
- Where
- United Kingdom
- Volunteers
- 833 people
- Sponsor
- Bayer
Hyperthermia
Cold Water Immersion Stirring in Hyperthermic Individuals
The best way to cool a very hot person is using cold water immersion, however, the optimization of this technique has not been established.
- Trial name
- NCT04613843
- Testing
- Water Stirring, No Water Stirring
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
COPD (Chronic Obstructive Pulmonary Disease), Rhinovirus Infection
Using Multiomics to Define Mechanisms of Rhinovirus-induced Chronic Obstructive Pulmonary Disease Exacerbations to Develop Novel Therapies and Therapeutic Targets
The goal of this study is to examine exacerbations of chronic obstructive pulmonary disease (COPD) caused by a common cold virus called rhinovirus, to identify new treatments.
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), Rhinovirus Infection, Exacerbation of COPD
- Trial name
- MRVCOPD (NCT07112235)
- Testing
- Rhinovirus-A16
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Upper Resp Tract Infection
Prospective Clinical Evaluation of the FilmArray Respiratory Panel 2
This is a performance study to test the sensitivity and specificity of the BioFire FilmArray Respiratory Panel (RP) 2. The purpose of this study is to prospectively collect and test residual NPS specimens and generate performance…
- Trial name
- RP2 (NCT03012217)
- Testing
- Observational Study
- Where
- 3 sites in United States
- Volunteers
- 1,612 people
- Sponsor
- BioFire Diagnostics, LLC
Bronchiolitis, Viral
Glucocorticoid Therapy Impact on the Inflammatory Response and Clinical Evolution in Patients With Severe Bronchiolitis
The purpose of this study is to to demonstrate that a 7-day course of systemic glucocorticoids decreases the inflammatory activity of moderate or severe bronchiolitis in paediatric patients compared to the standard treatment.
- Trial name
- NCT02571517
- Testing
- Glucocorticoids
- Volunteers
- 94 people
- Sponsor
- Fundació Sant Joan de Déu
Influenza, Human
A Study to Evaluate the Efficacy and Safety of ZX-7101A Tablets in Adults with Uncomplicated Influenza
The goal of this clinical trial is to compare ZX-7101A in Chinese Adults patients with uncomplicated influenza. The main questions it aims to answer are: The efficacy of ZX-7101A in Chinese Adults patients with uncomplicated…
- Trial name
- NCT05702489
- Testing
- ZX-7101A
- Where
- China
- Volunteers
- 900 people
- Sponsor
- Nanjing Zenshine Pharmaceuticals
Sepsis
Efficacy & Safety of Resatorvid in Adults With Severe Sepsis
The purpose of this study is to determine the optimal dose of Resatorvid for reducing 28-day all-cause mortality in subjects with severe sepsis.
- Trial name
- NCT00143611
- Testing
- Resatorvid
- Where
- 144 sites in United States, Australia and 15 more
- Volunteers
- 277 people
- Sponsor
- Takeda
Sinusitis
Xolair in Patients With Chronic Sinusitis
The purpose of this study is to determine if treatment with the anti-IgE antibody, Xolair (omalizumab), will improve objective and subjective evidence of chronic sinusitis.
- Trial name
- NCT00117611
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Chicago
House Dust Mite Allergy, House Dust Mite Rhinitis
A Randomized, Double-Blind, Placebo-Controlled, Multi-Centre Study to Assess the Efficacy of PURETHAL Mites Mixture 50,000 AUeq/mL Subcutaneous Immunotherapy in Adult Subjects With Moderate to Severe Allergic Rhinitis/Rhinoconjunctivitis With or Without Asthma Induced by House Dust Mite (HDM)
Rationale: Allergic rhinitis/rhinoconjunctivitis (ARC) is a global health problem, affecting 10-25% of the population. Allergen-specific immunotherapy is the only disease-modifying therapeutic option for subjects with house dust…
- Trial name
- NCT06920771
- Testing
- PURETHAL Mites 50,000 AUeq/ml
- Where
- 68 sites in Bulgaria, Germany and 3 more
- Volunteers
- 691 people
- Sponsor
- HAL Allergy
COVID19
Efficacy and Safety Study of Nangibotide in Patients With COVID-19 Receiving Ventilatory Support
This is a randomized, double-blind, placebo-controlled, in which one dose of nangibotide will be tested versus placebo. All patients with a diagnosis of COVID-19, and a requirement for respiratory support will be considered for…
- Trial name
- ESSENTIAL (NCT04429334)
- Testing
- nangibotide
- Where
- 17 sites in Belgium, France
- Volunteers
- 220 people
- Sponsor
- Inotrem
COVID-19
A Study to Learn About Bivalent COVID-19 RNA Vaccine Candidate(s) in Healthy Infants and Children
The purpose of this clinical trial is to learn about the safety and immune responses of the study vaccine (called a bivalent BNT162b2 Omicron containing vaccine) in healthy infants and children.
