Clinical trials: Retinal Artery Occlusion
Carotid Stenosis
Chorioretinal Vascularization and Electrophysiological Changes After Carotid Revascularization
The aim of the study is to evaluate changes in retinal function by means of electro-functional examinations of the retina and to associate them with any changes in chorioretinal vascular density occurring in the ipsilateral eye…
- Trial name
- CAS-AOCT (NCT05835869)
- Testing
- Optical coherence tomography angiography and pattern electroretinogram
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Dementia, Neurodegenerative Diseases
Retinal Hyperspectral Imaging in Neurodegenerative Diseases
Hyperspectral retinal imaging is a non-invasive imaging modality in which a series of images of the retina are captured using light of different wavelengths.
- Conditions
- Dementia, Neurodegenerative Diseases, Alzheimer Disease, Parkinson Disease
- Trial name
- NCT07545473
- Testing
- Hyperspectral camera
- Where
- Australia
- Volunteers
- 930 people, healthy volunteers welcome
- Sponsor
- Center for Eye Research Australia
Retinal Artery Occlusion, Fibrinolysis
EAGLE - Multicenter Study of the European Assessment Group for Lysis in the Eye
The aim of the EAGLE Study is to compare the efficacy of conservative medical treatment and local intraarterial fibrinolysis in patients with central retinal artery occlusion and to evaluate benefit and risk for the patient of…
- Conditions
- Retinal Artery Occlusion, Fibrinolysis, Visual Acuity, Stroke
- Trial name
- EAGLE (NCT00637468)
- Testing
- Intravenous injection of heparin, Intravenous injection of acetazolamide, Local intra-arterial fibrinolysis
- Where
- 21 sites in Austria, Germany and 1 more
- Volunteers
- 84 people
- Sponsor
- University Hospital Freiburg
Glaucoma, Glaucoma Suspect
Philadelphia Telemedicine Glaucoma Detection and Follow-Up Study
The goal is to conduct a 5-year prospective, randomized controlled trial to test an innovative, community-based intervention using posterior and anterior fundus photography of the optic nerve and macula and intraocular eye…
- Conditions
- Glaucoma, Glaucoma Suspect, Diabetic Retinopathy, Ocular Hypertension
- Trial name
- NCT02390245
- Testing
- Free Eye Screenings, Enhanced Intervention, Usual Care
- Where
- United States
- Volunteers
- 906 people, healthy volunteers welcome
- Sponsor
- Wills Eye
Central Retinal Artery Occlusion
A Phase III Randomized, Blind, Double Dummy, Multicenter Study Assessing the Efficacy and Safety of IV THrombolysis (Alteplase) in Patients With acutE Central retInal Artery Occlusion
The aim of the THEIA study is to determine if Alteplase administrated within 4.5 hours improve visual deficit due to acute CRAO with a good safety profile.
- Trial name
- THEIA (NCT03197194)
- Testing
- Alteplase, acetylsalicylic acid
- Where
- 17 sites in France
- Volunteers
- 70 people
- Sponsor
- Nantes University Hospital
Age-related Macular Degeneration, Diabetic Retinopathy
Comparison of Phase-variance Optical Coherence Tomography and Fluorescein Angiography in Retinovascular Imaging
The purpose of this study is to determine whether phase variance optical coherence tomography (PV-OCT), a software-based optical coherence tomography(OCT) image processing technology, can be used to generate angiographic images…
- Conditions
- Age-related Macular Degeneration, Diabetic Retinopathy, Hypertensive Retinopathy, Retinal Vein Occlusion
- Trial name
- PVOCT (NCT01717937)
- Testing
- Phase variance optical coherence tomography (PV-OCT)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of California, San Francisco
Age-related Macular Degeneration, Coronary Artery Disease
Ranibizumab and the Risk of Arterial Thromboembolic Events
The investigators assume that ranibizumab might be dangerous in patients with history of coronary artery disease or cerebrovascular events.
- Conditions
- Age-related Macular Degeneration, Coronary Artery Disease, Cerebrovascular Disorders
- Trial name
- RATE (NCT01319188)
- Testing
- 0.5 mg of ranibizumab, 0.5 mg of ranibizumab + photodynamic therapy
- Where
- 2 sites in Netherlands, Russia
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Ural State Medical University
Retinal Artery Occlusion
The Effect of A2A Adrenoceptor Stimulation on the Diameter of Retinal Arterioles During Hypoxia in Vivo
The purpose is to investigate how the adenosine affects the diameter regulation of retinal arterioles during changes in oxygen tension.
- Trial name
- NCT03090087
- Testing
- Hypoxia, Regadenoson
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Branch Retinal Artery Occlusion, Central Retinal Artery Occlusion
Retinal Oxygen Saturation, Blood Flow, Vascular Function and High Resolution Morphometric Imaging in the Living Human Eye
Canadians fear loss of vision more than any other disability. Vision loss has an enormous impact on quality-of-life and is extremely costly from a societal and economic perspective.
- Conditions
- Branch Retinal Artery Occlusion, Central Retinal Artery Occlusion, Branch Retinal Vein Occlusion, Central Retinal Vein Occlusion
- Trial name
- NCT01348633
- Where
- Canada
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Choroid Disease, Carotid Stenosis
Ophthalmologic Outcomes in Patients With Carotid Artery Stenosis
The retinal vessels have been shown to reflect vascular changes inherent to systemic pathologies, even when no ocular disease is identified.
