Clinical trials: Restoration
Caries Class II
Evaluation of Performance and Occlusal Wear of Low Shrinkage Giomer Compared to Nanohybrid Resin Composite
A clinical trial, comparing the clinical performance and occlusal wear resistance of two different restorative materials in restoring proximal caries in permanent posterior teeth.
- Trial name
- NCT05949502
- Testing
- Beautifil II LS (Low-Shrinkage), 3M Filtek Z250 XT Universal
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Cairo University
Sensory Restoration of the Reconstructed Finger Pulps, Cold Intolerance of the Reconstructed Finger
Nerve Transfer for Finger Sensory Reconstruction With Dorsal Branch of the Digital Nerve
A proper digital nerve (PDN) defect causes partial or complete sensory loss of the finger pulp, which results in functional disability.The dorsal branch of the PDN can be transferred for reconstruction of such nerve defects.In…
- Conditions
- Sensory Restoration of the Reconstructed Finger Pulps, Cold Intolerance of the Reconstructed Finger, Pain of the Reconstructed Finger
- Trial name
- NCT01559337
- Testing
- Nerve transfer
- Where
- China
- Volunteers
- 17 people
- Sponsor
- The Second Hospital of Tangshan
Endodontically Treated Molar, Dental Restoration, Permanent
3D Printed Ceramic-Filled Photopolymer Resin Vs. CAD/CAM Resin Composite Overlays for Restoration of Extensively Damaged Endodontically Treated Posterior Teeth. An 18-month Follow-up
II. Introduction: 6. Background and rationale: Restoring badly mutilated teeth was and has always been a challenge in restorative dentistry.
- Trial name
- 3D CAD/CAM RCT (NCT07378982)
- Testing
- 3D printed overlay restorations, CAD/CAM restorations
- Where
- Egypt
- Volunteers
- 32 people
- Sponsor
- Cairo University
Tryptophan Metabolism Alterations, Celiac Disease
Tryptophan for Impaired AhR Signaling in Celiac Disease
This is a prospective, randomized, double-blind, placebo-controlled exploratory trial to evaluate the effect of L-tryptophan supplementation on celiac-related symptoms in individuals who have biopsy-confirmed celiac disease (CeD)…
- Trial name
- TIARSCeD (NCT05576038)
- Testing
- L-Tryptophan, Freedom SimpleCap Powder
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- McMaster University
Age-Related Macular Degeneration, Retinitis Pigmentosa
Non-invasive Ultrasound Retinal Stimulation for Vision Restoration
This clinical trial aims to test the safety and feasibility of using a non-invasive ultrasound device to stimulate retinal nerve cells and restore vision in patients with age-related macular degeneration.
- Conditions
- Age-Related Macular Degeneration, Retinitis Pigmentosa, Ultrasound Therapy; Complications
- Trial name
- NCT05914233
- Testing
- Non-invasive ultrasound retinal stimulation Device
- Volunteers
- 5 people
- Sponsor
- University of Southern California
Junctional Epidermolysis Bullosa
Gentamicin for Junctional Epidermolysis Bullosa
Herlitz junctional epidermolysis bullosa (H-JEB), an incurable, fatal, inherited skin disease, is caused by loss-of-function mutations in the LAMA3, LAMB3 or LAMC2 genes, resulting in loss of laminin 332 and poor epidermal-dermal…
- Trial name
- NCT03526159
- Testing
- Gentamicin Sulfate
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Southern California
Hearing Loss, Sensorineural
Efficacy and Safety of AC102 Compared to Steroids in Adults With Idiopathic Sudden Sensorineural Hearing Loss (ISSNHL)
The purpose of this Phase 2 clinical trial is to evaluate the safety, tolerability and efficacy of AC102 administered as single intratympanic injection compared to oral steroid treatment in patients with Idiopathic Sudden…
- Trial name
- NCT05776459
- Testing
- AC102 gel, Prednisolone
- Where
- 39 sites in Austria, Czechia and 4 more
- Volunteers
- 210 people
- Sponsor
- AudioCure Pharma GmbH
Furcation Defects
Restorations and Furcation Involvement on Molars
The aim of this study will be to analyze the relationship between the presence of second class restorations (interproximal fillings) or prostheses (crowns, bridges) on molar teeth and the presence of bone resorption between the…
- Trial name
- NCT05481580
- Testing
- Periodontal probing
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Cagliari
Fractured Tooth
Comparison of Surgical Extrusion vs. Fibre Post Restoration for Crown-root Fractured Maxillary Incisors.
A total of 124 samples was calculated to be sufficient with G*power software ver 3.1.9.2 with effect size of 0.4 alpha probability error and power 0.95.With drop out estimate of 10% the final sample size decided was 140 samples.