- Trial name
- NCT05630352
- Testing
- Bivalent BNT162b2 (original/Omicron BA.4/BA.5) 3 microgram dose, Bivalent BNT162b2 (original/Omicron BA.4/BA.5) 6 microgram dose, Bivalent BNT162b2 (original/Omicron BA.4/BA.5) 10 microgram dose
- Volunteers
- healthy volunteers welcome
- Sponsor
- BioNTech SE
COVID-19
Open Multicentre Study of the Safety and Efficacy Against COVID-19 of Nirmatrelvir/Ritonavir in the Adult Population
This is open-labe randomized multicenter comparative Phase III study conducted in 11 medical facilities. The objective of the study is to evaluate efficacy and safety of the drug JTBC00201, tablets in the setting of pathogenetic…
- Trial name
- NCT05601167
- Testing
- nirmatrelvir/ritonavir, Standard of care
- Where
- 11 sites in Russia
- Volunteers
- 264 people
- Sponsor
- Promomed, LLC
Hypoxemia, Pneumonia, Viral
Nitric Oxide Therapy for COVID-19 Patients With Oxygen Requirement
Preliminary data support the effect of Nitric Oxide (NO) on improving the oxygenation in mechanically ventilated patients and spontaneously breathing patients with COVID-19.
- Conditions
- Hypoxemia, Pneumonia, Viral, Coronavirus Infection
- Trial name
- NICOR (NCT04476992)
- Testing
- Nitric Oxide-Sessions, Nitric Oxide-Continuous and Sessions
- Where
- Russia
- Volunteers
- 20 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Influenza
Evaluation of the Alere i Influenza A&B Nucleic Acid Amplification Versus Xpert Flu/RSV
The rapid and accurate detection of influenza virus in respiratory specimens is required for optimal management of patients with acute respiratory infections.
- Trial name
- NCT02846311
- Testing
- Flu Test
- Where
- France
- Volunteers
- 92 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Influenza
Influenza Vaccine in Lung Transplant Patients - Persistence of Antibodies
This a sub-study of a 5-year study designed to investigate how antibody and T cell responses following influenza vaccine compare among lung transplant patients, patients waiting for lung transplantation, and healthy individuals.
- Trial name
- NCT04531787
- Testing
- Influenza vaccine
- Where
- United States
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Covid-19
Characterization in 18F-FDG PET-CT of Brain and Lung Lesions in Subjects With a History of Severe COVID-19
Patients with Covid-19 (Coronavirus disease 19) may experience multiple neurological symptoms . 18F-FDG PET-CT ( Positons EmissionTomography coupled with a Computer Tomography with flurodesoxyglucose labelled with fluor 18)…
- Trial name
- TEP-COV (NCT04764721)
- Testing
- 18F-FDG PET-CT
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Central Hospital, Nancy, France
COVID-19 Acute Respiratory Distress Syndrome, Extracorporeal Membrane Oxygenation Complication
Quality of Life 1y and 2 y After VV-ECMO for COVID-19
This study aims to investigate the quality of life and the outcome after veno-venous extracoporeal membrane oxygenation (ECMO) support fir severe acute respiratory syndrome (ARDS) in COVID-19 patients.
- Conditions
- COVID-19 Acute Respiratory Distress Syndrome, Extracorporeal Membrane Oxygenation Complication, Quality of Life, Death
- Trial name
- NCT05780255
- Testing
- VV-ECMO
- Where
- Belgium
- Volunteers
- 28 people
- Sponsor
- University Hospital, Ghent