- Conditions
- Choroid Disease, Carotid Stenosis, Carotid Atherosclerosis, Retinal Disease
- Trial name
- NCT05623293
- Testing
- eye - Optcial coherence tomography
- Where
- Portugal
- Volunteers
- 40 people
- Sponsor
- Universidade do Porto
Retinal Artery Occlusion
Reconstruction of Pathological Changes of the Ophthalmic Artery in Patients With Retinal Artery Occlusion
Retinal artery occlusions (RAO) cause deterioration in visual acuity and visual fields. In computational fluid dynamics (CFD) studies [1] 10% of ascending emboli caused RAO, the residual 90% embolized into the cerebral arteries.
- Trial name
- NCT02679716
- Testing
- MRI of the cerebral arteries
- Where
- 2 sites in Austria
- Volunteers
- 30 people
- Sponsor
- Vienna Institute for Research in Ocular Surgery
Coronary Artery Disease
Optina Eye to Heart Connection
This is a prospective cross-sectional, single-center retinal imaging study expecting to enroll approximately 400 male and female subjects ≥ 18 years of age.
- Trial name
- NCT05199428
- Where
- Canada
- Volunteers
- 308 people
- Sponsor
- Optina Diagnostics Inc.
Central Retinal Artery Occlusion
Early Reperfusion Therapy With Intravenous Thrombolysis for Recovery of VISION in Acute Central Retinal Artery Occlusion
Non-arteritic, thromboembolic central retinal artery occlusion (CRAO) is an acute neurovascular-ophthalmological emergency which leads to severe and permanent vision loss; no evidence-based therapy does exist.
- Trial name
- REVISION (NCT04965038)
- Testing
- Tenecteplase (until trial protocol V04: Alteplase)
- Where
- Germany
- Volunteers
- 127 people
- Sponsor
- University Hospital Tuebingen
Central Retinal Vein Occlusion
Spontaneous Retinal Artery Pulses (SPARs) as a Prognostic Determinant of Central Retinal Vein Occlusions (CRVO) in Patients With or Without Intravitreal Aflibercept Injections
Central retinal vein occlusion (CRVO) is the second most common retinal vascular disease after diabetic retinopathy. It induces circulatory slowdown and blood stasis, which can appear as retinal hemorrhages.
- Trial name
- PULSOV (NCT04793100)
- Testing
- Ophthalmologic exam at inclusion and 12 months after CRVO, Treatment standardization with aflibercept
- Where
- 3 sites in France
- Volunteers
- 60 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
SUSAC's Syndrome, Encephalopathy
Epidemiological, Clinical and Etiological Features of SUSAC's Syndrome
SUSAC's Syndrome (SS) is characterized by the clinical triad of encephalopathy, hearing loss, and retinal artery branch occlusions.
- Conditions
- SUSAC's Syndrome, Encephalopathy, Hearing Loss, Retinal Artery Branch Occlusions
- Trial name
- CARESS (NCT01481662)
- Testing
- Diffusion tensor magnetic resonance imaging of the brain
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiovascular Disease, Obesity
Exercise, Arterial Cross-Talk Modulation and Inflammation in an Ageing Population
The aims of the study are twofold. In the cross-sectional approach (Part I), the study will be conducted in an older population to assess the association of physical fitness on different parts of the human vascular bed.
- Conditions
- Cardiovascular Disease, Obesity, Atherosclerosis, Heart; Disease, Activity
- Trial name
- ExAMIN AGE (NCT02796976)
- Testing
- Training or control condition
- Where
- Switzerland
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- University of Basel
Retinal Vascular Occlusion
Obstructive Sleep Apnea, Retinal Vein Occlusion, Retinal Artery Occlusion
Obstructive sleep apnea is a common disorder linked to serious long-term adverse health consequences; such as hypertension, metabolic dysfunction, cardiovascular disease.
- Trial name
- NCT01291862
- Testing
- Watchpat 100
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Yonsei University
Glaucoma, New Onset Glaucoma
Lucentis for New Onset Neovascular Glaucoma
Neovascular glaucoma is a potentially debilitating disease of the eye. Vascular eye disease such as diabetes and vein occlusions can cause the retina to release factors that promote the growth of abnormal blood vessels.
- Conditions
- Glaucoma, New Onset Glaucoma, Neovascular Glaucoma, New Onset Neovascular Glaucoma
- Trial name
- NVG (NCT00727038)
- Testing
- Ranibizumab (Lucentis)
- Sponsor
- University of Illinois at Chicago
Air or Gas Embolism, Carbon Monoxide Poisoning
Hyperbaric Oxygen Therapy Registry
The purpose of the Hyperbaric Oxygen Therapy Registry (HBOTR) is to provide real world patient outcome and side effect information from electronic health records submitted to a specialty specific hyperbaric registry as part of…
- Conditions
- Air or Gas Embolism, Carbon Monoxide Poisoning, Clostridial Myositis and Myonecrosis (Gas Gangrene), Crush Injury, Compartment Syndrome & Other Acute Traumatic Ischemias
- Trial name
- HBOTR (NCT02483650)
- Volunteers
- 5,000 people
- Sponsor
- U.S. Wound Registry
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
CoRDS, or the Coordination of Rare Diseases at Sanford, is based at Sanford Research in Sioux Falls, South Dakota. It provides researchers with a centralized, international patient registry for all rare diseases.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- 2 sites in United States, Australia
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health