- Trial name
- NCT04685161
- Testing
- Surgical extrusion, Fibre post
- Where
- India
- Volunteers
- 140 people
- Sponsor
- Tamil Nadu Dr.M.G.R.Medical University
Dental Caries in Children
Efficacy of a Chemically Activated Composite Resin Alkasite in Atypical Caries Lesions of Deciduous Teeth
Atypical cavities, which involve more than two surfaces being one of them vestibular or lingual/palatine, are a challenge for restorative dentistry, since the risk of failure of the restorations are related to the number of…
- Trial name
- NCT04195386
- Testing
- Dental Restoration with Chemically activated Composite resin Alkasite, Dental Restoration with Resin-Modified Glass ionomer Cement
- Where
- Brazil
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Faculty Sao Leopoldo Mandic Campinas
Implant Dentistry
The Use of a Fully Digital Workflow in Immediate Implants With Immediate Restoration
Study hypothesis The hypothesis is that a full-digital workflow for immediate implant placement with immediate restoration is able to provide at least the same outcomes as standard analog implant placement in the same clinical…
- Trial name
- NCT07294820
- Testing
- oral implant
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Proed, Torino, Italy
Stress
Automated Stress Detection and Restoration in Office Workers
This study aims at establishing a laboratory experiment that mimics office work stressors, examining the feasibility of automated stress detection, and identifying the most significant physiological and/or behavioral features…
- Trial name
- NCT05242523
- Testing
- Bergamot scent, Natural wood scent
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Bracket Bonding, Orthodontic Treatment
A Split-Mouth Clinical Trial Evaluating the Bond Failure Rate of a New Etch-Free Orthodontic Adhesive
This randomized, split-mouth clinical trial will evaluate a new orthodontic adhesive that eliminates the need for acid etching before bracket bonding.
- Conditions
- Bracket Bonding, Orthodontic Treatment, Dental Adhesives/Restorations Performance, White Spot Lesion of Tooth
- Trial name
- NCT07091422
- Testing
- Etch-Free Adhesive, Conventional Etch-and-Bond Adhesive
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Coxarthrosis
Comparison of the Restoration of Hip Biomechanical Parameters by CT Measurement Between the 3 Surgical Techniques: RSA/Minihip/THA - Hip Replacement: 3D Planning
The study will analyze hip biomechanical parameters using EOS radiographic measurements pre- and post-operatively (3 months) and post-operatively (3 months) CT scans after total hip replacement (THR), neck-preserving THR of the…
- Trial name
- HIP3D (NCT06272422)
- Testing
- hip arthroplasty
- Where
- France
- Volunteers
- 165 people
- Sponsor
- University Hospital, Lille
Basilar Invagination Associated With Atlantoaxial Dislocation
Posterior Compression Distraction Reduction Technique System in the Treatment of BI-AAD
Posterior compression distraction reduction technique （PCDR） in the treatment of Basilar invagination associated with atlantoaxial dislocation
- Trial name
- PCDR-BIAAD (NCT03070743)
- Testing
- Posterior Approach Compression Distraction Reduction Surgery
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Xuanwu Hospital, Beijing
Biomechanical Phenomena, Partial Edentulism
Intraoral vs Extraoral Cementation of Zirconia Bridges on Ti-Bases: Microstrain Evaluation
This prospective clinical study compares two cementation techniques for implant-supported zirconia fixed partial dentures on titanium bases (Ti-bases): extraoral cementation performed on the working model and intraoral…
- Trial name
- NCT07448701
- Testing
- Extraoral cementation on Ti-bases, Intraoral cementation on Ti-bases
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Universitat Internacional de Catalunya
Dental Restoration Failure of Marginal Integrity
Different Application Strategies When Using Futurabond Universal in Class V Cavities
Treatment clinical trial, randomized, controled, parallel, double-blinded, with four groups, that aims to evaluate the best application strategy when using a new Universal Adhesive system, Futurabond Universal (VOCO GmbH…
- Trial name
- FUUC (NCT03244124)
- Testing
- Self-Etching Application Strategy, Enamel Etching Application Strategy, Etch&Rinse Dry Application Strategy
- Where
- 2 sites in Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidade Federal Fluminense
Mid-face Volume Deficit
Efficacy and Safety of Rejuviel V in the Correction of Midface Volume Deficit
The purpose is to evaluate the efficacy and confirm the safety of Rejeunesse Contour® with Lidocaine compared to Juvederm® Voluma® with Lidocaine for the temporary improvement of mid-face volume (including the cheekbone area, the…
- Trial name
- NCT07162610
- Testing
- Rejuviel V® with lidocaine, JUVEDERM® VOLUMA® with lidocaine
- Where
- South Korea
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- PharmaResearch Co.,Ltd
Ischemic Stroke
Safety and Preliminary Efficacy Study of SA4503 in Subjects Recovering From Ischemic Stroke
The purpose of this study is to evaluate the safety and tolerability of SA4503 in patients recovering from a recent stroke. Secondary, to evaluate the efficacy of SA4503 compared to placebo.
- Trial name
- NCT00639249
- Testing
- SA4503 Low, SA4503 High
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- M's Science Corporation
Chronic Musculoskeletal Pain
Functional and Occupational Rehabilitation of Troops
The proposed implementation science project will evaluate the factors that support or hinder the successful implementation of the FORT Functional Restoration Program at six Military Treatment Facilities (MTF) across the Military…
- Trial name
- FORT (NCT06898866)
- Volunteers
- 480 people
- Sponsor
- The University of Texas Health Science Center at San Antonio